A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…RESULTS: Log-normal functions best fitted the survival curves from CodeBreak 200. …”
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Effect of damage by Oryzaephilus surinamensis on the chemical components of honeysuckle by XIANG Yuyong, LUO Huihua, DING Yajuan

“…Honeysuckle was one of the rare Chinese herbal medicine with disease prevention and healthcare functions, such as heat-clearance and detoxification, anti-inflammation and dispelling swollen. …”
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Host-specific microbiome-rumination interactions shape methane-yield phenotypes in dairy cattle by Alejandro Castaneda, Nagaraju Indugu, Kathryn Lenker, Kapil Narayan, Sarah Rassler, Joseph Bender, Linda Baker, Ojas Purandare, David Chai, Xin Zhao, Dipti Pitta

“…Microbial analysis revealed conserved methanogen diversity across the rumen, bolus, and fecal microbiomes, though functional differences were evident. High-RT cows had a greater abundance of Methanosphaera stadtmanae, suggesting an increased potential for methylotrophic methanogenesis, whereas low-RT cows exhibited higher Methanobrevibacter YE315 abundance, indicative of CO2-utilizing methanogenesis. …”
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Quality of life, neuro-humoral status and physical performance in adolescents with sinus tachycardia by O. H. Іvanko, O. V. Solianyk, V. A. Deineha, M. V. Patsera, I. V. Pashchenko, V. Ya. Pidkova

“…ST was accompanied by hypersympathicotonic type of sinoatrial node humoral dysregulation, grade I arterial hypertension in boys, abnormal pubertal development in girls with elevated blood levels of total estradiol and osteocalcin and low free renin levels, lowered levels of quality of life on role functioning of the SF-36 questionnaire. Adolescents with ST had lower performance in the PWC170 tests. …”
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Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

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Postgraduate Clinical Residency: The Impact of Multiple-Choice Question Quality on Exam Success Rates by Mohammed OEAH, Srinivasamurthy SK, Bhat R, Alhassan YAM, Hamdy Elshamly HA, Mohammed F, Hamad B

“…MCQs were evaluated using standard item analysis parameters: questions were considered acceptable range if they had a difficulty index (DIF) between 0.30– 0.70, a discrimination index ≥ 0.2, and at least two functioning distractors.Results: Out of 175 candidates who appeared for the QRE, only 19 (10.86%) passed. …”
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The Effect of Wet and Dry Heating Process and Wheat Flour Particle Sizes on Dough Rheology and Staling of Bread by Mohammad Fazli Rad, Jafar Milani, Sepide Haghighat

“…Results and DiscussionThe results showed that the effect of particle size and dry heat treatment on dough rheology and water activity of bread core and crust was significant, while moist heat treatment had significantly more bread core moisture (p<0.05). …”
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Ruminal Yeast Strain with Probiotic Potential: Isolation and Characterization and Its Effect on Rumen Fermentation In Vitro by Pin Song, Xiaoran Yang, Manman Hou, Yue Chen, Liping Liu, Yuyan Feng, Yingdong Ni

“…Compared to the CON group, HYC had a significantly mitigated reduction in pH in fermentation, resulting in a significant increase in total VFAs and acetate levels (<i>p</i> < 0.05). …”
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Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial. by Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium

“…Between 27 and 28 weeks of pregnancy, participants had an oral glucose (75 g) tolerance test (OGTT), and GDM diagnosis was based on diagnostic criteria recommended by the International Association of Diabetes and Pregnancy Study Groups (IADPSG), with 159 women having a diagnosis of GDM. …”
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Impact of myosteatosis on prognosis in multiple myeloma patients: A subgroup analysis of 182 cases and development of a nomogram by Jun-Peng Liu, Xing-Chen Yao, Ming Shi, Zi-Yu Xu, Yue Wu, Xiang-Jun Shi, Meng Li, Xin-Ru Du

“…The FIR nomogram model had a C-index of 0.777, and the calibration curve, decision curve analysis, and clinical impact curve all validated its effectiveness. …”
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Abstract 027: Adjunctive Intra‐Arterial Tenecteplase Following Mechanical Thrombectomy. (ALLY) Pilot Trial by Hisham Alhajala, Alicia Castonguay, Mouhammad Jumaa, Rahul Rao, Sunil Sheth, Marion Oliver, Richard Burgess, Ashutosh Jadhav, Diogo Haussen, Osama O Zaidat, Syed Fazal Zaidi

“…Treatments were administered as a bolus in 3 divided doses given 5 minutes apart, with angiographic runs obtained before and after the final treatment. All patients had imaging follow up (MRI of CT) after 24 hours of treatment. …”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…Abstract Background Ageing results in diminished adaptability, as well as declines in physiological and psychological functions and resilience. The epigenetic clock ‘Phenotypic Age’ (PhenoAge) represents ‘preclinical ageing’. …”
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Effects of Substitution of Wheat Straw by Giant Reed on Growth Performance, Serum Biochemical Parameters, Nutrient Digestibility, and Antioxidant Properties of Sheep by Kai Zhang, Yibo Yan, Rui Zhao, Xianyi Song, Liying Du, Bochi Zhang, Chunlei Yang, Xiaopeng Tang

“…In conclusion, replacing wheat straw with giant reed can significantly enhance growth performance, nutrient digestibility, and antioxidant capacity in sheep without adverse effects on their normal physiological functions.…”
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Multi-omics analyses reveal fecal microbial community and metabolic alterations in finishing cattle fed probiotics-fermented distiller’s grains diets by Rong Zhang, Shihui Mei, Guangxia He, Miaozhan Wei, Lan Chen, Ze Chen, Min Zhu, Bijun Zhou, Kaigong Wang, Zhentao Cheng, Chunmei Wang, Erpeng Zhu, Chao Chen

“…Besides, the FDG-10% group had a significant drop in the relative abundance of Aspergillus and a noteworthy increase in the relative abundance of Candida when compared to the CON group. …”
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Interactive impact of biochar, selenium and water management on rice plants and soil microbial diversity in a cadmium-contaminated soil and assessment of health risk by Ofori Prince Danso, Gege Wu, Zhangmin Wang, Zezhou Zhang, Shanshan Niu, Emmanuel Osei Asamoah, Zhiwei Peng, Raza Farooq Muhammad, Jiaping Song, Xuebin Yin, Renbin Zhu

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Effects of two foliar fertilizers on fruit quality and volatile flavor compounds in Jinhuangjin peach by YANG Xingwang, WANG Zhiqiang, DUAN Chenlei, WANG Yingying, XUE Guihong, PANG Lingzhi, SHI Meng, JI Xiaohao, ZHANG Deyan, WANG Xiaodi, WANG Haibo

“…The comprehensive evaluation using principal component analysis combined with membership function analysis showed that the rankings for comprehensive evaluation in 2023 and 2024 were: amino acid selenium foliar fertilizer (AA-Se), water-soluble silicon fertilizer (WSF-Si), and control. …”
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Comparative analysis of composition and spatial variations in the foregut microbiota of male and female donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Xiaotong Li, Xiaotong Li, Xiaotong Li, Zuowei Li, Zuowei Li, Zuowei Li, Qiaoqiao Han, Qiaoqiao Han, Qiaoqiao Han, Tong Hu, Tong Hu, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Honglei Qu, Honglei Qu, Haihua Zhang, Yangyan Qu, Yangyan Qu, Donghui Shi, Qiugang Ma, Qiugang Ma, Shimeng Huang, Shimeng Huang

“…Similarly, female ileum had enriched Amnipila, Terrisporobacter, and Luteimonas, whereas males showed higher levels of Sarcina and Streptococcus. …”
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Efficacy of angiotensin receptor neprilysin inhibitor for maintenance hemodialysis patients with different types of left ventricular ejection fraction heart failure by Jin-cong Li, Nan-hui Zhang, Lei Wang, Jun-meng Peng, Hui-hui Wang, Wen-hui Chen

“…The difference in proportional distribution of New York Heart Association （NYHA） cardiac function class before and after drug administration was statistically significant（P＜0.05）. …”
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Tissue Distribution and Proliferation Characteristics of pVA1-like Plasmid After Infection with Vibrio parahaemolyticus in the Pacific White Shrimp Penaeus vannamei by Xingqi SU, Qiang FU, Xupeng LI, Jie KONG, Jiteng TIAN, Baoxiang CAO, Ning LIU, Sheng LUAN, Kun LUO, Xianhong MENG

“…Pathological studies indicate that when the toxin encounters the hepatopancreas (the target organ), it leads to the separation and disintegration of epithelial cells, turning them into substrates for bacterial replication, ultimately compromising the function of the hepatopancreas. Currently, research on AHPND primarily focuses on prevention and treatment strategies. …”
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Effects of di(2-ethylhexyl) phthalate on glucose homeostasis in rats due to impaired autophagy flux of islet β cells mediated by oxidative stress by Hongyang ZHOU, Yuting HU, Xue CHEN, Yunqiang ZHOU, Liping LI, Ling LI, Herong LIU

“…The OGTT showed that, following high-glucose gavage, the 187 mg·kg−1 DEHP group had elevated blood glucose at 30 min (P<0.05), the 375 mg·kg−1 DEHP group showed increased glucose levels at 15, 30, and 180 min (P<0.05), and the 750 mg·kg−1 DEHP group exhibited elevated levels at 15, 30, 60, and 180 min (P<0.05). …”
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