Definition of clinical immunology around the globe by José C. Crispín, José C. Crispín, José C. Crispín, Tineke Cantaert, Tineke Cantaert, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Alberto Pinzon-Charry, Domenico Mavilio, Domenico Mavilio, Domenico Mavilio, Ahmed Seri, Ahmed Seri, Pierre Miossec, Pierre Miossec

“…More than 500 participants answered the questionnaire, 80% of whom had completed their training. Roughly two thirds of respondents were physicians directly involved in patient care. …”
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The association between serum biomarkers and disease outcome in influenza A(H1N1)pdm09 virus infection: results of two international observational cohort studies. by Richard T Davey, Ruth Lynfield, Dominic E Dwyer, Marcello H Losso, Alessandro Cozzi-Lepri, Deborah Wentworth, H Clifford Lane, Robin Dewar, Adam Rupert, Julia A Metcalf, Sarah L Pett, Timothy M Uyeki, Jose Maria Bruguera, Brian Angus, Nathan Cummins, Jens Lundgren, James D Neaton, INSIGHT FLU 002 & 003 Study Groups

“…<h4>Conclusions</h4>In patients presenting with varying severities of influenza A(H1N1)pdm09 virus infection, a baseline elevation in several biomarkers associated with inflammation, coagulation, or immune function strongly predicted a higher risk of disease progression. …”
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End-stage renal disease after renal cancer surgery: risk factors and overall survival by John Åkerlund, Börje Ljungberg, Sven Lundstam, Ralph Peeker, Erik Holmberg, Marianne Månsson, Anna Grenabo Bergdahl

“…Efforts to spare renal function, including nephron-sparing surgery and active surveillance in appropriate cases, are highly relevant to reduce the development of severe kidney dysfunction. …”
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Treatment of Hallux Rigidus: Comparison of Hemiarthroplasty with Cartiva Implant, Allograft Interpositional Arthroplasty, and Arthrodesis by Ryan Sanii MD, MPH, Kevin Phan MD, Drew Krumm MD, Daniel J. Patton MD, Tyler Madden MD, John G. Anderson MD, John D. Maskill MD, Donald R. Bohay MD, FACS, Michelle A. Padley PhD, Cameron G. Patthanacharoenphon MD

“…Conclusion: Pain and function may be slightly more improved with interpositional arthroplasty and arthrodesis for the treatment of HR, when compared to hemiarthroplasty with the Cartiva implant. …”
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Is avoidable diabetes-related hospitalization in older patients with type 2 diabetes mellitus associated with increased health expenditure?: A nationwide retrospective cohort study... by Woo-Ri Lee, Gyeong-Min Lee, Noorhee Son, Kyu-Tae Han, Sungyoun Chun, Yehrhee Son, Ki-Bong Yoo

“…Regression analysis was performed using the generalized estimating equation (GEE) with a gamma distribution and log-link function. Inverse Probability of Treatment Weighting (IPTW) analysis was conducted to enhance the robustness of the results. …”
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The impact of liver steatosis on the severity of COVID-19 in patients with chronic coronary syndrome by M.M. Zhaivoronok, S.Ye. Mostovyi, O.M. Safonova

“…According to contemporary literature, COVID-19 may trigger a deterioration of liver function in patients with or without pre-existing liver diseases. …”
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Hashimoto’s thyroiditis and nanophthalmos in Gabriele-de Vries syndrome: a case report by Hui Huang, Dongguang Zhang, Yu Yang, Li Yang, Yong Chai

“…Clinically, children with GADEVS should undergo comprehensive assessments of thyroid function, thyroid autoantibodies, and ophthalmologic status to facilitate early diagnosis and treatment.…”
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How does internal fixation compared with arthroplasty affect quality of life for patients who have suffered femoral neck fractures? by Zafar Ahmad, MD, Daniel Axelrod, MD, MSc, Marianne Comeau-Gauthier, MD, MSc, Sofia Bzovsky, MSc, Rudolf W. Poolman, MD, PhD, Frede Frihagen, MD, PhD, FRCSC, Mohit Bhandari, MD, PhD, FRCSC, Marc Swiontkowski, MD, Sheila Sprague, PhD, Emil Schemitsch, MD, FRCSC

“…Internal fixation patients had higher WOMAC stiffness scores (leading to poorer function) at 24 months postoperatively compared with total hip arthroplasty patients (adjusted mean difference [AMD] 0.42 points, 99% confidence interval [CI] 0.09–0.75; P < 0.001) and hemiarthroplasty patients (AMD 0.39 points, 99% CI 0.04–0.74; P = 0.004). …”
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Sarcopenia index is associated with Alzheimer’s disease, mild cognitive impairment and their mortality in Chinese adults aged 65 and older by Chenxi Ren, Tingjun Hu, Jiehua Zhu, Heling Chu, Qihao Guo

“…Higher SI indicates a higher degree of muscle loss and reduced muscle function. The study aimed to determine whether SI could potentially serve as a predictive marker for MCI (Mild Cognitive Impairment) and AD (Alzheimer’s disease). …”
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Von Willebrand Factor Antigen Predicts Response to Double Dose of Aspirin and Clopidogrel by PFA-100 in Patients Undergoing Primary Angioplasty for St Elevation Myocardial Infarcti... by Jacopo Gianetti, Maria Serena Parri, Francesca Della Pina, Federica Marchi, Endrin Koni, Alberto De Caterina, Stefano Maffei, Sergio Berti

“…Von Willebrand factor (VWF) is an emerging risk factor in acute coronary syndromes. Platelet Function Analyzer (PFA-100) with Collagen/Epinephrine (CEPI) is sensitive to functional alterations of VWF and also identifies patients with high on-treatment platelet reactivity (HPR). …”
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Efficacies of continuous renal replacement therapy for severe patients with chronic renal failure and the influencing factors of long-term prognosis by Ma Qin-qin, Zhou Ying, Zhang Yan-nan, Chen Chen, Yu Ying-hua, Li Tian-min

“…According to treatment options， observation group received CRRT （<italic>n</italic>=120） while control group had hemodialysis （<italic>n</italic>=40）. Both groups were treated conventionally after enrollment. …”
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Truncating the spliceosomal ‘rope protein’ Prp45 results in Htz1 dependent phenotypes by Kateřina Abrhámová, Martina Groušlová, Anna Valentová, Xinxin Hao, Beidong Liu, Martin Převorovský, Ondřej Gahura, František Půta, Per Sunnerhagen, Petr Folk

“…The less truncated variant, prp45(1–330), had a synthetic growth defect with htz1Δ at 16°C, which also persisted in the srb2Δi background. …”
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Correction of mitochondrial dysfunction with trimethoxy-substituted monocarbonyl curcumin analogues in experimental Alzheimer’s disease by D. I. Pozdnyakov, A. A. Vikhor, V. M. Rukovitsina, E. T. Oganesyan

“…., a mitochondrial dysfunction.The aim of the work was to evaluate the effect of trimethoxy-substituted monocarbonyl curcumin analogues on changes in the mitochondrial function of the hippocampus in AD rats.Materials and methods. …”
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Immune Signatures of Solid Tumor Patients Treated With Immune Checkpoint Inhibitors: An Observational Study by Ling Chen, Hourui Tan, Ruixuan Geng, Yifan Li, Yingyi Wang, Taisheng Li

“…We further found that gynecological tumors with better prognoses had higher baseline activation levels of CD4+ T cells compared to other solid tumors with poorer prognoses. …”
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Safety of a pacemaker mode intended to protect patients by Robert G. Hauser, MD, FHRS, Melanie Kapphahn-Bergs, RN, CCDS, Ali Bahbah, MD, Dawn Witt, PhD, MPH, Larissa I. Stanberry, PhD, Jay D. Sengupta, MD, FHRS

“…Background: In 2021, Boston Scientific (BSC) announced that its Ingenio pacemakers (PMs) could exhibit high internal battery impedances (HIBIs) and trigger the safety mode (SM) that should preserve pacing when PM function is jeopardized. SM is VVI or biventricular pacing, 72.5 bpm, and unipolar, with a sensitivity of 0.25 mV. …”
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Combination therapy of GnRHa, RhGH and anastrozole to improve final adult height deficit in CAH children with CPP by Xiaoxiao Liu, Fei Liu, Yingyi Qi, Xinyi Han, Shifeng Ma, Rongxiu Zheng

“…Results All patients showed high levels of 17-hydroxyprogesterone, testosterone and adrenocorticotropic hormone. All patients had CYP21A2 gene mutations, and the newly discovered mutation c.79 A > G (p.Ser27Gly) may change the hydrophilicity of the protein and affect its function. …”
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Discussing sexual health with patients eligible for spine surgery: An online survey in spine surgeon and pain physicians by Lisa Goudman, David van Schaik, Tjeerd Jager, Maarten Moens, Thierry Scheerlinck

“…Introduction: Spinal pain syndromes have a severe impact on the patient's sex life, contributing to a decrease in sexual function and sexual satisfaction. Despite the importance of sexual health on mental and physical wellbeing, sexual health is rarely discussed during consultations. …”
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Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices by Mary Kate P. Joyce, Dibyadeep Datta, Jon I. Arellano, Alvaro Duque, Yury M. Morozov, John H. Morrison, John H. Morrison, Amy F. T. Arnsten

“…We found a larger population of extrasynaptic NMDAR-GluN2B in dendrites of putative pyramidal neurons in SGC as compared to the dlPFC, while the dlPFC had a higher proportion of synaptic NMDAR-GluN2B. …”
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Altered nasal and oral microbiomes define pediatric sickle cell disease by Audra L. Crouch, Beatrice M. Severance, Susan Creary, Darryl Hood, Michael Bailey, Asuncion Mejias, Octavio Ramilo, Michelle Gillespie, Stefanie Ebelt, Vivien Sheehan, Benjamin T. Kopp, Matthew Z. Anderson

“…We found that children with SCD (cwSCD) had more pathobiont bacteria in the nasal cavity and reduced bacterial diversity in the oral cavity compared to their healthy siblings. …”
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Impact of Absence Seizures on Physical Activity Levels in Children: A Cross-Sectional Study by Martina Gnazzo, Valentina Baldini, Marco Carotenuto, Giulia Pisanò, Giovanni Messina, Fiorenzo Moscatelli, Maria Ruberto

“…This limitation can negatively affect their quality of life, motor coordination, and cognitive function. Despite this, there is limited research focusing on the physical activity levels of children with absence seizures in comparison to healthy children. …”
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