Patient Reported Outcomes from an Open Label, Multi-Center, Retrospective Study of a Biodegradable Graft for Soft Tissue Reconstruction in Patients Suffering from Chronic Lateral A... by Bryan G. Vopat MD, Ryan Scott DPM

“…A total of 47 patients diagnosed with chronic lateral ankle instability that had failed conservative therapy, and required surgical intervention to repair the lateral ligament complex were enrolled across two different research centers. …”
Get full text

Virulence factors and biofilm forming ability of Staphyloccoccus species isolated from skeletal lesions of broiler chickens by Gustaw M. Szafraniec, Dorota Chrobak-Chmiel, Izabella Dolka, Krzysztof Adamczyk, Kamil Sułecki, Beata Dolka

“…Abstract Lameness in poultry is a significant issue in modern meat production that adversely affects both animal welfare and economic outcomes due to poor leg health, reduced locomotor function, increased feed conversion ratios, and poor performance. …”
Get full text

The Role of Hepatitis C Virus NS5A Region Mutation and SNP IL-28B of Host to Support Successful Pegylated Interferon and Ribavirin Treatment in Patients with HCV-HIV Coinfection: A... by Juferdy Kurniawan, Rino A Gani, Samsuridjal Djauzi, Fera Ibrahim, Kuntjoro Harimurti, nafrialdi nafrialdi, Suzanna Imannuel

“…Protein secondary structure and prediction of mutation function were analyzed using PredictProtein (PP) program. …”
Get full text

A CASE REPORT OF SUCCESSFUL TREATMENT OF STAGE IV EWING’S SARCOMA IN AN ADOLESCENT PATIENT by O. I. Kit, D. Yu. Yurchenko, D. V. Burtsev, S. A. Kuznetsov, O. P. Popovyan, A. A. Barashev, P. V. Chernogorov, E. M. Frantsiyants, A. B. Sagakyants, L. B. Kushtova, G. A. Mkrtchyan, A. I. Bespalova, M. V. Starzhetskaya

“…The patient was followed-up for 25 months after the combination treatment, had no complaints, and was able to ambulate without assistance; the motor function of the left hip joint was fully preserved. …”
Get full text

Severe Joubert syndrome in family with homozygous POC1B p.Arg106Pro variant is due to a co-inherited deep-intronic mutation in the neighboring CEP290 gene by Christian Betz, Björn Reusch, Thomas Langmann, Sandra Habbig, Bodo B. Beck, Hanno J. Bolz

“…We have previously reported a family with severe, mostly early-lethal Joubert syndrome (JBTS) with early-onset severe retinal dystrophy (EOSRD) and polycystic kidney disease (PKD), which at that time had been attributed to a homozygous pathogenic missense variant, p.Arg106Pro (c.317G>C), in the ciliary POC1B gene. …”
Get full text

Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

Get full text

CD73low B-cell phenotypes and distinct cytokine profiles in patients with active anti-Jo-1 antibody positive idiopathic inflammatory myopathies by Ingrid E Lundberg, Vivianne Malmstrom, Caroline Grönwall, Begum Horuluoglu, Charlotte De Vries, Maho Nakazawa, Karin Lodin

“…Patients with active IIM had significantly higher serum levels of B-cell activating factor, inducible protein-10, interleukin-6 and sCD40L which correlated with changes in B-cell populations.Conclusions Since CD73 has an immunoregulatory function by modulating the ATP/adenosine pathway, which is also targeted by methotrexate, the low CD73 B-cell expression in anti-Jo-1 antibody-positive IIM may lead to B-cell hyperactivation. …”
Get full text

The Impact of Nitrogen Addition on Soil Carbon Components and Understory Vegetation in Moso Bamboo Forests by Zhoubin Huang, Xiaotong Liu, Haoyu Chu, Hao Jia, Xianxian He, Canying Wang, Bing Zhang, Chuanxia Pan, Sufan Liu, Shaohui Fan, Wenhui Su

“…Nitrogen may promote certain carbon component accumulation but could weaken the forest’s carbon sink function.…”
Get full text

Relationship between serum ECP and TIgE levels and the risk of postoperative recurrence in patients with chronic rhinosinusitis with nasal polyps by Qing Zhang, Hui Li, Di Xie, SiJian Fan

“…Univariate analysis indicated that neutrophil ratio, lymphocyte ratio, Lund-Kennedy score, Lund-Mackay score, SNOT-22 score, olfactory function score, and postoperative recurrence were significantly correlated with serum ECP and TIgE levels. …”
Get full text

Perineal stapled prolapse resection in combination with Thiersch operation for relapsed rectal prolapse: a case report by Teppei Kamada, Hironori Ohdaira, Junji Takahashi, Yoshinobu Fuse, Wataru Kai, Keigo Nakashima, Yuichi Nakaseko, Norihiko Suzuki, Masashi Yoshida, Takeo Usui, Yutaka Suzuki

“…Three months after the operation, no recurrence was observed, and defecation function was good with improvements of Wexner score. …”
Get full text

Signs and symptoms of vulvovaginal atrophy (VVA) in clinical practice – the possible involvement of thyroid autoimmunity in genitourinary syndrome of menopause (GSM) by Laura Cucinella, Federica Barbagallo, Mariacristina Erroi, Chiara Procaccianti, Ellis Martini, Lara Tiranini, Giorgia E. Parrotta, Greta Monne, Giulia M. Colombo, Aldo Calogero, Rossella E. Nappi

“…VVA signs were assessed using the vaginal health index (VHI) and vulvar health index (VuHI); VVA symptoms were rated on a four-point severity scale.Results Among 112 women enrolled, 28 had thyroid ADs. A significantly higher percentage of women with thyroid ADs showed vaginal atrophy (75 vs. 45.2%, p < .05). …”
Get full text

TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1 by Xiaochuang Xia, Huajing Shan, Zhaoxia Jin, Tengfei Ma, Yemao Liu, Jianqing Zhang, Han Tian, Bizhen Dong, Chengsheng Xu, Shaoze Chen

“…In PE-treated NRCMs, Trim26 overexpression promoted cardiomyocyte enlargement and inflammation, while Trim26 knockdown had the opposite effects. RNA sequencing and molecular biology methodologies were performed to identify targets conducive to TRIM26 function. …”
Get full text

Intention to khat chewing among youths in Raya-Azebo district, southern zone of Tigray, Ethiopia: application of the theory of planned behavior by Abadi Hailay Atsbaha, Adugnaw Berhane Mekonnen, Bezawit Ketema, Tigist Haile Gebrehiwot, Hirut Teame Gebru, Embay Amare Alemseged, Yonas Angaw, Haftay Gebremedhin, Fre Gebremeskel, Hagos Degefa Hidru, Zenawi Hagos Gufue

“…A multivariable linear regression model was used to predict the contribution of independent variables and identify variables strongly associated with chewing among youths.ResultsA considerable proportion, 192 (30.62%) of youths, had the intention to chew khat in the next 6 months. …”
Get full text

Effects of a Mobile Storytelling App (Huiyou) on Social Participation Among People With Mild Cognitive Impairment: Pilot Randomized Controlled Trial by Di Zhu, Abdullah Al Mahmud, Wei Liu

“…Cognitive function, assessed via the Montreal Cognitive Assessment–Chinese questionnaire, also showed no significant differences at baseline (P=.20). …”
Get full text

Severe acute kidney injury with anuria induced by hypokalemia requiring hemodialysis: a case study by Seong-Wook Lee, Man-Hoon Han, Mee-Seon Kim, Yong-Jin Kim, You Hyun Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Jeong-Hoon Lim

“…Case presentation A 64-year-old man with a history of rectal cancer, ileostomy, and hypertension was admitted for severe AKI with anuria. He had developed severe hypokalemia due to chronic diarrhea. …”
Get full text

Gut microbiome and metabolome profiles in renal allograft rejection from multiomics integration by Xing Dai, Yu Cao, Lin Li, Yue-Xin Gao, Jian-Xi Wang, Yao-Juan Liu, Ting-Ting Ma, Jian-Ming Zheng, Pan-Pan Zhan, Zhong-Yang Shen

“…The balance of specific microbial species was associated with kidney function in rejection patients. Spearman analysis revealed that specific differential species like Agathobaculum butyriciproducens and Gemmiger qucibialis were closely linked to the levels of serum 4-pyridoxic acid, 4-acetamidobutanoate, and fecal tryptamine from specific differential pathways. …”
Get full text

Impact of psychological factors on the final clinical outcomes of patients undergoing ankle arthrodesis and ankle replacement by Hongze Wang, Shihang Cao, Geng Liu, Jun Lu, Junkui Xu

“…However, at the final follow-up, the clinical scores of the high-HADS group were significantly lower than those of the low-HADS group, and the incidence of complications in the high-HADS group was also higher.ConclusionThis study found that both TAR and AA significantly improved patients’ psychology, pain, and functional activities. …”
Get full text

Glymphatic dysfunction in classical trigeminal neuralgia: DTI-ALPS index stratification from healthy controls to post-MVD by Xiaolin Hou, Bo Wu, Ruxiang Xu, Cheng Yin

“…Abstract Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index is a non-invasive marker of glymphatic function. Its relevance in classical trigeminal neuralgia (CTN), postoperative glymphatic changes after microvascular decompression (MVD), and associations with clinical and structural measures remain unclear. …”
Get full text

Chronic latent inflammatory processes of reproductive organs of dairy cows by S. O. Sidashova, B. V. Gutyj, T. V. Martyshuk, V. L. Shnaider

“…The application of differential palpation diagnostics of the ovaries with the use of in vivo data visualization revealed the spread of hypotrophic lesions of the ovaries together with the course of chronic inflammatory pathologies of the uterine tissues (latent endometritis): 54.69 ± 19.80 % of cows were diagnosed with significantly pronounced hypotrophic processes in the functional tissues of the gonads, and 34.87 ± 19.59 % had moderate lesions. …”
Get full text

MYRF gene mutation leading to coronary artery anomaly combined with 46,XY sex development disorder, a case report and literature review by Jianhua Ding, Zhenyu Lv, Zhen Zhen, Yong Gai, Yanyan Xiao

“…The infant underwent further surgical treatment which confirmed the prior diagnosis and had a good postoperative recovery. Conclusion This case represents an exceptionally rare instance of MYRF-CUGS combined with coronary artery anomaly. …”
Get full text