Vessel Fractional Flow Reserve and Graft Vasculopathy in Heart Transplant Recipients by Sakura Nagumo, Emanuele Gallinoro, Alessandro Candreva, Takuya Mizukami, Giovanni Monizzi, Monika Kodeboina, Sofie Verstreken, Riet Dierckx, Ward Heggermont, Jozef Bartunek, Marc Goethals, Dimitri Buytaert, Bernard De Bruyne, Jeroen Sonck, Carlos Collet, Marc Vanderheyden

“…Recently, vessel fractional flow reserve (vFFR) derived from COR has emerged as a diagnostic computational tool to quantify the functional severity of coronary artery disease. Purpose. …”
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N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility by Yalun He, Jie Ding, Tonglin Bai, Yangshuo Li, Xiaolan Liang, Yiming Chen, Yi Lin, Wen Cheng, Chaoqin Yu

“…Immune cell infiltration analysis further demonstrated that the expression levels of m6A regulators had a notable impact on immune cell infiltration. …”
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Identification of bioaccessible and neuroprotective peptides from fermented casein hydrolysate by Ruirui Li, Shufang Shan, Yujie Xu, Jingyuan Xiong, Guo Cheng

“…Among these peptides, 7 nontoxic small peptides had relatively high predicted affinities for Keap1 and were verified in LPS-treated BV2 cells. …”
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Endovascular therapy and medical management of large-core infarcts: prognostic determinants in a retrospective cohort by Yi Li, Yi Li, Hao Tao, Hao Tao, Huan Liu, Huan Liu, Xiang Fan, Xiang Fan, Meng-Yu Zhong, Meng-Yu Zhong, Jie Huang, Neng-Wei Yu, Neng-Wei Yu, Bing-Hu Li, Bing-Hu Li

“…In the EVT subgroup (n = 62), hyperglycemia remained significantly associated with poor outcomes (OR = 1.70, 95% CI: 1.04–2.78, p = 0.034).ConclusionEVT significantly improves functional outcomes in large-core infarcts. Preoperative hyperglycemia and elevated platelet count are independent predictors of poor outcomes. …”
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Blood RNA-seq in rare disease diagnostics: a comparative study of cases with and without candidate variants by Xiaomei Luo, Bing Xiao, Lili Liang, Kaichuang Zhang, Ting Xu, Huili Liu, Yi Liu, Yongguo Yu, Yanjie Fan

“…Blood RNA sequencing (RNA-seq) complements DNA-level diagnosis by revealing the functional impact of variants on gene expression and splicing, but to what extent RNA-driven approaches offer diagnostic benefits across different scenarios—with and without pre-existing candidate variants—remains uncertain. …”
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Early markers of renal damage in type 2 diabetes: role of vitamin D-binding protein by V.M. Yerokhovych, O.V. Karpenko, Ye.I. Ilkiv, N.M. Kobyliak, I.A. Paliienko, I.V. Dumka, Yu.I. Komisarenko

“…Recently, increasing attention has been focused on the extraskeletal functions of vitamin D, the role of vitamin D-binding protein (VDBP), and their pathogenetic link to kidney damage in people with type 2 diabetes. …”
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Nutrient, Organic Matter and Shading Alter Planktonic Structure and Density of a Tropical Lake by Marina Isabela Bessa da Silva, Luciana Pena Mello Brandão, Ludmila Silva Brighenti, Peter A. U. Staehr, Cristiane Freitas de Azevedo Barros, Francisco Antônio Rodrigues Barbosa, José Fernandes Bezerra-Neto

“…On the other hand, physical shading had less influence on these communities, presenting densities similar to those found in the control mesocosms. …”
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Pathway to care, treatment and disease burden of pulmonary arterial hypertension: a real-world survey of physicians and patients in Latin America by Mauricio Orozco-Levi, Rogerio Souza, Ignacio M Bluro, Julia Harley, Jose Luis Hernández Oropeza, Adrian Lescano, Gisela Meyer, Tatiana Pineda, Alicia Ramirez, Mark Small, Angelo Valencia, Tomás Pulido

“…Objectives To investigate clinical characteristics, symptom profile, testing practices, treatment patterns and quality of life (QoL) among patients with pulmonary arterial hypertension (PAH) in Latin America.Design Data from the Adelphi Real World PAH Disease Specific Programme, a cross-sectional survey with retrospective data collection.Setting University/teaching hospital, regional centres, private practices and government institutions in Argentina, Brazil, Colombia and Mexico.Participants 246 physicians provided data for 958 patients, of which 533 patients also self-reported data.Results Mean (SD) patient age was 53.7 (17) years, 70% of patients were female and 79% were WHO functional class (WHO FC) I–II. Overall, 76% had undergone a right heart catheterisation, ranging from 92% in Argentina to 64% in Brazil (p<0.0001). …”
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Identification of anoikis-related molecular patterns and the novel risk model to predict prognosis, tumor microenvironment infiltration and immunotherapy response in bladder cancer by Luochen Zhu, Feng Xiao, Yi Hou, Shenjun Huang, Yanyan Xu, Xiaohong Guo, Xinwei Dong, Chunlu Xu, Xiaolei Zhang, Haijuan Gu

“…In addition, representative genes were evaluated using immunohistochemistry in clinical specimens, and in BLCA cell lines, functional experiments were performed to determine the biological behavior of hub gene PLOD1.ResultTwo definite anoikis subgroups were identified. …”
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The Arabic Satisfaction with Life Scale (SWLS) and its three-item version: Factor structure and measurement invariance among university students by Amira Mohammed Ali, Saeed A. Al-Dossary, Musheer A. Aljaberi, Maha Atout, Rasmieh Alamer, Mohamed M.H. Suliman, Feten Fekih-Romdhane

“…Satisfaction with life implicates the psychological, social, and educational functioning of students—justifying its use for clinical screening and monitoring of treatment outcomes. …”
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Component Composition and Antimicrobial Activity of CO2 Extract of Portulaca oleracea, Growing in the Territory of Kazakhstan by Meruyert I. Tleubayeva, Ubaidilla M. Datkhayev, Mereke Alimzhanova, Margarita Yu Ishmuratova, Nadezhda V. Korotetskaya, Raisa M. Abdullabekova, Elena V. Flisyuk, Nadezhda G. Gemejiyeva

“…Studies of antimicrobial activity showed that CO2 extract of Portulaca oleracea had the expressed effect against clinically significant microorganisms such as Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicans. …”
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Adaptive evolution of sesquiterpene deoxyphomenone in mycoparasitism by Hansfordia pulvinata associated with horizontal gene transfer from Aspergillus species by Kazuya Maeda, Takuya Sumita, Oumi Nishi, Hirotoshi Sushida, Yumiko Higashi, Hiroyuki Nakagawa, Tomoko Suzuki, Eishin Iwao, Much Zaenal Fanani, Yoshiaki Nishiya, Yuichiro Iida

“…Here, we identified deoxyphomenone biosynthesis (DPH) gene clusters conserved in both H. pulvinata and Aspergillus section Flavi, including A. oryzae and A. flavus. Functional disruption of DPH1 orthologous genes encoding sesquiterpene cyclase in H. pulvinata, A. oryzae, and its close relative A. flavus revealed that deoxyphomenone in H. pulvinata had exogenic antifungal activity against C. fulvum and controlled endogenic sporulation in Aspergillus species. …”
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Variations of microbial communities and enzyme activities in rhizosphere and non-rhizosphere soils of aged Loropetalum chinense forests in karst rocky mountains during dry and rain... by WANG Yanan1,2, MA Jiangming1,2*, LIANG Yueming3, YANG Hao1,2

“…In addition, soil enzyme activity was significantly correlated with carbon, nitrogen, phosphorus, potassium, and soil water content.(4)Compared to bacteria, fungal functions in rhizosphere and non-rhizosphere soils were more sensitive to seasonal changes. …”
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Rheumatoid arthritis and psoriatic arthritis: is the disease impact different? A large matching study at diagnosis and after 1 year of treatment by Annette H M van der Helm-van Mil, Pascal H P de Jong, Sytske Anne Bergstra, Elise van Mulligen, Ilja Tchetverikov, Jolanda J Luime, Marijn Vis, Marc R Kok, Maikel van Oosterhout, Jos H van der Kaap, Selinde V J Snoeck Henkemans, Anne-Fleur van den Biggelaar

“…This difference still existed after 1 year of treatment (3.88 (95% CI 1.90 to 5.86)). PsA-EAC patients had more activity limitations after 1 year of treatment compared with RA-EAC patients (−0.30 (95% CI −0.50 to −0.10)). …”
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Whether the Indications for Reverse Shoulder Arthroplasty Should Continue to Be Expanded? A Systematic Review and Meta‐Analysis by Huankun Li, Hangsheng Bao, Zhidong Yang, Baijun Hu, Yaocheng Pan, Yi Wang, Jiayi Chen, Hongjun Chen, Bisheng Shen, Yonggen Zou

“…Overall, RTSA did not demonstrate advantages in postoperative functional scores and range of motion. In terms of complication and revision rates, RTSA had lower rates compared to HA and ATSA, except for the complication rate, where there was no significant difference between RTSA and ATSA (p = 0.521), but statistically significant differences were observed in other measures. …”
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BCMA CAR-T therapy combined with pomalidomide is a safe and effective treatment for relapsed/refractory multiple myeloma by Yuhan Yan, Yixuan Tu, Qian Cheng, Jian Zhang, Erhua Wang, Zuqun Deng, Yan Yu, Liwen Wang, Rui Liu, Ling Chu, Liqing Kang, Jing Liu, Xin Li

“…Long-term pomalidomide therapy, which potentiates T-cell functionality, might enhance the efficacy of BCMA CAR T-cell therapy. …”
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A pilot study of PSMA-targeted F-18-DCFPyL PET imaging of patients with adenoid cystic carcinoma by Andrew F. Voter, Alireza Amindarolzarbi, Colette J. Shen, Jarey Wang, Hyunseok Kang, Rajni Sharma, Lilja B. Solnes, Martin G. Pomper, Justin A. Bishop, Steven P. Rowe, Ana P. Kiess

“…Prostate-specific membrane antigen (PSMA) expression has been observed in ACC and preliminary studies have demonstrated PET imaging using 68Ga-functionalized PSMA agents for positron emission tomography (PET). …”
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Ways to predict interstitial lung disease in patients with systemic sclerosis: results of an observational study by D. V. Khorolsky, A. A. Klimenko, E. S. Pershina, N. M. Babadeva, A. A. Kondrashov, N. A. Shostak, E. P. Mikheeva, E. V. Zhilyaev

“…In patients with systemic sclerosis (SSc), interstitial lung disease (ILD) is a factor in the decline of functional capacity up to disability and is also the leading cause of death. …”
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Valorization of Residual Silica from the Aqueous-Phase Silicate Conversion of Microsilica as Sustainable Reinforcing Fillers in Rubber Composites by Hai Wang, Gang Hu, Linwei Yan, Xia Hou, Junfeng Gao, Guoyun Zhao, Lei Wang, Ruilong Zhao, Yifan Zhang

“…The optimized protocol, which combines NaOH activation, H _2 SO _4 reprecipitation, and SN 5040 steric stabilization, had superior filler properties: SiO _2 purity of 95.68%, BET surface area of 233.99 m ^2 g ^−1 (4.3× improvement), and D50 particle size of 3.03 μm. …”
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Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome by H. Keskin, K. Cadirci, K. Gungor, T. Karaaslan, T. Usta, A. Ozkeskin, A. Musayeva, F. Yesildal, F. Isman, H. Y. Zengin

“…Independent of age and BMI, elevated TSH even in the euthyroid range showed an association with the eGFR in female MetS cases who had normal kidney functions. This correlation was stronger than the correlations between the eGFR and the MetS diagnostic parameters. …”
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