Effect of Osmotic Dehydration on Physico-Chemical Characteristics, Bioactive Compounds and Volatiles Profile of <i>Diospyros kaki</i> Subjected to Different Drying Methods by Cecília Morais Santana Matos, Mônica Silva de Jesus, Augusto de Souza da Silva, Nayjara Carvalho Gualberto, Hannah Caroline Santos Araujo, Rafael Donizete Dutra Sandes, Raquel Anne Ribeiro dos Santos, Maria Terezinha Santos Leite Neta, Narendra Narain

“…Compounds such as nonanal and 6-methyl-5-hepten-2-one were identified in all the dehydrated products and the OD had a positive influence on their retention, especially for the lyophilized samples. …”
Get full text

Decoding MexB efflux pump genes: structural, molecular, and phylogenetic analysis of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa by Muhammad Bilal Habib, Naseer Ali Shah, Afreenish Amir, Huda Ahmed Alghamdi, Muhammad Haseeb Tariq, Kiran Nisa, Mariam Ammoun

“…The current investigation aims to detect MexB genes in P. aeruginosa, their structural and molecular analysis and their impact on antimicrobial susceptibility profiling.MethodsA total of 42 clinical specimens were aseptically collected from hospitalized patients who had underlying infections related to medical implants. …”
Get full text

Total thyroidectomy performed under general anesthesia with venovenous extracorporeal membrane oxygenation during a thyroid storm: a case report by Hyung Gon Lee, Joon-Suk Bom, Leyeoin Lee, Joungmin Kim

“…ECMO is categorized into two types: venoarterial (V-A) ECMO, which provides both cardiac and pulmonary support, and venovenous (V-V) ECMO, which supports only pulmonary function. Surgery is generally not recommended for patients with unstable TS due to the high risk of complications, even when ECMO support is in place. …”
Get full text

Breaking age barriers: the efficacy of ERCP in advanced age patients by Zhuang Li, Zhenyu Qiao, Wenfei Wang, Yanjun Sun, Dengqun Sun, Minghui Sheng

“…However, the elderly group had a notably higher incidence of a history of cholecystolithiasis and cholecystectomy (p < 0.05). …”
Get full text

Two Pathogenic Gene Mutations Identified Associating with Congenital Cataract and Iris Coloboma Respectively in a Chinese Family by Bin Li, Bin Lu, Xuewen Guo, Shenghui Hu, Guihu Zhao, Weihong Huang, Jianzhong Hu, Kun Song

“…Bioinformatics analysis and three-dimensional structure predictions were used to predict the impact of amino acid changes on protein structure and function. Results. The candidate genes of cataract and iris coloboma were successfully screened out. …”
Get full text

AERIFY-1/2: two phase 3, randomised, controlled trials of itepekimab in former smokers with moderate-to-severe COPD by Klaus F. Rabe, Fernando J. Martinez, Surya P. Bhatt, Tomotaka Kawayama, Borja G. Cosio, Robert M. Mroz, Maarten M. Boomsma, Helene Goulaouic, Michael C. Nivens, Michel Djandji, Xavier Soler, Ying Liu, Matthew P. Kosloski, Christine R. Xu, Nikhil Amin, Heribert Staudinger, David J. Lederer, Raolat M. Abdulai

“…In a phase 2 study, itepekimab, a human monoclonal antibody against IL-33, reduced exacerbations and improved lung function in a subgroup analysis of former smokers with COPD with an acceptable safety profile. …”
Get full text

Rehabilitation training robot using mirror therapy for the upper and lower limb after stroke: a prospective cohort study by Xixi Wu, Xu Qiao, Yudi Xie, Qingyan Yang, Wenting An, Lingfeng Xia, Jiatao Li, Xiao Lu

“…In the upper-limb group, region-of-interest (ROI) -to-ROI analysis revealed enhanced functional connectivity between the left hemisphere’s motor control region and the auditory network. …”
Get full text

Dissatisfaction Risk Factors of Patients after Laminectomy for Thoracic Ossification of Ligamentum Flavum: A Retrospective Cohort Study of Different Follow-Up Periods by Zhiwei Wang, Sidong Yang, Xianda Gao, Zheng Wang, Wenyuan Ding, Dalong Yang

“…The JOA scores of patients in the satisfied group and the dissatisfied group increased gradually with the improvement of neurological function in different follow-up periods, but, at the last follow-up, the JOA scores of patients in the satisfied group were significantly higher than those in the dissatisfied group. …”
Get full text

The effect of calf muscular vein thrombosis on the prognosis within one year postoperatively of geriatric hip fracture patients: a propensity score-matched analysis by Jiabao Jiang, Fei Xing, Rong Luo, Zhao Chen, Hao Liu, Zhou Xiang, Xin Duan

“…However, patients with CMVT had longer hospital stays, a higher incidence of postoperative complications, and a higher incidence of thrombosis progression than patients without CMVT in the follow-up. …”
Get full text

Prevalence of and risk factors for chronic kidney disease in ten metropolitan areas of China: a cross-sectional study using three kidney damage markers by Tianxing Feng, Yaqing Xu, Jiali Zheng, Xiaoxiao Wang, Yisen Li, Yilei Wang, Beili Zhu, Li Zhao, Huiyan Zhao, Jiawei Yu

“…Introduction To estimate the up-to-date prevalence of chronic kidney disease among the health check-up population in economically developed areas of China using estimated glomerular filtration rate, urinary albumin creatinine ratio, and kidney ultrasound.Methods Healthcare data from 38,093 subjects in 10 megalopolises of China who had an annual health check-up in 2021 were used. …”
Get full text

Effects of Varicocelectomy Surgery on Sperm Morphology and Male Fertility by Mir Abid Jan, Shaukat Fiaz, Ismail Khan, Syed Zia Ur Rahman, Khalil Ur Rehman

“…It has been demonstrated that microsurgical varicocelectomy enhances testicular function. The present study aimed to investigate the effect of microsurgical varicocelectomy on sperm morphology. …”
Get full text

Genome-wide identification, characterization, and expression analysis of the SOS1 gene family in the medicinal plant Paeonia ostii under salt stress by Yahong Chen, Huabing Liang, Zhanchang Wang, Quaid Hussain, Xuexiong Zhang, Fazhi Chen, Xiaohua Wang

“…This study offers new insights into the SOS1 gene family in P. ostii, elucidating its function in salt stress tolerance and establishing a foundation for future research on the functional characterization of SOS1 genes in P. ostii.…”
Get full text

Mechanisms of Neuronal Differentiation and Notch Signaling as a Potential Therapeutic Target in Olfactory Dysfunction of Allergic Rhinitis by Duan C, Ma X, Liu F, Xie X, Wu C, Zhang X, Ye P, Yuan Y, Feng X

“…Significant increases in the symptom scores, eosinophil infiltration, OVA-specific IgE levels and worse olfactory function were observed in the AR mice model compared to the Control group. …”
Get full text

Radioiodine Thyroid Ablation in Graves′ Hyperthyroidism: Merits and Pitfalls by J. Nwatsock, D. Taieb, L. Tessonnier, J. Mancini, F. Dong-A-Zok, O. Mundler

“…The aim of this study was to evaluate thyroid function, TSH-receptor antibodies (TRAb) and Graves′ ophthalmopathy (GO) occurrence after radioiodine thyroid ablation in GD. …”
Get full text

HOMA-beta independently predicts survival in patients with advanced cancer on treatment with immune checkpoint inhibitors by Mayu Watanabe, Mayu Watanabe, Jun Eguchi, Atsushi Takamoto, Hiromitsu Kanzaki, Yohei Noda, Syunsuke Kagawa, Syunsuke Kagawa, Jun Wada

“…The deleterious action of ICI on pancreatic beta-cell function is a concern. However, the influence of ICI on insulin synthesis and secretion in patients with cancer without diabetes remains unknown.MethodsThis study included 87 patients diagnosed with advanced cancer. …”
Get full text

CHANGES IN A-AMYLASE ACTIVITY OF ORAL FLUID IN THE PROCESS OF COMPLEX TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE WITH DEFECTS OF DENTITION by N. Riabushko, V. Dvornik, A. Baranova, G. Balia

“…The main indicators displaying the functioning of the mouth as biological system are enzymes and indexes of immune system. …”
Get full text

Relationship Between Tooth Loss Due to Chronic Periodontitis and Lower Urinary Tract Symptoms by Tomohiro Matsuo, Shota Kakita, Hiroyuki Honda, Shintaro Mori, Kyohei Araki, Kensuke Mitsunari, Kojiro Ohba, Yasushi Mochizuki, Ryoichi Imamura

“…<i>Results</i>: Compared with the non-OAB group, the OAB group had significantly fewer remaining teeth (<i>p</i> < 0.001). …”
Get full text

Mesenchymal Stem Cells and Their Derived Exosomes Mitigated Hepatic Cirrhosis in Rats by Altering the Expression of miR-23b and miR-221 by Somia H. Abd-Allah, Tarek Khamis, Walaa Samy, Amira Ebrahim Alsemeh, Doaa M. Abdullah, Samia Hussein

“…Additionally, the treatment of cirrhotic rats with hUCB-MSCs, exosomes, or the combination of them significantly upregulated mTOR, Beclin, LC3, and Smad7 (P<0.001, for each) and miRNA-23 (P=0.021, P<0.001, P<0.001, respectively).Conclusion: hUCB-MSCs and their derived exosomes ameliorated liver cirrhosis by anti-inflammatory and anti-fibrotic effects besides modulation of autophagy. The exosomes had a better improvement effect either alone or combined with hUCB-MSCs, as proved by improvement in liver function tests, and molecular, histopathological, and immunohistochemical profiles.…”
Get full text

Identification and validation of biomarkers, construction of diagnostic models, and investigation of immunological infiltration characteristics for idiopathic frozen shoulder by Han-tao Jiang, Li-ping Shen, Meng-Qi Pang, Min-jiao Wu, Jiang Li, Wei-jie Gong, Gang Jin, Rang-teng Zhu

“…The nomogram constructed based on them had a good predictive value for the occurrence of FS. …”
Get full text

Prospective outcomes following drainless superficial parotidectomy with sternocleidomastoid flap reconstruction by Jonathan C. Melong, Matthew H. Rigby, Martin Corsten, Jonathan R. B. Trites, Angela Bulter, S. Mark Taylor

“…Seven patient’s (14%) developed temporary facial paresis following surgery. All patients had resultant normal facial function at follow-up in 1 year. …”
Get full text