Unawareness of the disease in patients with schizophrenia: diagnosis and insight-oriented psychotherapy by O. I. Osokina, B. B. Ivnyev, G. G. Putyatin, Ye. M. Denisov, S. G. Ushenin

“…To study social indicators the scale of social functioning in various spheres was used (Zaitsev, 1999). …”
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Enhancing the effects of nusinersen with cybernic treatment using Hybrid Assistive Limb (HAL) in spinal muscular atrophy: a real-world case series and exploratory cohort analysis by Takashi Nakajima, Toshio Saito, Akihiro Hashiguchi, Taiki Nakabayashi, Kazuki Kodera, Kota Utsumi, Takeshi Kanayama, Haruka Urabe, Satoru Kinoshita

“…Abstract Background Nusinersen therapy for spinal muscular atrophy (SMA) provides significant functional improvement when initiated pre-symptomatically or early in life. …”
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Research on the Flavor and Physicochemical Characteristics of Yogurt Fermented by Different Starter Cultures by Xulong CHANG, Qingxia ZHOU, Wencong MA, Zhenming ZHAN, Xinxin YAO, Aimei ZHOU

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Development of the ELISA Test System for Quantitative Determination of IgG to the Varizella zoster virus in Human Serum and Assessment of its Diagnostic Efficiency by L. N. Lukhverchyk, G. L. Alatortseva, L. N. Nesterenko, V. Y. Kabargina, V. V. Dotsenko, I. I. Amiantova, O. B. Vylivannaya, A. V. Sidorov, A. V. Milovanova, O. S. Oksanich, S. Y. Konanykhina, V. V. Zverev

“…The main functional characteristics of the developed enzyme-linked immunosorbent assay are determined in accordance with GOST 51352-2013. …”
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Effects of a WHO-guided digital health intervention for depression in Syrian refugees in Lebanon: A randomized controlled trial. by Pim Cuijpers, Eva Heim, Jinane Abi Ramia, Sebastian Burchert, Kenneth Carswell, Ilja Cornelisz, Christine Knaevelsrud, Philip Noun, Chris van Klaveren, Edith Van't Hof, Edwina Zoghbi, Mark van Ommeren, Rabih El Chammay

“…<h4>Methods and findings</h4>We conducted a single-blind, 2-arm pragmatic randomized clinical trial, comparing guided Step-by-Step with enhanced care as usual (ECAU) among displaced Syrians suffering from depression and impaired functioning in Lebanon. Primary outcomes were depression (Patient Health Questionnaire, PHQ-9) and impaired functioning (WHO Disability Assessment Schedule-12, WHODAS) at posttreatment. …”
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Early intensive blood pressure management after endovascular treatment in ischaemic stroke (IDENTIFY): a multicentre, open-label, blinded-endpoint, randomised controlled trialResea... by Xuening Zhang, Le Cao, Simiao Wu, Duolao Wang, Hang Wang, Dingwen Zhang, Jian Wang, Lizhang Chen, Xue Lin, Decai Qian, Qinjun Zhang, Lan Xiong, Weiping Wang, Yufeng Tang, Bo Lei, Tianzhu Liu, Jie He, Li Wang, Fuqiang Guo, Guangzong Li, Kuiyun Wang, Jinglun Li, Jun Luo, Jian Shen, Mangmang Xu, Hongbo Zheng, Dong Zhou, Ming Liu, Fayun Hu, Bo Wu, Bo Wu, Fayun Hu, Hongbo Zheng, Yufeng Tang, Decai Qian, Xiang Luo, Wenjie Zi, Xin Hu, Qingwu Yang, Weihai Xu, Anxin Wang, Duolao Wang, Le Cao, Dingwen Zhang, Xing Zhao, Bo Chen, Fayun Hu, Dong Zhou, Ming Liu, Hongbo Zheng, Xuening Zhang, Hang Wang, Mangmang Xu, Ping Wang, Zilong Hao, Jian Wang, Lizhang Chen, Xue Lin, Yuying Yan, Shuai Jiang, Chen Ye, Ruosu Pan, Tang Yang, Kun Lu, Wenzuo Shang, Jingyu Cui, Xueling Bai, Luyao Zhong, Yajun Cheng, Tianxiang Lan, Yuting Wu, Lanhua Liao, Xinyan Peng, Zengju Wue, Fayun Hu, Shuai Jiang, Chen Ye, Ruosu Pan, Tang Yang, Yuying Yan, Yuting Wu, Hang Wang, Ping Wang, Luyao Zhong, Yajun Cheng, Youjie Wang, Congjun Li, Ruishan Liu, Yuan Yao, Jian Wang, Lizhang Chen, Xue Lin, Decai Qian, Lei Deng, Weiping Wang, Yong Yan, Lan Xiong, Chao Li, Qinjun Zhang, Wei Zhang, Yufeng Tang, Zhaokun Li, Bo Lei, Li Chen, Gaoxian Tianzhu Liu, Jie He, Li Wang, Yu Xie, Guangzong Li, Xiaojing Luo, Fuqiang Guo, Shu Yang, Jian Shen, Lei Zhang, Jun Luo, Zhenxuan Tian, Jinglun Li, Yuan Yang, Kuiyun Wang, Weigang Kong, Jie Shen, Xiangping Cheng, Huan Ren, Youlin Wu, Liu Hua, Hui Zheng, Dong Wei, Hong WangZ, Qingwei Yang, Yufeng Hou, Zhou Yu, Miao Peng, Haizhi Guo, Xiangrong Sun, Wei Fan, Zicheng Hu, Jun Liu, Bo Zhang, Yunbo Chen, Lei Liu, Long Zhou, Bo Li, Jiachuan Liao, Xin Zhou, Li Zhou, Xiaolin Tan, Jian Fan, Daqing Xu, Qin Liu, Jia Duan, Xiaojun Luo, Yuqi Peng, Chao He, Jiajun Huang, Jin Fan, Tiao Qiu, Xuanye Yue, Zhijin Yang, Zhuobo Zhang, Yifei Chen, Pingyun Zeng, Haowen Xu, Shenglin Deng, Xiaoyun She, Chunyu Lei, Yifei Ji

“…The primary outcome was unfavourable functional outcome (modified Rankin Scale score of 3–6) at 90 days. …”
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PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample by Stefania Tognin, Sandra Vieira, Dominic Oliver, Alexis E. Cullen, Mathew J. Kempton, Paolo Fusar-Poli, Andrea Mechelli, Paola Dazzan, Kate Merritt, Arija Maat, Lieuwe de Haan, Stephen M. Lawrie, Thérèse van Amelsvoort, Celso Arango, Barnaby Nelson, Silvana Galderisi, Rodrigo Bressan, Jun Soo Kwon, Romina Mizrahi, the PSYSCAN Consortium, Rene S. Kahn, Philip McGuire

“…Cannabis and tobacco use did not significantly differ between groups, however CHR individuals had higher proportion of moderate to high risk of tobacco abuse. …”
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Introduction by Verena Balz

“…While the national government had first been involved in the practices incidentally from around 2000 and onward its engagement became more structural. …”
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Le fromage en Gaule à l’âge du Fer et à l’époque romaine : état des lieux pour sa production et analyse de sa place dans le monde antique by Alain Ferdière, Jean-Marc Séguier

“…Curiously enough, no research of this kind had been carried out previously, at least not with such spatial and temporal scope. …”
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Identification of novel antisense long non-coding RNA APMAP-AS that modulates porcine adipogenic differentiation and inflammatory responses by Lin-zhen ZHANG, Li HE, Ning WANG, Jia-hua AN, Gen ZHANG, Jin CHAI, Yu-jie WU, Chang-jiu DAI, Xiao-han LI, Ting LIAN, Ming-zhou LI, Long JIN

“…Long non-coding RNAs (lncRNAs) are emerging as powerful regulators of adipocyte differentiation, fat metabolism and gene expression. However, the functional roles and mechanisms of lncRNAs in these processes remain unclear. …”
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Production, characterization and antioxidant analysis on the Undaria-based alcoholic beverages using response surface method and HS-SPME-GC × GC-TOF-MS by Fangru Nan, Xinyi Li, Jia Feng, Junping Lv, Qi Liu, Xudong Liu, Yang Liu, Ruikai Zhang, Baoqing Bai, Shulian Xie

“…After optimization, UBL had a polysaccharide content (PC) of 0.66 g/L and an alcohol content (AC) of 39.2 % vol, while UFW showed a PC of 9.81 g/L and an AC of 8.3 % vol. …”
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Effect of Ultrasound/Ultra-high Pressure Combined with Sous-vide Cooking on the Quality of Spiced Beef by Zhenhua SHI, Daobang TANG, Huaigu YANG, Xueming LIU, Xuping WANG, Yaosheng LIN, Jinhao ZOU, Jingrong CHENG, Mingjun ZHU

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Preparation and characterization of lactoferrin-polyphenol conjugate with stabilizing effects on fish oil high internal phase Pickering emulsions by Ying Sun, Mantong Zhao, Zhongyuan Liu, Haohao Shi, Xueying Zhang, Yongqiang Zhao, Zhenhua Ma, Gang Yu, Guanghua Xia, Xuanri Shen

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scRNA-Seq reveals age-dependent microglial evolution as a determinant of immune response following spinal cord injury by Lufei Shao, Yueliang Chang, Jinfang Liu, Leilei Lin, Long Chang, Jialin Zhang, Zhibin Lan, Honglai Zhang, Xiaolei Chen

“…Spinal cord injury (SCI) is a debilitating condition of the central nervous system (CNS) that leads to severe impairments in sensory and motor functions. Previous studies have pointed out that patient age is a critical factor influencing SCI prognosis. …”
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Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma by Zhang Feng, Yuhang Yang, Wenqi Luo, Jinqing Li, Zhenlian Xie, Long Zuo, Meijiao Duan, Dongzhi Zuo, Ruwei MO, Xuejing Tang, Shijiang Yi, Xiaosong He, Fangxian Liu, Ning Ma, Feng He

“…Molecular docking verified the interaction between these three core genes and taurine, which was further supported by single-cell sequencing showing significant expression variation among different cell clusters in NPC. We had elucidated the functions, therapeutic potential, and prognostic significance of three key genes related to taurine metabolism in NPC through multidimensional research and experimental validation. …”
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Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma by Jiazhou Ye, Yan Lin, Zhiling Liao, Xing Gao, Cheng Lu, Lu Lu, Julu Huang, Xi Huang, Shilin Huang, Hongping Yu, Tao Bai, Jie Chen, Xiaobo Wang, Mingzhi Xie, Min Luo, Jinyan Zhang, Feixiang Wu, Guobin Wu, Liang Ma, Bangde Xiang, Lequn Li, Yongqiang Li, Xiaoling Luo, Rong Liang

“…Remarkably, M1-types TAMs had been characterized by disturbance of metabolism, poor antigen-presentation and immune-killing abilities. …”
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Fine mapping of a major QTL on chromosome A05 conferring pod size in peanut by Kunkun Zhao, Xufa Du, Jingjing Zhang, Yi Fan, Qian Ma, Yaoyao Li, Zenghui Cao, Di Cao, Sasa Hu, Ding Qiu, Kai Zhao, Fangping Gong, Zhongfeng Li, Rui Ren, Lin Zhang, Xingli Ma, Xingguo Zhang, Dongmei Yin

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Bioactive ECM-mimicking nerve guidance conduit for enhancing peripheral nerve repair by Shuang Liu, Julia Simińska-Stanny, Lizhao Yan, Lihong Fan, Xiaoyue Ding, Tengda Ma, Wei Guo, Yingsong Zhao, Ming Li, Jianghai Chen, Oseweuba Valentine Okoro, Armin Shavandi, Lei Nie

“…The hydrogels had matrices that could promote the growth of axons and the transmission of neural signals. …”
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PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS by Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench‐Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva

“…Overexpressing p110α in CNS neurons had no effect; however, expression of p110δ restored axonal PIP3 and increased regenerative axon transport. p110δ expression enhanced CNS regeneration in both rat and human neurons and in transgenic mice, functioning in the same way as the hyperactivating H1047R mutation of p110α. …”
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Mitigating microplastic toxicity: How particle size and degrading bacteria influence Cucumis sativus L. seedlings by Shuyi Chen, Peng Wu, Hao Ren, Guohua Shen, Zhuang Xiong, Wenlin Zhao, Xiang Guo, Peng Xiang, Junqiang Xu, Qiang Li

“…The PS-MPs treatment affected bacterial enzyme functions, including oxidoreductases, while the degrading bacteria enhanced reductase and hydratase functions. …”
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