Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy by Pingping Li, Xuefei Ji, Ming Shan, Yi Wang, Xingliang Dai, Mengyuan Yin, Yunlong Liu, Liao Guan, Lei Ye, Hongwei Cheng

“…Microglia (MG), a resident immunocyte localizing in central nervous system is reported to play important functions in the animal model of temporal lobe epilepsy (TLE). …”
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Introducing Legumes into Wheat–Maize Rotation Complicates Soil Microbial Co-Occurrence Network and Reduces Soil Allelochemicals in Succeeding Wheat Season by Yaqian Yan, Haiyang Jin, Fei Zheng, Xiwen Yang, Hang Song, Jiarui Wang, Baoting Fang, Hongjian Cheng, Xiangdong Li, Dexian He

“…This rotation adjustment had a substantial impact on the structure and taxa composition of the soil microbial community. …”
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Structural network topologies are associated with deep brain stimulation outcomes in Meige syndrome by Bin Liu, Zhiqi Mao, Xinyuan Yan, Hang Yang, Junpeng Xu, Zhebin Feng, Yanyang Zhang, Xinguang Yu

“…We constructed group-level structural covariance networks in each group and compared the graph-based topological properties and interregional connections between groups. Subsequent functional annotation and correlation analyses were also conducted. …”
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Comparison of early clinical outcomes between CR and PS prostheses in total knee arthroplasty for rheumatoid arthritis patients - a retrospective cross-sectional study by Haoyuan Ding, Haoyuan Ding, Dapeng Han, Nanshan Ma, Nanshan Ma, Chenxin Gao, Jie Yao, Guilin Ouyang

“…Between-group comparisons showed no statistical differences in postoperative AKSS, VAS, HAQ scores. However, the CR group had significantly higher FJS-12 scores at 6 and 12 months postoperatively compared to the PS group.ConclusionBoth CR and PS prostheses can achieve good clinical outcomes in TKA for RA patients. …”
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A comparative study of arthroscopic treatment of popliteal cyst with internal drainage and internal drainage combined with cyst wall resection by Peng-Fei Fu, Cong-Yong Ye, Ao-Ran Sun, Zi-Hao Wang, Hao Liu, Li-Gong Fu, Lian-Xu Chen

“…Results With mean follow-up of 12.2 ± 1.2 months, baseline characteristics were comparable (P > 0.05). Group B had longer operative time and greater blood loss (both P < 0.05). …”
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Development trend of primary healthcare after health reform in China: a longitudinal observational study by Hui Li, Jie Feng, Zuxun Lu, Yanhong Gong, Xuan Zhou, Guopeng Zhang, Xiaoxv Yin, Jianxiong Wu

“…However, compared with the indicators in 2009, excepting that the proportion of grants from the government in the whole health system has an upward trend, the proportions of other indicators had an escalating trend in 2018 by 3.66% for practicing (assistant) physicians, by 2.69% for nurses, by 3.99% for total revenues, by 5.87% for beds, by 8.39% for outpatient visits.Conclusion The primary healthcare system has developed rapidly, but its development speed lagged behind the entire health system, resulting in the weakening of its actual functions, which is not in line with the goal of health reform. …”
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Age at diagnosis as a prognostic factor in selected categories of juvenile idiopathic arthritis by Kristiina Aalto, Hannu Kautiainen, Anders Fasth, Marek Zak, Troels Herlin, Marite Rygg, Ellen Berit Nordal, LILLEMOR BERNTSON, Mia Glerup, Veronika Rypdal, Ellen Arnstad, Suvi Peltoniemi, Katariina Rebane, Anna-Kaisa Tuomi

“…In the seronegative polyarthritis group, this was not true for female patients. Age at diagnosis had no significant effect on HRQoL or functional ability.Conclusions Age at diagnosis in the oligoarthritis was inversely and in the seronegative polyarthritis positively associated with long-term remission in JIA, primarily in females.…”
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Assembly of MSCs into a spheroid configuration increases poly(I:C)-mediated TLR3 activation and the immunomodulatory potential of MSCs for alleviating murine colitis by Chao-Ting Ho, Ying-Chi Kao, Yueh-Ming Shyu, I-Ching Wang, Qiao-Xuan Liu, Shao-Wen Liu, Shih-Chen Huang, Han Chiu, Li-Wen Hsu, Tzu-Sheng Hsu, Wan-Chen Hsieh, Chieh-Cheng Huang

“…However, the therapeutic efficacy of these cells remains suboptimal, primarily due to the harsh peritoneal microenvironment, which compromises MSC viability and functional capacity after transplantation. Methods To address these limitations, this study aimed to improve MSC engraftment and functionality by assembling MSCs into three-dimensional (3D) spheroids and priming them with the Toll-like receptor 3 (TLR3) agonist polyinosinic-polycytidylic acid (poly(I:C)). …”
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Isolation, Purification, and Structural Characterization of Antioxidant Polysaccharides Isolated from the Fruiting Bodies of Cordyceps militaris by Yanan WANG, Xinyi QIAN, Yidan YONG, Mengmeng WU, Yihao LI, Yuhang CHEN, Zaizhong NI, Lulu LI, Anhui CHEN, Peng ZHANG, Ying GENG, Ying SHAO

“…STP-4 was an α-type configuration oligosaccharide composed of arabinose, mannose, and glucose, with a molecular weight of approximately 1434 Da. It had the functional groups such as O-H, C-H, COOH, C=O, and C-O-C. …”
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Outcome of creatine supplementation therapy in phosphoglucomutase-1 deficiency associated congenital disorders of glycosylation: Novel insights by Anastasia Ambrose, Morganne McCabe, Clara Hung, Iveta Sosova, Peter Seres, Saadet Mercimek-Andrews

“…Her plasma guanidinoacetate was low. She had elevated urine galactitol on D-galactose therapy. …”
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Three-dimensional genomic characterization of two multiple myeloma patients with normal karyotype and complex karyotype by WANG Yue, CHEN Mengsi, CHEN Ming, LI Yanju, GUAN Xiaohong, LEI Lihua, TAO Li, LIU Xiaoxiao, HE Dong, FEI Xiaoli, ZHANG Kaiji

“…[Methods] High-throughput chromosome conformational capture (Hi-C) analysis was performed on plasma cells of 1 case with 1q21 complex karyotype and 1 case with normal karyotype multiple myeloma, and the differences in three-dimensional genome structure between the two patients were analyzed, and the transcriptome characteristics of plasma cells were combined to investigate the differential features through gene functional enrichment. [Results] A/B switch occurred in 36% of the chromatin compartments in two cases, and 1 041 genes in patient with complex karyotype had B/A switch. …”
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Integrated analysis of hub genes and intrinsically disordered regions in triple-negative breast cancer by Azhar Iqbal, Faisal Ali, Sulaiman Ali Alharbi, Muhammad Sajid, Saleh Alfarraj, Momina Hussain, Tehmina Siddique, Rakhshanda Mustaq, Fakhra Shafique, Muhammad Sarfaraz Iqbal

“…KEGG pathway enrichment and Gene Ontology functions were assessed for DEG pathways and functional annotation using ShinyGO 0.77. …”
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Application of Biochar on Soil Improvement and Speciation Transformation of Heavy Metal in Constructed Wetland by Yuan Zhou, Xiaoqin Nie, Yao Zhao, Liqiu Zhang, Yatian Cheng, Cancan Jiang, Wenbin Zhao, Xiangchun Wang, Chao Yang

“…The results showed that SMB had a high carbon content (28.58%) and was rich in functional groups (e.g., -C-O, -C-N). …”
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Small mammal activities structure fine-scale soil microbial communities and coordinate rodenticide effects in the typical steppes of China by Wei Liu, Tingbei Bo, Ning Zhao, Bin Hu, Gaojian Li, Zhishu Xiao

“…Yet the impacts of rodenticides on soil microbial diversity and ecosystem functions in Brandt’s vole habitats are not well-known. …”
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An Increase in Academic Ebook Preferences: A Decade Comparison of Ebook Use versus Non-Use by Kathy Grams

“…Other complaints were related to their functionality and usability, such as lag time, clunky interface, accessibility, and challenges with annotation and note-taking. …”
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Regeneration of triploid citrus germplasm by the crossing between tetraploid Huyou and Cocktail grapefruit by XU Tianyu, ZHANG Chi, WANG Gang, YE Xiaoling, CHEN Xiang, YE Shengyue, ZHANG Xiaoqin, ZHANG Min

“…[Results] The pollen grains of Cocktail grapefruit had a staining activity of 89.40% and in vitro germination rate of 30.02%, indicating that the pollen of Cocktail grapefruit had satisfactory vitality for further pollination. …”
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Sleep disturbance, cancer-related fatigue, and depression as determinants of quality of life among breast cancer patients undergoing chemotherapy: a cross-sectional study by Abdelaziz Hendy, Rasha Kadri Ibrahim, Amani Darwish, Saher Al Sabbah, Abeer Yahia Mahdy Shalby, Rahmah Khubrani, Amal Elhaj Alawad, Sally Mohammed Farghaly Abdelaliem, Nadia Mohamed Ibrahim Wahba

“…Regression analysis demonstrated that sleep disturbance had the strongest negative impact on QoL (B = -1.506, p < 0.001), overshadowing both fatigue and depression. …”
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Intratumor microbiome-derived butyrate enhances progesterone sensitivity by inducing ferroptosis in endometrial cancer by Xingchen Li, Yiqin Wang, Yuman Wu, Jingyuan Wang, Yue Qi, Xinyi Bi, Jianliu Wang

“…We found that patients who were sensitive to medroxyprogesterone acetate (MPA) had significantly higher alpha and beta diversity of intratumor microbiota compared to resistant patients. …”
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The Effect of Cholesterol‐Loaded Cyclodextrin and Resveratrol Compounds on Post‐Thawing Quality of Ram Semen by Eser Ahmet, Arıcı Ramazan, Yağcıoğlu Selin, Sandal Asiye İzem, Ersoy Nur, Demir Kamber, Evecen Mithat, Ak Kemal

“…Post‐thawing, the samples were analysed for motility, acrosome and membrane integrity, membrane functionality, mitochondrial activity, capacitation status, oxidative stress and DNA integrity. …”
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SURGERY OF BRAIN STEM CAVERNOUSES MALFORMATION by V. V. Stupak, Sh. Aul, A. G. Bobylev, M. V. Kutsenko, D. A. Dentsel, T. M. Shogunbekov, V. M. Bon, A. M. Gazeev, A. E. Simonovich, S. V. Tsvetovskiy

“…Materials and methods. the study included 16 patients who had hemorrhages in different parts of the brain stem. …”
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