Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix by Jianbing Liu, Meiying Zhong, Kai Yang, Jinjuan Wang, Haixia Ma, Wei Wang, Lin Sun, Lingling Liu, Jing Xu, Xiaohua Cui, Jianqing Hao, Li Li

“…SC13, a FEN1 inhibitor, also had similar effects. Furthermore, silencing FEN1 markedly reduced PIK3CA, PCNA, and BCL-2 levels, while elevating Caspase-9 expression. …”
Get full text

A review of 3D bioprinting for organoids by Li Zeqing, Chen Long, Wu Jialin, Chen Yikang, Zhu Yizhun, Li Gang, Xie Guoxi, Tang Guosheng, Xie Maobin

“…Three-dimensional (3D) organoids models hold immense potential in mimicking the key functions of human organs by overcoming the limitations of traditional 2D cell models. …”
Get full text

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation by Antje Isernhagen, Dörthe Malzahn, Elena Viktorova, Leslie Elsner, Sebastian Monecke, Frederike von Bonin, Markus Kilisch, Janne Marieke Wermuth, Neele Walther, Yesilda Balavarca, Christiane Stahl‐Hennig, Michael Engelke, Lutz Walter, Heike Bickeböller, Dieter Kube, Gerald Wulf, Ralf Dressel

“…Overall survival of MICA‐129Val/Val genotype carriers was improved when treated with anti‐thymocyte globulin (HR = 0.54, P = 0.0166). Functionally, the MICA‐129Met isoform was characterized by stronger NKG2D signaling, triggering more NK‐cell cytotoxicity and interferon‐γ release, and faster co‐stimulation of CD8+ T cells. …”
Get full text

Variation in Nutritional Quality of By-Products from Nine Organic Apple Cultivars by Elisabeta Elena Popa, Laurentiu Mihai Palade, Violeta Alexandra Ion, Andreea Barbu, Oana Crina Bujor, Vlad Ioan Popa, Paul Alexandru Popescu, Amalia Carmen Mitelut, Mihaela Cristina Draghici, Mihaela Geicu-Cristea, Mona Elena Popa

“…Recently, consumers have been increasingly interested in highly nutritional and health-promoting products in the form of functional foods that are produced using environmentally friendly processes as part of the circular economy. …”
Get full text

Application of the Biorefinery Concept in the Processing of Crambe (<i>Crambe abyssinica</i> Hochst) Seed Defatted Meal in a Pressurized Medium by Camila da Silva, Jefferson Alessandro Schmitz, Djéssica Tatiane Raspe, Natália Stevanato, Jaqueline Hoscheid, Marcelino Luiz Gimenes, Beatriz Cervejeira Bolanho Barros, Lúcio Cardozo-Filho

“…The PF also presented adequate functional properties, such as water solubility and absorption, which suggest potential use in pet food formulations.…”
Get full text

The Development of an Air Suction Precision Seed-Metering Device for Rice Plot Breeding by Wei Qin, Yuwu Li, Cheng Qian, Zhuorong Fan, Daoqing Yan, Guo Zou, Siqian Liu, Zaiman Wang, Ying Zang, Minghua Zhang

“…The results showed that the seed-switching mechanism had single and cumulative errors under 0.4°, and the seed-clearing rate reached 100% with an average clearing time below 0.88 s. …”
Get full text

Microbial community shifts drive biodegradable microplastic inhibition of seed germination in plateau wetlands by Hong Xiang, Jia-Xian Luo, Hao-Ran Bao, Xiao-Long Sun, Hao-Qin Xiong

“…These alterations in soil chemistry had a cascading effect on the composition of germinating species. …”
Get full text

Bioactive Profiling of Cowpea Pods via Optimized Extraction and Experimental–Computational Approaches by María Victoria Traffano-Schiffo, Margarita M. Vallejos, Andrea G. Gómez, Beatriz I. Avalos, Belén A. Acevedo, María Victoria Avanza

“…Phytochemical profiling showed that E2 was enriched in caftaric acid, <i>p</i>-coumaric acid, and morin, while W2 had higher levels of caftaric, <i>p</i>-coumaric, and caffeic acids. …”
Get full text

Alkaline DMSO superoxide and radical scavenging, cupric reducing antioxidant capacity (CUPRAC) and polyphenol contents of aqueous and methanol extract from Achilllea santolinoides... by Soulaf Mehlous, Smain Amira, Fatima Benchikh, Hassiba Benabdallah, Walid Mamache, Chawki Bensouici, Hocine Laouer, Karima Loucif

“…Nowadays, different medicinal functions of yarrow such as spasmolytic, choleretic, treatment of wounds and anti-inflammatory activities, make it as an important medicinal plant. …”
Get full text

Intratumorally specific microbial-derived lipopolysaccharide contributes to non-small cell lung cancer progression by Guomeng Sha, Zhengwen Wu, Biao Wang, Yi Ding, Zhaohua Xiao, Wenhao Zhang, Jie Zhou, Yongjia Zhou, Guanhong Ji, Zhongxian Tian, Weiquan Zhang, Xiaogang Zhao

“…Mechanistically, we found that Escherichia-Shigella- and unclassified_f__Enterobacteriaceae-derived LPS activated the TLR4-mTOR-NF-κB-IL-6 axis to facilitate NSCLC cell proliferation, whereas rapamycin effectively delayed LPS-induced tumor cell proliferation in vitro and in vivo functional experiments. Receiver operating characteristic curves revealed that the combination of intratumoural bacterial concentration, Escherichia-Shigella abundance, unclassified_f__Enterobacteriaceae abundance, and LPS content had greater diagnostic validity in predicting the probability of NSCLC, and the detection of these factors in blood has potential for using the non-invasive diagnosis of NSCLC. …”
Get full text

Lactic acid bacteria reduce the toxicity of tetrodotoxin through peptidoglycan mediated binding by Chang Liu, Jingqin Ye, Chang'e Wang, Hengliang Wang, Ying Lu

“…It was found that thermal inactivated LABs had the best effect, which could reduce the TTX amount by 49.0%–60.33% and decrease the toxicity of TTX by 57.0%–83.67%. …”
Get full text

Increased organic fertilizer significantly increases leaf nitrogen and phosphorus but not carbon content in a tropical tea plantation by Jing-li Lu, Ying Wang, Di Li, Qiu Yang, Yamin Jiang, Peng Wang, Tianyan Su, Geming Li, Qian Shi, Huai Yang, Wenjie Liu, Mengyang Fang

“…Abstract Carbon (C), nitrogen (N), and phosphorus (P) are essential elements for plant growth and metabolism, with their stoichiometry playing a pivotal role in ecosystem functioning. In tea plantations, fertilization strongly influences the balance of these elements. …”
Get full text

Identification of fatty acid anabolism patterns to predict prognosis and immunotherapy response in gastric cancer by Weijie Sun, Yanhong Xia, Feifan Jin, Jinghao Cao, Gaoping Wu, Keyi Li, Yanhua Yu, Yunyi Wu, Gaoqi Ye, Ke Xu, Dengpan Liu, Weidong Jin

“…Through consistent clustering and functional enrichment analysis, three distinct fatty acid anabolism clusters and three gene subtypes were identified to participate in different biological pathways, and correlated with the characteristics of immune cell infiltration and clinical prognosis. …”
Get full text

Comparative impacts of polyethylene and biodegradable film residues on soil microbial communities and rapeseed performance under field conditions by MiaoMiao Xie, MiaoMiao Xie, Maolu Wei, Maolu Wei, Qian Sun, Qian Sun, Ge Wang, Ge Wang, Ting Shen, Ting Shen, Xinyi He, Xinyi He, Dongyan Liu, Dongyan Liu

“…However, both residue types reduced the complexity and stability of the bacterial co-occurrence network, suggesting potential risks to the soil microbial habitats.ConclusionThese findings demonstrate that conventional film residues had no significant effect on rapeseed productivity, whereas biodegradable films exhibited superior performance in maintaining soil fertility and microbial functions under field conditions. …”
Get full text

Mapping QTLs Affecting Economic Traits on BTA3 in Chinese Holstein with Microsatellite Markers by Chun-hua QIN, Qin CHU, Gui-yan CHU, Yi ZHANG, Qin ZHANG, Sheng-li ZHANG, Dong-xiao SUN

“…These findings provided a general idea for the fine mapping of the causal mutation for milk production and functional traits on BTA3 in the future.…”
Get full text

Unveiling plant adaptations: How limestone outperforms dolomite in water supply capacity by Yali Ding, Yunpeng Nie, Wei Zhang, Kelin Wang, Li Wen, Hongsong Chen

“…Plants on dolomite exhibited significantly lower LWC and smaller LA (P < 0.01), indicating limited access to root-zone water. Dolomite plants had lower SLA and chlorophyll (P < 0.01), and showed shifts in water source use between dry and wet seasons, whereas limestone plants exhibited fewer variations in traits beyond water source shifts. …”
Get full text

The Effect of Pupil Size on Cone Contrast Sensitivity by Ali Almustanyir, Meznah S. Almutairi, Amal Aldrwish, Nabeela Hasrod, Bader A. Alqhtani, Tahani Alqahtani, Muteb Alanazi, Mansour Alghamdi, Essam Almutleb, Balsam Alabdulkader, Faisal Fakhouri, Mosaad Alhassan

“…There was no significant main effect of sex (F = 0.96, df = 1, <i>p</i> = 0.32) on the log cone contrast sensitivity of the L-cone. However, pupil size had a significant main effect (F = 116.1, df = 6, <i>p</i> < 0.001). …”
Get full text

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies by Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs

“…The generated cell lines were validated for CAIX production and characterised functionally in vitro and in vivo after orthotopic implantation in syngeneic BALB/c mice. …”
Get full text

Unveiling kaempferol glycosides as the key antiglycative components in butterfly pea (Clitoria ternatea) flower by Jun Wu, Jun Gong, Qiaochun Chen, Wen Hao, Jiayi He, Mingfu Wang, Qian Zhou

“…Collectively, our findings highlight the beneficial effects of BFPF with clearly identified active components, which might further promote its application in functional food and medical industry.…”
Get full text

Bta-novel-miR-25336 enhanced adipose differentiation and unsaturated fatty acid synthesis by targeting ACADS in intramuscular adipocytes of river buffalo by Ruirui Zhu, Fangfang Zou, Hao Tian, Hongfang Mo, Qilin Chen, Xinyu Zeng, Shan Han, Deshun Shi, Jianghua Shang, Jieping Huang

“…Functional studies showed that bta-novel-miR-25336 was positively correlated with the proliferation and adipogenic differentiation of both buffalo preadipocytes and intramuscular adipocytes. …”
Get full text