Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker by Xiaoliang Chen, Lina Chen, Li Bi, Shunying Zhao, Xiaoyan Hu, Ni Li, Linwen Zhu, Guofeng Shao

“…Future studies should investigate these circRNAs' functional roles to fully elucidate their contribution to RHD development.…”
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Results of long-term riociguat therapy, including a switching strategy from sildenafil, in patients with pulmonary hypertension of various genesis by S. A. Musashaykhova, Z. S. Valieva, T. V. Martynyuk

“…Aim: to study the influence of riociguat on the functional and hemodynamic status, remodeling of the right heart, as well as the safety of therapy in both previously untreated patients with idiopathic pulmonary arterial hypertension (IPAH) and inoperable chronic thromboembolic PH (CTEPH), and those not achieved treatment goals with sildenafil therapy and switching to riociguat.Materials and methods. …”
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Effect of foliar spray of Spermine and Spermidine on growth and some physiological characteristics of chickpea (Cicer arietinum L) under salt stress by Ali Ashori, Manoochehr Gholipoor, Mostafa Heidari

“…Concerning relative water content (RWC) and enzymes activity, interaction of spermine and spermidine had significant effects on RWC and activity of polyphenol oxidase, catalase and guaiacol peroxidase enzymes. …”
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Genetic Polymorphisms on TNFA, TNFRSF1A, and TNFRSF1B Genes Predict the Effectiveness of Anti-TNF-α Treatment in Inflammatory Bowel Disease Patients by Michelangelo Rottura, Igor Pirrotta, Domenico Antonio Giorgi, Natasha Irrera, Vincenzo Arcoraci, Federica Mannino, Rosario Campisi, Chiara Bivacqua, Laura Patanè, Giuseppe Costantino, Socrate Pallio, Walter Fries, Anna Viola, Giovanni Pallio

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Social Relations and Interpersonal Dialogue among Couples: A Study in the City of Yazd Based on the Grounded Theory by Lida Hatefi rad, Mehraban Parsamehr, Ali Ruhani

“…It assumes distinct roles and functions and addresses a range of human needs. Central to family life and functioning are the relationships among family members. …”
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Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults by Julianna M. Nemeth, Clarice Decker, Rachel Ramirez, Luke Montgomery, Alice Hinton, Sharefa Duhaney, Raya Smith, Allison Glasser, Abigail (Abby) Bowman, Emily Kulow, Amy Wermert

“…Survivor behavior was then interpreted by staff as a “can’t” not a “won’t”, and social and functional supports were offered.…”
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THE "LARGE BARYON PUMP OF THE EARTH" AS A NATURAL IMAGE OF THE "TREE OF LIFE" AND AN OBJECT OF ENVIRONMENTAL LAW, WHICH IS INTEGRATED WITH THE NATURAL ENVIRONMENT OF MAN by Mykhaylo O. Baymuratov, Volodymyr P. Ozhereliev

“…In turn, the need to study the functions of the Earth's natural resources in the environmental discourse and its qualification as an object of law is a natural stage in the development of the system of ecological, noospheric law, and in the future - anthropic law as a metasystem of the natural law of our universe. …”
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Does the Ischemic Core Really Matter? An Updated Systematic Review and Meta‐Analysis of Large Core Trials After TESLA, TENSION, and LASTE by Mohammad AlMajali, Mahmoud Dibas, Malik Ghannam, Milagros Galecio‐Castillo, Abdullah Al Qudah, Farid Khasiyev, Juan Vivanco‐Suarez, Aaron Rodriguez‐Calienes, Mudassir Farooqui, Sophie L. Shogren, Fawaz AlMajali, Albert Yoo, Edgar Samaniego, Tudor Jovin, Amrou Sarraj, Santiago Ortega‐Gutierrez

“…Secondary outcomes included functional independence (mRS score 0–2), independent ambulation (mRS score 0–3), 90‐day mortality, and symptomatic intracranial hemorrhage. …”
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s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight by K. V. Zhdanov, A. V. Semenov, S. S. Karyakin, K. V. Kozlov, V. S. Sukachev, Yu. V. Ostankova, D. E. Valutite, E. B. Zueva, R. S. Sidorov, A. V. Saulevich, Yu. I. Bulan’kov, Yu. I. Lyashenko, K. S. Ivanov

“…Conclusion: Progressing of fibrosis and functional disturbances in intestines are interconnected with increase in concentration of MadCAM-1 in blood that allows to consider pathological changes in intestines of various genesis as the accessory factor promoting progressing of СHC at patients with excess body weight. …”
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CPAP modulation of sleep microstructure (N2-SSD and REM-AHI) as predictors of neurological recovery in ischemic stroke patients with moderate-to-severe OSA by Tianyu Jing, Tianyu Jing, Tianyu Jing, Liwen Xu, Liwen Xu, Shutong Sun, Wenyi Yu, Wenyi Yu, Yixi Zheng, Yixi Zheng, Gang Xu, Xinhao Shen, Tieyu Tang, Cheng Chu, Cheng Chu

“…N2-SSD, REM-AHI, and Mean SpO2 are mechanistically linked to functional prognosis and CPAP exerts therapeutic effects through the modulation of these biomarkers. …”
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Validation of a 60K SNP chip for caribou (Rangifer tarandus) for use in wildlife forensics, conservation, and management by Trottier-Lavoie Mallorie, Prunier Julien, Poisson William, Carrier Alexandra, Gilbert Isabelle, Mastromonaco Gabriela, Albert Vicky, Cecilia Hernandez, Bourret Vincent, Taillon Joëlle, Droit Arnaud, Côté Steeve D., Robert Claude

“…Biological source of DNA had minor impact, even with fecal pellets given sufficient amount of host DNA. …”
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Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy by Lu Liu, Yuanlai Qiu, Yuying Suo, Siyao Tong, Yiqing Wang, Xi Zhang, Liang Chen, Yue Huang, Huchen Zhou, Hu Zhou, Ze Dong, Cai-Guang Yang

“…The fat mass and obesity-associated protein (FTO) is an RNA demethylase required for catalytic demethylation of N6-methyladenosine (m6A); it is highly expressed and functions as an oncogene in acute myeloid leukemia (AML). …”
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Bacteria Derived from Diamondback Moth, <i>Plutella xylostella</i> (L.) (Lepidoptera: Plutellidae), Gut Regurgitant Negatively Regulate Glucose Oxidase-Mediated Anti-Defense Agains... by Qingxuan Qiao, Huiting Feng, Lu Jiao, Uroosa Zaheer, Chanqin Zheng, Li Zhou, Guifang Lin, Xiujuan Xiang, Huang Liao, Shanyu Li, Haiyan Lu, Anyuan Yin, Yussuf Mohamed Salum, Hui Wei, Wei Chen, Weiyi He, Feiying Yang

“…These RB strains suppressed genes related to jasmonic acid and glucosinolate signaling pathways but had little effect on salicylic acid signaling pathway genes in <i>Arabidopsis thaliana</i> wounds. …”
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Investigating the Effect of Microcystins on the Transcriptomics of Hepatopancreas in Penaeus vannamei Using Reverse-Gavage by Haiqing YUAN, Rongsheng JIN, Baoran WANG, Daiqiang CHEN, Shuangyong ZHANG, Zhiqiang CHANG

“…The differentially expressed genes were categorized based on biological processes, cellular components, and molecular functions using the Gene Ontology (GO) database, resulting in 33 functional entries. …”
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Investigating the relationship between the monetary policy shock through the exchange rate channel on the management quality index in the banking system: by examining the productiv... by Farhad Sharifi Bagha, Jafar Haqiqat, Zahra Karimi Takanloo

“…In the present study, we show that replacing ECB balance sheet size with random numbers leads to statistically indistinguishable shock response functions and time series of abnormal monetary policy shocks. …”
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Deciphering the microbiome–metabolome landscape of an inflammatory bowel disease inception cohort by Shiva T. Radhakrishnan, Benjamin H. Mullish, Marton L. Olbei, Nathan P. Danckert, Maria A. Valdivia-Garcia, Jose I. Serrano-Contreras, Despoina Chrysostomou, Sharmili Balarajah, Robert W. Perry, John P. Thomas, Lejla Potari-Gul, Dezso Modos, Lucy C. Hicks, Nick Powell, Timothy R. Orchard, Jia V. Li, Julian R. Marchesi, Tamas Korcsmaros, James L. Alexander, Horace R. T. Williams

“…The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and the recruitment of patients with well-established disease (introducing potential confounders, such as immunomodulatory medication). …”
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Genetic association of the kynurenine pathway to suicidal behavior by Rabah Tamimou, Christine Montout, Thibault Mura, Ismael Conejero, Alexandre Evrard, Philippe Courtet, Pablo Bonilla-Escribano, Carlos Riaza, Concepción Vaquero-Lorenzo, Enrique Baca-Garcia, Fabrice Jollant, Serge Lumbroso, Kevin Mouzat, Jorge Lopez-Castroman

“…To validate our findings, it is crucial to conduct functional analyses to investigate the impact of rs10109853 and rs1053230 SNPs on the expression and/or catalytic activity of the corresponding enzymes.…”
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Exploring patient preferences for intraocular lenses selection in age-related cataract: a discrete choice experiment study by Qiaolin Zhu, Qiaolin Zhu, Qiaolin Zhu, Qianqian Sun, Qianqian Sun, Qianqian Sun, Yujia Huo, Yujia Huo, Yujia Huo, Xiaoling Yang, Xiaoling Yang, Xiaoling Yang, Hehe Huang, Hehe Huang, Hehe Huang, Shanshan Qian, Shanshan Qian, Shanshan Qian, Wenjing Lin, Wentao Yan, Wentao Yan, Wentao Yan

“…The inclusion of blue-blocking functionality and the surgeon’s recommendation had minimal influence on patient choice. …”
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Prevalence and Clinical Characteristics of NEUROD1‐MODY in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review by Tianhao Ba, Qian Ren, Siqian Gong, Meng Li, Hong Lian, Xiaoling Cai, Wei Liu, Yingying Luo, Simin Zhang, Rui Zhang, Lingli Zhou, Yu Zhu, Xiuying Zhang, Jing Chen, Jing Wu, Xianghai Zhou, Yufeng Li, Xirui Wang, Fang Wang, Liyong Zhong, Xueyao Han, Linong Ji

“…Results Four rare variants were identified in 679 patients with EOD, but only P197H decreased the transcriptional activity in in vitro functional assays to an extent comparable to the well‐known mutation causing NEUROD1‐MODY. …”
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Biallelic variants in the NDUFAF6 cause mitochondrial respiratory complex assembly defects associated with Leigh syndrome in probands by Yuwei Zhou, Xiaofei Zeng, Luyi Zhang, Xiaojie Yin, Xue Ma, Keyi Li, Peijing Qiu, Xiaoting Lou, Liqin Jin, Ya Wang, Yanling Yang, Ting Shen

“…We identified that patient 1 and patient 2 had two missense changes (NM_152416 c.371 T > C, c.923 T > C and c.371 T > C, c.920 A > T) in NDUFAF6, respectively. …”
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