Key motor and non-motor features in early dementia with Lewy bodies by Anna Planas-Ballvé, Anna Planas-Ballvé, José Rios, Lourdes Ispierto, Mireia Gea, Laia Grau, Marta Jiménez, Cynthia Cáceres, Sílvia Martínez, Katrin Beyer, Ramiro Álvarez, Pau Pastor, Dolores Vilas, Dolores Vilas

“…Compared to AD, all non-motor symptoms were significantly more frequent in DLB. Finally, DLB patients had lower functional independence and quality of life than both PD and AD (p < 0.0001).ConclusionEarly-stage DLB closely resembles PD in motor symptoms but has more neuropsychiatric non-motor symptoms compared to PD and overall non-motor symptoms than AD.…”
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Inhibition of carbohydrate digestive enzymes by a complementary essential oil blend: in silico and mixture design approaches by El Hassania Loukili, Mouhcine Fadil, Amal Elrherabi, Mohammed Er-rajy, Mohamed Taibi, Khalil Azzaoui, Khalil Azzaoui, Rachid Salghi, Rachid Sabbahi, Mohammed M. Alanazi, Larbi Rhazi, Aleksandar Széchenyi, Aleksandar Széchenyi, Mohamed Siaj, Belkheir Hammouti

“…I. viscosa contained 18 metabolites, dominated by 2-camphanol acetate (51.12%) and camphol (19.32%), while C. citratus had 23 metabolites, with α-citral (24.70%) and 2-isopropenyl-5-methylhex-4-enal (29.25%) as key constituents. …”
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Evaluation of antimicrobial, anticancer, and neuroprotective activities of silver nanoparticles (AgNPs) green-synthesized using a red pigment produced by Streptomyces sp. A23 strai... by Mokhnache Mohamed, Hani Belhadj, Koca Fatih Dogan, Unal Gokhan, Rahman Nasrat Abdul, Basma Aysegul, Bozkurt Nuh Mehmet, Bachir Ahmed Alien Mohamed, Daoud Harzallah

“…Intriguingly, all the synthesized AgNPs at concentrations of 2, 4 and 8 μg mL-1 had cytotoxic effects on SHSY5Y neuroblastoma cell lines. …”
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Haplotype Analysis of the GL7/GW7/SLG7 Gene and Its Application in Improving the Grain Quality of Three-Line Hybrid Rice by Duo Xia, Peizhou Xu, Shuqin Zheng, Le Xue, Yuejiao Yin, Zhuchen Yao, Sikai Ding, Yusen Lai, Yipei Wang, Xiaoding Ma, Xianjun Wu, Hao Zhou

“…Among nine haplotypes of GL7 (H1-9), H1-H4, which harbored an 11-bp deletion, were designated as the functional GL7 allele and were primarily present in Geng/Japonica (GJ) rice. …”
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Identification of prognostic biomarkers related to epithelial-mesenchymal transition and anoikis in hepatocellular carcinoma using transcriptomics and single-cell sequencing by Maobing Wang, Lu Cheng, Lu Cheng, Lu Cheng, Lu Cheng, Kuo Qi, Kuo Qi, Kuo Qi, Kuo Qi, Haiping Wang, Haiping Wang, Haiping Wang, Haiping Wang, Xun Li, Xun Li, Xun Li, Xun Li

“…Subsequently, the potential functions of biomarkers were explored through methods such as enrichment analysis and immune microenvironment analysis. …”
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Effects of High-Concentrate Diets on Growth Performance, Serum Biochemical Indexes, and Rumen Microbiota in House-Fed Yaks by Ben Zhang, Xingdong Wang, Ziqiang Ding, Yandong Kang, Shaoke Guo, Mengli Cao, Liyan Hu, Lin Xiong, Jie Pei, Xian Guo

“…In conclusion, high-concentrate diets can enhance growth performance and alter the compositions and functions of ruminal bacterial communities in yaks.…”
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MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…None of the variants or large deletions identified had an impact on prognosis. MtDNAcn variation in tumor relative to normal kidney appears as an independent prognostic factor in ccRCC, which was also associated with eosinophilic morphology. …”
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Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture by Rajendra A. Morey, Yuanchao Zheng, Henry Bayly, Delin Sun, Melanie E. Garrett, Marianna Gasperi, Adam X. Maihofer, C. Lexi Baird, Katrina L. Grasby, Ashley A. Huggins, Courtney C. Haswell, Paul M. Thompson, Sarah Medland, Daniel E. Gustavson, Matthew S. Panizzon, William S. Kremen, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue

“…This pleiotropy may be harnessed to identify unique genetically-informed parcellations of the cortex that are neurobiologically distinct from functional, cytoarchitectural, or other cortical parcellation schemes. …”
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Characteristics and driving factors of power generation performance in microbial fuel cells: an analysis based on the CNKI database by Ruikai Zhang, Wentao Dai, Hongyong Xiang, Hongyong Xiang, Hongyong Xiang, Jie Chen, Jie Chen, Jie Chen, Ting Yi, Jiayi Li, Jiebin Zhang, Qiuxi Yang, Rui Xiao, Xiang Li

“…Microbial fuel cells (MFCs) have become one of the most promising technologies in the field of ecology and environmental science due to their dual functions of power generation and pollutant removal. …”
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High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…Results We included 1097 participants; 78.7% had positive RF, with high titers (≥ 3 × the upper limit of normality) in 56.2%. …”
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Effects of 52 weeks of precuneus rTMS in Alzheimer’s disease patients: a randomized trial by Giacomo Koch, Elias Paolo Casula, Sonia Bonnì, Ilaria Borghi, Martina Assogna, Francesco Di Lorenzo, Romina Esposito, Michele Maiella, Alessia D’Acunto, Matteo Ferraresi, Lucia Mencarelli, Valentina Pezzopane, Caterina Motta, Emiliano Santarnecchi, Marco Bozzali, Alessandro Martorana

“…Here we sought to investigate the effects of 52 weeks of rTMS applied over the PC on cognitive functions in patients with mild-to-moderate dementia due to AD. …”
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Machine Learning Reveals Aneuploidy Characteristics in Cancers: The Impact of BEX4 by Aizhong Xu, Jianjun Liu, Li Tong, Tingting Shen, Songlin Xing, Yujie Xia, Bosen Zhang, Zihao Wu, Wenkang Yuan, Anhai Yu, Zijie Kan, Wenqi Yang, Chao Zhang, Chong Zhang

“…Mfuzz expression pattern clustering and functional enrichment were applied to genes with BEX4 as the core to explore their regulatory mechanisms. …”
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HLF and PPARα axis regulates metabolic‐associated fatty liver disease through extracellular vesicles derived from the intestinal microbiota by Xingzhen Yang, Jiale Wang, Xinyu Qi, Menglong Hou, Mengkuan Liu, Yang Xiao, Siqi Liu, Jinfeng Zhou, Jingsu Yu, Yang Wang, Guo Chen, Lin Yu, Khongorzul Batchuluun, Batbold Batsaikhan, Turtushikh Damba, Yuehui Liang, Xue Liang, Jie Ma, Yunxiao Liang, Yixing Li, Lei Zhou

“…The HLF/PPARα axis alleviated MAFLD by mediating gut microbiota‐derived extracellular vesicles (fEVs), thereby inhibiting hepatocyte ferroptosis. Lipidomics and functional experiments verified that taurochenodeoxycholic acid (TCDCA), a conjugated bile acid contained in the fEVs, had a key role in the process. …”
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VCP regulates early tau seed amplification via specific cofactors by Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White, Marc I. Diamond

“…The inhibitors only functioned when administered within 8 h of seed exposure, indicating a role for VCP early in seed processing. …”
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Study on the changes in the microbiome before and after seed embryo after-ripening of Fritillaria cirrhosa by Wenshang Li, Wenshang Li, Can Zhao, Can Zhao, Qian Tao, Qian Tao, Weimin Zhang, Weimin Zhang, Hai Wang, Guiqi Han, Guiqi Han, Zhuyun Yan, Zhuyun Yan

“…After embryo after-ripening, the dominant fungal genera were Botrytis (SBAR, 29.35%), Tetracladium (SBAR, 15.86%), Ilyonectria (SBAR, 15.35%), and Mrakia (SBAR, 13.14%), while the dominant bacterial genera were Pseudomonas (SBAR, 26.69%) and Stenotrophomonas (SBAR, 16.30%).Prediction results suggested that the bacterial communities with sharply increased relative abundance after embryo after-ripening may interact with seeds through various pathways, including carbohydrate metabolism, absorption and utilization of nitrogen (N), sulfur (S), phosphorus (P), and iron (Fe), as well as secretion of antibiotics, vitamins, cytokinins, and amino acids. Functional validation revealed that most culturable fungi with sharply increased relative abundance had cellulase-degrading abilities, while most of the bacterial isolates were capable of absorbing and utilizing C, N, S, P, and Fe elements. …”
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Comorbidity Burden in Chronic Thromboembolic Pulmonary Hypertension: Implications and Outcome by Burcak Kilickiran Avci, Ibrahim Basarici, Mehmet Akbulut, Halil Atas, Yalin Tolga Yaylali, Umit Yasar Sinan, Ersan Atahan, Murat Meric, Baris Kaya, Kardelen Ohtaroglu Tokdil, Ozden Calay, Hasan Tokdil, Bulent Mutlu, Mehmet Serdar Kucukoglu, Zeki Ongen

“…<i>Conclusions</i>: A high comorbidity burden is common in CTEPH and influences functional status, hemodynamics, and operability decisions. …”
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External negative pressure improves lung aeration in near-term rabbit kittens at risk of developing respiratory distress by C. Diedericks, C. Diedericks, K. J. Crossley, K. J. Crossley, D. Jurkschat, M. J. Wallace, M. J. Wallace, I. M. Davies, I. M. Davies, P. J. Riddington, P. J. Riddington, A. B. te Pas, M. J. Kitchen, M. J. Kitchen, S. B. Hooper, S. B. Hooper

“…Lung liquid was drained in Control kittens to simulate expected volumes following vaginal delivery. EL kittens had lung liquid drained before 30 ml/kg was returned to simulate expected volumes after caesarean section. …”
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Enhancing nurses’ communication about psychosocial needs and changes in intimacy and sexuality in patients with advanced cancer: a mixed-method study by Susanne A.M. Arends, Corien M. Eeltink, Floortje K. Ploos van Amstel, Astrid W. Oosten, Donna C. Ruijter, Nelleke van der Loo, Barbara Harterink-Poker, Anneke L. Francke, Irene P. Jongerden

“…Conclusion: After the programme, more nurses felt competent in discussing psychosocial needs in patients with advanced cancer, especially with regard to changes in intimacy and sexual functioning. The training had little effect on nurses’ notes about psychosocial needs in patient records; the focus remained on physical aspects. …”
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Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations by Harjot Uppal, MBA, George Abdelmalek, MD, Neil Patel, MD, Daniel Coban, MD, Stuart Changoor, MD, Nikhil Sahai, MD, Kumar Sinha, MD, Ki Hwang, MD, Arash Emami, MD

“…More CDA patients resumed work by 6 weeks (p=.018) and 3 months (p=.022), though these differences waned by 6 months. WC patients had slower returns overall (CDA WC: 7.5 vs 5.0 weeks for non-WC, p=.015). …”
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Health-related quality of life in rare bleeding disorders: results from the Rare Bleeding Disorders in the Netherlands study by Sterre P.E. Willems, Marjon H. Cnossen, Nick van Es, Paul L. den Exter, Ilmar C. Kruis, Karina Meijer, Laurens Nieuwenhuizen, Joline L. Saes, Nicole M.A. Blijlevens, Waander L. van Heerde, Saskia E.M. Schols

“…Patients reporting severe disease had worse pain interference and mental health scores (PROMIS-29) than those reporting nonsevere disease. …”
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