Enhanced chemotherapy response in hepatocellular carcinoma: synergistic effects of miR-122 and doxorubicin co-delivery system inducing apoptosis and DNA damage by Xiuyun Lin, Jie Liu, Guangfeng Wu, Xiu Yang, Wenqiang Yan, Nanfeng Fan, Hui Li

“…Abstract Background Cancer cells can resist chemotherapy through various mechanisms, diminishing treatment outcomes. Research had indicated that combining miR-122 with doxorubicin (DOX) can improve hepatocellular carcinoma (HCC) therapy. …”
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A miR-JL-5 inhibitor modulates the proliferation of Nosema ceranae in Apis cerana by Xu Han, Xu Han, Jin Hua Xiao, Wei Yu Yan, Xu Jiang He, Xu Jiang He, Zhi Jiang Zeng, Zhi Jiang Zeng

“…Previous studies reported that N. ceranae was more harmful to the new host (Apis mellifera) than the original host that had spread globally and become one of the factors implicated in honeybee colony collapses. …”
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Genetic Insights Into Hyaline Fibromatosis Syndrome: A Case Report of an ANTXR2 Mutation Featuring a Rare Variant c.697+1G>A by Shabnam Hajiani Ghotbabadi, Reza Shiari, Shayan Yousufzai, Simin Sharifi

“…By 2005, 20 mutations in ANTXR2 linked to ISH and JHF had been documented, impairing cellular adhesion to the laminin matrix. …”
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ASSOCIATION OF CLINICAL MANIFESTATIONS AND COMORBIDITIES WITH QUALITY-OF-LIFE MEASURES IN PATIENTS WITH GOUT by M. S. Eliseev, M. V. Mukagova, S. I. Glukhova

“…Pearson’s and Spearman’s correlation analyses were made to reveal correlations between QL measures according to the EQ-5D and SF-36v1 questionnaires, HAQ functional status (FS), and the clinical characteristics of the disease, as well as comorbidities. …”
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Study protocol for a network meta-analysis of digital-technology-based psychotherapies for PTSD in adults by Jinhui Tian, Longtao He, Yanling Geng, Yangu Pan, Xinyu He, Xiangshu Deng, Wenjie Duan, Huamin Peng

“…Secondary outcome measures will include (1) dropout rate; (2) effectiveness at longest follow-up, but not more than 12 months and (3) patients’ functional recovery ratio (such as the return-to-work ratio or percentage of sick leave). …”
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Event-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control by Andreas Wulff-Abramsson, Ana Zvornik, Keenie Ayla Andersen, Yan Yang, Mikael Novén, Jesper Lundbye-Jensen, Leo Tomasevic, Anke Ninija Karabanov

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Effectiveness of treatment of bitches for infertility by O. M. Chekan, A. G. Bilokurov

“…Also, the restoration of the functional state of the ovaries was established in females of the 1st and 3rd experimental groups, which was characterized by the presence of follicles at the 2nd stage of development in histological preparations. …”
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Investigating the Design and Manufacture of a Silicone Texture Pad in a Lumbosacral Orthosis for a Patient With Chronic Low Back Pain by Bahareh Delshad, Mokhtar Arazpour, Akbar Biglarian, Seyed Reza Mousavi, Mohammad Ali Mardani

“…The patient was satisfied with the treatment method used. She had gradually increased the use of the belt due to its positive effects. …”
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Maternal pre‐pregnancy overweight or obesity and risk of birth defects in offspring: Population‐based cohort study by Weiying Liu, Luzhong Ren, Fang Fang, Ruoqing Chen

“…The importance of improving weight management and assessment of glucose and metabolic functions was emphasized among women planning for pregnancy who are overweight or obese.…”
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Sarcopenia and it’s influencing factors among adults with asthma, chronic obstructive pulmonary disease, and tuberculosis in Penang, Malaysia by Radhiyatul Akma Mohamad Zani, Hazwani Ahmad Yusof, Nurul ‘Ain Azizan, Irfhan Ali Hyder Ali, Suhaila Ismail, Noorsuzana Mohd Shariff

“…Ageing and physical inactivity exacerbate sarcopenia, reducing functional capacity, disability, and quality of life. …”
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Results of anti-VEGF therapy in patients with uveal melanoma by V.A. Yarovaya, E.O. Malakshinova, V.A. Pismenskaya, R.A. Loginov, A.A. Yarovoi

“…Based on the data of changes in VA, 22 (32%) patients had stabilization of the process, 30 (43%) showed improvement, 18 (25%) – deterioration. …”
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Network pharmacological approach combined with weighted gene co-expression network analysis identifies CDKN2A as the keg target of Changweiqing against colorectal cancer by Ma Zushuai, Ji Yanrong, Zhao Chengdu, Zhu Xu, Ding Qianshan

“…CWQ contained a total of 70 bioactive ingredients, of which 64 ingredients had a total of 836 therapeutic targets. Functional enrichment analysis indicated that CWQ may be involved in regulating pathways in cancer, MAPK signaling pathway and AGE-RAGE signaling pathway, and further analysis identified 14 core targets of CWQ. …”
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Reduced apple crop density enhances total polyphenol accumulation via upregulation of anthocyanidin reductase and other phenylpropanoid pathway genes by Shanthanu Krishna Kumar, Kamal Tyagi, Michael Brown, Lailiang Cheng, Zhangjun Fei, Gregory Peck

“…In order to better understand polyphenol biosynthesis in cider apples, four-year-old ‘Porter’s Perfection’ and ‘Binet Rouge’ trees were left unthinned (control), or had fruitlets adjusted to low, medium, or high crop density. …”
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Cost-Effectiveness Analysis of a Machine Learning–Based eHealth System to Predict and Reduce Emergency Department Visits and Unscheduled Hospitalizations of Older People Living at... by Charlotte Havreng-Théry, Arnaud Fouchard, Fabrice Denis, Jacques-Henri Veyron, Joël Belmin

“…After each home visit, the home care aides completed a questionnaire on participants’ functional status using a smartphone app, and the information was processed in real time by a previously developed machine learning algorithm that identifies patients at risk of an emergency visit within 7 to 14 days. …”
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Hemodynamic and Genetic Associations with the Risk of Idiopathic Pulmonary Arterial Hypertension Development in an Ethnic Cohort of Kazakhs by Dana Taizhanova, Togzhan Nurpissova, Gulshara Abildinova, Tamilla Martynyuk, Nazgul Kulmyrzayeva, Elena Zholdybayeva

“…Materials and methods: A total of 53 patients of only Kazakh nationality with IPAH participated in the study. Clinical, functional, and hemodynamic characteristics, as well as the outcome of the disease, were compared among carriers and non-carriers of the BMPR2 mutation. …”
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POSSIBILITIES OF DIAGNOSIS OF RADIATION INJURIES AND REHABILITATION OF PATIENTS AFTER COMBINED TREATMENT OF MALIGNANT TUMORS OF THE BREAST by A. V. Kondakov, M. E. Borodina, O. V. Andrianov, N. I. Rozhkova

“…The study included 259 women who had undergone combined treatment of breast cancer. …”
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THE PREVALENCE OF SECONDARY DENTO-MAXILLAIRE DEFORMITIES ASSOCIATED WITH UNCOMPENSATED DENTITION DEFECTS IN CHILD POPULATION by S.I. Doroshenko, A.Ju. Zrazhevska, K.V. Storozhenko

“…The results of the obtained findings show a high prevalence of dento-maxillary anomalies among the child population – 65.2% (1484 people), and only 34.8% (792 people) had no orthodontic pathology. Dentition defects were diagnosed in 359 people, which is 15.8% of the total number of the examined children. …”
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Abstract 216: Endovascular Thrombectomy +/‐ Thrombolytics In Patients With Cocaine‐Related Acute Ischemic Stroke by Sachin A. Kothari, Harsh Desai, Rami Z. Morsi, Julian Carrion‐Penagos, Matthew Smith, Elisheva Coleman, Tareq Kass‐Hout, James Brorson, Shyam Prabhakaran, Scott Mendelson

“…Conclusion Our data suggest that cocaine patients who underwent EVT on average had unfavorable functional outcomes defined as mRS > 2, on follow‐up mRS at 3 months. …”
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Innate Immunity Stimulation during the COVID-19 Pandemic: Challenge by Parvulan by Beniamino Palmieri, Antonio Manenti, Francesca Galotti, Maria Vadalà

“…The main efficacy endpoints, as assessed by the SF-36 questionnaire are: significant improvements in the mental and physical role functioning score (p<0.02), better general health; social role performance (p<0.02), vitality (p<0.03), and a significant pain reduction (p<0.03). …”
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Does weightbearing status impact mortality and other complications in hip fracture patients when accounting for frailty? by Makoa Mau, Tyler Thorne, Kai Rossbach, Eleanor H. Sato, Chong Zhang, Angela P. Presson, Justin M. Haller

“…Controlling for RAI-Rev, age, sex, BMI, functional status, and CPT, weightbearing patients had a 42% lower odds of 30-day mortality (p < 0.001), a 31% lower odds of a SAE (p < 0.001), and a 24% lower odds of a MAE (p < 0.001) in comparison to non-weightbearing patients. …”
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