Prediction of basal glycaemia dynamics during treatment with 6-month lipid-lowering therapy in patients at high risk of cardiovascular disease by Olga A. Koshelskaya, Anastasiya S. Sushkova, Olga A. Zhuravleva, Irina V. Vinnizkaya, Nataliya G. Brazovskaya, Elena S. Kravchenko, Tatyana E. Suslova, Rostislav S. Karpov

“…Of note, 29 of the 50 diabetic or glucose intolerant patients had documented ischaemic heart disease (stable angina). …”
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Rearing system and immune status influence the small intestinal microbiota of IPB-D3 chickens: A full-length 16S rRNA metagenomic approach by Wawan Kuswandi, Cahyo Budiman, Isyana Khaerunnisa, Cece Sumantri

“…Background and Aim: The small intestinal microbiota plays a pivotal role in poultry digestion and immune function. Rearing systems can influence their composition, thereby affecting the overall health and performance of the birds. …”
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The association between HDL-c levels and computed tomography-based osteosarcopenia in older adults by Rongzhou Wang, Yu Wang, Zicheng Wei, Jiangchuan Wang, Hongye Tang, Xifa Gao, Jianhua Wang, Chao Zhang, Xiao Chen

“…The individuals with osteosarcopenia had significantly greater HDL-c levels than did those without osteosarcopenia (1.65 ± 0.30 vs. 1.49 ± 0.34 mmol/L, P < 0.001). …”
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CHANGE IN TESTOSTERONE LEVELS IN ENDOSCOPIC OPERATIONS ON THE PROSTATE GLAND by E. A. Efremov, S. Yu. Shekhovtsov, D. S. Merinov, A. O. Butov, Yu. V. Kastrikin, T. I. Garaev

“…In addition to standard general clinical examinations, all patients had a blood test for total testosterone, luteinizing hormone, sex hormone binding globulin. …”
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Hematological toxicity of [225Ac]Ac-PSMA-617 and [177Lu]Lu-PSMA-617 in RM1-PGLS syngeneic mouse model by Meryl Maria Vilangattil, Abir Swaidan, Jonathan Godinez, Marco F. Taddio, Johannes Czernin, Christine E. Mona, Giuseppe Carlucci

“…Blood samples were collected at different time points to assess blood cell counts and liver and kidney function. Results Both treatments significantly slowed tumor progression and extended survival. [225Ac]Ac-PSMA-617-treated mice had a median survival of 70 days, compared to 58 days for [177Lu]Lu-PSMA-617-treated mice and 30 days for the control group. …”
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Cardiac power output ratio: Novel survival predictor after percutaneous ventricular assist device in cardiogenic shock by Calvin Leung, Ivan Man Ho Wong, Cheuk Bong Ho, Michael Chi Shing Chiang, Yan Hang Fong, Pok Him Lee, Tai Chung So, Yin Kei Yeung, Chung Yin Leung, Yuet Wong Cheng, Shing Fung Chui, Alan Ka Chun Chan, Chi Yuen Wong, Kam Tim Chan, Michael Kang Yin Lee

“…Patients with lower CPO ratio had significantly lower coronary perfusion pressure, worse right heart indices, and higher pulmonary vascular resistance. …”
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Associations of circulating omentin-1 levels and long noncoding RNA MALAT1 expression with coronary heart disease in patients with type 2 diabetes mellitus by Meimei Tian, Jinchao Cao, Min Li, Pingping Lou, Huijie Ma, Yan Liu, Yukun Li

“…Receiver operating characteristic (ROC) curve analysis demonstrated that both Oment-1 (AUC = 0.663, sensitivity = 75%, specificity = 49%) and MALAT1 (AUC = 0.749, sensitivity = 73%, specificity = 66%) had significant diagnostic value for CHD among T2DM patients. …”
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Clinical value of free ubiquitin in the identification of diabetic nephropathy in patients with type 2 diabetes mellitus and preliminary exploration of its protective effect by Jing Bian, Jianhui Li, Lina Zhou, Yue Cao, Jinhui Fang

“…However, its levels and functional role in diabetic nephropathy (DN) remain unclear. …”
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Sustained capillary enlargement induced by angiogenic gene therapy does not support post-ischemic muscle recovery of hyperlipidemic mice by Galina Wirth, Galina Wirth, Greta Juusola, Greta Juusola, Hanne Laakso, Nihay Laham-Karam, Seppo Ylä-Herttuala, Seppo Ylä-Herttuala, Petra Korpisalo, Petra Korpisalo

“…However, capillary enlargement induced by AdVEGF in the hyperlipidemic mice was delayed, had a long-lasting effect (P &lt; 0.05) and did not promote intussusception. …”
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Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma by Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong

“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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PCSK9 promotes T helper 1 and T helper 17 cell differentiation by activating the nuclear factor‐κB pathway in ankylosing spondylitis by Jianfei Cai, Yinghui Jiang, Fucai Chen, Shubin Wu, Hongjun Ren, Pingping Wang, Jiayong Wang, Wei Liu

“…PCSK9 overexpression increased the CD4+IFN‐γ+ cells (p < .05), CD4+IL‐17A+ cells (p < .01), IFN‐γ (p < .01), and IL‐17A (p < .01), while it exhibited no effect on CD4+IL‐4+cells or IL‐4 (both p > .05); its knockdown displayed the opposite function on them. Moreover, PCSK9 overexpression upregulated the p‐NF‐κB p65/NF‐κB p65 (p < .01), while it had no effect on p‐ERK/ERK or p‐JNK/JNK (both p > .05); its knockdown decreased p‐NF‐κB p65/NF‐κB p65 (p < .01) and p‐JNK/JNK (p < .05). …”
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A case of rhabdomyolysis after atorvastatin therapy of a liver transplant recipient receiving immunosuppressive therapy with cyclosporine by A. V. Shabunin, S. P. Loginov, P. A. Drozdov, I. V. Nesterenko, D. A. Makeev, O. S. Zhuravel, L. R. Karapetyan

“…The patient was discharged with satisfactory renal and hepatic function. The pain syndrome completely resolved. Conclusion. …”
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Chlamydomonas IC97, an intermediate chain of the flagellar dynein f/I1, is required for normal flagellar and cellular motility by Ryosuke Yamamoto, Yui Tanaka, Shunsuke Orii, Kogiku Shiba, Kazuo Inaba, Takahide Kon

“…Further analysis revealed that the mutant had low flagellar beat frequency and miscoordination between the two (cis- and trans-) flagella. …”
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Adjuvant endocrine treatment strategies for non-metastatic breast cancer: a network meta-analysisResearch in context by Andri Papakonstantinou, Guillermo Villacampa, Victor Navarro, Mafalda Oliveira, Antonios Valachis, Tomas Pascual, Alexios Matikas

“…Findings: A total of 37 RCT that had enrolled 107,684 patients were included in the study. …”
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ACE Loss Drives Renal Cell Carcinoma Growth and Invasion by Modulating AKT-FOXO1 by Yin L, Mao L, Yin R, Lv C, Shi X, Yue C, Chen Y, Lu C, Wu Z, Xu K, Cao W

“…High ACE expression was positively associated with a favorable prognosis in ccRCC patients. Functional studies showed that ACE overexpression suppressed ccRCC cell line OS-RC-2 and A498 growth, metastasis, and glycolysis activities, while its knockdown had the opposite effect. …”
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Cell-free plasma telomere length correlated with the risk of cardiovascular events using machine learning classifiers by Mengjun Dai, Kangbo Li, Mesud Sacirovic, Claudia Zemmrich, Oliver Ritter, Peter Bramlage, Anja Bondke Persson, Eva Buschmann, Ivo Buschmann, Philipp Hillmeister

“…SHAP analysis revealed that cf-TL had minimal impact on the predictions of the CAD model, as indicated by consistently low SHAP values, whereas in the HF model, cf-TL exhibited a broader range of SHAP values, indicating a greater contribution to the model’s classification. …”
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Docking Simulations of G-Protein Coupled Receptors Uncover Crossover Binding Patterns of Diverse Ligands to Angiotensin, Alpha-Adrenergic and Opioid Receptors: Implications for Car... by Harry Ridgway, Graham J. Moore, Laura Kate Gadanec, John M. Matsoukas

“…Moreover, ARBs had a higher affinity for αARs than either alpha agonists (epinephrine and phenylephrine) or inhibitors (prazosin and doxazosin). …”
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The Impact of Smoke Curtains on the Operation of ESFR Sprinklers in Terms of NFPA 204 and NFPA 13 Standards by Kamila Sikorska-Podyma, Aleksandra Byczyk, Jacek Podyma, Paulina Stanek, Przemysław Kubica

“…The literature has reported cases of fires in which smoke curtains had a negative effect on the activation of the sprinkler system, which is also confirmed by numerical analyses. …”
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Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial by Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J. Metzner, Laurent Decosterd, Huldrych F. Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, Alexandra Calmy

“…Secondary outcomes included differences between monitoring arms for renal function, lipids and glucose values, and weight over 48 weeks. …”
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Different Types of Blood Pressure Variability in Hypertensive Patients with Chronic Lower Airway Diseases by M. I. Smirnova, V. M. Gorbunov, A. S. Kurekhyan, Ya. N. Koshelyaevskaya, A. D. Deev

“…This prospective cohort study included hypertensive patients, approximately half of whom had asthma or chronic obstructive pulmonary disease (COPD). …”
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