Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism by Tasneem Cheytan, Martin Schneider, Roberto Würth, Paul Schwerd-Kleine, Ewgenija Gutjahr, Verena Thewes, Laura L. Michel, Rebecca Weber, Tim Vorberg, Sabrina Lohr, Katja Nitschke, Michelle Neßling, Peter Lichter, Andreas Schneeweiss, Karsten Richter, Dominic Helm, Martin Sprick, Andreas Trumpp

“…Here, we characterized and studied the function of sEVPs secreted from tumor-free pre-metastatic organs (TuFMO-sEVPs) such as the brain and lungs in both immunocompetent and patient-derived xenograft models. …”
Get full text

Clopidogrel Versus Aspirin as Chronic Maintenance Antiplatelet Monotherapy in Patients After Percutaneous Coronary Intervention With Chronic Kidney Disease: A Post Hoc Analysis of... by Jeehoon Kang, Sang‐Hyeon Park, Kyung Woo Park, Bon‐Kwon Koo, Huijin Lee, Minju Han, Doyeon Hwang, Han‐Mo Yang, In‐Ho Chae, Won‐Yong Shin, Ju Hyeon Oh, Yong Hoon Kim, Tae‐Ho Park, Bum Soo Kim, Jung‐Kyu Han, Eun‐Seok Shin, Hyo‐Soo Kim

“…However, it is uncertain whether the beneficial effect of clopidogrel over aspirin is different according to the renal function. Methods and Results We conducted a post hoc analysis of the HOST‐EXAM trial. …”
Get full text

Risk factors for pneumonia after radical gastrectomy for gastric cancer: a systematic review and meta-analysis by Siyue Fan, Hongzhan Jiang, Qiuqin Xu, Jiali Shen, Huihui Lin, Liping Yang, Doudou Yu, Nengtong Zheng, Lijuan Chen

“…The quality was assessed using the Newcastle–Ottawa Scale after the chosen studies had been screened and the data retrieved. RevMan 5.4 and R 4.4.2 were the program used to perform the meta-analysis. …”
Get full text

Fast-acting treatment of myasthenic crisis with efgartigimod from the perspective of the neuro intensive care unit by Fangyi Shi, Rong Lai, Li Feng, Hongyan Zhou, Xunsha Sun, Cunzhou Shen, Jiezhen Feng, Zhilong Xu, Haiyan Wang, Huiyu Feng

“…After discharge, all patients showed a clinically meaningful decrease in Myasthenia Gravis Activities of Daily Living (MG-ADL) scale (a decrease of ≥ 2 points) and an improvement in their lung function. Additionally, all patients had a decrease in IgG levels (58.59 ± 18.48% after one cycle of efgartigimod). …”
Get full text

Characteristics and Outcomes of Older Patients Undergoing Protected Percutaneous Coronary Intervention With Impella by Philipp Jakob, Alexandra J. Lansky, Mir B. Basir, Michael J. Schonning, Batla Falah, Zhipeng Zhou, Wayne B. Batchelor, Arsalan Abu‐Much, Cindy L. Grines, William W. O'Neill, Barbara E. Stähli

“…Patients ≥75 years of age had less diabetes and prior myocardial infarction, more hypertension and dyslipidemia, worse renal function, more severe valvular heart disease, but higher left ventricular ejection fraction (P<0.05 for all comparisons). …”
Get full text

Skimming and storage factors affect the detection of heat shock protein 70 in raw bovine milk by M.R.H. Rakib, V. Messina, J.I. Gargiulo, N.A. Lyons, I.N. Pathirana, P.C. Thomson, S.C. Garcia

“…Result showed that SBS samples had the smallest reduction in HSP70 levels on d 3 when stored at T2 or T3, with decreases of 4.4% and 7.9%, respectively. …”
Get full text

Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes by Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck

“…Objectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function. While MG-induced DNA and protein adducts have been extensively studied and associated with type 2 diabetes (T2D) and its complications, the formation, biological relevance, and functional consequences of MG-induced RNA adducts remain poorly understood. …”
Get full text

Validation of Revised Chinese Version of PD-CRS in Parkinson’s Disease Patients by Yuyan Tan, Weiguo Liu, Juanjuan Du, Miaomiao Hou, Cuiyu Yu, Yang Liu, Shishuang Cui, Lei Yan, Yizhou Lu, Hong Lv, Lijun Han, Xi Wang, Shengyu Zha, Xiaoguang Luo, Huidong Tang, Shengdi Chen

“…All the frontal-subcortical and instrumental-cortical functions showed significant decline in PDD compared with the PD-NC group (p≤0.001). …”
Get full text

The contribution of a short electrocardiographic diastolic interval to diastolic dysfunction and HFpEF by A. M. L. N. van Ommen, L. R. Bear, C. Carlos Sampedrano, N. C. Onland-Moret, M. J. Cramer, F. H. Rutten, E. Dal Canto, I. I. Tulevski, G. A. Somsen, N. K. Sweitzer, R. Coronel, H. M. den Ruijter

“…We validated the TQ interval’s association with diastolic function using right atrial pacing and sotalol infusion in a pig model (n = 6). …”
Get full text

Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease by I-Wen Wu, Yu-Chieh Liao, Tsung-Hsien Tsai, Chieh-Hua Lin, Zhao-Qing Shen, Yun-Hsuan Chan, Chih-Wei Tu, Yi-Ju Chou, Chi-Jen Lo, Chi-Hsiao Yeh, Chun-Yu Chen, Heng-Chih Pan, Heng-Jung Hsu, Chin-Chan Lee, Mei-Ling Cheng, Wayne Huey-Herng Sheu, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai

“…This study aims to elucidate the functional capability of gut microbiota to affect kidney function of DKD patients. …”
Get full text

Mechanisms of ag85a/b DNA vaccine conferred immunotherapy and recovery from Mycobacterium tuberculosis‐induced injury by Nan Wang, Yan Liang, Qianqian Ma, Jie Mi, Yong Xue, Yourong Yang, Lan Wang, Xueqiong Wu

“…After MTB infection, most of the upregulated DE genes were related to the digestion and absorption of nutrients or neuroendocrine (such as Iapp, Scg2, Chga, Amy2a5), and most of the downregulated DE genes were related to cellular structural and functional proteins, especially the structure and function proteins of the alveolar epithelial cell (such as Sftpc, Sftpd, Pdpn). …”
Get full text

Sensus Fidei as a Gift of the Holy Spirit to the Church by Leon Sawicki

“…Consensus fidei has always had value in Catholic theology. e testimony of God’s people helps to recognise the revealed truth. e Holy Spirit gives believers the ability to understand the supernatural truth revealed by Christ. …”
Get full text

Curcumin promotes spermatogenesis in mice with cryptorchidism by regulating testicular protein O-GlcNAcylation by Zhen Wang, Fujia Chen, Yun Li, Chaoying Liu, Lizhen Wang, Weilun Shao, Zhen Lu, Li Hu, Longxuan Li, Yue Wang, Jinyang Lin, Yaxuan Yu, Shengjun Sun, Yurong Yang, Zhijian Zhu, Siqiang Li, Enzhong Li

“…After five weeks of treatment, evaluations based on organ coefficients, sperm count detection, testicular pathology analysis, and hormone level assessments determined the most effective curcumin dosage.Results and disccusionThe findings indicated that cryptorchidism had a detrimental impact on reproductive function, evident by decreased testicular coefficient, cessation of sperm production, abnormal testicular tissue morphology, and hormonal imbalances. …”
Get full text

Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia by Natasha Ting Lee, Ioanna Savvidou, Carly Selan, David K. Wright, Robert Brkljaca, Joanne S.J. Chia, Ilaria Calvello, Daphne D.D. Craenmehr, Pia Larsson, Volga Tarlac, Amy Vuong, Irena Carmichael, Xiaowei Wang, Karlheinz Peter, Simon C. Robson, Harshal H. Nandurkar, Maithili Sashindranath

“…Assessments at 24 h included neurological function, infarct volume, perfusion, and albumin extravasation to assess blood-brain barrier (BBB) permeability. …”
Get full text

Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy by Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

“…We aimed to test the degree of concordance in preterm lung function, and correlate this with genomic, transcriptomic, and pharmacokinetic variables in preterm dizygotic twin ovine fetuses. …”
Get full text

Characterisation of airway disease associated with Sjögren disease by Eric Hachulla, Xavier Mariette, Jacques-Eric Gottenberg, Marie-Pierre Debray, Philippe Dieude, Alain Saraux, Olivier Vittecoq, Emanuelle Dernis, Raphaele Seror, Gaetane Nocturne, Cindy Marques, Veronique Le Guern, Claire Larroche, Robin Dhote, Pierre-Antoine Juge, Anne Laure Fauchais, Antoine Beurnier, Loïc Meudec

“…Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. …”
Get full text

Assessment of Coagulopathy Risk in Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study in Thumbay Hospital, UAE by Fawzia Abdalla Alobeidli, Israa M. M. Abdalhadi, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Ammar Abdelmola, Israa Omer Mahmoud Yousif, Muhammad Saboor, Khalid Abbas Owish Sukar, Noha Kamal Abdmomen, Ayman H. Alfeel

“…Background: Type 2 diabetes mellitus(T2DM) is associated with coagulation abnormalities and a higher risk for blood clots due to changes in the clotting factors and platelet function. This study aimed to assess blood clotting parameters in T2DM patients within a single research center in the UAE. …”
Get full text

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms by Daniel H. Solomon, Misti Paudel, Shravani Chitineni, Ana Fernandes, Tammy Pham, Shreya Billa, Chio Yokose, Kiara Tan, Julien J. Dedier, Maureen D. Dubreuil, John D. Fitzgerald, Sally L. Hodder, Tuhina Neogi, Michael H. Pillinger, Kevin R. Riggs, Kenneth G. Saag, Paul G. Shekelle, Zoe Tseng, Michael Toprover, David S. Wei, Michael J. Barry, Hyon K. Choi

“…Blood pressure control, kidney function, glycemic control, and coronary atherosclerosis are exploratory secondary outcomes. …”
Get full text

Prediction of 10‐Year Fragility Fractures Using Muscle Health Indicators in Postmenopausal Women: The OsteoLaus Cohort by Colin Vendrami, Elena Gonzalez Rodriguez, Guillaume Gatineau, Peter Vollenweider, Pedro Marques‐Vidal, Olivier Lamy, Didier Hans, Enisa Shevroja

“…ABSTRACT Background Muscle strength, mass and function have been associated with falls, fractures and mortality, but the results vary between previous studies. …”
Get full text

Colistimethate sodium is efficacious and safe for the management of sepsis in hematological diseases patients: a retrospective study in China by Yan Xie, Ziyi Liu, Peiqi Liang, Dong Wang, Qian Li, Meng Gao, Jindan Kong, Depei Wu, Jiajun Qi, Jie Xu, Jianhong Fu

“…The univariate analysis of renal insufficiency demonstrated that allogeneic hematopoietic stem cell transplantation, aplastic anemia, and gastrointestinal infection had a statistically significant impact on renal function.ConclusionsThe findings of our study demonstrated that CMS was an efficacious treatment for sepsis in Chinese patients with hematological diseases, while concurrently exhibiting an acceptable toxicity profile.…”
Get full text