Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB). by Gayathri N Sekhar, Ana R Georgian, Lisa Sanderson, Gema Vizcay-Barrena, Rachel C Brown, Paula Muresan, Roland A Fleck, Sarah A Thomas

“…Furthermore, the presence of OCTN, MATE, PMAT, ENT or CNT inhibitors/substrates had no significant effect on the accumulation of [3H]pentamidine in both cell lines. …”
Get full text

An ultrasensitive electrochemical immunosensor for CA72-4 based on a signal amplification strategy of MoS2 nanoflower-supported Au nanoparticles by Qinghua Yan, Ruixue Wu, Hongli Chen, Wenbin Nan

“…The electrochemical immunosensor also had a low detection limit of 2.0 × 10−5 U/mL (S/N = 3) in a concentration range of 0.001–200 U/mL, with good selectivity, stability, and repeatability. …”
Get full text

In Silico Study of Bis(6-Amino-1,3-Dimethylpyrimidine-2,4(1H,3H)-Diones) as EGFR Inhibitors: Synthesis, DFT, Molecular Docking, and MD Simulation Studies by Zeynab masoumi, Mohammad Bayat, Davood Gheidari

“…Computational methods, including density functional theory (DFT), molecular docking, and molecular dynamics (MD), were utilized to investigate the chemical properties, drug-like characteristics, and anticancer potential of the molecule. …”
Get full text

Crosstalk between miRNAs, high mobility group box-1 and complement system in epilepsy: relevance of response to valproic acid by Dalia Kamal Mostafa, Dina Elsayed Gaber, Passanite S. Hassaan, Fatma I. Dwedar, Abeer E. Dief, Mona Hassan Fathelbab

“…Abstract Background Epileptogenesis is a complex alteration of brain functions with subsequent development of seizures. …”
Get full text

Artificial intelligence policies in bioethics and health humanities: a comparative analysis of publishers and journals by Christopher Bobier, Daniel Rodger, Daniel Hurst

“…Results Of the 50 journals analyzed, only 8 (16%) had a clear AI policy, while 27 (54%) were published by a publisher with an identifiable AI policy. …”
Get full text

Prevalence, Predictive Factors, and Characteristics of Osteoporosis in Hyperthyroid Patients by Ayotunde O. Ale, Anthonia O. Ogbera, Henry O. Ebili, Olusola L. Adeyemo, Taiwo O. Afe

“…Biochemical tests included blood, thyroid functions, intact parathyroid hormone, corrected calcium, and 25-hydroxyvitamin D tests. …”
Get full text

Metabolic alterations in experimental models of depression by Maria G. Puiu, Mihnea C. Manea, George L. Paraschiv, Traian Purnichi, Ecaterina Ionescu, Simona Tache, Ioana Paunica, Mirela Manea

“…Introduction: Major depressive disorder is one of the most prevalent psychiatric disorders and is associated with a severe impact on the personal functioning, thus with incurring significant direct and indirect costs. …”
Get full text

Bilateral SUNCT syndrome associated to chronic maxillary sinus disease Síndrome SUNCT de ocorrência bilateral associada a sinusopatia maxilar crônica by Denis Bernardi Bichuetti, Wellington Yugo Yamaoka, João Ricardo Parrela Bastos, Deusvenir de Souza Carvalho

“…He was submitted to a functional endoscopic sinus surgery and evolved with milder pain. …”
Get full text

Effect of anti-tumor necrosis factor alpha therapy on bone health and biomarkers of bone turnover in Indian patients with ankylosing spondylitis by Shefali Khanna Sharma, Sandeep Mohanan, Surender K Sharma

“…Detailed assessments of erythrocyte sedimentation ratio (ESR), Bath AS disease activity index (BASDAI), Bath AS functional index (BASFI), Bath AS metrological index (BASMI), AS disease activity score-ESR, and AS quality of life (AsQOL) questionnaire were done at baseline and 6 months. …”
Get full text

Evaluating the Impact of Early Intervention on Developmental Outcomes in Children with Autism Spectrum Disorder: A Comparative Study in Bangladesh by Anika Ferdous, MD Nahid Hassan Nishan, Siva Ganesan

“…Children in the ASD group had received EI since diagnosis before age three. …”
Get full text

Comparison of Different Materials Used in The Preparation Of Household Bioplastics and Evaluation of a Mixture of Animal Gelatin and Cornstarch by Kamar Shayah, Joseph Shenekji, Durra Balt, Siran Arabanian, Joudy Awyga, Sawsan Salloum

“…Microscopic analysis revealed that the final product had a denser texture and more granular appearance than the starch-based products. …”
Get full text

PKA activity is essential for relieving the suppression of hyphal growth and appressorium formation by MoSfl1 in Magnaporthe oryzae. by Yang Li, Xue Zhang, Shuai Hu, Shuai Hu, Huiquan Liu, Jin-Rong Xu

“…Two suppressor strains of cpkA cpk2 had deletion and insertion mutations in the MoSFL1 transcription factor gene. …”
Get full text

Ligneous Periodontitis in a Patient with Type 1 Plasminogen Deficiency: A Case Report and Review of the Literature by Arun Sadasivan, Roshni Ramesh, Deepu George Mathew

“…He was the third child of consanguineous parents and had multicystic congenital hydrocephalus at birth. …”
Get full text

Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision by Chenglong Fan, Guanglin Yang, Cheng Li, Jiwen Cheng, Shaohua Chen, Hua Mi

“…Results Eleven GRGs showed abnormal expression in DN samples, leading to the identification of two distinct glycolysis clusters, each with its own immune profile and functional pathways. The analysis of the GSE142153 dataset showed that these clusters had specific immune characteristics. …”
Get full text

Tuning surface properties of thiophene-based thin films on glass substrates for cancer cell adhesion, drug release control, and computational analysis by Heba M. Metwally, Omar M. El-Banna, Ehab Abdel-Latif, Raghda Abo Gabal

“…DFT calculations further revealed that 5b had the lowest calculated energy values; -4.89 eV (HOMO) and − 3.22 eV (LUMO), and the energy gap was found to be 1.66 eV, supporting its role in JAK1 inhibition and cancer cell adhesion reduction. …”
Get full text

Professional stress in general practitioners and psychiatrists: The level of psycologic distress and burnout risk by Vićentić Sreten, Jovanović Aleksandar, Dunjić Bojana, Pavlović Zorana, Nenadović Milutin, Nenadović Nenad

“…However, even 35 physicians from the sample were affected with a high burnout risk measured with subscales Emotional Ehausation (MBI-EE) and MBI-DP, showing that both groups of physicians had risk for the appearance of burnout syndrome. …”
Get full text

Central amygdala astrocyte plasticity underlies GABAergic dysregulation in ethanol dependence by Todd B. Nentwig, J. Daniel Obray, Anna Kruyer, Erik T. Wilkes, Dylan T. Vaughan, Michael D. Scofield, L. Judson Chandler

“…Slice electrophysiology confirmed that the upregulation in astrocytic GAT3 levels was functional, as CIE exposure unmasked a GAT3-sensitive tonic GABA current in the CeA. …”
Get full text

Reduced hair cortisol concentrations are associated with improved emotional wellbeing in older adults following repeated forest walking by Jezova Daniela, Hlavacova Natasa, Karailievova Lucia, Lamatungga Kiki Ekiawan, Halamova Julia, Tamatam Dhanalakshmi, Pichlerova Magdalena, Pichler Viliam

“…No differences in salivary alpha-amylase activity were noticed. Walking activities had no negative impact on the diurnal rhythmicity of stress markers. …”
Get full text

Study on the Preparation and Properties of Lubricating and Anti-Corrosion Seal Coating on the Chromium-Free Dacromet Coating Surface by LI Qing-peng, ZHANG Deng-hua, YANG Hong-qiang, WANG Na, KONG Xiang-feng, GUAN-yong, LIU Jian-guo, YAN Chuan-wei, ZHANG Liang, YIN Yue-jun, HAN Chang-zhi

Get full text

The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride. by Rossana Segreto, Hoda Bazafkan, Julia Millinger, Martina Schenk, Lea Atanasova, Maria Doppler, Christoph Büschl, Mélanie Boeckstaens, Silvia Soto Diaz, Ulrike Schreiner, Fabiano Sillo, Raffaella Balestrini, Rainer Schuhmacher, Susanne Zeilinger

“…Deletion of the gene encoding the GTPase RHE2, whose mammalian orthologue activates mTORC1, led to rapamycin hypersensitivity and altered secondary metabolism, but had an only minor effect on vegetative growth and mycoparasitic overgrowth. …”
Get full text