Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. by Mélissa Beaudoin, Philippe Goyette, Gabrielle Boucher, Ken Sin Lo, Manuel A Rivas, Christine Stevens, Azadeh Alikashani, Martin Ladouceur, David Ellinghaus, Leif Törkvist, Gautam Goel, Caroline Lagacé, Vito Annese, Alain Bitton, Jakob Begun, Steve R Brant, Francesca Bresso, Judy H Cho, Richard H Duerr, Jonas Halfvarson, Dermot P B McGovern, Graham Radford-Smith, Stefan Schreiber, Philip L Schumm, Yashoda Sharma, Mark S Silverberg, Rinse K Weersma, Quebec IBD Genetics Consortium, NIDDK IBD Genetics Consortium, International IBD Genetics Consortium, Mauro D'Amato, Severine Vermeire, Andre Franke, Guillaume Lettre, Ramnik J Xavier, Mark J Daly, John D Rioux

“…These discoveries have already had a tremendous impact on our understanding of the genetic architecture of these diseases and have directed functional studies that have revealed some of the biological functions that are important to IBD (e.g. autophagy). …”
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High tibial osteotomy in geriatric patients with gonarthrosis by Bedrettin Akar, Yusuf Oztürkmen, Mehmet B. Balioglu, Fatih Ugur, Erhan Sükür

“…Conclusion MOWHTO is a highly effective procedure for mitigating pain and functional limitations associated with osteoarthritis in geriatric patients with grade I-II gonarthrosis. …”
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Mesoporous Silica Administration as a New Strategy in the Management of Warfarin Toxicity: An In-Vitro and In-Vivo Study by Fatemeh Farjadian, Fatemeh Parsi, Reza Heidari, Khatereh Zarkesh, Hamid Reza Mohammadi, Soliman Mohammadi-Samani, Lobat Tayebi

“…Purpose: Warfarin is one of the most widely used anticoagulants that functions by inhibiting vitamin K epoxide reductase. …”
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Two-stage total elbow arthroplasty after reconstruction of a soft tissue defect by V. A. Kalantyrskaya, I. O. Golubev, A. Y. Zarov, K. A. Egiazaryan

“…The OBJECTIVE of the study was to analyze the results of treatment of patients with severe injuries of the elbow joint, who underwent two-stage reconstruction of soft tissues and total elbow arthroplasty (TEA), to assess of the effectiveness of tactics, early and long-term functional state.METHODS AND MATERIALS. A retrospective analysis of the treatment of 8 patients from 2009 to 2019, who had extensive soft tissue injuries that required complex soft tissue reconstruction and total elbow arthroplasty, was carried out. 6 male and 2 female patients, average age 33.5 years (min. 27, max. 39 years), no concomitant diseases. …”
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Long-term changes in cognitive status of patients with type 2 diabetes mellitus after coronary artery bypass graft surgery by A. S. Sosnina, I. V. Tarasova, I. D. Syrova, O. V. Maleva, O. A. Trubnikova, O. L. Barbarash

“…Higher HbA1c level was also associated with deteriorated executive functions and short-term memory.Conclusion. 5−7 years after CABG surgery, patients with type 2 DM suffer from a cognitive decline and reduced psychomotor and executive functions.…”
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Neural Activity for Uninvolved Knee Motor Control After ACL Reconstruction Differs from Healthy Controls by Meredith Chaput, Cody R. Criss, James A. Onate, Janet E. Simon, Dustin R. Grooms

“…Recovery from anterior cruciate ligament reconstruction (ACLR) induces bilateral functional and physiological adaptations. Neurophysiologic measures of motor control have focused on the involved knee joint, limiting understanding regarding the extent of bilateral neural adaptations. …”
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Geographic Socioeconomic Influences on Disease Activity in Rheumatoid Arthritis in an Academic and Safety Net Hospital System by Joseph Kim, Song Zhang, Ang Gao, Donglu Xie, Salahuddin Kazi, David R. Karp, Christie M. Bartels, E. Blair Solow

“…In the academic cohort, those with high ADI scores (>8, more deprivation) had higher RA disease activity scores (Routine Assessment of Patient Index Data 3 mean ± SD: high 13.83 ± 6.94 vs low 11.17 ± 7.37, P < 0.0001; Clinical Disease Activity Index mean ± SD: high 11.97 ± 11.74 vs low 9.40 ± 7.97, P < 0.05), more functional impairment (Multidimensional Health Assessment Questionnaire mean ± SD: high 2.99 ± 2.29 vs low 2.34 ± 2.23, P < 0.01), lower MyChart use (P < 0.001), and different smoking history (P < 0.01) compared to those with low ADI scores (<3, less deprivation). …”
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Exploring the Patterns of In-Between Spaces in Guilan Historical Houses by seyedehmahdieh Mirmiran, Aliasghar Malekafzali, Leyla Karimifard

“…The aim of this paper is to explain the spatial patterns of in-between spaces in Guilan historical houses in order to show their potential capacity in having various functions, and thus different forms, in the course of history. …”
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Impaired degree centrality and effective connectivity contributed to deficits in cognition and depression in patients with temporal lobe epilepsy by Bailing Qin, Shujun Su, Xuemei Chen, Yuting Sun, Qin Zhou, Huoyou Hu, Lu Qin, Jinou Zheng

“…Cerebral functional activity and neuroimaging features were differentiated between the patient and HC groups based on rsfMRI data, DC, EC, and MVPA. …”
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Central venous catheters in hemodialysis: To accept recommendations or to stick to own experience by Stolić Radojica, Trajković Goran, Perić Vladan, Jovanović Aleksandar, Stolić Dragica, Sovtić Saša, Lazarević Tatjana, Živić Živa, Šubarić-Gorgieva Gordana

“…The average of femoral catheter functioning was 17 catheter days, in jugular catheters it was 17.3 days while the subclavian catheters had an average rate of functioning of 25.9 catheter days; there was found a statistically significant difference regarding the duration of functioning (p = 0.03). …”
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Insulin resistance in drug naive patients with multiple sclerosis by Kostić Smiljana, Kolić Ivana, Raičević Ranko, Stojanović Zvezdana, Kostić Dejan, Dinčić Evica

“…The patients with MS had significantly higher values of homeostasis model assessment indexes of IR (HOMA-IR) (p = 0.027; p = 0.028). …”
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Comparative analysis of the efficacy of oblique lateral interbody fusion versus transforaminal lumbar interbody fusion in the treatment of lumbar disc herniation by Daodong Chen, Tao Liu, Kunyang Du, Zhenjun Zhu

“…This study aimed to compare the efficacy of OLIF versus TLIF in terms of pain relief, functional outcomes, spinal alignment correction, fusion success, and postoperative recovery. …”
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Analysis of the therapeutic efficacy of arthroscopic repair of the subscapularis tendon combined with coracoplasty by Hanlin Zheng, Yulong Liu, Bizhi Tu, Guang Chen, Rende Ning

“…The functional scores significantly increased in both groups post-surgery compared to preoperative values (p < 0.01). …”
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Assessment of Efficiency of Retrobulbar Infusion of Neurometabolic Preparations in Increase of Hemodynamic of Optic Nerve at Acute Ischemic Optic Neuropathy by V. V. Egorov, L. P. Emanova, L. P. Danilova, G. P. Smoliakova

“…The control group consisted of 20 patients who had the traditional method of medicines injection. …”
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Freedom of movement and health of nursing home residents with dementia: an exploratory cross-sectional study by Suzan P. van Liempd, Sascha R. Bolt, Katrien G. Luijkx

“…Data were collected using questionnaires to cover health dimensions according to the concept of Positive Health, including quality of life and participation, mental functioning and perception, daily functioning and bodily functions. …”
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The Serratia sp. strain C2 confers tomato tolerance to high salt, virus infection and both stresses in combination by Naima Sayahi, Giorgia Sportelli, Anna Vittoria Carluccio, Chantal Ebel, Tahar Mechichi, Fabrizio Cillo, Moez Hanin, Livia Stavolone

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Short-term mating success in relation to fluctuating wing asymmetry in the male azure damselfly Coenagrion puella by Ken M. Mauser, Jann Baumeyer, Shahab Eshghi, Stanislav N. Gorb, Alessandro Manfrin, Carsten A. Brühl

“…As top flying predators, damselflies rely on wing symmetry and functionality. However, already during aquatic larval development, environmental stressors, including anthropogenic ones, can affect their development and impair wing morphology raising the question whether such alterations affect reproductive fitness. …”
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Shoulder Pain among Rehabilitated Spinal Cord Injured Persons Using Manually Propelled Wheelchairs in the Gaza Strip: A Survey by Ziad Al Hawamdah, Jadallah M El-Shafie, Khamis El Essi, Sami I Zaqout

“…It also aimed to detect the degree of satisfaction with shoulder functioning wheelchair users who were paraplegic due to  spinal cord injury, in the Gaza strip.…”
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Evaluation of efficacy and safety of combined use of nonsteroidal anti-inflammatory drugs and extended release tolperisone in patients with ankle injuries by R. I. Sadykov, I. F. Akhtyamov, K. T. Shoshorina, S. A. Lapshina

“…Combined use of aceclofenac and tolperisone in patients with acute ankle ligament injuries resulted in more clinically significant pain reduction and improvement in functional indicators than aceclofenac monotherapy. …”
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Safety and Efficacy of Thrombectomy in Vietnamese Stroke Patients Selected through Perfusion Imaging with an Onset Time between 6 and 24 Hours by Binh Nguyen Pham, Hang T. Minh Tran, An Thai Thanh Nguyen, Huan Nguyen Pham, Anh Tuan Le Truong, Trung Quoc Nguyen, Huong Bich Thi Nguyen, Tri Quang Nguyen, Huy Quoc Do, Tra Vu Son Le, Vu Thanh Tran, Ryan Anh-Quang Nguyen, Huy Nguyen, Thang Ba Nguyen, Thang Huy Nguyen

“…Patients with good collaterals had better functional outcome. Conclusions: This real-world observational study suggests that late-window EVT may be safe and effective in eligible Vietnamese patients selected based on perfusion imaging, thus supporting its practical use in this patient population. …”
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