Whole-Genome Sequencing and Comparative Genomic Analysis of Three Clinical Bloodstream Infection Isolates of <i>Trichosporon austroamericanum</i> by Takanori Horiguchi, Takashi Umeyama, Hiroko Tomuro, Amato Otani, Takayuki Shinohara, Masahiro Abe, Shogo Takatsuka, Ken Miyazawa, Minoru Nagi, Yasunori Muraosa, Yasutaka Hoshino, Takashi Sakoh, Hideki Araoka, Naoyuki Uchida, Tomoyoshi Kaneko, Yuko Nagano, Hiroki Tsukada, Taiga Miyazaki, Yoshitsugu Miyazaki

“…These findings highlight the genomic diversity and infection-associated traits of <i>T. austroamericanum</i>, providing a framework for future functional studies.…”
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DGKα Enhances Tumorigenic Activity in Bladder Cancer Patients With Chronic Kidney Disease by Kenshiro Takemoto, Kohei Kobatake, Tomoya Hatayama, Shinsaku Tasaka, Mai Okazaki, Yoshinori Nakano, Hiroyuki Shikuma, Kazuma Yukihiro, Kyosuke Iwane, Ryoken Yamanaka, Ryo Tasaka, Yuki Kohada, Miki Naito, Shunsuke Miyamoto, Yohei Sekino, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Nobuyuki Hinata

“…Second, we conducted a molecular functional analysis of DGKα in BC and investigated the contribution of DGKα to cell invasion, migration, and proliferation activity using human BC cell lines. …”
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Epidemiologic threats and outcome of evolving COVID-19-associated mucormycosis from a referral hospital in Egypt by Safaa Elserougy, Muhammad Abdel-Ghaffar, Eman Medhat, Ahmed Heiba, Weam Shaheen, Elham Mostafa, Hala Mahfouz, Samah Abdel-Hafez, Mohammad S Mahfouz, Shimaa Afify, Omnia Ali, Enass El-Sayed, Ahmed M Mostafa, Ahmed M Salah, Anwar Elbatawy, Hanan M Elghoneimy, Amr A Elshafey, Ahmed Abou-ElFotouh, Tareq Abdul-Ghani, Fatma I Ibrahim, Sarah M Samy, Manal S Elhussini

“…CAM patients with death outcomes had orbital invasion, disturbed consciousness level, referral to intensive care units, and invasive mechanical ventilation. …”
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The aperiodic and periodic activities of EEG dynamically relate with cognitive performance in schizophrenia by Kexin Zhang, Yunfei Ji, Xiaodong Guo, Tianqi Gao, Xuemin Zhang, Xin Yu, Jing Wang

“…The findings suggest that aperiodic exponent holds strong cognitive functional implications in SCZ.…”
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Closing the Sex-Based Differences in Stroke Care: Insights from a Large Telestroke Network on Treatment and Postacute Management by Soledad Pérez-Sánchez, Ana Barragán-Prieto, Juan Bautista Loscertales, Juan Antonio Cabezas Rodríguez, Elena Zapata-Arriaza, Laura Amaya Pascasio, Andrés Hermosín Gómez, Miguel Ángel Gamero García, Benito Galeano, Javier Fernández, Blanca Pardo Galiana, Ana Domínguez Mayoral, Leire Ainz Gómez, Jose Fernández Navarro, Cristina del Toro, Manuel Medina, Reyes de Torres, Pablo Baena, Francisco Moniche, Roberto Valverde Moyano, Patricia Martínez, Alejandro González, Joan Montaner

“…At 3 months post-stroke follow-up, women had fewer imaging tests (p = 0.018) and fewer outpatient visits (p < 0.001) than men. …”
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Fluorescent competitive assay for melamine using dummy molecularly imprinted polymers as antibody mimics by Xin-wei DU, Yan-xin ZHANG, Yong-xin SHE, Guang-yang LIU, Feng-nian ZHAO, Jing WANG, Shan-shan WANG, Fen JIN, Hua SHAO, Mao-jun JIN, Lu-fei ZHENG

“…The evaluation results showed that the synthesized DMIPs had specific recognition sites for melamine and the maximum adsorption amount was 1 066.33 μg g−1. …”
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From geriatric assessment to inflammation. A pilot, observational, study about frailty components in older patients with persistent atrial fibrillation by Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Elisa Berni, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Romoli, Emanuele Santamaria, Giulia Spanalatte, Camilla Cagnoni, Arianna Tariello, Giada Alla Viligiardi, Agostino Virdis, Igor Diemberger, Andrea Ungar, Niccolò Marchionni

“…Cluster analysis described two different patterns; the second (N = 18, 36.7 %), when compared to the first one (N = 31, 63.3 %), was characterized by a worse phenotype, identified by the simultaneous presence of lower body mass index, higher CHA2DS2-VASc score (index of clinical complexity), worse SPPB functional performance, and high IL-6 levels. Second cluster patients had a higher concentration of 13 of the 35 acylcarnitines evaluated and increased 5-year mortality. …”
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Contribution of gait speed, grip strength, and depression on the risk of serious falls among older adults by Temam Beshir Raru, Julie A. Pasco, Mojtaba Lotfaliany, Shiva Ganjali, Malcolm Forbes, Alice J. Owen, Robyn L Woods, Anna Barker, Suzanne G. Orchard, Joanne Ryan, John J. McNeil, Michael Berk, Mohammadreza Mohebbi

“…Results: Of 16,357 participants, 1505 (9.2 %) had serious falls over the median (IQR) follow-up of 4.4 (3.3–5.5) years. …”
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CLIC2 regulates immunosuppression and macrophage differentiation in genomically stable gastric cancer by Viviana Longo, Pellegrino Mazzone, Giovanni Calice, Pietro Zoppoli, Giuseppina Di Paola, Giuseppe Cesta, Margherita Luongo, Claudia Sabato, Sabino Russi, Simona Laurino, Tiziana Notarangelo, Giuseppe Patitucci, Chiara Balzamo, Valeria Lucci, Elena Amendola, Giuseppina Amodio, Paolo Remondelli, Valentina Pagliara, Maria Rita Milone, Roberta Guadagno, Cristofaro De Stefano, Ferdinando De Vita, Geppino Falco, Francesco Albano

“…Abstract Chloride intracellular channels (CLICs) are a family of six evolutionarily conserved proteins with diverse functions. Previously, we identified CLIC2, as the fifth-ranked master regulator associated with diffuse-type gastric cancer (dGC) showing increased expression in tumors. …”
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Phyllotaxy and environmental factors influences on leaf trait dimensions in Fraxinus mandshurica: a multidimensional approach within temperate forests by Mingyue Jin, Mingyue Jin, Mingyue Jin, Yunfei Diao, Yunfei Diao, Yunlong Wang, Mingke Zhang, Tianyi Wang, Yajun Ren, Yajun Ren, Yajun Ren, Ming Zhong, Ming Zhong, Ming Zhong, Wanting Cheng, Wanting Cheng, Wanting Cheng, Chengdong Wang, Chengdong Wang, Chengdong Wang, Honghui Teng, Honghui Teng, Honghui Teng

“…No significant variation in the dimensions of economic and stomatal traits was observed across the phyllotaxy gradient; (2) phyllotaxy modulates trait coordination, with decoupled economic and stomatal traits at phyllotaxy 1 but coupled relationships at phyllotaxy 2–6; (3) environmental factors had a greater impact on economic trait dimensions variation, whereas phyllotaxy was more important for stomatal trait dimensions.DiscussionOur study highlights the significance of trait dimensions in understanding plant functional strategies. …”
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Small Heart Size and Premature Death in 366,484 Individuals With Normal Ejection Fraction by Stephanie J. Rowe, BBiomed, MD, Elizabeth D. Paratz, MBBS, PhD, Louise Fahy, MB, BCh, BAO, Kristel Janssens, BNurs, Luke W. Spencer, BBiomed(Hons), Paolo D’Ambrosio, MBBS, Geoff Strange, PhD, David L. Prior, MBBS(Hons), BMedSc, PhD, David Playford, MBBS, PhD, Andre La Gerche, MBBS, PhD

“…Background: In patients with preserved left ventricular ejection fraction (LVEF), small ventricular size has been associated with reduced functional capacity, but its impact on clinical outcomes is unclear. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Although recent advances have improved the overall prognosis, they have not had an important impact on survival of patients with MPM, such that more effective treatments are needed. …”
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Generative AI’s healthcare professional role creep: a cross-sectional evaluation of publicly accessible, customised health-related GPTs by Bianca Chu, Natansh D. Modi, Bradley D. Menz, Stephen Bacchi, Ganessan Kichenadasse, Ganessan Kichenadasse, Catherine Paterson, Catherine Paterson, Catherine Paterson, Joshua G. Kovoor, Joshua G. Kovoor, Joshua G. Kovoor, Imogen Ramsey, Jessica M. Logan, Michael D. Wiese, Ross A. McKinnon, Andrew Rowland, Michael J. Sorich, Ashley M. Hopkins

“…This study aims to evaluate the accessibility and functionality descriptions of customised GPTs on the OpenAI GPT store that provide health-related information or assistance to patients and healthcare professionals.MethodsWe conducted a cross-sectional observational study of the OpenAI GPT store from September 2 to 6, 2024, to identify publicly accessible customised GPTs with health-related functions. …”
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Drone mapping links reindeer browsing during an herbivory pulse to divergent vegetation community responses by Marcus P Spiegel, Jeffrey T Kerby, Dorothée Ehrich, Alexander Volkovitskiy, Alexandra Terekhina, Violetta Filippova, Kirill Shklyar, Natalia Sokolova, Aleksandr A Sokolov, Marc Macias-Fauria

“…Large herbivores regulate ecosystem structure and functioning across Earth’s biomes, but vegetation community responses to herbivory depend on complex interactions involving the timing and intensity of herbivory pressure and other, often abiotic, controls on vegetation. …”
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Transcriptomic and proteomic analysis reveals wall-associated and glucan-degrading proteins with potential roles in Phytophthora infestans sexual spore development. by Xiaofan Niu, Audrey M V Ah-Fong, Lilianna A Lopez, Howard S Judelson

“…Rising by >10-fold in at least one cross were 455 genes, and 182 in all three crosses. Most genes had elevated expression in a self-fertile strain. …”
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Impact of the Use of 2-Phospho-L Ascorbic Acid in the Production of Engineered Stromal Tissue for Regenerative Medicine by David Brownell, Laurence Carignan, Reza Alavi, Christophe Caneparo, Maxime Labroy, Todd Galbraith, Stéphane Chabaud, François Berthod, Laure Gibot, François Bordeleau, Stéphane Bolduc

“…This study aims to demonstrate the functional equivalence of 2-phospho-L-ascorbate (2PAA), a stable form of AA, for tissue reconstruction. …”
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255 The impact of a personal cancer diagnosis on adolescent and young adult cancer survivors’ social connectedness: A qualitative analysis by Pooja Rao, Joel E Segel, Kristin Bingen, Katie A Devine, Allison M Scott, Laura M Koehly, Ashton M Verdery, Courtney L Rumbaugh, Emily Wasserman, Heather J Costigan, Smita Dandekar, Kevin Rakszawski, Natthapol Songdej, George F Blackall, Monali Vasekar, Seema Naik, Eugene J. Lengerich, Lauren J Van Scoy

“…Participants (and consenting parents of participants 18 years old and older) had to have fluency in written and spoken English and access to a computer or smartphone. …”
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Cutaneous dysbiosis in girls with vulvar lichen sclerosus by Liying Sun, Huihui Gao, Hongyu Chen, Chenfei Ren, Junwen Zhang, Qiuxiang Shen, Li Zhu, Dandan Chen, Lingling Jin, Chaoqun Wang, Fengxia Li, Lan Yu

“…Microbial diversity was assessed using α diversity, β diversity, and LEfSe, and functional microbial pathways were predicted. No differences were observed in α diversity among groups. …”
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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…In vitro, LPS-stimulated Cal-27 cells had a stronger potential to induce PD-L1 expression in macrophages compared with unstimulated Cal-27 cells. …”
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Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients... by Hongkai Wang, Shusuan Jiang, Hong Luo, Fangjian Zhou, Dalin He, Lulin Ma, Hongqian Guo, Chaozhao Liang, Tie Chong, Jun Jiang, Zhiwen Chen, Yong Wang, Qing Zou, Ye Tian, Jun Xiao, Jian Huang, Jinchao Chen, Qiang Dong, Xiaoping Zhang, Hanzhong Li, Xinfeng Yang, Jianpo Lian, Wenliang Wang, Dingwei Ye

“…Both study groups displayed comparable baseline pain scores and functional status. Patients administered REZ-ADT had an extended time to progression of worst pain intensity in comparison to those treated with BIC-ADT (25th percentile, 9.2 [95% CI 7.4–16.6] vs. 6.4 months [95% CI 5.5–8.3]; HR 0.75 [95% CI 0.57–0.97]; p = 0.026). …”
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