Integrative multi-omics and Mendelian randomization analysis reveal SPP1+ tumor-associated macrophage-driven prognostic signature for hepatocellular carcinoma by Kai Lei, Yichun Lei, Zeyao Wang, Zhixin Ye, Jiawei Liu, Wenhao Chen, Caihong Zhou, Jinmei Tan, Shuxian Chen, Yifan Zhang, Jiehui Tan

“…Patients in the high-STRS group had significantly worse OS than those in the low-STRS group (p < 0.001). …”
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Effects of Mg-Palygorskite Modified Biochar on the Growth of <i>Sedum alfredii</i> Hance in Heavy Metal Contaminated Soil by Tianwen Wang, Xianxiang Luo, Kun Chen, Hao Zheng, Zewei Song, Lize Zhao, Junhua Gong, Fengmin Li, Ruhai Liu

“…This study provides data support for the development of functionalized biochar for the remediation of heavy metal pollution in soil.…”
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Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…OPCs were differentiated from NSCs and had their identity confirmed by gene expression analysis and immunocytochemistry. …”
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Genetic insights from whole-exome sequencing in Moroccan patients with non-small cell lung cancer: a case report by Meryem Fakhkhari, Manikandan Vinu, Houda Chaibi, Mame Massar Dieng, Meryem Chebak, Khadija Hajjout, Rachida Zahraoui, Nawal Bouyahyaoui, Jamal-Eddine Bourkadi, Youssef Idaghdour, Khalid Sadki

“…The patients included two with stage III lung squamous cell carcinoma (P1 and P2) and one with stage IV adenocarcinoma (P3). All three had significant smoking histories, ranging from 40 to 45 pack-years, but no family history of tumors or respiratory diseases. …”
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Bibliometric and visualization analysis of temporomandibular joint osteoarthritis from 2004 to 2024 by Chi Xu, Chi Xu, Chi Xu, Chongqing Yu, Chongqing Yu, Chongqing Yu, Tao Wang, Tao Wang, Tao Wang, Xiang Gao, Xiang Gao, Xiang Gao

“…BackgroundTemporomandibular joint osteoarthritis (TMJOA) is a severe condition affecting the temporomandibular joint, impairing essential oral functions such as chewing, speaking, and swallowing. …”
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Comparative response mechanisms of two cultivars of Musa paradisiaca L. to Fusarium oxysporum f.sp. cubense infection by Yajie Duan, Yajie Duan, Zhiwei Jia, Zhiwei Lu, Huigang Hu, Rulin Zhan

“…For our analysis, root tissues from seedlings that had been in contact with Fusarium oxysporum for four days were harvested, including both infected and uninfected samples, which served as our study specimens. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…Conclusions: SIRT1 expression seems to be involved in different molecular pathways either suppressing or promoting tumor growth depending on the subtype of BC. These molecular functions require further investigations and validation on larger BC cohorts.…”
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The Impact of Screw Density on the Outcomes of Adolescent Idiopathic Scoliosis Correction Surgery: A Multicenter Retrospective Study by ZhaoJun Lu, Chong Liu, JiaKun Li, XiaoPeng Qin, Jiarui Chen, Jiang Xue, Hao Li, Tianyou Chen, Tao Chen, XinLi Zhan

“…Compared with high-density constructs, low-density constructs demonstrated shorter operative time (median: 17.93 min, IQR: 14.66–20.50 vs. 22.15 min, IQR: 16.80–24.77; p = 6.30e−07), lower intraoperative blood loss (median: 762.29 ml, IQR: 600–900 vs. 954.19 ml, IQR: 800–1030; p = 7.70e−07), fewer postoperative pain (median: 4.719, IQR: 3–7 vs. 5.505, IQR: 3.5–7; p = 0.009), and shorter hospital stays (median: 11.15 days, IQR: 7–13.5 vs. 12.48 days, IQR: 8–15; p = 0.04). Both groups had equivalent Cobb angle correction (median: 67.31%, IQR: 60.50% –76.84% vs. 67.97%, IQR: 62.54%–73.52%; p = 0.90).Conclusion Optimizing screw density may minimize intraoperative blood loss and postoperative pain without affecting correction efficacy in AIS; however, longitudinal studies are needed to assess long-term functional and quality-of-life outcomes.…”
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Experience of application of proproceptive modeling of walking in children of early age with motor disorders by A. G. Prityko, N. V. Chebanenko, V. P. Zykov, P. L. Sokolov, E. A. Bukreeva, T. A. Sednenkova, E. Yu. Sergeenko

“…As a result of treatment, positive dynamics of motor functions was noted. It was expressed in the normalization of muscle tone and with its decrease, and with an increase. …”
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Complete remission of advanced hepatocellular carcinoma following transient chemoembolization and portal vein ligation by Yuki Koga, Toru Beppu, Katsunori Imai, Kunitaka Kuramoto, Tatsunori Miyata, Yuki Kitano, Shigeki Nakagawa, Hirohisa Okabe, Kazutoshi Okabe, Yo-ichi Yamashita, Akira Chikamoto, Hideo Baba

“…As the thrombus had progressed to the bifurcation of the right and left portal veins, the right vein was surgically ligated. …”
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Modulation of flowering by an alternatively spliced AGL18-1 transcript in Brassica juncea by Qinlin Deng, Huanhuan Lu, Dakun Liu, Yifang Huang, Junjie Feng, Dayong Wei, Zhimin Wang, Qinglin Tang

“…Further investigation showed that the two isoforms had similar subcellular localizations but different expression patterns in various plant tissues. …”
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Prevalence and Mortality of Heart Failure Stages in a Free‐Living Older Adult Population: Data From the Brazilian Longitudinal Study of Adult Health by Altair I. Heidemann, Angela B. S. Santos, Marcio S. Bittencourt, Antonio L. P. Ribeiro, Luis E. Rohde, Paulo A. Lotufo, Bruce B. Duncan, Murilo Foppa

“…In this analysis, we included participants 60 years old and over who had an echocardiogram performed at baseline visit and additional information regarding risk factors and functional capacity. …”
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Nutrition and Antioxidant Potential of Three Cauliflower (Brassica oleracea L. Var. Botrytis) Cultivars Cultivated in Southern Part of Bangladesh by Mousumi Jahan Sumi, Sharmin Akter Serity, Tusar Kanti Roy, Keya Akter, Shishir Rasul, Mostofa Jaman Depro, Md. Masum Abdullah, Md. Nesar Uddin

“…The findings highlight the potential of Carotena and Valentena for health-conscious consumers seeking nutrient-rich, antioxidant benefits in functional meals.…”
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The potential of biogas production and effects of alfalfa silage under the synergistic influence of Lactobacillus acidophilus and Rosa roxburghii pomace waste on the fermentation q... by Maoya Li, Jiachuhan Wang, Qiming Cheng, Zhongfu Long, Chao Chen, Yixiao Xie, Yao Lei, Yulian Chen, Yuanyuan Zhao, Xiangjiang He, Wei Yan, Zhijun Wang

“…ABSTRACT The process of ensiling serves as a dual-purpose technique, functioning as a means of preserving biomass for biogas production while serving as a biological pretreatment method with the potential for little fermentation loss. …”
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Health-Related Quality of Life and Fatigue in Children with Pompe Disease by Linda E. Scheffers, Karolijn Dulfer, PhD, Charlotte Lanser, Maarten Mackenbach, MD, Ans T. van der Ploeg, MD, PhD, Johanna M.P. van den Hout, MD, PhD, Linda E. van den Berg, MD, PhD

“…Results: In total, of 24 patients with Pompe disease (and their parents) participated, with a median age of 9.6 years [IQR 7.7-11.9], 14 had classic infantile Pompe disease. Self-reported HR-QOL was comparable with the healthy Dutch population on most domains, and patients with the classic infantile type scored mainly lower on physical functioning. …”
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Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study by Misbah Unnisa, Mahya Faghih, Asbjørn Mohr Drewes, Vikesh K. Singh, Dhiraj Yadav, Rupjyoti Talukdar, Søren Schou Olesen, Anna Evans Phillips

“…The Western cohort also reported lower global health and worse scores in physical, role, cognitive, and social functioning with a reduction in overall global health in multivariable regression analyses (−7.2 points [95% confidence interval −13.5 to −1.0] P = .023). …”
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Predictors and Outcomes of Hematoma Expansion and Neurological Decline in Intracerebral Hemorrhage: A Multisite Mobile Stroke Unit Study by Asish K. Gulati, Tianwen Ma, Isaiah Rolle, Ryan Peterson, Bianca Pirlog, Justine Chen, Megan Heckathorn, Jonathan Ratcliff, Nicolas Bianchi, Carol Fleming, Michael Frankel, James Grotta, Ritvij Bowry, Stephanie Parker, William Hicks, Digvijaya Navalkele

“…Patients with HE and ND had a higher discharge modified‐Rankin Scale score and mortality rates. …”
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Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation by Jana Ramon, Cláudio Pinheiro, Charysse Vandendriessche, Estefanía Lozano-Andrés, Herlinde De Keersmaecker, Deep Punj, Juan C. Fraire, Edward Geeurickx, Marca H. M. Wauben, Pieter Vader, Roosmarijn E. Vandenbroucke, An Hendrix, Stephan Stremersch, Stefaan C. De Smedt, Koen Raemdonck, Kevin Braeckmans

“…We established that photoporation had minimal impact on EV characteristics such as concentration, size, zeta potential and the enrichment of EV tetraspanin membrane surface molecules. …”
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Glycopattern comparison of sperm and exosomes from conventional in vitro fertilization and rescue intracytoplasmic sperm injection: Enhancing sperm motility through exosome‐mediate... by Muhammad Anas Ramzan, Zhedong Yang, Li Cao, Jinyuan Zhang, Fei Wu, Miaomiao Xin, Bo Guo, Lumin Wang, Lingyu Zhao, Yannan Qin, Chengcheng Liu

“…Clinical data from 2023 at Northwest Women and Children's Hospital, China, showed that RICSI couples had longer infertility durations, and younger ages, required lower gonadotropin doses, and retrieved more oocytes, despite lower sperm quality. …”
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Detailed Investigation of Cobalt-Rich Crusts in Complex Seamount Terrains Using the Haima ROV: Integrating Optical Imaging, Sampling, and Acoustic Methods by Yonghang Li, Huiqiang Yao, Zongheng Chen, Lixing Wang, Haoyi Zhou, Shi Zhang, Bin Zhao

“…To enhance surveys of cobalt-rich crusts (CRCs) on complex seamount terrains, the 4500-m-class Haima ROV integrates advanced payloads, such as underwater positioning systems, multi-angle cameras, multi-functional manipulators, subsea shallow drilling systems, sediment samplers, and acoustic crust thickness gauges. …”
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