Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention by Fuli Fan, Shubei Liu, Bin Wang, Xiaojian Song, Wei Wang

“…Both transcriptome analyses and CyTOF-based immune phenotyping confirmed that AMB had increased levels of TBX21 (T-bet), ITGAX (CD11c), CD19, CD20 and CXCR3 (P < 0.05), and it had decreased expressions of CD27, CD38, CXCR4, CXCR5 and CD62L (P < 0.05). …”
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Rare filamin C variants among patients with hypertrophic cardiomyopathy referred for septal myectomy by S. E. Andreeva, A. V. Gurshchenkov, V. V. Zajcev, A. A. Kozyreva, A. I. Mihaleva, A. S. Murav'ev, V. K. Grebennik, L. B. Mitrofanova, M. L. Gordeev, O. M. Moiseeva, A. A. Kostareva

“…One patient with p.His1834Tyr FLNC variant had reverse curve interventricular septum morphology, whereas other patients had predominant hypertrophy of basal segment of interventricular septum. …”
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The accuracy of diagnosis of major depression in patients with Parkinson's disease: a comparative study among the UPDRS, the geriatric depression scale and the Beck depression inve... by Vitor Tumas, Guilherme Gustavo Ricioppo Rodrigues, Tarsis Leonardo Almeida Farias, José Alexandre S. Crippa

“…All depression scales were highly correlated but UPDRS depression item had the lowest diagnostic value. The GDS15 had the more appropriate "receiver operating characteristics" curve. …”
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Effect of Sociodemographic Factors, Concomitant Disease States, and Measures Performed in the Emergency Department on Patient Disability in Ischemic Stroke: Retrospective Study fro... by Diana Malaeb, Souheil Hallit, Hiba Al Harfany, Sara Mansour, Frederic Faugeras, Pascale Salameh, Hassan Hosseini

“…Patients were excluded if they had been discharged from ED without hospital admission or if mRS was not performed. …”
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COVID-19 case fatality ratio and survival among hospitalized adults in Goiás, 2020: a cohort study by Moara Alves Santa Bárbara Borges, Ana Laura de Sene Amâncio Zara, Lísia Gomes Martins de Moura Tomich, Adriana Oliveira Guilarde, Cacilda Pedrosa de Oliveira, Deborah Lopes Mota Carvajal, Marina Mascarenhas Roriz Pedrosa, Paulo Sérgio Sucasas da Costa, Marília Dalva Turchi

“…Results The sample consisted of 651 adults, whose median age was 59 years, 57.0% were admitted to public hospitals, 61.1% had severe acute respiratory syndrome on admission and 72.0% had at least one comorbidity, the most frequent being hypertension , diabetes and obesity. …”
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Drug-eluting stents versus bare-metal stents for intracranial atherosclerotic stenosis: a systematic review and meta-analysis by Yan Ma, Liqun Jiao, Tao Wang, Bin Yang, Jie Wang, Jichang Luo, Renjie Yang, Wenlong Xu, Haozhi Gong

“…Secondary outcomes included procedure-related adverse events, technical success, functional evaluation findings, restenosis degree and other safety endpoints within 1 year. …”
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Telepharmacy for outpatients with cancer: An implementation evaluation of videoconsults compared to telephone consults using the CFIR 2.0 by Marissa Ryan, Elizabeth C. Ward, Clare Burns, Christine Carrington, Katharine Cuff, Mhairi Mackinnon, Centaine L. Snoswell

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Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…Melatonin and CAPE were found to have the highest inhibition values on CYP1A2, while CAPE had the highest inhibition values on CYP2C19 and CYP2C9. …”
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COMORBIDITIES IN PATIENTS WITH ISCHEMIC HEART DISEASE: GENDER DIFFERENCES by A. N. Sumin, E. V. Korok, A. V. Shcheglova, O. L. Barbarash

“…The evaluation of the severity of angina pectoris and chronic heart failure (CHF) revealed that in men the I and II functional classes (FC) of angina (p=0.057 and p=0.007, respectively) and stage I CHF (p&lt;0.001) were prevailed, whereas women had angina FC 3-4 (p=0.005 and p=0.050, respectively) and stage IIa CHF (p&lt;0.001). …”
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The Effects of Pediatric Acute Lymphoblastic Leukemia Treatment on Cardiac Repolarization by Diana R. Lazar, Simona Cainap, Florin Leontin Lazar, Dana Maniu, Cristina Blag, Madalina Bota, Marius C. Colceriu, Mihnea Zdrenghea

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Physical Activity as a Factor to Improve the Quality of Student Life by M. M. Kolokoltsev, S. S. Iermakov, N. V. Tretyakova, V. L. Kraynik, E. V. Romanova

“…The values of indicators such as “role functioning”, “pain intensity”, “mental health”, “emotional state”, “social and life activity” fell substantially. …”
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Modulatory effect of Picralima Nitida on oxidative stress: Cobalt, thiol, total protein in Drosophila melanogaster exposed to lead by Osunbor, J.O. Osakue, J.E.

“…D. biochemical, neurological and physiological sim ilarities with human beings and has about 75% functional homologs of genes causing diseases in humans. …”
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A novel founder variant in BEST1 gene causing autosomal recessive bestrophinopathy by Nagham Maher Elbagoury, Caroline Atef Tawfik, Asmaa Fawzy Abdel-Aleem, Heba Mahmoud Fathy, Dina Nabil Baddar, Mona Lotfi Essawi

“…On top of the classical retinal phenotype of ARB, some patients had other ocular associations: four patients were found to have angle-closure glaucoma, one patient had associated corneal dystrophy, one developed a macular hole, and one patient developed uveitis. …”
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PDX1 in early pregnancy is associated with decreased risks of gestational diabetes mellitus and adverse pregnancy outcomes by Qian Zhang, Qing-qing Zhang, Shu-qin Dong, Xia Liu, Jing Wei, Kai Li, Kai Li, Yu Lu

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Impact of dual sensory impairment on cognition in older Chinese adults: a moderated chain-mediated effect by Qingyun Mao, Qingyun Mao, Heting Liang, Xiaoli Yuan, Zhixia Jiang, Rujun Hu, Yumeng Zhang, Shuang Li, Xiaoling Yang

“…This finding also implies that therapies for psychological issues, frailty, and sensory functioning in older adults can preserve their cognitive ability.…”
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Postimplementation Evaluation in Assisted Living Facilities of an eHealth Medical Device Developed to Predict and Avoid Unplanned Hospitalizations: Pragmatic Trial by Jacques-Henri Veyron, François Deparis, Marie Noel Al Zayat, Joël Belmin, Charlotte Havreng-Théry

“…System performance to predict hospitalization had a high specificity (96%) and negative predictive value (99.4%). …”
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Long-term effectiveness and safety of infliximab, golimumab and ustekinumab in patients with psoriatic arthritis from a Canadian prospective observational registry by Emmanouil Rampakakis, Proton Rahman, Majed Khraishi, Maqbool Sheriff, Dalton Sholter, Allen J Lehman, François Nantel, Regan Arendse

“…The proportion of patients who discontinued treatment were 63.1%, 50.9% and 50.0%, respectively.Conclusions IFX, GLM and UST treatment significantly reduced disease activity and improved functionality in patients with PsA followed by routine clinical practice and had a safety profile similar to that previously reported in the literature.Trial registration number NCT00741793.…”
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Reverse shoulder arthroplasty for fracture sequelae: How the initial fracture treatment influences the outcomes of joint replacement by Fernando Santana, Eduard Alentorn-Geli, Pau Guirro, Carlos Torrens

“…All complications and reoperations during follow-up were also recorded. Results: Both groups had significantly increased Constant Scores after surgery (p < 0.0001), but the patients in the conservative group had significantly better outcomes for the total Constant Score (p = 0.024), for forward elevation (p = 0.026) and for external rotation (p = 0.004).A total of 4 complications (14.8%) were present during the follow-up period. …”
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A qualitative study on optimizing influenza vaccination services and strategies for people aged 60 and above in Shanghai by WANG Xiaolan, YANG Tian, XUE Caoyi, WU Linlin, FEI Yi, YANG Xiaoguang, XU Biao

“…The study found that Shanghai had a well-managed and standardized influenza vaccination service. …”
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Relationship between the ideal and reality in civil service: retrospective approach towards ethical problems in the interwar Lithuanian Republic by Jolanta Palidauskaitė

“…Šimkus, etc. Some of them had studied at western universities and were familiar with the newest managerial theories or were writing themselves on various questions including state administration or governance. …”
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