Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review by Ivan Lehman, Ivan Lehman, Matija Matošević, Lovro Lamot, Lovro Lamot, Branka Bunoza, Branka Bunoza

“…Onasemnogene abeparvovec-xioi, an adeno-associated viral vector-based gene therapy delivering a functional copy of the SMN1 gene, has shown significant efficacy in improving motor function and survival rates. …”
Get full text

Exploring the safety, effect on the tumor microenvironment, and efficacy of itacitinib in combination with epacadostat or parsaclisib in advanced solid tumors: a phase I study by Michael Smith, Ignacio Garrido-Laguna, Aung Naing, Lance Leopold, Jason J Luke, Kai Ding, Solmaz Sahebjam, Ryan Geschwindt, John D Powderly, John J Nemunaitis, Aaron S Mansfield, Wells A Messersmith, Patricia M LoRusso, Jordan D Berlin

“…In the itacitinib plus epacadostat group, no patient had an objective response. Among patients receiving itacitinib 100 mg once a day plus parsaclisib 0.3 mg once a day, three achieved partial response for an objective response rate (95% CI) of 7.1% (1.50 to 19.48). …”
Get full text

A modified liver retraction method decreases liver dysfunction after laparoscopic gastrectomy by Hao-Jie Li, Lang Zhou, Wei-Han Zhang, Kai Liu, Kun Yang, Jian-Kun Hu, Xiao-Long Chen

“…This study aims to explore the effect of a modified liver retraction method (MLR) we designed on the postoperative liver function of patients receiving laparoscopic radical gastrectomy. …”
Get full text

Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study by Peter P. Nghiem, Alexis M. Rutledge, Kyle Tehas, Corine Kaderli, Meredith Poling, Sidney Arnim, Vitaliy Dernov, Celine van Sas, Macie L. Mackey, Gabriella A. M. ten Have, Mariëlle P. K. J. Engelen, Nicolaas E. P. Deutz

“…DMD dogs treated with HMB as compared to placebo had a respective 40% increase in exertional (play) (951 [827, 1075] versus 569 [491, 647]; p < 0.0001) and 10.5% increase in non-exertional (active) activity (15,366 [14742, 15990] versus 13,806 [13148,14466]; p = 0.0016). …”
Get full text

MdUGT88F4 involved in the synthesis of isosalipurposide positively regulates the salt stress response of apple plants by Ying Ye, Yanrong Hu, Yuan Liu, Cheng Yu, Kun Zhou, Fengwang Ma, Xiaoqing Gong

“…In order to verify whether it had biological function in apple plants, we generated transgenic apple plants overexpressed MdUGT88F4 and treated them with salt stress. …”
Get full text

Changes in the soil and rhizosphere microbiomes associated with bacterial wilt decline in the tomato monoculture field by Junwei Peng, Jinfeng Hou, Hong Liu, Dmitri V. Mavrodi, Olga V. Mavrodi, Feifei Sun, Minchong Shen, Xia Wang, Keke Dang, Min Yan, Hui Liang, Yuanhua Dong, Jiangang Li

“…Moreover, functional analysis of the suppressive rhizosphere metagenome revealed enrichment of genes for the synthesis of antibiotics, polysaccharides, nitrogen metabolism, mineral absorption, and energy production. …”
Get full text

Oxygen systems to improve clinical care and outcomes for children and neonates: A stepped-wedge cluster-randomised trial in Nigeria. by Hamish R Graham, Ayobami A Bakare, Adejumoke I Ayede, Amy Z Gray, Barbara McPake, David Peel, Olatayo Olatinwo, Oladapo B Oyewole, Eleanor F G Neal, Cattram D Nguyen, Shamim A Qazi, Rasa Izadnegahdar, John B Carlin, Adegoke G Falade, Trevor Duke

“…Limitations of our study are a lower-than-anticipated power to detect change in mortality outcomes (low event rates, low participant numbers, high intracluster correlation) and major contextual changes related to the 2016-2017 Nigerian economic recession that influenced care-seeking and hospital function during the study period, potentially confounding mortality outcomes.…”
Get full text

Early reduction of skin potassium without sodium accumulation in the pathogenesis of salt sensitivity in primary aldosteronism by Petr Mlejnek, František Liška, František Liška, Jan Šilhavý, Kateřina Večerková, Kateřina Večerková, Miroslava Šimáková, Michal Pravenec, Michal Pravenec, Theodore W. Kurtz

“…At 14 days, biological processes related to muscle function and calcium ion transport were significantly altered.ConclusionAldosterone-treated rats on a high-salt diet for 2 days had lower skin and plasma potassium levels compared to salt-loaded controls, suggesting early potassium depletion precedes significant sodium accumulation and blood pressure increases. …”
Get full text

“Kynurenine switch” and obesity by A. V. Shestopalov, O. P. Shatova, M. S. Karbyshev, A. M. Gaponov, N. E. Moskaleva, S. A. Appolonova, A. V. Tutelyan, V. V. Makarov, S. M. Yudin, S. A. Roumiantsev

“…It was found that obese patients had higher concentrations of kynurenine, quinolinic and kynurenic acids, indole-3-acetate, indole-3-lactate, indole-3-butyrate, and 5-hydroxyindole-3-acetate. …”
Get full text

Construction of water injection seepage model for coal body and microscopic dominant influence law by Enmao WANG, Gang WANG, Shuliang XIE, Hongzhao WEI, Jing FENG, Handan LIANG

“…The coal body strength coefficient demonstrated the highest sensitivity at 16.765, whereas the pore throat radius had the lowest sensitivity at 0.00117. (3) The study thoroughly evaluated how these key factors affect water injection capacity. …”
Get full text

Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia by Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni

“…A large panel of 18 transmembrane regulators of platelet function and activation were analyzed, at baseline and after ex-vivo stimulation with thrombin receptor-activating peptide (TRAP). …”
Get full text

Clinical and Radiological Comparison of Unilateral Biportal Endoscopic and Percutaneous Transforaminal Endoscopic Discectomy in the Treatment of Lumbar Spinal Degenerative Disease by Hongtao Ding, Xiao Han, Yonggang Xing, Yajun Liu, Da He, Xiaoguang Han

“…Despite the dural sac area increased in both groups, the UBE group had a statistically significant greater improvement than the PTED group (p = 0.000). …”
Get full text

Prognostic genes in colon cancer and their correlation with immune cells: an analysis based on bioinformatics by Gu Zhiwen, Wu Yinteng, Liao Cun, Ma Hui, Zhang Sen, Zhang Xiaolong

“…The R clusterprofile package was used for functional enrichment analysis. The prognosis-related genes were screened and their expression was verified by qPCR. …”
Get full text

Cloning of claudin-5 Gene from Oreochromis niloticus and Analysis of Its Expression Under Streptococcus agalactiae by Yanghui CHEN, Suying ZHANG, Yongxiong HUANG, Zirui ZHANG, Bei WANG

“…The expression level of claudin-5 in the brain of O. niloticus was extremely high, about 300 times that of blood cells. Therefore, it had obvious tissue specificity of expression of claudin-5. …”
Get full text

Carbohydrate antigen-125 (CA125): a marker of right ventricular dysfunction and poor prognosis in heart failure with preserved ejection fraction by Sher May Ng, Geert H.D. Voordes, Michelle Lobeek, Michiel Rienstra, Adriaan A. Voors, Elke S. Hoendermis, Dirk J. van Veldhuisen, Thomas M. Gorter

“…Results: 19 patients with HFpEF (25 %) had RVD. The Olink proteomic analysis identified carbohydrate antigen 125 (CA125) as the most differentially abundant in plasma of patients with HFpEF and RVD as compared to those without RVD, which corroborated with further immunoassay analysis − median CA125 in patients with RVD was 23 kU/L [21–47] vs. 16 [12–20] in patients without RVD (p < 0.001). …”
Get full text

Advantages of long-term combination pharmacotherapy with a beta-blocker and eplerenone in patients with ST-segment elevation acute coronary syndrome by O. A. Osipova, V. P. Mikhin, A. I. Golovin, O. N. Belousova, D. N. Perutsky, P. K. Alferov, S. L. Konstantinov

“…Comparative analysis also found that combination therapy had a more pronounced positive effect on LVEF (p&lt;0,05), ESVI (p&lt;0,05), WMSI (p&lt;0,05), LVMI (p&lt;0,01), as well as diastolic function in the form of a significant increase in E/A (p&lt;0,05) and E/e’ (p&lt;0,01), which recovered to normal values.Conclusion. …”
Get full text

How to measure the effectiveness of recovery community centers: insights gained from a nationwide survey of directors of RCCs by Bettina B. Hoeppner, Bettina B. Hoeppner, Alivia C. Williamson, Hazel Simpson, Diadora DeCristofaro, Catherine Weerts, Marion J. Riggs, Allison Futter, Amy A. Mericle, Philip X. Rutherford, Lauren A. Hoffman, Vinod Rao, Patty McCarthy, Julia Ojeda, Susanne S. Hoeppner, Susanne S. Hoeppner

“…Close collaboration with RCCs is needed to ensure that research on the effectiveness of RCCs is congruent with how RCCs function and seek to confer benefit.…”
Get full text

Metodologia para determinação das necessidades nutricionais de melão e melancia Metodology for assessment of nutritional requirements of melon and watermelon by José A. de A. Paula, José F. de Medeiros, Neyton de O. Miranda, Francisco de A. de Oliveira, Carlos J. G. de S. Lima

“…<br>This work was carried out aiming to determine nutritional requirements of nitrogen, phosphorus and potassium for melon and watermelon, as a function of estimated yield, and validate them with experimental data obtained from melon and watermelon trials carried out in Assu-Mossoró region. …”
Get full text

Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

Get full text

Fermentation Characteristics, Nutrient Content, and Microbial Population of <i>Silphium perfoliatum</i> L. Silage Produced with Different Lactic Acid Bacteria Additives by Yitong Jin, Bao Yuan, Fuhou Li, Jiarui Du, Meng Yu, Hongyu Tang, Lixia Zhang, Peng Wang

“…The experimental results revealed that inoculation with <i>L. buchneri</i> had a stronger effect on <i>S. perfoliatum</i> silage than inoculation with <i>L. plantarum</i>. …”
Get full text