A hybrid construct with tailored 3D structure for directing pre-vascularization in engineered tissues by Sara C. Neves, Aureliana Sousa, Diana S. Nascimento, Iasmim D. Orge, Sílvia A. Ferreira, Carlos Mota, Lorenzo Moroni, Cristina C. Barrias, Pedro L. Granja

“…Hybrid 3D constructs combining different structural components afford unique opportunities to engineer functional tissues. Creating functional microvascular networks within these constructs is crucial for promoting integration with host vessels and ensuring successful engraftment. …”
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Real-world evaluation of ImmuCare-PRO patient-reported outcomes in melanoma patients treated with immune checkpoint inhibitors by S. Belkaïd, S. Milley, R. Saux, M. Bonjour, A. Augros, P.-J. Souquet, D. Maillet, D. Maucort-Boulch, C. Dolla, L. Thomas, S. Dalle

“…False alerts often resulted from functional or non-specific symptoms (32.3%), such as fatigue or general pain. …”
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Midline 1 associated with Fas signaling enhances murine antigen-induced arthritis by Nina Lukač, Nina Lukač, Darja Flegar, Darja Flegar, Sara Priselac, Tomislav Kelava, Tomislav Kelava, Alan Šućur, Alan Šućur, Maša Filipović, Maša Filipović, Dino Šisl, Dino Šisl, Martina Fadljević, Igor Radanović, Vedran Katavić, Vedran Katavić, Nives Zimmermann, Danka Grčević, Danka Grčević, Nataša Kovačić, Nataša Kovačić

“…Stimulation of bone marrow cells with low doses of soluble Fas agonist upregulated expression of Mid1. Inactivation of Mid1 had a variable anti-inflammatory effects in vitro and partial anti-arthritic effect in vivo.ConclusionFunctional Fas is required for the recruitment and accumulation of innate inflammatory cells in arthritic joints. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…IntroductionThe HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. …”
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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. by Lea K Davis, Dongmei Yu, Clare L Keenan, Eric R Gamazon, Anuar I Konkashbaev, Eske M Derks, Benjamin M Neale, Jian Yang, S Hong Lee, Patrick Evans, Cathy L Barr, Laura Bellodi, Fortu Benarroch, Gabriel Bedoya Berrio, Oscar J Bienvenu, Michael H Bloch, Rianne M Blom, Ruth D Bruun, Cathy L Budman, Beatriz Camarena, Desmond Campbell, Carolina Cappi, Julio C Cardona Silgado, Danielle C Cath, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, David V Conti, Edwin H Cook, Vladimir Coric, Bernadette A Cullen, Dieter Deforce, Richard Delorme, Yves Dion, Christopher K Edlund, Karin Egberts, Peter Falkai, Thomas V Fernandez, Patience J Gallagher, Helena Garrido, Daniel Geller, Simon L Girard, Hans J Grabe, Marco A Grados, Benjamin D Greenberg, Varda Gross-Tsur, Stephen Haddad, Gary A Heiman, Sian M J Hemmings, Ana G Hounie, Cornelia Illmann, Joseph Jankovic, Michael A Jenike, James L Kennedy, Robert A King, Barbara Kremeyer, Roger Kurlan, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Leonhard Lennertz, Chunyu Liu, Christine Lochner, Thomas L Lowe, Fabio Macciardi, James T McCracken, Lauren M McGrath, Sandra C Mesa Restrepo, Rainald Moessner, Jubel Morgan, Heike Muller, Dennis L Murphy, Allan L Naarden, William Cornejo Ochoa, Roel A Ophoff, Lisa Osiecki, Andrew J Pakstis, Michele T Pato, Carlos N Pato, John Piacentini, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias J Renner, Victor I Reus, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, Maria C Rosàrio, David Rosenberg, Guy A Rouleau, Stephan Ruhrmann, Andres Ruiz-Linares, Aline S Sampaio, Jack Samuels, Paul Sandor, Brooke Sheppard, Harvey S Singer, Jan H Smit, Dan J Stein, E Strengman, Jay A Tischfield, Ana V Valencia Duarte, Homero Vallada, Filip Van Nieuwerburgh, Jeremy Veenstra-Vanderweele, Susanne Walitza, Ying Wang, Jens R Wendland, Herman G M Westenberg, Yin Yao Shugart, Euripedes C Miguel, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L Hanna, Peter Heutink, Damiaan Denys, Paul D Arnold, Ben A Oostra, Gerald Nestadt, Nelson B Freimer, David L Pauls, Naomi R Wray, S Evelyn Stewart, Carol A Mathews, James A Knowles, Nancy J Cox, Jeremiah M Scharf

“…We examined genomic architectures of TS and OCD by chromosome, MAF bin, and functional annotations. In addition, we assessed heritability for early onset and adult onset OCD. …”
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Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity by Duo Gao, Yimin Zhuang, Shuai Liu, Boyan Ma, Yiming Xu, Hongxing Zhang, Yiliyaer Nuermaimaiti, Tianyu Chen, Guobin Hou, Wenli Guo, Jingtao You, Zhiyu Huang, Jianxin Xiao, Wei Wang, Mengmeng Li, Shengli Li, Zhijun Cao

“…Using a multi-omics approach, we performed 16S rRNA gene sequencing to evaluate microbial diversity, conducted metagenomic analysis to identify functional bacteria, and utilized untargeted metabolomics to profile serum metabolites. …”
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Post-Surgical Central Nervous System Infections in the Era of Multidrug Antibiotic Resistance in Greece—A Single-Center Experience of a Decade by Konstantinos Markakis, Konstantina Kapiki, Angela Ava Arbelle Edric, Asimina Aphrodite Pappas, Georgios Feretos, Sideris Nanoudis, Dimitrios Pilalas, Theodoros Michailidis, Efthymia Protonotariou, Lemonia Skoura, Nikolaos Foroglou, Symeon Metallidis, Olga Tsachouridou

“…Post-surgical central nervous system infections (PCNSIs) are a major cause of morbidity, poor functional outcomes and mortality in neurosurgical patients. …”
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Glucocorticoid Receptor (GR) Expression in Human Tumors: A Tissue Microarray Study on More than 14,000 Tumors by Maria Christina Tsourlakis, Simon Kind, Sebastian Dwertmann Rico, Sören Weidemann, Katharina Möller, Ria Schlichter, Martina Kluth, Claudia Hube-Magg, Christian Bernreuther, Guido Sauter, Andreas H. Marx, Ronald Simon, Ahmed Abdulwahab Bawahab, Florian Lutz, Viktor Reiswich, Davin Dum, Stefan Steurer, Eike Burandt, Till S. Clauditz, Till Krech, Christoph Fraune, Seyma Büyücek, Neele Heckmann, Natalia Gorbokon, Maximilian Lennartz, Sarah Minner, Florian Viehweger

“…Associations between reduced GR expression and unfavorable tumor features in certain cancers suggest that the functional importance of GR-regulated genes in cancer progression depends on the cell of tumor origin.…”
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Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data by Erli Wu, Xuan Yin, Feng Liang, Xianqing Zhou, Jiamin Hu, Wanting Yuan, Feihan Gu, Jingxin Zhao, Ziyang Gao, Ming Cheng, Shouxiang Yang, Lei Zhang, Qingqing Wang, Qingqing Wang, Xiaoyu Sun, Xiaoyu Sun, Wei Shao, Wei Shao

“…Consensus cluster analysis based on these 5 genes showed that there were differences in immune cells and immune functions among subtypes associated with ICD. Finally, qPCR and immunohistochemistry confirmed the ability of these five genes as biomarkers for the diagnosis of periodontitis.ConclusionFibroblasts may be the main cell source of ICD in periodontitis. …”
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Thinning intensity influences the C:N:P stoichiometry in forest ecosystems: A global synthesis by Chongwei Fan, Guiyao Zhou, Hongyang Chen, Zhenggang Du, Ruiqiang Liu, Yanghui He, Changjiang Huang, Shuying Qiu, Yimin Zhu, Jie Li, Xuhui Zhou

“…Specifically, heavy thinning significantly decreased plant C:N ratios and soil N:P ratios, whereas light and moderate thinning had positive or insignificant effects on C:N:P stoichiometry. …”
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M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer by Vladimir Benes, Ladislav Pecen, Jelena Pistolic, Lorenzo Galluzzi, Iva Truxova, Radek Špíšek, Lenka Kasikova, Michal Hensler, Petr Skapa, Jan Laco, Ivan Praznovec, Tomas Brtnicky, Lukas Rob, Catherine Sautes-Fridman, Ales Ryska, Jitka Fucikova, Wolf Herve Fridman, Vít Drochýtek, Sarka Vosahlikova, Karel Fiser, Jana Rakova, Tereza Lanickova, Irena Moserova, Martina Rehackova, Ludek Sojka

“…M-TME infiltration by immune effector cells had little impact on patient survival. Accordingly, M-TME-infiltrating T cells were functionally impaired, but not upon checkpoint activation. …”
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Intrinsic capacity in patients with dementia with Lewy bodies compared with those with Alzheimer’s disease: A cross-sectional study by Marie Collin, Justine Bonnet-Chateau, Victor Gilles, Sophie Dautricourt, Thomas Gilbert, Zaza Makaroff, Marie-Hélène Coste, Virginie Dauphinot, Antoine Garnier-Crussard

“…As IC decline is associated with the risk of frailty, functional decline and disability and is potentially reversible after targeted interventions, a monitoring and specific management of IC decline in patients with DLB could promote healthy aging in this population. …”
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Some epidemiological indicators and results of surgical treatment of children with unstable and complicated spine injuries using different models of medical care based on the examp... by I.V. Basankin, S.V. Vissarionov, A.A. Gyulzatyan, A.A. Afaunov, K.K. Takhmazyan, V.K. Shapovalov, L.A. Tarasenko, A.M. Efremov, A.V. Sobolev, A.A. Danileichenko

“…In 2017–2023, 95 victims underwent surgical treatment, of which 28 (29.4 %) had neurological deficit. After changing the concept of determining the grounds for surgical treatment and routing of victims (2017), a disproportionate increase in their total number (22 versus 95) and the number of victims with complicated spinal fractures (15 versus 28) was noted. …”
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Association between care complexity individual factors and older inpatients with COVID-19: a cross-sectional study by Jordi Adamuz, Jordi Adamuz, Jordi Adamuz, Julia González-Vaca, Julia González-Vaca, Maribel González-Samartino, Maribel González-Samartino, Maribel González-Samartino, María-Magdalena López-Jiménez, María-Magdalena López-Jiménez, María-Magdalena López-Jiménez, Andrea Urbina, Andrea Urbina, Andrea Urbina, Oliver Polushkina-Merchanskaya, Sergio Alonso-Fernández, Sergio Alonso-Fernández, Silvia Esteban-Sepúlveda, Silvia Esteban-Sepúlveda, Sergio Barrientos-Trigo, Maria-Eulàlia Juvé-Udina, Maria-Eulàlia Juvé-Udina

“…The analysis shows that middle-old (75–84 years) patients were associated with chronic disease, position impairment, urinary or fecal incontinence, anatomical and functional disorders, vascular fragility, involuntary movements, fear or anxiety and mental status impairments. …”
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Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy by Shing Ching, Jeffrey Ji-Peng Li, Stefanie Maria Werhahn, Rebecca Elisabeth Beyer, Misael Estepa, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Henryk Dreger, Sebastian Kelle, Patrick Doeblin

“…We assessed CMR-derived morphological and functional parameters with regard to the echocardiographic response, defined as a reduction in the left ventricular end-systolic volume of ≥15%. …”
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Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover studyResearch in context by Ebenezer O. Chinedu-Eneh, Sharon Chiang, John P. Andrews, Ehsan Tadayon, Joline M. Fan, Paul A. Garcia, Ernesto Gonzalez-Giraldo, Manu Hegde, Patrick Hullett, Vikram R. Rao, Robert C. Knowlton, Edward F. Chang, Jonathan K. Kleen

“…Interpretation: Epileptologists using higher-density depth and subdural intracranial EEG recordings had higher inter-rater agreement and identified larger extents of SOZs compared to lower-density recordings. …”
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HEALTH TECHNOLOGIES FOR INCREASING ADAPTIVE CAPABILITIESOF PREGNANT WOMEN by T. S. Krivonogova, O. M. Gerget, A. A. Ber, Ya. S. Pekker

“…Subsequently, these women have a disease recurrence contributed to a further decrease in functional reserves, which led to the breakdown of adaptation in 35% of cases.The performing of breathing exercises and aqua-gymnastics had a positive effect on the hormonal and metabolic status of pregnant women. …”
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A novel single-port robotic system in urology: A prospective multicenter single-arm clinical trial evaluating feasibility and efficacy of first 50 cases by Zheng Wang, Chao Zhang, Taile Jing, Yong Wei, Chengwu Xiao, Yang Wang, Yu Fang, Xiaofeng Wu, Shouyan Tang, Hong Xu, Yi Liu, Bo Yang, Shuo Wang, Bin Xu, Qingyi Zhu, Dan Xia, Zhenjie Wu, Xiaofeng Gao, Linhui Wang

“…Secondary endpoints encompassed a range of surgical metrics, functional outcomes, and patient demographic data. Clinical assessments were conducted before surgery, before discharge, and 1 month after discharge. …”
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Genetic Analysis and Fine Mapping of QTLs for Stigma Exsertion Rate in Rice by Hanyuan Yang, Yin Zhou, Pingbo Li, Enyu Liu, Ping Sun, Yiting Ao, Rongjia Liu, Haozhou Gao, Zherui Xu, Ping Yang, Xinyue Wang, Guanjun Gao, Qinglu Zhang, Lizhong Xiong, Yuqing He

“…Furthermore, examination of floral organ traits revealed that both the Hua6S allele of qSE1 and the B805D allele of qSE9 increased pistil size to improve SER, but they had contrasting effects on spikelet shape. Subsequently, qSE1 and qSE9 were fine-mapped to intervals of 246.5 kb and 341.4 kb, respectively. …”
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Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma by Xiaoxuan Tang, Shanxing Dang, Jie Qiu, Ruilan Zhou, Jing Ling, Limei Zhang, Xiaopeng Peng, Qingyun Li, Jin Liu, Wei Liao, Qingxiu Mei, Miao Xie, Yehong Sun, Jianmei Huang, Xuelian Du, Wencong Song

“…Additional analyses included functional enrichment, tumor mutational burden, tumor microenvironment (TME) estimates via ESTIMATE, and immune infiltration assessment to clarify CDH18’s potential mechanisms in UCEC. …”
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