Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study by Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang

“…Abstract Background Recent studies suggest that neutrophil elastase inhibitor (Sivelestat) may improve pulmonary function and reduce mortality in patients with acute respiratory distress syndrome. …”
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Expression of kinetochore component NDC80 promotes esophageal squamous cell carcinoma cells proliferation and migration by Youwu Shi, Jing Sun, Feng Du, Zhiwei Sun, Ying Yang, Jing Yu, Yanjie Xiao, Xiaoyu Sun, Wen Zhang, Hongkun Zheng, Xiaodong Zhang, Jun Jia

“…However, the biological function and mechanism of NDC80 in esophageal squamous cell carcinoma (ESCC) have not yet been elucidated. …”
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An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis by Xiaolu Yang, Xiaolu Yang, Yilun Li, Yilun Li, Yaqi Peng, Yuan Chang, Binglu He, Binglu He, Tianqi Zhang, Tianqi Zhang, Shiyu Zhang, Cuizhi Geng, Yunjiang Liu, Xiaolong Li, Jun Hao, Li Ma

“…Overexpression of ASCL1 enhanced BC cell proliferation, migration and invasion, while its knockdown had the opposite effect. Notably, inhibition of ASCL1 increased BC cell sensitivity to paclitaxel both in vitro and in vivo. …”
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Effectiveness and Safety of Immunotherapy for Hepatocellular Carcinoma in Clinical Practice: A Brazilian Multicenter Study by Leonardo Gomes da Fonseca, Cecília Souza Freire, Rodrigo Antonio Vieira Guedes, Marcos Castro Lyra, Maria Ignez Freitas Melro Braguiroli, Mariana Bruno Siqueira, Maria De Lourdes Lopes de Oliveira, Alexandre de Mendonça Palladino, Henry Luiz Najman, Rodrigo Tancredi, Duilio Reis Da Rocha Filho, Markus Cavalcante Gifoni, Guilherme Luiz Stelko Pereira, Marcela Crosara Alves Teixeira, Lucila Soares Da Silva Rocha, Raimundo Paraná, Paulo Marcelo Hoff

“…Liver cirrhosis was present in 70.6%, and 77% had Barcelona Clinic Liver Cancer stage C. Immunotherapy was predominantly first-line (91.4%), with atezolizumab plus bevacizumab as the most common regimen (77.9%). …”
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Disparities in dolutegravir utilisation in children, adolescents and young adults (0–24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort by Valériane Leroy, Anandi Sheth, Julie Jesson, Jean Jacques Koffi, Antoine Jaquet, François Dabis, Didier Koumavi Ekouevi, Karen Malateste, Olivia Keiser, Lehila Bagnan, Simon Boni, Madeleine Amorissani Folquet, Mariam Sylla, Olivier Marcy, Raoul Moh, Gildas Boris Hedible, Sophie Desmonde, Joycelyn Dame, Agatha David, Madeleine Amorissani-Folquet, Sylvie N'Gbeche, Elom Takassi, François Tanoh Eboua, Kouadio Kouakou, Lehila Bagnan Tossa, Caroline Yonaba, Jocelyn Dame, Sylvie Marie N’Gbeche, Fatoumata Dicko Traore, Oliver Ezchechi, Rosemary Audu, Charlotte Bernard, Caroline Couturier, Marie Kerbie Plaisy, Elodie Rabourdin, Thierry Tiendrebeogo, Désiré Dahourou, Emile Sodinyessi, Jean-Claude Azani, Kadidja Diarra, Maika Bengali, Abdoulaye Cissé, Guy Gnepa, Eric Komena, Séverin Lenaud, Eulalie Kangah, Igho Ofotokun, Cecile Delille Lahiri, Noëlle Benzekri, Geoffrey Gottlieb

“…We computed the cumulative incidence function for DTG initiation; associated factors were explored in a shared frailty model, accounting for clinic heterogeneity.Results Since 2019, 3350 patients were included; 47.2% were female; 78.9% had been on ART ≥12 months. …”
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Excellent patient-reported long-term quality of life after an Ivor Lewis esophagectomy for cancer by Alisa N. Blumenthaler, Cyrus A. Feizpour, Shadia I. Jalal, Kevin J. Lopez, Neal K. Ramchandani, Joshua McAlister, Susan M. Perkins, Yan Han, Karen M. Rieger, JoAnn Brooks, Kenneth A. Kesler

“…Survey participants had higher Charlson-Comorbidity Indices (p = 0.01) and pathologic tumor stages (p = 0.04) compared to non-participants. …”
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Enhancing access to specialist appointments in tertiary healthcare in Shanghai, China: a structured reservation pathway using digital health technologies by Li Li, Tao Zheng, Enhong Dong, Minjie Chen, Xiaojing Zhao, Binyuan Zhang, Xuji Zhao, Weijun Shao, Yiling Fan

“…Objective The aim of this study is to develop, implement the precise reservation path (PRP) and investigate its prediction function for scheduling shunting patients for specialist appointment registration in Shanghai, China.Design The PRP system was built on the hospital’s existing information system, integrated with WeChat (WeCom) for user convenience. …”
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Disaggregation of luminal alimentary tract tumors by E-cad disruption: a report of six cases by Man Li, Qunqun Bao, Jing Guo, Ruting Xie, Min Yuan, Jinguo Liu, Jianguo Wu, Kan Chen, Hualing Wu, Yangyang Geng, Peiwen Sun, Jingqi Zhu, Qing Lin, Qing Xu, Feng Liu, Binghui Zhao, Qing Wei, Ping Hu, Jianlin Shi, Huanlong Qin

“…Four esophagus cancer patients experienced 6.7%, 26.7%, 16.7% and 15.4% reductions in tumor size, respectively, and symptoms of dysphagia were largely alleviated. All enrolled patients had normal physical condition based on blood routine examinations and hepatic and renal function examinations. …”
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In Vitro Anthelmintic Activities of Khaya anthotheca and Faidherbia albida Extracts Used in Chad by Traditional Healers for the Treatment of Helminthiasis and In Silico Study of Ph... by Baigomen Christalin, Masoud Besati, Noumedem Anangmo Christelle Nadia, Mahdi Yaghoobi, Yamssi Cédric, Claire Ciancia, Mounvera Abdel Azizi, Gamago Nkadeu Guy-Armand, Vincent Khan Payne, Haibo Hu

“…Docking studies were carried out using the Schrodinger Maestro software’s Glide module. The score function in the software was used to rank and group distinct possible adduct structures generated by molecular docking. …”
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Proteomic pathways across the ejection fraction spectrum in patients with heart failure and diabetes mellitus: an EXSCEL trial substudy by Anthony E. Peters, Maggie Nguyen, Jennifer B. Green, Ewan R Pearson, John B. Buse, Harald Sourij, Adrian F. Hernandez, Naveed Sattar, Rury R. Holman, Robert J. Mentz, Svati H. Shah

“…Of N = 1199 EXSCEL participants with prevalent HF, 284 (24%), 704 (59%) and 211 (18%) had HFpEF, HFmrEF and HFrEF, respectively. Eight principal components analysis (PCA) protein factors differed significantly across the three EF groups, of which 270 individual proteins within those factors were significant. …”
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Trauma center vs. nearest non-trauma center: direct transport or bypass approach for out-of-hospital traumatic cardiac arrest by Ming-Fang Wang, Chen-Bin Chen, Chip-Jin Ng, Wei-Chen Chen, Shang-Li Tsai, Chien-Hsiung Huang, Chi-Yuan Chang, Li-Heng Tsai, Chi-Chun Lin, Cheng-Yu Chien

“…Abstract Background Out-of-hospital traumatic cardiac arrest (TCA), a sudden loss of heart function caused by severe trauma such as blunt, penetrating, or other injuries, presents significant public health challenges due to its high severity and extremely low survival rates. …”
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Antioxidant Peptides from the Fruit Source of the Oil Crop <i>Litsea cubeba</i> Ameliorate FFA-Induced Oxidative Stress Injury: Based on Nrf2/Keap1 Pathway and Molecular Dynamics S... by Li Li, Ying Hu, Yu-Mei Wang, Xiao-Xue Wu, Si-Tong Lin, Hang Li, Ji Zhang, Guo-Rong Fan, Zong-De Wang, Bin Wang, Shang-Xing Chen

“…JC-1 fluorescence staining experiments showed that the mitochondrial membrane potential function of NAFLD cells was restored under the effect of the antioxidant peptides. …”
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Continuity of care in lumbar disc herniation: a systematic review and meta-analysis providing a deeper look into postoperative efficacy by Ying Lin, Ying Lin, Qiaoling Chen, Qiaoling Chen, RouMei Wang, Bing Zhang, Bing Zhang, Rui Huang, Yiguang Bai, Yiguang Bai

“…Additionally, the Japanese Orthopedic Association (JOA) score of the experimental group was significantly higher than that of the conventional control group at 3 months post-operation [SMD = 1.70, 95%CI (1.01, 2.39), p &lt; 0.01].ConclusionOur meta-analysis indicates that continued care interventions significantly alleviate postoperative pain, enhance lumbar function, reduce anxiety, and improve overall functional recovery in LDH patients. …”
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Integration of transcriptome and metabolome reveals tolerance mechanism to high salinity stress in Crassostrea hongkongensis by Yixin Zhang, Qiwen Liang, Feifei Yu, Jiexiong Zhu, Jianfang Gui, Jinji Lin, Yishan Lu, Haiyuan Tao

“…After high salinity stress at sub-lethal concentration (40 ‰) for 48 h, the enzyme activities of SOD, CAT, LZM, GSH-PX and AKP were measured to confirm that C. hongkongensis had activated the physiological stress reoponses. …”
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QuantiFERON^® Monitor Test as a Potential Tool for Stratifying Patients by Infection Risk and Tailoring Follow-Up Care in Lung Transplant Recipients: A Single-Center Retr... by Paolo Solidoro, Antonio Curtoni, Filippo Patrucco, Eleonora Russo, Francesca Sidoti, Giorgia Piccinini, Alessandro Bondi, Paolo Valesella, Mattia Genco, Massimo Boffini, Rocco Francesco Rinaldo, Cristina Costa

“…QFM assays were performed after 18 months post-transplant. Results: HI patients had lower QFM levels compared to LI (68.84 ± 21.98 vs. 380.54 ± 104.64 UI/mL, <i>p</i> = 0.033). …”
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Sexual epigenetics: genome-wide analysis revealed differential DNA methylation in the vector tick Haemaphysalis longicornis by Han Wang, Ziyan Bing, Lu Li, Ziwen Gao, Chuks Fidelis Nwanade, Na Dong, Ke Li, Leyan Du, Zhijun Yu

“…The 3′ untranslated region (UTR) had the highest methylation in the CG context, followed by exons, introns, and CGI_shore regions. …”
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Experimental Study of Modified Videman Method to Replicate Knee Osteoarthritis in Rabbits by Jing LIU, Qiaoxuan LIN, Liming LU, Zexing GUO, Hong LIU, Liangzhi ZHANG, Zhongbiao XIU

“…Lequesne MG knee grade score method was used to evaluate the left knee joint motor function of rabbits after modeling. The joint space, effusion, cartilage surface smoothness were evaluated by X-ray and MRI. …”
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Subclinical Myocardial Injury and Global Cognitive Performance by Shubham Tomar, MBBS, MPH, Karita C.F. Lidani, MD, MSc, PhD, Aline A.I. Moraes, MD, PhD, Shi Huang, PhD, Christian Oakley, BS, Khurram Nasir, MD, MPH, Michael J. Blaha, MD, MPH, Susan R. Heckbert, MD, PhD, Timothy M. Hughes, PhD, Christopher R. deFilippi, MD, Yader Sandoval, MD, Allan S. Jaffe, MD, Andrew P. DeFilippis, MD, MSc

“…At baseline and exam 5, 63% and 87% had subclinical myocardial injury, respectively. …”
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Comparison of Glasgow coma scale, motor component, eye component, and simplified motor scale for predicting trauma outcomes: a 13-year multicenter retrospective cohort study by Shu-Jui Lee, Yu-Long Chen, Tsung-Hsien Wu, Chi-Yuan Liu, Chien-Hsing Wang, Chia-Hung Tsai, Jui-Yuan Chung, Giou-Teng Yiang, Meng-Yu Wu

“…Abstract Background To address the complexity and time-consuming nature of the full Glasgow Coma Scale (GCS), various simplified tools for assessing brain function have been proposed, such as the eye (GCSE) and motor component of the GCS (GCSM), and the Simplified Motor scale (sMS). …”
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Dietary micronized hemp fiber enhances in vitro nutrient digestibility and cecal fermentation, antioxidant enzyme, lysosomal activity, and productivity in finisher broilers reared... by Tossaporn Incharoen, Tossaporn Incharoen, Manatsanun Nopparatmaitree, Adisak Kongkeaw, Keatisak Soisuwan, Wirot Likittrakulwong, Atichat Thongnum, Nima Norbu, Jigme Tenzin, Natphapat Supatsaraphokin, Juan J. Loor

“…These findings underscore the potential of MHF as a functional feed additive in broiler production.…”
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