Impact of MBBS Curriculum on Knowledge, Attitude, and Practices of Organ Donation by Pari Sharma, Ketaki Poorey, Amol Rajendra Gite, Nakul Sharma

“…As doctors play a major role in establishing and ensuring smooth functioning of organ donation programme. The importance to assess the future health care professionals about the knowledge, Attitude and Practice regarding organ donation is the basis of our study. …”
Get full text

The Role of Adenosine A1 and A2a Receptors in Cerebral Blood Vessel Reactivity of Sprague Dawley Rats Exposed to Hyperbaric Oxygenation by Vedran Đambić, Zrinka Mihaljević, Ines Drenjančević, Ivana Jukić, Petar Šušnjara, Aleksandar Kibel

“…Hyperbaric oxygenation (HBO₂) can modify gene and protein expression, signaling pathways, and vascular function, leading to altered vasomotor responses. Adenosine receptors (ARs) may mediate these effects by modulating vasoactivity. …”
Get full text

Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation by Zhaoxuan Wang, Cheng Wang, Cheng Wang, Shilei Zhao, Chundong Gu

“…High-risk LUAD patients had an immunosuppressive microenvironment and activated metabolic reprogramming. …”
Get full text

Preparation and characterization of human decellularized ovarian scaffold based on supercritical carbon dioxide protocol by Fatemeh Hosseinpour, Ali Zeinolabedini Hezave, Tahereh Talaei-Khozani, Mojtaba Rastgou-Maeini, Ashraf Hassanpour-Dehnavi

“…A bioengineered ovary is one of the strategies to replace or enhance ovarian tissue function. A key advancement in bioengineering is the development of ovarian decellularized extracellular matrix scaffolds that mimic natural ovarian niche. …”
Get full text

Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats [version 2; peer rev... by Kulsum Kulsum, Syahrul Syahrul, Kartini Hasbalah, Ummu Balqis

“…Background Traumatic brain injury (TBI) is a change in brain function or evidence of brain pathology caused by external mechanical forces. …”
Get full text

Evaluation of Ocular and Systemic Oxidative Stress Markers in Patients with Diabetic Retinopathy by Ana Karen López-Contreras, Diana Esperanza Arévalo-Simental, Fermín Paúl Pacheco-Moisés, María Guadalupe Martínez-Ruíz, Cecilia Olvera-Montaño, Ricardo Raúl Robles-Rivera, Sonia Sifuentes-Franco, Tannia Isabel Campos-Bayardo, Selene Guadalupe Huerta-Olvera, Adolfo Daniel Rodríguez-Carrizalez

“…Proliferative diabetic retinopathy (PDR) is the most severe complication of chronic hyperglycaemi stimulates oxidative stress that changes the retinal basement membrane function and provokes neovascularization, macular edema and retinal detachment. …”
Get full text

Impact of vitamin D supplementation on cognitive impairment in elderly individuals with hypertension by Lili Tan, Hongyan Li, Linya Zhao

“…However, evidence on whether correcting vitamin D insufficiency can improve recognition memory and blood pressure (BP) control in this population remains inconclusive.ObjectiveTo evaluate the association between vitamin D supplementation and improvements in cognitive function and BP among older adults with hypertension and mild cognitive deficits.MethodsWe conducted a retrospective review of patient records from individuals aged ≥65 years who had documented hypertension, baseline 25-hydroxyvitamin D (25(OH)D) levels < 30 ng/mL, and mild cognitive impairment (Montreal Cognitive Assessment [MoCA] < 26) or subjective cognitive complaints. …”
Get full text

Effects of biochar on the contents of potassium and phosphorus, and their leaching rates in red soil under simulated leaching condition by ZHU Pan, YING Jieguan, PENG Shu’ang, JIANG Cuncang

“…Therefore, investigation on improvement of use efficiency and reduction of leaching rate for K and P will have great economic significance on agricultural production, help maintaining good ecological function.In this study, to investigate the effects of different biochar additions on available potassium and phosphorus and their leaching rates in red soil, a simulated rainfall experiment was conducted in laboratory. …”
Get full text

Clinical Outcomes of Conventional Fistulotomy versus Ligation of Intersphincteric Fistula Tract in Patients with Fistula-in-ano: A Prospective Interventional Study by R Sahasra Serisha, Jayakanthan Saravanan, P Suganya

“…Introduction: Fistula-in-ano is a common anorectal condition that poses significant challenges for surgical management, with the primary concern being the preservation of sphincter function and prevention of complications such as recurrence and incontinence. …”
Get full text

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles. by Cunjin Luo, Kuanquan Wang, Henggui Zhang

“…SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr) of SQTS, results from an inactivation-attenuated, gain-of-function mutation (N588K) in the KCNH2-encoded potassium channels. …”
Get full text

Microincision combined with vacuum sealing drainage with modified columnar sponge for deep anal abscess by Liu Xuanliang, Yang Zhongquan, Liao Xinfang

“…The followings were compared between the two groups: duration of surgery, time to wound healing, incision length, number of incisions, duration of hospitalization, anal pain score during change of dressing at different time points after surgery (1, 3, and 5 days), postoperative anal function score, and overall effectiveness. [Results] Compared with the control group, the treatment group had significantly shorter time to wound healing, shorter duration of hospitalization, shorter length of incision, and fewer incisions, but longer duration of surgery (P < 0.05). …”
Get full text

A study on relationship between the abnormal thyroid hormone and traditional chinese medical syndrome in patients with chronic kidney disease by LU Jin-lian, LIU Tao, LI Gen

“…Objective By analyzing serum thyroid hormone in patients with chronic kidney disease(CKD),to discuss the relationship between hypothyroidism and normal hypothyroidism and syndrome differentiation of CKD.Methods The general data of patients and syndrome differentiation of traditional Chinese medicine were recorded,and the serum thyroid hormone levels were determined.The abnormal thyroid hormone was analyzed in patients with CKD and the relationship between syndrome differentiation of traditional Chinese medicine and abnormal thyroid hormone was evaluated.Results 220 CKD patients with stage 1-5were enrolled in this study.There were 130 males and 90 females with the average age of(35.8±13.9)years old.There are 72 cases of primary nephrotic syndrome,and 10 cases of secondary nephrotic syndrome.Of 70 cases of nephritis syndrome,there were28 cases of lupus nephritis.Of 68 cases of chronic renal failure,49 patients received renal biopsy.Pathologically,there were 24 cases of IgA nephropathy,6cases of segmental glomerular sclerosis in the foci segment,9cases of atypical film stasis,8cases of membranous nephropathy,and 2cases of mild mesangial hyperplasia.Twenty-six cases had abnormal thyroid function(11.8%),in which the serum T3 of 18cases(69.2%)was decreased.The serum T3 and T4levels in 4cases(15.4%)were decreased.In one case(3.9%),the serum T3 and thyroid stimulating hormone(TSH)levels were increased.The serum T4 levels in 3cases(11.5%)were decreased.The serum T3 levels in the patients with CKD 5were significantly lower than in those with CKD 1-2and CKD 3-4(P<0.05).There was no significant difference in serum T4 and serum TSH levels among three groups(P>0.05).Through syndrome differentiation of traditional Chinese medicine in CKD patients with abnormal thyroid hormone,it was found that the patients with decreased T2,and normal T4 and TSH showed the main manifestation of spleen kidney Yang deficiency type,and the secondary manifestation of Qi deficiency type in spleen and kidney.The patients with decreased T3 and T4 with/without increase of TSH showed the main manifestation of deficiency type of both yin and yang,and the secondary manifestation of Qi Yin deficiency and spleen kidney Yang deficiency type.Conclusions In CKD patients,serum T3 level was decreased,T4 level was normal or decreased,and TSH level was in the normal range.There is a certain relationship between the thyroid hormone level and syndrome differentiation of traditional Chinese medicine.For CKD patients combined with non-thyroid disease syndrome,traditional Chinese medicine dialectical treatment with warming Yang,tonifying spleen and replenishing qi as the main therapeutic principles can treat subclinical hypothyroidism and normal thyroid sick syndrome.…”
Get full text

Suitability of Utilization of Compositional Nutrient Diagnosis on Diagnosis of Foliar Nutrient in Litchi and Longan by Yongcong ZHU, Donglin LUO, Cuihua BAI, Lixian YAO

“…The removal of the abnormal values had significant influence on the yield models and nutrient cutoff values, and the influence was irregular. …”
Get full text

Heterogeneity of autoimmune diabetes mellitus in adults: real-world clinical practice by N. V. Rusyaeva, I. V. Kononenko, O. K. Vikulova, O. M. Smirnova, M. V. Shestakova

“…Autoimmune DM in adults demonstrates heterogeneity in the rate of β-cell function decline and the development of insulin dependence. …”
Get full text

Optimizing HVAC&R System Efficiency and Comfort Levels Using Machine Learning-Based Control Methods by Suroor M. Dawood, Raad Z. Homod, Alireza Hatami

“…The HVAC&R system control trouble is defined as a specific Markov Decision Processes (MDPs) model. The reward function balances the ability to increase energy conservation while preserving the interior comfort requirements of occupants. …”
Get full text

Smyd1b_tv1, a key regulator of sarcomere assembly, is localized on the M-line of skeletal muscle fibers. by Huiqing Li, Jin Xu, Yue-Hong Bian, Pep Rotllant, Tiansheng Shen, Wuying Chu, Jianshe Zhang, Martin Schneider, Shao Jun Du

“…In contrast, other substitutions had no effect. Moreover, replacing Ser225 with threonine (S225T) retained the strong sarcomeric localization of Smyd1b_tv1.…”
Get full text

Predictive value of the triglyceride-glucose index for coronary artery bypass grafting-acute kidney injury patients by Biao Hou, Xuejian Hou, Dong Liu, Taoshuai Liu, Kui Zhang, Yang Li, Ran Dong

“…Patients were categorized into AKI and non-AKI groups based on postoperative renal function. The preoperative TyG index was calculated from fasting blood glucose and triglyceride levels. …”
Get full text

The effect of preoperative oral carbohydrate administration on postoperative glucometabolic response, subjective well being and quality of life in patients undergoing colorectal su... by Murat Urkan, Cemile Celebi, Ulvi Mehmet Meral, Ikbal Cavdar

“…The SF-36 physical functioning score was significantly higher in the intervention group compared to the control group (82.00 ± 11.81 vs 61.40 ± 16.17, p < 0.001). …”
Get full text

Association between compound dietary antioxidant index and all-cause and cancer mortality in patients with chronic obstructive pulmonary disease: results from NHANES 1999–2018 by Wenqiang Li, Jingshan Bai, Yanlei Ge, Yuting Fan, Yuting Fan, Qian Huang, Zhiping Deng

“…In maintaining human health, the composite dietary antioxidant index (CDAI) plays an important function. Therefore, the purpose of the current study was to investigate the relationship between CDAI and all-cause and cancer mortality in individuals with COPD.MethodsA prospective cohort study was conducted by investigating NHANES data between 1999–2018. …”
Get full text

Malignant solitary fibrous tumor of the pancreas: a case report by Yuka Taguchi, Takanobu Hara, Hiroaki Tamura, Masahito Ogiku, Mana Watahiki, Toru Takagi, Takashi Harada, Shinichiro Miyazaki, Tadataka Hayashi, Toshikazu Kanai, Hiroki Mori, Takachika Ozawa, Yoshiro Nishiwaki

“…On histopathological examination of the resected specimen, infiltrating spindle-shaped cells had proliferated, containing numerous mitotic figures, with necrotic findings inside the tumor. …”
Get full text