Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Two hundred and twelve participants were included in the study and had an equal chance of being prescribed either lithium or quetiapine. …”
Get full text

CASE REPORT: THE POSSIBILITY OF SPECIFIC THERAPY OPTIMIZATION BY SWITCHING FROM BOSENTAN TO MACITENTAN IN A PATIENT WITH CONGENITAL HEART DISEASE AND EISENMENGER SYNDROME by S. Ye. Gratsianakaya, O. A. Arkhipova, A. I. Davydov, T. V. Martynyuk, N. A. Ananicheva, O. S. Belkorey, I. Ye. Chazova

“…With treatment, the patient's condition had been stable, however, by the second year, worsening shortness of breath, reduced exercise tolerance and an increase of the right heart were noted. …”
Get full text

Production of Whey Powder Added Fruit Beverages and Some Quality Characteristics by Büşra Ece Argan, Onur Güneşer, Ayşegül Kırca Toklucu, Yonca Karagül Yüceer

“…In this study, functional fruit beverages were produced by mixing whey with fruit concentrates (apple and cherry) or pulp (apricot) at certain amounts, and some physical, chemical and sensory characteristics of the beverages were revealed during storage. …”
Get full text

Radiological distribution patterns in restrictive chronic lung allograft dysfunction: Impact on survival across all phenotypes by Taiki Fukuda, MD, PhD, Yusei Nakamura, MD, Shu-Chi Tseng, MD, Yuki Ko, MD, PhD, Staci M. Gagne, MD, Takeshi Johkoh, MD, PhD, Yi Li, PhD, David C. Christiani, MD, MPH, MS, Hiroya Ojiri, MD, PhD, Lynette Sholl, MD, Mizuki Nishino, MD, MPH, Hiroto Hatabu, MD, PhD

Get full text

Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children by Thomas C. Seijbel, BSc, Levi Hoste, MD, Corinne M. P. Buysse, MD, PhD, Karolijn Dulfer, PhD, Filomeen Haerynck, MD, PhD, Matthijs de Hoog, MD, PhD, Naomi Ketharanathan, MD, PhD

“…One year after PICU admission, most children had normalized functional performance as measured by three validated performance scores. …”
Get full text

Integrated genomic analysis of the stemness index signature of mRNA expression predicts lung adenocarcinoma prognosis and immune landscape by Xingzhao Lu, Wei Du, Jianping Zhou, Weiyang Li, Zhimin Fu, Zhibin Ye, Guobiao Chen, Xian Huang, Yuliang Guo, Jingsheng Liao

“…The differentially expressed genes between the high and low risk groups were mainly enriched in the metabolism, cell cycle functions pathway. The low risk score group had higher immune cell scores. …”
Get full text

THE ASSESSMENT OF SURGICAL TREATMENT OF PATIENTS WITH MALIGNANT PLEURAL EFFUSION by S. M. Lasarev, A. V. Reshetov, O. E. Kakysheva, G. V. Nikolaev, Yu. V. Kirillov, G. N. Volgin

“…In an assessment of each method of treatment, the researchers came to the conclusion that in case when the patient had the sufficient functional capabilities, the doctors should give preference to the thoracoscopy operations and in case of severe somatic status the doctors should give preference to the drainage of pleural cavity with release from exudates and with subsequent introduction of talc as the most effective sclerosing agent.…”
Get full text

Prognostic gene expression and microRNA profiling signatures and genetic alterations in primary testicular diffuse large B-cell lymphoma by Wenyu Shi, Zijun Y. Xu-Monette, Youchao Jia, Alexandar Tzankov, Heounjeong Go, Ling Li, Maurilio Ponzoni, Yafei Wang, Qiongli Zhai, Anamarija M. Perry, Shi Wang, Xiaoxiao Wang, April Chiu, Mina L. Xu, Carlo Visco, Karen Dybkaer, Henry Withers, Mark Long, Alyssa F. Yuan, Yi Miao, Everardo Macias, Dehong Wu, Wen Shuai, Bangchen Wang, Jianyong Li, Govind Bhagat, Youli Zu, Zenggang Pan, William Choi, Santiago Montes-Moreno, Weina Chen, J. Han van Krieken, Michael B. Møller, Xinfang Yu, Benjamin M. Parsons, Shanxiang Zhang, Eric D. Hsi, Aliyah R. Sohani, Jeremy S. Abramson, Andrés J. M. Ferreri, Bing Xu, Yong Li, Ken H. Young

“…Genetic alteration analysis found that multiple chromosomal copy number variations (CNVs), TP53 transcript mutations with high variant allele frequency, and MCD subtype had significantly adverse prognostic effects, whereas elevated microsatellite instability had a significantly favorable prognostic effect in PT-DLBCL. …”
Get full text

Abstract 215: A Sweet Indicator: HbA1C and Thrombectomy Outcomes in Hispanics by Zorain M. Khalil, Samantha D. Miller, Yazan D. Abualnadi, Sohum K. Desai, Kaiser O. Sadiq, Wondwossen G. Tekle, Ameer E. Hassan

“…Results 495 patients met the inclusion criteria out of which 69 had HbA1c of 9% or greater. Patients with poorly controlled diabetes were significantly younger (median age 63 vs 72, p <0.001), had a lower prevalence of atrial fibrillation (7.69% vs 29.8%, p <0.001) and a higher median LDL level (95.5 vs 72, p<0.001) compared to patients who did not have poorly controlled diabetes. …”
Get full text

Mycophenolate mofetil exerts broad-spectrum antiviral activity against coronaviruses including SARS-CoV-2 by Mengyuan Wu, Kun Wang, Huiqiang Wang, Haiyan Yan, Shuo Wu, Ge Yang, Yuhuan Li, Yongsheng Che, Jiandong Jiang

Get full text

Effects of early stimulation of the quadriceps femoris on pain-related quality of life in total hip arthroplasty patients: a pilot study by Călin Vutan, Alina Totorean, Jenel-Marian Pătrașcu, Alexandra Mihaela Stănilă, Ana Maria Vutan, Mihaela Oravițan

“…The application of NMES resulted in pain reduction in patients with THA, but statistical analysis revealed that this had no significant impact on the final score of the questionnaires. …”
Get full text

JAK/STAT signaling in hepatocellular carcinoma by Justin Jit Hin Tang, Dexter Kai Hao Thng, Jhin Jieh Lim, Tan Boon Toh

“…Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has had increasing global incidence over the past few years. …”
Get full text

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet by Wen-Ying Huang, Hui-Ju Chen, Chia-Ching Lin, Chin-Shuh Chen, Yung-Sheng Lin

“…A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. …”
Get full text

Immunoreactivity parameters in cardiosurgery patients by A. A. Silaev, E. P. Turmova, V. V. Volkov, E. V. Markelova, D. B. Andreev

“…Functional cell activity was decreased, humoral immunity was disturbed. …”
Get full text

The First Case of E-Cigarette-Induced Polycythemia by Marika Okuni-Watanabe, Keiji Kurata, Kimikazu Yakushijin

“…Other laboratory data and his cardiopulmonary functions were almost normal, and JAK2 V617F mutation was negative. …”
Get full text

Effects of Different Cooking Methods on the Quality of Golden Pomfret Fillets by Keyi YUAN, Tiantian ZHAO, Wenjuan JIAO, Jun LIU, Fang ZHOU, Weifeng LIU, Yehui ZHANG, Lanqing PENG, Haijun NAN, Xiaoying CHEN

Get full text

Prognostic Role of Ultrasound Diagnostic Methods in Patients with Acute Decompensated Heart Failure by Zhanna D. Kobalava, Tolkacheva Veronika Vladimirovna, Sarlykov Bekbolot Kanatbekovich, Rena Sh Aslanova, Lapshin Artem Alekseevich, Nazarov Ivan Sergeevich, Smirnov Ilya Pavlovich, Maria V Vatsik-Gorodetskaya, Ghazaal Alavi Tabatabaei, Ibrahim Al-Zakwani, Mohammed Al Jarallah, Georgiana Luisa Baca, Peter A Brady, Rajesh Rajan, Bhavesh Talera

Get full text

Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate by Yunuen Avalos-Padilla, Yunuen Avalos-Padilla, Inés Bouzón-Arnáiz, Inés Bouzón-Arnáiz, Miriam Ramírez, Claudia Camarero-Hoyos, Claudia Camarero-Hoyos, Claudia Camarero-Hoyos, Marc Orozco-Quer, Elsa M. Arce, Diego Muñoz-Torrero, Diego Muñoz-Torrero, Xavier Fernàndez-Busquets, Xavier Fernàndez-Busquets, Xavier Fernàndez-Busquets

“…While this poses challenges for the parasite, the propensity for protein aggregation may also serve functional roles, such as stress adaptation, and could therefore be exploited by targeting it as a potential vulnerable spot in the pathogen. …”
Get full text

Preparation and performance evaluation of cyclodextrin bifunctional monomer molecularly imprinted polymers by YU Haining, HUANG Haiyong, HE Chengzijing, LAY Sovichea, SHEN Shengrong

“…A series of di (2-ethylhexyl) phthalate (DEHP) imprinted polymers were prepared using allyl-β-cyclodextrin (allyl-β-CD) either alone or in conjunction with methacrylic acid (MAA), methyl methacrylate (MMA), acrylonitrile (AN), and acrylamide (AA) as the binary functional monomers. According to values of the binding specificity experiment, the binary functional monomers (M-MAA, M-MMA, and M-AN) were superior to a single functional monomer (M-β-CD); the average value of bound substrates from binary functional monomers was 110 μmol/g, whereas a single was 90 μmol/g. …”
Get full text

Long-term patient-reported outcomes following congenital heart surgery in adults by Thibault Schaeffer, Thibault Schaeffer, Pauline Bossers, Doris Kienmoser, Doris Kienmoser, Oktay Tutarel, Paul Philipp Heinisch, Paul Philipp Heinisch, Masamichi Ono, Masamichi Ono, Julie Cleuziou, Julie Cleuziou, Jelena Pabst von Ohain, Jelena Pabst von Ohain, Jürgen Hörer, Jürgen Hörer

“…The majority of patients reported improved subjective wellbeing after cardiac operation and were in functional New York Heart Association class I or II. …”
Get full text