Design, synthesis, biological evaluation and computational studies of 4-Aminopiperidine-3, 4-dihyroquinazoline-2-uracil derivatives as promising antidiabetic agents by Ladan Baziar, Leila Emami, Zahra Rezaei, Aida Solhjoo, Amirhossein Sakhteman, Soghra Khabnadideh

“…The biological evaluation revealed that compound 9i bearing chloro substitution on phenyl moiety of 6-bromo quinazoline ring had promising inhibitory activity with IC50 = 9.25 ± 0.57 µM. …”
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Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling. by Silvia M A Pedroni, Sophie Turban, Tiina Kipari, Donald R Dunbar, Kerry McInnes, Philippa T K Saunders, Nicholas M Morton, Jane E Norman

“…In contrast, in control animals, pregnancy had no effect on visceral fat mass proportion. Obesity exaggerated glucose intolerance at mid-pregnancy (E14.5). …”
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THE FREQUENCY AND FITNESS OF m6A-ASSOCIATED VARIANTS COULD BE MODULATED BY THE THERMODYNAMIC STABILITY OF AN OVERLAPPING G-QUADRUPLEX by Çağrı Güleç

“…In contrast, rare variants with the same feature were higher outside the G4-structure and had uneven distribution alongside the premRNA. The uneven distribution of the DRACH-creating rare variants was observed to correlate with their effect on thermodynamic stability of the overlapping G4. …”
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Multi-Index Assessment of Hydrometeorological Droughts in the Tekeze River Basin, Northwestern Ethiopia by Teame Yisfa, Mulugeta Tekleyohannes, Berhane Grum, Shishay Yemane, Gebremeskel Teklay Berhe, Haddush Goitom, Bizuneh Asfaw Abebe

“…Monthly rainfall and temperature data from 15 meteorological stations with varying record lengths (28–59 years) and streamflow data from nine functional stations (1991–2018) were used to compute hydrometeorological drought indices. …”
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Structure Characterization of Four New Sesquiterpene Pyridine Alkaloids from <i>Tripterygium wilfordii</i> Hook. f. and Anti-Inflammatory Activity Evaluations by Yong-Jian Wang, Jian-Gong Yan, Zhong-Mou Zhang, Qiu-Fang Fang, Ya-Dan Wang, Shuang-Cheng Ma

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Phenolics and Flavonoid Content in Selected Seeds from the Serbian Market by Margarita Dodevska, Nevena Ivanovic, Jelena Kukic-Markovic, Verica Jovanovic

“…Results: In general, hydro-methanol extracts of seed samples defatted using Soxhlet extraction had the highest TPC and TFC contents. TPC values ranged from 9.47 g GAE/mg (raw pumpkin seed) to over 170 g GAE/mg (raw sunflower seeds). …”
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Synthesis, biological evaluation, molecular docking, and DFT calculation of novel 4-(1H-indol-3-yl)-3-methyl-1-phenyl-1H-furo[2,3-c]pyrazole derivatives by Mahmoud Nassiri, Jaber Salehzadeh, Sahar Mohajeri

“…In fact, this compound had the most negative ΔGbind (−9.21 kcal/mol) that showed favorable interactions with the key amino acid residues at active site of EGFR receptor. …”
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A comparative study of machine learning models for automated detection and classification of retinal diseases in Ghana. by Gifty Duah, Eric Nyarko, Anani Lotsi

“…MobileNet achieved the highest accuracy at 96% and AUC of 0.975, closely followed by DenseNet121, which had 95% accuracy and an AUC of 0.963. Inception V3 and ResNet50, while not as high in accuracy, showed potential in specific contexts, with 83% and 79% accuracy, respectively.…”
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Pancreatitis as a Main Consequence of APOC2-Related Hypertriglyceridemia: The Role of Nonsense and Frameshift Variants by Bahareh Rabbani, Mohadeseh Aghli Moghadam, Shiva Esmaeili, Amirhassan Rabbani, Bahman Akbari, Nejat Mahdieh

“…For this study, patients were selected who had a plasma triglyceride level above 250 mg/dL. …”
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The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells by Mohamed M. A. El Husseiny, Roland Nilsson

“…Metabolite uptake/release was measured using isotope dilution and MTR activity was assessed using metabolic flux analysis (MFA). Functional rescue experiments were performed by overexpressing the B12-independent methionine synthase enzyme. …”
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Analysis of physicochemical and sensory properties of plant-based protein powder drinks by Odelia Sephira, Umar Lina Mardiyah, Zhe Gabrielle, Lo Diana

“…Protein is an essential macronutrient that plays a crucial role in maintaining body structure and supporting various physiological functions in humans. While animal products are traditionally the primary sources of dietary protein, their processing requires precise handling and they contain high levels of saturated fatty acids. …”
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Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. by Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge

“…However, in contrast to canonical lipid-kinase functions, the role of PI3K protein kinase activity in regulating cell survival is unknown. …”
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Impact of implementing evidence-based acute stroke interventions on survival: the South London Stroke Register. by Juliet Addo, Siobhan Crichton, Ajay Bhalla, Anthony G Rudd, Charles D A Wolfe, Christopher McKevitt

“…Patients managed on a stroke unit, those with deficits receiving specific rehabilitation therapies and those with ischaemic stroke subtype receiving aspirin in the acute phase had better one year survival compared to those who did not receive these interventions. …”
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A toolkit for facilitating markerless integration of expression cassettes in Komagataella phaffii via CRISPR/Cas9 by Laura García-Calvo, Charlotte Kummen, Solvor Rustad, Sissel Beate Rønning, Annette Fagerlund

“…Abstract Background The yeast Komagataella phaffii (formerly known as Pichia pastoris) has been widely used for functional expression of recombinant proteins, including plant and animal food proteins. …”
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Effects of soil organic matter properties and microbial community composition on enzyme activities in cryoturbated arctic soils. by Jörg Schnecker, Birgit Wild, Florian Hofhansl, Ricardo J Eloy Alves, Jiří Bárta, Petr Capek, Lucia Fuchslueger, Norman Gentsch, Antje Gittel, Georg Guggenberger, Angelika Hofer, Sandra Kienzl, Anna Knoltsch, Nikolay Lashchinskiy, Robert Mikutta, Hana Santrůčková, Olga Shibistova, Mounir Takriti, Tim Urich, Georg Weltin, Andreas Richter

“…Microbial community composition had no effect. In contrast, models for cryoturbated material showed that enzyme activities were also related to microbial community composition. …”
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Conscious sedation in pediatric dental procedures: Experience from Usmanu Danfodiyo University Teaching Hospital, Sokoto, Northwestern Nigeria by Mujtaba Bala, Ramat Oyebunmi Braimah, Rufai Jaafaru, Akinwaleola Adeyinka Akinlade, Galadima Ibrahim Bello, Muhammad Abdullahi

“…After obtaining ethical approval from the research and ethics committee of the institution, the case records of all patients from 15 years and below who had a dental procedure under conscious sedation were retrieved. …”
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Improved Binary Grey Wolf Optimization Approaches for Feature Selection Optimization by Jomana Yousef Khaseeb, Arabi Keshk, Anas Youssef

“…Both S-shaped and V-shaped binary transfer functions were used to convert the continuous solutions obtained from each proposed approach to their corresponding binary versions. …”
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Does access to clinical study reports from the European Medicines Agency reduce reporting biases? A systematic review and meta-analysis of randomized controlled trials on the effec... by Eliane Rohner, Michael Grabik, Thomy Tonia, Peter Jüni, Frank Pétavy, Francesco Pignatti, Julia Bohlius

“…For 80 of those (63%) we noted discrepancies, but these had little impact on the pooled effect estimates. …”
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Electrolysis of Liquefied Biomass for Sustainable Hydrogen and Organic Compound Production: A Biorefinery Approach by Ana P. R. A. Ferreira, M. Margarida Mateus, Diogo M. F. Santos

“…FTIR analysis revealed no significant functional group changes in the electrolyte post-electrolysis. …”
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Exploring the Acetobacteraceae family isolated from kombucha SCOBYs worldwide and comparing yield and characteristics of biocellulose under various fermentation conditions by Azadeh Khiabani, Mahboobe Sarabi-Jamab, Monir-sadat Shakeri, Abolfazl Pahlevanlo, Bahareh Emadzadeh

“…On the other hand, K. xylinus CH1, from Chinese SCOBY, had the highest yield under stirred conditions, producing 12.689 ± 0.808 gL−1 of BC. …”
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