Biochemical, coagulation, and platelet count profiles among Schistosoma mansoni infected patients attending at selected Dembiya health institutions, Northwest Ethiopia by Wagaw Abebe, Wossenseged Lemma, Yalewayker Tegegne, Assefa Sisay, Tadesse Misganaw, Sisay Ayana, Desie Kasew, Marye Nigatie Debash, Alemu Birara Zemariam, Tadele Emagneneh, Adane Derso

“…This is due to liver failure, platelet destruction, disruption of blood flow, and endothelial function by the schistosomes. However, there is no adequate data on biochemical and coagulation profiles and platelet count of patients infected with Schistosoma mansoni in Dembiya Selected Health Institutions. …”
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Population Pharmacokinetics and Model-Informed Precision Dosing of Clobazam Based on the Developmental and Genetic Characteristics of Children with Epilepsy by Yali Tuo, Xiaolong Yu, Sichan Li, Jun Wang, Maochang Liu, Xinwen Song, Jiehui Ma, Yang Wang, Zhisheng Liu, Dan Sun

“…<b>Conclusions</b>: Body weight and CYP2C19 genotype had an impact on CLB and/or N-CLB clearance in children with epilepsy. …”
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Effects of aspirin and omega-3 fatty acids on age-related macular degeneration in ASCEND-Eye: a randomised placebo-controlled trial in a population with diabetes by Praveen Patel, Rory Collins, Richard Peto, Mark Davies, Sanjiv Banerjee, David Simpson, John Anderson, Louise Bowman, Peter Scanlon, Amanda Adler, Andrew Farmer, Helen Cook, Laura Evans, Elizabeth Williamson, Louis Bolter, Jane Armitage, Peter Sandercock, Richard Gray, Nilesh Samani, Tasso Gazis, Richard Haynes, Arun Sachdev, Eric Wu, Elizabeth Wincott, Peter Sleight, Colin Baigent, Marion Mafham, Sarah Parish, Gavin Brown, Susan Hurley, Lynne Allsop, William Stevens, Theingi Aung, Allen Young, Emily Sammons, Georgina Buck, Imen Hammami, Jill Barton, Jonathan Bodansky, Roger McPherson, Lucy Fletcher, Murphy Kevin, Ryonfa Lee, Sandra Pickworth, Monica Willett, Michael Lay, Ola Murawska, Karen Melham, Jonathan Latham-Mollart, Anna Brewer, Mike Olson, Jude Kay, Alisha Griffiths, Helen Clayton, Philip Kirby, Mike Pennington, Dominic Clarke, Jenny Anslow, Alex Hallam, Jenny Witts, Sarah Egan, Alex Wharton, Amy Derbyshire, Katherine Hepplestone, Sujit Mithra, Su Oliver, Pauline Wiatrak-Olszewska, Kelly Alvey, Nick Gregory, Priyai Parkinson, Prema Maharajan, Rachel McFee, Donna Sowter, John Featonby, Richard Furnival, Helen Lipinski, Hazel Benjamin, Tanisha McAfee, Emma Payne Payne, Liz Still

“…Reports of AMD diagnoses were sourced from 6 monthly ASCEND follow-up questionnaires and a Visual Function Questionnaire.Participants 15 480 UK adults at least 40 years of age with diabetes but no evident cardiovascular disease.Interventions 100 mg aspirin daily versus placebo and, separately, 1 g omega-3 FAs daily versus placebo.Main outcome measure The first post-randomisation reports of AMD.Results During 7.4 years of follow-up, 122 (1.6%) participants randomised to aspirin were reported as having AMD, compared with 138 (1.8%) randomised to placebo (rate ratio 0.88; 95% CI 0.69 to 1.12; p=0.31). …”
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Role of impulse oscillometry in chronic obstructive pulmonary disease and asthma‐chronic obstructive pulmonary disease overlap by Yuning Huang, Xue Zhang, Jinwen Wang, Wuping Bao, Chengjian Lv, Yingying Zhang, Xue Tian, Yan Zhou, Min Zhang

“…Methods Pathological specimens from 64 patients with normal lung function were divided into small airway pathological abnormalities (PAs, n = 38) and normal pathology (PN, n = 26). …”
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Association between the triglyceride-glucose index and silent myocardial infarction in the general population by Min Dai, Dongze Li, Jing Yu, Yi Liu, Qin Zhang, Wei Zhang, Yan Zhong, Zhi Wan, Menglin Tang, Yongli Gao, Li Rao

“…Results of the Kaplan–Meier analysis suggested that participants with a higher TyG index had a lower cumulative survival rate for SMI (P < 0.001). …”
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Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study by Libin Liao, Weiquan Huang, Rongchao Ma, Wentong Hu, Hui Wu, Moxi Su, Dujuan Sha, Dujuan Sha, Dujuan Sha

“…All blood samples were collected within 24 h after admission, and the cognitive function of patients was assessed within 2 weeks using the Chinese version of the Montreal Cognitive Assessment (MoCA). …”
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Analysis of the expression levels and diagnostic value of serum tumor necrosis factor-like weak inducer of apoptosis and vasohibin-1 in children with purpura nephritis by Hou Xiao-feng, Chen Bin

“…Compared with the low expression groups of TWEAK and VASH-1， patients in the high expression groups of TWEAK and VASH-1 had significantly higher renal pathological grade， 24 h urinary protein， Cystatin C （Cys C）， serum creatinine （Scr）， urinary albumin （Alb）， blood urea nitrogen （BUN）， and urinary immunoglobulin A （IgA） （P<0.05）. …”
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Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial by Fan Zhang, Danyang Peng, Faming He, Ying Liu, Binbin Zang, Yanqiu Gao, Chao Qin, Suping Guo, Yawei Qi, Xisheng Zheng, Lin Guo, Tingting Zhao, Yue Jin, Rongqi Su, Juan Du, Jiazhan Pan, Bingyu Qin, Huanzhang Shao

“…Results Of 240 critically ill adult patients with confirmed CRO infection, 91.3% had pulmonary infection, and 77.1% and 52.5% achieved clinical and microbiological response, respectively. …”
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Application of copy number variation sequencing combined with whole exome sequencing in prenatal left–right asymmetry disorders by Yu Qin, Muon Senglong, Koksear Touch, Juan Xiao, Ruijie Fang, Qingling kang, Lei Fan, Shufang Li, Jing Liu, Jianli Wu, Yuanyuan Wu, Xinwei Shi, Haiyi Liu, Xun Gong, Xingguang Lin, Ling Feng, Suhua Chen, Wei Li

“…Further bioinformatics scrutiny was conducted to assess the protein structure and function prediction of these variants, ultimately indicating their potential pathogenicity. …”
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Component characterization of Smilax glabra Roxb., and its inhibitory activity against Helicobacter pylori through targeted suppression of its secreted urease by Ying Tang, Fan Yang, Xia Wen, Yi Zhou, Rong Tang, Xiuzhi He, Qiang Lu, Cailan Li, Cailan Li, Cailan Li

“…However, the precise mechanism underlying the anti-H. pylori function of SGR remains to be elucidated.AimThe inhibitory impact of SGR on the growth of H. pylori was examined. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…We assessed treatment response with Reveal Lite 2 scores (all patients had N-terminal-pro-brain natriuretic peptide, 6-minute walk, and functional class assessment at both visits) and followed clinical outcomes for 3 years. …”
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A Narrative Review in Hip Surgery: Key Findings from a Leading Orthopedic Journal in 2022–2023 by Nikolai Ramadanov, Maximilian Voss, Robert Prill, Jonathan Lettner, Aleksandra Królikowska, Krzysztof Korolczuk, Roland Becker

“…Femoroacetabular impingement (FAI) was investigated in a total of 23 studies, followed by hip micro-instability in 7 studies, dysplasia in 5 studies, and gluteal and hamstring tears in 4 studies. The RCT had a low risk of bias. Of the 22 non-RCTs, 16 had a low risk of bias, 5 had a moderate risk of bias, and 1 had a high risk of bias. …”
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SITE CHARACTERISTICS AND VEGETATION DRIVE THE ABUNDANCE AND DIVERSITY OF ARBUSCULAR MYCORRHIZA FUNGI IN SELECTED LAND DEGRADATION SURVEILLANCE FRAMEWORK STUDY SITES IN KENYA by Lukelysia Nyawira Mwangi, S. Kamau, G. Cheruto, T. Vågen, D. Lelei, L. Winowiecki

“…Taxonomic diversity as shown by the Shannon diversity index (Hʹ) had a similar trend as richness. However, vegetation type only had a significant effect on AMF richness and diversity. …”
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Effect of sarcopenia combined with Metabolic Syndrome (MS) on the prognosis of intertrochanteric fractures: a retrospective clinical study by Cheng Zhang, Ding Wang, Xitao Wu, Qinrui Zhang, Lei Chen, Junzhe Lang, Congcong Wu

“…This study investigates the individual and combined influence of MS and sarcopenia on complications and functional recovery in elderly patients with intertrochanteric fractures. …”
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A study on the relationship between personality and motivation in leisure participants. by Gül Yağar, Gamze Deryahanoğlu, Emine Bal

“…It was determined that for the first set of canonical functions, the relationship between self-control and internal regulation had a unidirectional correlation, whereas, for the second set of canonical functions, the relationship between extraversion and external regulation had an inverse correlation. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Secondary: evaluate the impact of pramipexole on mood and anxiety, psychosocial function, cost-effectiveness, and safety and tolerability over 48 weeks. …”
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Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL by Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu

“…On follow‐up MRI scans at month 12, the majority of ACMIs vanished. Patients with ACMIs had worse functional outcomes, as indicated by higher mRS scores and lower MoCA scores at months 12 and 24 compared with those without ACMIs. …”
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Autoimmune liver damage in patients with primary Sjogren's syndrome associated with anticentromeric antibodies by B. D. Chalcev, V. I. Vasiliev, S. G. Palshina, A. V. Torgashina, E. V. Sokol, J. I. Khvan, E. B. Rodionova, T. N. Safonova, T. P. Nekrasova

“…Objective: to determine the frequency, spectrum and severity of liver affection in anti-centromere antibodies (ACA) positive patients with primary Sjogren's syndrome (pSS).Patients and methods. 119 ACA-positive patients with pSS were included in the study, 37 (31%) of them had signs of liver damage, 3 of these patients were excluded from the study (2 had cholelithiasis, 1 had viral hepatitis B). …”
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Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

“…Trpv5(682P/682P) mice also had normal plasma parathyroid hormone but increased 1,25-dihydroxyvitamin D(3) concentrations without increased bone resorption, consistent with a renal defect for the hypercalciuria. …”
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Investigating the new environmental attitude of native communities towards forest ecosystem services (Case study: Shiadeh and Diva forests) by Hamid Hajizadeh, Asghar Fallah, sare hoseini

“…Introduction: The forest ecosystem, as a valuable natural resource, provides various functions and services for human beings, the maintenance of which should be the main goal of human activities. …”
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