Identification of a series of pyrrolo-pyrimidine-based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication by Jessica J. Pfannenstiel, Men Thi Hoai Duong, Daniel Cluff, Lavinia M. Sherrill, Iain Colquhoun, Gabrielle Cadoux, Devyn Thorne, Johan Pääkkönen, Nathaniel F. Schemmel, Joseph O’Connor, Pradtahna Saenjamsai, Mei Feng, Srivatsan Parthasarathy, Michael J. Hageman, David K. Johnson, Anuradha Roy, Lari Lehtiö, Dana V. Ferraris, Anthony R. Fehr

“…Recombinant virus with these mutations had enhanced replication compared with the WT virus when treated with 5a, demonstrating the specificity of these compounds during infection. …”
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The Trend of Residential-Livelihood Changes in Nomadic Ecosystems with Environmental Sustainability Approach (Case Study: Farsimadan Tribe Ecosystem, Fars Province) by Siamak Tahmasbi, Seyed Ali Badri, Mohammad Reza Rezvani

“…In this change, a lot of structures and functions of nomadism have changed. In the past, livestock was impartible components of nomadic life having the value and dignity among nomads and well- known people who had more livestock in the tribe. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…To explore the mechanism of action of transcranial magnetic stimulation through effective and functional connectivity, and gamma-aminobutyric acid and glutamate+glutamine in the prefrontal cortex, subgenual anterior cingulate cortex and right anterior insula. …”
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Genetic risk-dependent brain markers of resilience to childhood Trauma by Han Lu, Edmund T. Rolls, Hanjia Liu, Dan J. Stein, Barbara J. Sahakian, Rebecca Elliott, Tianye Jia, Chao Xie, Shitong Xiang, Nan Wang, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Luise Poustka, Sarah Hohmann, Nathalie Holz, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Jianfeng Feng, Qiang Luo, IMAGEN Consortium

“…By analyzing brain responses to angry faces in a large-scale longitudinal adolescent cohort (IMAGEN), we identified two functional networks located in the orbitofrontal and occipital regions. …”
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Selection and evaluation of reference genes for expression analysis using quantitative real-time PCR in the Asian Ladybird Harmonia axyridis (Coleoptera: Coccinellidae). by Cheng Qu, Ran Wang, Wunan Che, Xun Zhu, Fengqi Li, Chen Luo

“…Genes encoding ribosomal proteins typically had the most stable expression, though EF1A was the most stable across developmental stages and photoperiods. …”
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Patients with chronic hepatitis B under nucleos(t)ide analog therapy with Omicron BA.5 infection: A retrospective study in South China by Peipei Wang, Junjian Chen, Dabiao Chen, Ziying Lei, Zhishuo Mo, Ying Zhang

“…Patients with CHB treated with TFV had significantly higher levels of SARS-CoV-2 antibodies than those treated with ETV (1065.1 (346.9–1188.5) COI vs. 765.5 (24.5–1119.1) COI, P = 0.025). …”
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Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial by Sergio España-Cueto, Cora Loste, Gemma Lladós, Cristina López, José Ramón Santos, Gemma Dulsat, Anna García, João Carmezim, Julia Carabia, Águeda Ancochea, Carla Fernández-Prendres, Cristian Morales-Indiano, Bibiana Quirant, Eva Martínez-Cáceres, Anna Sanchez, Ivonne Graciela Parraga, Anna Chamorro, Alba San José, Elena Abad, Jose A. Muñoz-Moreno, Anna Prats, Carmina R. Fumaz, Roser Coll-Fernández, Carla Estany, Pamela Torrano, Jordi Puig, Bonaventura Clotet, Cristian Tebé, Marta Massanella, Roger Paredes, Lourdes Mateu

“…Both study arms had a similarly favorable safety profile. There were no diferences between groups in any of the efficacy parameters evaluated. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…In the 12 months after fracture, patients are at increased risk of cognitive and functional decline, admission to long-term care institutions and higher mortality. …”
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Identifying and Validating Indicators of Ritualism in the Iranian Higher Education System: A Mixed-Methods Study by Seyed Hedayat Davarpanah, Reza Hoveida, Mostafa Bagherian Far

“…Neglecting its indicators in the core functions of the university—teaching, research, and services—can lead to institutions that lack quality and fail to make a significant impact on society, both formally and functionally.  …”
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Evolutionary Analysis of Structural Protein Gene VP1 of Foot-and-Mouth Disease Virus Serotype Asia 1 by Qingxun Zhang, Xinsheng Liu, Yuzhen Fang, Li Pan, Jianliang Lv, Zhongwang Zhang, Peng Zhou, Yaozhong Ding, Haotai Chen, Junjun Shao, Furong Zhao, Tong Lin, Huiyun Chang, Jie Zhang, Yonglu Wang, Yongguang Zhang

“…The result suggested that the virus had a high mutation rate (5.745 × 10−3 substitutions/site/year) in comparison to the other serotypes of FMDV VP1 gene. …”
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Malnutrition and Disability: A Retrospective Study on 2258 Adult Patients Undergoing Elective Spine Surgery by Matteo Briguglio, Andrea Campagner, Francesco Langella, Riccardo Cecchinato, Marco Damilano, Pablo Bellosta-López, Tiziano Crespi, Elena De Vecchi, Marialetizia Latella, Giuseppe Barone, Laura Scaramuzzo, Roberto Bassani, Andrea Luca, Marco Brayda-Bruno, Thomas W. Wainwright, Robert G. Middleton, Giovanni Lombardi, Federico Cabitza, Giuseppe Banfi, Pedro Berjano

“…<i>Background and Objectives</i>: Malnutrition’s prevalence and its relationship with functional ability in patients with end-stage spine pathologies, i.e., any disease of the vertebral bodies, intervertebral discs, and associated joints requiring surgical intervention, are yet to be explored. …”
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Impact of metabolic-associated fatty liver disease on the cholesterol efflux capacity of high-density lipoproteins in adolescents with type 2 diabetes by José Antonio Orozco Morales, José Antonio Orozco Morales, Aída Xochitl Medina Urrutia, Margarita Torres Tamayo, Margarita Torres Tamayo, Juan Reyes Barrera, Esteban Jorge Galarza, Juan Gabriel Juárez Rojas, Pilar Dies Suarez, Nahum Méndez Sánchez, Nahum Méndez Sánchez, Luis Enrique Díaz Orozco, Luis Enrique Díaz Orozco, Lubia Velázquez-López, Patricia Medina Bravo, Patricia Medina Bravo

“…Current evidence suggests that the physicochemical and functional features of HDLs may play a key role in the pathogenesis of atherosclerosis.ObjectiveWe aimed to assess the impact of MAFLD on cholesterol efflux capacity (CEC) in adolescents with DM2.DesignA cross-sectional study.SettingAttention clinic for Children with Diabetes of the Hospital Infantil de México Federico Gómez.Patients or other participantsThis study included a total of 70 adolescents, 47 of which had DM2 and 23 were healthy individuals.InterventionsThe presence of MAFLD was determined by MR spectroscopy with proton density fat fraction. …”
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Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction by Santtu Hellström, Antti Sajanti, Abhinav Srinath, Carolyn Bennett, Romuald Girard, Aditya Jhaveri, Ying Cao, Johannes Falter, Janek Frantzén, Fredrika Koskimäki, Seán B. Lyne, Tomi Rantamäki, Riikka Takala, Jussi P. Posti, Susanna Roine, Sulo Kolehmainen, Kenneth Nazir, Miro Jänkälä, Jukka Puolitaival, Melissa Rahi, Jaakko Rinne, Anni I. Nieminen, Eero Castrén, Janne Koskimäki

“…In this longitudinal prospective observational study, serum samples were collected early (46 ± 24 h) and late (142 ± 52 h) post-injury from 70 patients with ischemic stroke, aneurysmal subarachnoid hemorrhage, and traumatic brain injury that had outcomes dichotomized as favorable (modified Rankin Scores (mRS) 0–3) and unfavorable (mRS 4–6) three months post-injury. …”
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Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…TVB-2640 combined with cisplatin had superior synergistic antitumor effects in cisplatin-resistant CC models.…”
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Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways by Rafiqi SI, Aldasouqi A, Paparodis RD, Dewan S, Farooqi A, Faisal S, Nemat Y, Salim N, Qureshi S, Mahmood A, Tovar Y, Jun JY, Kalinoski AL, Mirmira RG, Jaume JC, Imam S

“…GAD65+GC7+anti-DLL4 treatment plasticized Tregs withstanding a proinflammatory milieu mimicking T1D/LADA, and the plasticized Tregs exhibited a stable and suppressive functional phenotype. Furthermore, GAD65+GC7+anti-DLL4 treatment had no adverse effects on immune cells.The present approach is a multipronged approach involving the inhibition of eIF5a and Notch pathways that addresses the upregulation of immune tolerance, differentiation, and proliferation of cytotoxic T cells and alleviates β-cell dysfunction. …”
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Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. by Darren M Lipnicki, John D Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole A Kochan, Gavin Andrews, M Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona E Matthews, Blossom C M Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda C W Lam, Candy H Y Wong, Ada W T Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Perminder S Sachdev, Cohort Studies of Memory in an International Consortium (COSMIC)

“…The studies began between 1989 and 2011, with all but three ongoing, and each had 2-16 assessment waves (median = 3) and a follow-up duration of 2-15 y. …”
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Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice by Alexandra V Bruter, Ekaterina A Varlamova, Nina I Stavskaya, Zoia G Antysheva, Vasily N Manskikh, Anna V Tvorogova, Diana S Korshunova, Alvina I Khamidullina, Marina V Utkina, Viktor P Bogdanov, Iuliia P Baikova, Alyona I Nikiforova, Eugene A Albert, Denis O Maksimov, Jing Li, Mengqian Chen, Gary P Schools, Alexey V Feoktistov, Alexander A Shtil, Igor B Roninson, Vladislav A Mogila, Yulia Y Silaeva, Victor V Tatarskiy

“…Cdk8/19 double knockout (iDKO) males, but not single Cdk8 or Cdk19 KO, had an atrophic reproductive system and were infertile. …”
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Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury by Xin Xu, Xinxin Yang, Meng Wang, Jingrong Zhu, Jing Li, Caiyue Chen, Jiameng Liu, Jiahuan Zheng, Bei Fan, Fengzhong Wang, Jing Sun

“…Subsequent structural analysis revealed that BRLPP had an average molecular weight of 5.72 × 104 Da and was primarily composed of glucose and arabinose in a molar ratio of 94.29:3.06. …”
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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study by Ziyao Meng, MEng, Zhouyu Guan, MD, Shujie Yu, MBBS, Yilan Wu, BSc, Yaoning Zhao, BSc, Jie Shen, PhD, Cynthia Ciwei Lim, MMed, Tingli Chen, MD, Dawei Yang, PhD, An Ran Ran, PhD, Feng He, MSc, Haslina Hamzah, BSc, Sarkaaj Singh, MSc, Anis Syazwani Abd Raof, MSc, Jian Wen Samuel Lee-Boey, MBBS, ProfMBBS Soo-Kun Lim, MBBS, ProfMD Xufang Sun, MBBS, Shuwang Ge, MD, ProfMD Gang Xu, MD, Prof Hua Su, MD, Yang Cheng, MD, Feng Lu, PhD, ProfPhD Xiaofei Liao, PhD, ProfPhD Hai Jin, PhD, Chenxin Deng, MMed, Lei Ruan, MD, ProfMD Cuntai Zhang, MD, Chan Wu, MD, ProfMD Rongping Dai, MD, Yixiao Jin, MSc, Wenxiao Wang, PhD, Tingyao Li, BSc, Ruhan Liu, PhD, Jiajia Li, PhD, Jia Shu, BEng, Yuwei Lu, MBBS, Xiangning Wang, MD, Qiang Wu, MD, Yiming Qin, BEng, Jin Tang, MD, Xiaohua Sheng, MD, Qiong Jiao, MD, ProfPhD Xiaokang Yang, MD, ProfPhD Minyi Guo, MD, Gareth J McKay, PhD, ProfPhD Ruth E Hogg, PhD, Gerald Liew, MBBS, Evelyn Yi Lyn Chee, PhD, ProfPhD Wynne Hsu, PhD, ProfPhD Mong Li Lee, PhD, Simon Szeto, MBChB, ProfMD Andrea O Y Luk, MBChB, ProfMD Juliana C N Chan, MBChB, Carol Y Cheung, PhD, Gavin Siew Wei Tan, FRCSEd, Yih-Chung Tham, PhD, ProfMD PhD Ching-Yu Cheng, PhD, Charumathi Sabanayagam, MD PhD, ProfPhD Lee-Ling Lim, MD PhD, ProfMD PhD Weiping Jia, MD PhD, ProfMD PhD Huating Li, MD PhD, Bin Sheng, Prof, Tien Yin Wong, Prof

“…In the longitudinal study, participants with isolated diabetic nephropathy and participants with NDKD identified by DeepDKD had a significant difference in renal function outcomes (proportion of estimated glomerular filtration rate decline: 27·45% vs 52·56%, p=0·0010). …”
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Interplay of health-related quality of life and comorbidities in people with type 2 diabetes mellitus treated in primary care settings in Austria: a countrywide cross-sectional stu... by Faisal Aziz, Martin Clodi, Michael Resl, Julia K Mader, Harald Kojzar, Susanne Kaser, Harald Sourij, Peter Fasching, Norbert Joachim Tripolt, Kehkishan Azhar, Caren Sourij, Bernhard Ludvik, Gersina Rega-Kaun, Claudia Ress, Lars Stechemesser, Harald Stingl, Thomas Wascher

“…Age and body mass were inversely associated with physical, mental and social HRQoL (p&lt;0.05). Women had lower mental health (β: −5.44 [95% CI −9.43 to −1.44], p&lt;0.05) than men. …”
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