Anti-MDA5 antibody IgG1 subtype is associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis by Yun Wu, Yue Wang, Yulu Qiu, Chengying Lv, Yujing Zhu, Lei Wang, Lingxiao Xu, Hanxiao You, Fang Wang, Wenfeng Tan

“…Result Of the 71 patients, 30% developed RP-ILD. RP-ILD patients had a shorter disease course and a higher mortality rate than non-RP-ILD patients (both P < 0.001). …”
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Long Noncoding RNA GATA3-AS1 Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Suppression of PTEN, CDKN1A, and TP53 by Xuee Luo, Ning Zhou, Le Wang, Qinghua Zeng, Hongying Tang

“…However, the expression pattern and function of GATA3-AS1 in hepatocellular carcinoma (HCC) remain unknown. …”
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A clinical study to evaluate the effect of umami taste on the oral stereognostic ability of complete denture patients by Vinod Bandela, Shital Sonune, Kulashekar Reddy Nandalur, Eatedal Mukhlef Alruwaili, Alreem Abdulaziz Alnuman, Miad Abdulnasser Alahmed, Faisal Abdullah Eldosary, Lama Naif Alsayil, Faisal Nami Alsinani

“…The umami group achieved a mean score of 8.3 (±1.5), whereas the control group had a slightly lower mean score of 6.7 (±1.2). This difference was consistent across all test shapes, indicating a potential enhancement in oral sensory function associated with umami taste perception. …”
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Suspensão temporofrontal gálea-periostal com duplo acesso: tática conservadora Temporofrontal galea periosteal lifting with double access: a conservative procedure by Chang Yung Chia

“…METHODS: A retrospective analysis of 20 consecutive female patients who underwent cervicofacial facelift from February 2008 to July 2011 was performed. The patients had a mean age of 53.3 years (range, 46-71 years). …”
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Comprehensive biomarker assessment for predicting severe acute kidney injury and need of kidney replacement therapy in liver transplantation patients by Camila Lima, Gillene Santos Ferreira, Maria de Fátima Fernandes Vattimo, Luciana Bertocco de Paiva Haddad, Luiz Marcelo Malbouisson, Luiz Augusto Carneiro D’Albuquerque, Alexandre Toledo Maciel, Etienne Macedo

“…U-OSM alone, measured within 48 h post-LT, had an accuracy of 83% for predicting KRT need, outperforming any BM combination.Conclusions Combined BM analysis can accurately predict severe AKI and KRT needs in the perioperative period of LT. …”
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The best ovarian reserve marker to predict ovarian response following controlled ovarian hyperstimulation: a systematic review and meta-analysis by Fateme Salemi, Sara Jambarsang, Amir Kheirkhah, Amin Salehi-Abargouei, Zahra Ahmadnia, Haniye Ali hosseini, Marzieh Lotfi, Saad Amer

“…Abstract Background One of the most challenging aspects of treating patients facing primary ovarian insufficiency, especially those eligible for controlled ovarian hyperstimulation (COH), is the assessment of ovarian function and response to stimulatory protocols in terms of the number of oocytes retrieved. …”
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Damage to the Cardiovascular System in Patients with SARS-CoV-2 Coronavirus Infection. Part 1: Predictors of the Development of an Unfavorable Prognosis by V. I. Podzolkov, A. I. Tarzimanova, A. E. Bragina, I. I. Shvedov, E. E. Bykova, A. A. Ivannikov, L. V. Vasilyeva

“…More than half of the patients admitted to the hospital had a history of cardiovascular diseases: hypertension was diagnosed in 915 (56%) patients, coronary artery disease – in 563 (34%), chronic heart failure – in 410 (25%). 294 (17.9%) patients suffered from diabetes mellitus. …”
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Development of a predictive risk model for all-cause mortality in patients with diabetes in Hong Kong by William Ka Kei Wu, Tong Liu, Ian Chi Kei Wong, Qingpeng Zhang, Jiandong Zhou, Sharen Lee, Keith Sai Kit Leung, Kamalan Jeevaratnam, Wing Tak Wong

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Advancing diagnosis of feline Leishmania infantum infection through experimental insights by Akhtardanesh Baharak, Mostafavi Ali, Mostafavi Mahshid, Zamani-Ahmadmahmudi Mohamad, Sharifi Iraj, Abbaszadeh Hasiri Mohammad, Kheirandish Reza, Hajipour Pooneh, Barkhordarnasab Azimeh, Shokrollahi Nasim, Keyhani Alireza, Sina kakooei

“…Further studies are crucial to elucidate the immune system function and pathogenesis of L. infantum in cats.…”
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RADIONUCLIDE METHODS IN THE DETECTION AND FORECAST OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY IN BREAST CANCER PATIENTS by V. I. Chernov, T. L. Kravchuk, R. V. Zel’chan, V. E. Gol’dberg, N. O. Popova, E. I. Simolina, V. V. Vysockaja, Ju. V. Belevich, I. G. Sinilkin, A. А. Medvedeva, O. D. Bragina

“…Significant inhibition of systolic function in this patient group remained after the 4th course treatment. …”
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Selective Mapping of Brain COX-1 with [11C]PS13: Pharmacokinetic Evidence from human PET Imaging by Kiana Orangi, Kimiya Batebi, Farnoosh Vosough, Mahdiyeh Nozad Varjovi, Fatemeh Salehian, Sahar Mesbah, Mehrnaz Salahi, Sajjad Hajihosseini, Mohammad Yousef Fazel, Saman Zaman, Reza Hossein Zadeh, Alaleh Alizadeh, Mahsa Asadi Anar, Niloofar Deravi

“…Material and methods: Eight healthy volunteers had baseline [11 C]PS13 brain PET scans, and then images were blocked with either aspirin, celecoxib, or ketoprofen. …”
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Cerebral palsy in children born after assisted reproductive technology in Norway: Risk, prevalence, and clinical characteristics by Henriette Carlsen, Torstein Vik, Guro L. Andersen, Kristine Stangenes, Solveig Bjellmo, Kjersti Westvik‐Johari, Sandra Julsen Hollung

“…Conclusions Children born after ART had a risk of cerebral palsy that was twice that of children born after natural conception. …”
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Alkaline phosphatase–streptavidin conjugate (APSA) enzyme and binding activity over time and storage conditions by Nan Cheng, Lloyd Johnson, Jaimie Dufresne, Sina Mazinani, John G. Marshall

“…Random sampling of the enzyme activity in the liquid phase (ANOVA p < 2E-16; Regression p < 0.043) and the binding plus enzyme activity of APSA in the model assay (R2 > 0.99) of biotinylated human IgG (B-h-IgG) directly adsorbed to 96 well plates showed a similar loss of function over time (ANOVA p < 9.15E-15, Regression p <1.1E-9). …”
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Patient-reported outcomes and radiographic progression in patients with rheumatoid arthritis in sustained remission versus low disease activity by Annette H M van der Helm-van Mil, Pascal H P de Jong, Marijn Vis, Selinde V J Snoeck Henkemans, Agnes E M Looijen

“…Radiographic progression (modified Total Sharp Score (mTSS)) was compared over 2 years.Results Patients in sLDA in the first year had worse PROs during follow-up, compared with patients in sREM: pain (0–10 Likert) was 0.90 units higher (95% CI 0.52 to 1.27), fatigue (Visual Analogue Scale) was 12.10 units higher (95% CI 7.27 to 16.92), functional impairment (Health Assessment Questionnaire—Disability Index) was 0.28 units higher (95% CI 0.17 to 0.39), physical HRQoL (36-item Short Form Health Survey (SF-36) Physical Component Summary score) was 4.42 units lower (95% CI −6.39 to –2.45), mental HRQoL (SF-36 Mental Component Summary score (MCS)) was 2.95 units lower (95% CI −4.83 to –1.07), health status (European Quality of life 5-Dimensions 3-Levels (EQ-5D-3L)) was 0.06 units lower (95% CI −0.09 to –0.03) and productivity loss (0%–100%) was 7.76% higher (95% CI 2.76 to 12.75). …”
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Population pharmacokinetics/pharmacodynamics analysis confirming biosimilarity of SB16 to reference denosumab by Seungchan Choi, Seungchan Choi, Suemin Park, Jinah Jung, Siook Baek, Hyeong-Seok Lim, Hyeong-Seok Lim

“…The study population had a minimal effect on drug exposure and on changes in BMD, with &lt;5% difference. …”
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Yttrium oxide nanoparticles induce selective cytotoxicity, genomic instability and ROS mitochondrial P53 mediated apoptosis in human pancreatic cancer cells by Hanan R. H. Mohamed, George M. Hakeem, Yasmin Abdel Latif, Shahd H. Elnawasani, Maria Nagy, Basma A. Mohamed, Rawan Essam, Gehan Safwat

“…Our findings exhibited that Y2O3-NPs had strong selective cytotoxicity against PANC-1 cells with an IC50 value of 31.06 µg/ml, while having minimal effect on normal HSF cells (IC50 = 319.21 µg/ml). …”
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Metabolic Syndrome Spectrum in Children with Classic Congenital Adrenal Hyperplasia—A Comprehensive Review by Sanja Panic Zaric, Tatjana Milenkovic, Sladjana Todorovic, Katarina Mitrovic, Dimitrije Cvetkovic, Maja Cehic, Jelena Vekic, Katja Dumic, Rade Vukovic

“…Higher indices of insulin resistance were also a frequent finding in children with CCAH. CCAH patients had higher systolic blood pressure and more frequently loss of nocturnal blood pressure dipping, particularly among salt-wasting subtypes and in younger children. …”
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Diurnal Urinary Aldosterone Excretion and Potassium Intake During Pregnancy Are Associated With High Normal Blood Pressure in Early Childhood by Hajir Al‐Jorani, Richard Christian Jensen, Tina K. Jensen, Henrik Thybo Christesen, Jan Stener Jørgensen, Lucas Bacmeister, Ralf Dechend, Dorte Glintborg, Boye L. Jensen, Marianne S. Andersen

“…Methods In the prospective OCC (Odense Child Cohort), 475 mother–child dyads had 24‐hour urine aldosterone from gestational week 29 and OBP (systolic and diastolic), at ages 3 and 18 months and 3 and 5 years. …”
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A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL by Xueying Wang, Yan Deng, Guangcui He, Sihan Lai, Yecheng Li, Shan Zhang, Ying He, Ying Han, Lilan Zhang, Yi Su, Fang Liu, Hai Yi

“…The endpoints were relapse, graft-versus-host disease (GVHD), transplant-related mortality (TRM), progression-free survival (PFS), overall survival (OS), and adverse events (AEs).Results All of the patients had uneventful post-transplant hematopoietic reconstitution, and all achieved complete molecular remission within 30 days. …”
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Association of estimated glucose disposal rate with chronic kidney disease: comparative analysis against traditional insulin resistance indices by Yuanxin Liu, Mingda Liu, Yuyin Jiang, Siyuan Cui, Siyuan Cui, Wei Tang

“…Additionally, the performance of these indices was evaluated using receiver operating characteristic (ROC) curve analysis.ResultsElevated levels of the eGDR were significantly correlated with improved kidney function and a reduced prevalence of chronic kidney disease (CKD) and albuminuria. …”
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