Mavacamten maintenance dose determination: insights into individualised therapy for hypertrophic cardiomyopathy by Kawa Mohemed, Smita Scholtz, Volker Rudolph, Jan-Christian Reil, Max Potratz, Cédric Coppée, Vasco Sequeira, Werner Scholtz

“…Clinical status was evaluated using New York Heart Association (NYHA) class and Kansas City Cardiomyopathy Questionnaire (KCCQ) score.Results The mean age of patients was 60.6±12.1, and all had normal CYP2C19 metabolic status. LVEF was 68% (IQR 8) at baseline and decreased mildly to 60.5% (IQR 7.25; p=0.0004) without cases dropping below 50%. …”
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Immunotoxicity Studies on the Insecticide 2-((1-(4-Phenoxyphenoxy)propan-2-yl)oxy)pyridine (MPEP) in Hsd:Harlan Sprague Dawley SD^® Rats by Victor J. Johnson, Stefanie C. M. Burleson, Michael I. Luster, Gary R. Burleson, Barry McIntyre, Veronica G. Robinson, Reshan A. Fernando, James Blake, Donna Browning, Stephen Cooper, Shawn Harris, Dori R. Germolec

“…However, MPEP treatment had no effect on the ability of rats to clear the influenza virus nor the T-dependent IgM and IgG antibody response to the virus. …”
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Assessment of the E-Selectin rs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels by Elena Sandoval-Pinto, Jorge Ramon Padilla-Gutiérrez, Emmanuel Valdes-Alvarado, Ilian Janet García-González, Angelica Valdez-Haro, Jose Francisco Muñoz-Valle, Hector Enrique Flores-Salinas, Fernando Rivas, Yeminia Valle

“…The sE-selectin levels were significantly higher in ACS patients compared to HS (54.58 versus 40.41 ng/ml, P=0.02). The C allele had no effect on sE-selectin levels. Conclusions. …”
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Effects of including different levels of equal mix of soybean and flaxseed oils in Japanese quail diets on the growth, carcass quality, and blood biomarkers by Mohamed E. Abd El-Hack, Ahmed K. Aldhalmi, Adel I. Attia, Zenat A. Ibrahem, Garsa Alshehry, Mohamed Loutfi, Ahmed A. Elolimy, Mohamed S. El-Kholy

“…Birds fed diets with oil mixes also had increased serum concentrations of immunoglobulin G (IgY), immunoglobulin M (IgM), and superoxide dismutase (SOD). …”
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Modeling Whole-Plant Carbon Stock in <i>Olea europaea</i> L. Plantations Using Logarithmic Nonlinear Seemingly Unrelated Regression by Yungang He, Weili Kou, Ning Lu, Yi Yang, Chunqin Duan, Ziyi Yang, Yongjun Song, Jiayue Gao, Weiyu Zhuang

“…Carbon stock (CS) is an important indicator of the structure and function of forest ecosystems, and plays an important role in mitigating climate change, maintaining ecological system balance, promoting carbon trading, and other socioeconomic and ecological values. …”
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Effect of theaflavins on inflammatory degeneration of rat chondrocytes induced by interleukin-1β by ZHOU Ying, HUANG Qian, WANG Shuai, CHEN Ping

“…Osteoarthritis (OA) is a degenerative joint disease with an obviously increasing morbidity as age increases, which seriously affects old people’s joint function and life quality. The key to pathological changes in OA is the damage and loss of articular cartilage. …”
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Distribution, behavior and diet of the Asiatic black bear in human modified landscapes by Hadi Fahimi, Mahmood Soofi, Nahid Ahmadi, Ali T. Qashqaei, Hamidreza Heidari, Haaken Bungum, Bent Rech, Jonas Trepel, Matthias Waltert

“…Date palm area size (β = 2.07; 95 % Credible Interval = 0.67 to 3.89) and distance to croplands had a strong and significant (β = −1.06, 95 % CrI = −2.10 to −0.20) influence on the occupancy. …”
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Measurement properties of health-related quality of life instruments for people living with scoliosis in China: A systematic review. by Liu-Qing Jing, Qi-Xing Shen, Yi-Lin Jin, Shao-Jie Du, Ting-Zhen Liu, Ni Chen, Guo-Dong Wang, Wen Mo, Jie Ye, Jin-Hai Xu

“…<h4>Purpose</h4>Scoliosis is a three-dimensional structural deformity of the spine that leads to restricted spinal motion, weakness in the paraspinal muscles, reduced cardiopulmonary function, and chronic physical and psychological pain. …”
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Associação singular de síndrome de Kallmann e cisto aracnóide da fossa média: relato de caso Singular association of Kallmann's syndrome and arachnoid cyst of middle fossa: case re... by Yvens B. Fernandes, Gil Guerra Jr, Sofia H. V. Lemos, Maria T. Matias, Benito P. Damasceno, Osmi Hamamoto, Ary Marconi Jr, Donizetti C. Honorato, José L. C. Marins

“…Laboratory investigation revealed pre-pubertal levels of testosterone and normal results of the combined test of anterior pituitary function, except for in GnRH acute and prolonged test. …”
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Laparoscopic hepatectomy for hepatocellular carcinoma in a patient with congenital factor V deficiency: a case report by Takaomi Seki, Mariko Tsukagoshi, Norifumi Harimoto, Kenichiro Araki, Akira Watanabe, Norihiro Ishii, Kei Hagiwara, Kouki Hoshino, Ryo Muranushi, Satoru Kakizaki, Yoshiyuki Ogawa, Hiroshi Handa, Ken Shirabe

“…Preoperative evaluation of cardiac function to determine tolerance to high doses of FFP and ingenuity of surgery and intraoperative management to minimize blood loss are important.…”
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Factors promoting development of renal tubulointerstitial lesions in patients with diabetes mellitus by Minara Shamkhalovna Shamkhalova, Kseniya Olegovna Kurumova, Inna Igorevna Klefortova, Ivan Ivanovich Sitkin, Alexander Viktorovich Il'in, Margarita Ivanovna Arbuzova, Nikolay Petrovich Goncharov, Gul'nara Viktorovna Katsiya, Andrey Alexeevich Aleksandrov, Svetlana Semenovna Kukharenko, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov

“…Results. DM patients with CKD had elevated blood profibrogenic cytokine (MCP-1, TGF-1b, IL-6) and extracellular matrix degradation factor(MMP-9) levels compared with patients without CKD and healthy subjects. …”
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Incidence of cardiovascular risk factors and exercise phenotyping in cardiomyopathies: One size does not fit all by Simon Wernhart, Florian Karcher, Mark J Haykowsky, Martin Halle

“…DCM displayed significantly lower resting left ventricular ejection fraction (40.5 %, interquartile range, IQR, 11.5 %, p < 0.001), diastolic function (E/e‘ 9.3, IQR 5.5, p < 0.001), and had the lowest peak systolic blood pressure (170.0 mmHg, IQR 52.5 mmHg, p = 0.011), predicted peak oxygen consumption (82.0 %, IQR 39.8 %, p = 0.003), oxygen pulse (101.0 %, IQR 28.8 %, p = 0.030) as well as lower ventilatory (VP, 5.5 mmHg, IQR 1.4 mmHg, p = 0.033) and circulatory (CP, 4096.0 mL/kg/min x mmHg, IQR 2299.3 mL/kg/min x mmHg, p = 0.015) power compared to the other groups. …”
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Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT by Merve Postalcioglu, Ronit Katz, Simon B. Ascher, Trenton Hall, Pranav S. Garimella, Stein I. Hallan, Joachim H. Ix, Michael G. Shlipak

“…Introduction: Urine epidermal growth factor (uEGF) has been found to be inversely associated with kidney function loss, whereas its associations with cardiovascular disease (CVD) and mortality have not been studied. …”
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Rifaximin treatment in patients with severe alcohol-associated hepatitis: A multicenter, randomized controlled, open-label, pilot trial by Do Seon Song, Jin Mo Yang, Young Kul Jung, Hyung Joon Yim, Hee Yeon Kim, Chang Wook Kim, Soon Sun Kim, Jae Youn Cheong, Hae Lim Lee, Sung Won Lee, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim

“…Material and Methods: In this randomized controlled open-label trial, patients with SAH (Maddrey's discriminant function≥32) were randomized to the rifaximin or control group. …”
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Comparison of Prolonged Transversus Abdominis Blockade with Systemic Anesthesia During Local Access to Double-Barreled Intestinal Stoma Closure (Preliminary Results of a Prospectiv... by I. A. Ermakov, V. V. Valetova, A. V. Savushkin, I. E. Gridchik, I. V. Molchanov, A. I. Moskalev, D. O. Kiselev

“…The main group consisted of 41 patients who, for pain relief after surgery, had a catheter installed for prolonged blockade of the transverse abdominal space. …”
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Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome by Yongwei Huang, Xiaoshuang Yin, Zongping Li

“…Inflammatory markers, including the systemic immune inflammation index (SII) and the systemic inflammation response index (SIRI), function as composite indicators for assessing immune-related inflammatory status. …”
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Sinbaglustat ameliorates disease pathology in a murine model of GM1 gangliosidosis without affecting CNS ganglioside levels by Rouven Wannemacher, Lorna Jubran-Rudolf, Isabel Zdora, Eva Leitzen, Karl Rohn, Virginie Sippel, Christoph Paschen, Peter Blattmann, Wolfgang Baumgärtner, Ingo Gerhauser, Michel Alexander Steiner

“…We conclude that sinbaglustat had a therapeutic-like effect in the GM1 gangliosidosis mouse model.…”
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Impact of Surgical Margin Status and Tumor Volume on Mortality After Robotic Radical Prostatectomy by Zaki Zeidan, Joshua Tran, Yeagyeong Hwang, Linda My Huynh, Mai Xuan Nguyen, Erica Huang, Whitney Zhang, Thomas Ahlering

“…However, a large international multi-institutional study recently revealed that unifocal PSMs (UPSMs) had no impact on prostate cancer–specific mortality (PCSM), whereas multifocal PSMs (MPSMs) did. …”
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Awake versus intubated video-assisted thoracoscopic surgery for pleural disease: a retrospective cohort study from a single tertiary center by Omer Faruk Saglam, Burcu Kilic, Merve Ekinci Fidan, Nevzat Cem Sayilgan, H. Volkan Kara, Akif Turna, Kamil Kaynak, Ezel Ersen

“…Earlier oral intake, mobilization, and return of bowel function were observed in the A-VATS group (all values compared were p &lt; 0.001). …”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Results of anti-thyroid autoantibodies (anti-thyroid peroxidase/ATPO/and antithyroglobulin/ATG/), thyroid function tests (TFTs) and thyroid ultrasound examinations were obtained. …”
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