Predicting trajectories of the north star ambulatory assessment total score in Duchenne muscular dystrophy. by Francesco Muntoni, James Signorovitch, Nathalie Goemans, Adnan Y Manzur, Nicolae Done, Gautam Sajeev, Jiayang Li, Hanane Akbarnejad, Aarushi Sharma, Susan J Ward, Erik H Niks, Laurant Servais, Eugenio Mercuri, Michela Guglieri, Volker Straub, Imelda de Groot, Deborah Ridout, PRO-DMD-01 study investigators, Association Française contre les Myopathies, NorthStar Clinical Network, Craig McDonald

“…The North Star Ambulatory Assessment (NSAA) is a widely used functional endpoint in drug development for ambulatory patients with Duchenne muscular dystrophy (DMD). …”
Get full text

Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients by Nancy Hilda Joseph, Alangudi Palaniappan Natarajan, Saravanan Natarajan, Chinnaiyan Ponnuraja, Madeshwaran A, Gunaparvathy I, Hemalatha P, Rajeshwari S, Lavanya Jayabal, Mahilmaran Ayyamperumal, Ramesh P. M., Luke Elizabeth Hanna

“…As it has been discovered that Neutrophil extracellular traps (NETs) result in caseating granulomas in TB and pathology in COVID-19, we conducted this work to determine the amounts of NET molecules in the bloodstream and to comprehend their function during TB and subsequent SARS-CoV-2 infection.MethodsWe recruited 43 healthy volunteers, 40 newly diagnosed pulmonary tuberculosis patients who were negative for SARS-CoV-2 IgG antibody and 18 newly diagnosed pulmonary tuberculosis patients who were positive for SARS-CoV-2 IgG.ResultsAlthough Citrullinated Histone H3 and myeloperoxidase, did not show any difference in their levels, the NET marker elastase had significantly reduced circulatory levels in the tuberculosis group with SARS-CoV IgG positivity compared to tuberculosis group without SARS-CoV-2 IgG positivity.DiscussionThe substantial decrease in elastase levels observed in the diabetic cohort of TB patients with SARS-CoV-2 IgG positivity is intriguing and needs large cohort studies in the future to understand the influence of diabetes in TB patients exposed to SARS-CoV-2.…”
Get full text

The association of BMI and subclinical myocardial dysfunction in breast cancer patients after single or dual anti-HER2 targeted therapy by Feng Zhang, Siyuan Wang, Chao Yu, Wenying Jin, Dan He, Xiaoxiao Hu, Shu Wang, Tiangang Zhu

“…Some patients with normal myocardial function may suffer from subclinical myocardial dysfunction after anti-HER2 targeted therapy. …”
Get full text

Airway inflammation, bronchial hyperresponsiveness, and anti-asthma therapy responses in cough variant asthma and classic asthma with FEV1% ≥80% predicted by Xue Zhang, Chengjian Lv, Huijuan Hao, Jingwang Lin, Min Zhang, Xue Tian

“…Following four weeks anti-asthma therapy, both the CVA and CA groups showed significant improvement in both the large and small airway function and symptom relief. There was no significant difference between the respective groups. …”
Get full text

Operative Technique: Proximal Femur Allograft Reconstruction and Subtalar Fusion after Total Calcanectomy for a Large Giant Cell Tumor of the Calcaneus by Israel C Manuel, Ilian Dominiq D Eusebio, Emilleo A Dacanay, Bernardino B Alpuerto II

“…At 5 months follow-up, the patient had an excellent clinical appearance with a fused subtalar joint and stable calcaneocuboid joint. …”
Get full text

542 The association between cell-free DNA and lung transplant survival by Rohan Meda, Yi-Ping Fu, Hyesik Kong, Moon Kyoo Jang, Temesgen Andargie, Woojin Park, Jae Lee, Ilker Tunc, Gerald J Berry, Charles C Marboe, Pali D Shah, Steven D Nathan, Michael B Keller, Sean Agbor-Enoh

“…Lung transplant recipients had serial blood collected as part of two prospective cohort studies. …”
Get full text

Experimental investigation of solar PVT collector with the dryer on mass and temperature of dried red chili with Machine Learning Models by Miroslav Mahdal, K. Rajathi, Muniyandy Elangovan, Prabhukumar Sellamuthu, Amit Verma

“…The research finds that the RBF model had the highest capacity to forecast drying efficiency and that forced convection drying is more effective than open solar drying.…”
Get full text

Musical auditory feedback BCI: clinical pilot study of the Encephalophone by Thomas A. Deuel, Thomas A. Deuel, James Wenlock, Alana McGovern, James Rosenthal, Juan Pampin

“…Innovative technologies such as brain-computer interfaces (BCIs) have been developed recently that might benefit certain types of patients.MethodsHere, we tested a previously described auditory BCI, the Encephalophone, which may offer new options to improve quality of life and function. Eleven subjects with acquired moderate to severe motor disability, who had lost their ability to express themselves musically, were enrolled and 10 completed a clinical pilot study of the hands-free Encephalophone brain-computer interface (BCI). …”
Get full text

Nurse's Knowledge about Modifiable and Non-Modifiable Risk Factors of Heart Failure Patient in Erbil Teaching Hospitals by Yousif Mohammed Younis

“… Background: The changes in cardiac function are associated with heart failure which result in a decrease of cardiac output. …”
Get full text

Gal-3 blocks the binding between PD-1 and pembrolizumab by Henrik Schmidt, Torben Steiniche, Bent Deleuran, Malene Hvid, Morten Aagaard Nielsen, Stinne Ravn Greisen, Mia Bendix, Kathrine Pedersen, Nina Haunstrup Jensen, Jakob Hauge Mikkelsen, Taner Drace, Thomas Boesen

“…T cells cultured with Gal-3 had reduced pro-inflammatory cytokine production, which could not be rescued by pembrolizumab. …”
Get full text

Development and Experiment of Adaptive Oolong Tea Harvesting Robot Based on Visual Localization by Ruidong Yu, Yinhui Xie, Qiming Li, Zhiqin Guo, Yuanquan Dai, Zhou Fang, Jun Li

“…Additionally, the robot had a harvesting efficiency of 260.14 kg/h, which was superior to existing handheld and riding-type tea pickers. …”
Get full text

The Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and Metabolic Consequences of Uric Acid by Nicole P. Remund, John G. Larsen, Marley J. Shin, Cali E. Warren, Isabelle L. Palmer, Iris J. Kim, Elijah T. Cooper-Leavitt, Derek M. Clarke, Colson G. Beus, Richard J. Johnson, Juan A. Arroyo, Paul R. Reynolds, Benjamin T. Bikman

“…Additionally, uric acid impaired mitochondrial function and increased oxidative stress, which were mitigated by BHB. …”
Get full text

SPINT1-AS1 promotes oxidative damage and apoptosis of gastric cancer cells via the miR-656-3p/PLCXD3 axis by Duo Xu, Tong Wu, Xin Zhao, ShaoHai Li, XiaoHui Wei

“…Abstract Background and objectives In the study of gastric cancer (GC), long non-coding RNAs (lncRNAs) have been identified and their functions have been partly characterized; however, the specific function of SPINT1 antisense RNA 1 (SPINT1-AS1) in GC remains unclear. …”
Get full text

IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis by Jennifer Claire Hoving, Roanne Keeton, Maxine A. Höft, Mumin Ozturk, Patricia Otieno-Odhiambo, Frank Brombacher

“…By deleting IL-4Rα on specific cell subsets shown to play a role in mediating colitis, we determined their role in a loss of function approach. Our data demonstrated that the loss of IL-4Rα signalling on intestinal epithelial cells, smooth muscle cells, and macrophages/neutrophils had no effect on alleviating the pathology associated with colitis. …”
Get full text

Serum Sclerostin, Body Composition, and Sarcopenia in Hemodialysis Patients with Diabetes by Maria Carolina Medeiros, Natalia Rocha, Elba Bandeira, Isabel Dantas, Conceição Chaves, Mario Oliveira, Francisco Bandeira

“…Mean age was 63.3 ± 13.6 years, 63% of patients were male, and 44.6% had diabetes. Mean body mass index (BMI) was higher in diabetics (26.6 ± 5.2 vs. 24.1 ± 3.7; p=0.01) and there were no differences in gait speed and handgrip strength between diabetic and non-diabetic subjects. …”
Get full text

Optimal Outcome Reporting 5 and 8 Years Following Cleft Palate Repair by Daniel M. Balkin, MD, PhD, Joseph Incorvia, MScGH, Brianna Reed, BS, Laura C. Nuzzi, BA, Christopher D. Hughes, MD, MPH, Liza Catallozzi, MS, CCC-SLP, Roseanne Clark, MS, CCC-SLP, Ann W. Kummer, PhD, CCC-SLP, FASHA, John G. Meara, MD, DMD, MBA

“…We created a novel quality metric, optimal outcome reporting (OOR), reflecting patients who experienced the best outcome: normal velopharyngeal function and no unintended fistula after a single operation. …”
Get full text

Pathogenic morphological signatures of perturbations in mitochondrial-related genes revealed by pooled imaging assay by Colin Kremitzki, Jason Waligorski, Graham Bachman, Lina Mohammed Ali, John Bramley, Maria Vakaki, Vinay Chandrasekaran, Purva Patel, Dhruv Mathur, Paul Hime, Robi Mitra, Jeff Milbrandt, William Buchser

“…By examining multiple features instead of a single readout, this analysis was powered to detect genes which had morphological ‘signatures’ aligned with MFN2-mutant phenotypes. …”
Get full text

Dynamic Tracking of Injected Mesenchymal Stem Cells after Myocardial Infarction in Rats: A Serial 7T MRI Study by Xiuyu Chen, Minjie Lu, Ning Ma, Gang Yin, Chen Cui, Shihua Zhao

“…The temporal stem cell location, signal intensity, and cardiac function were dynamically assessed using a 7T MRI at 24 h before transplantation (baseline), 3 days, 2 weeks, and 4 weeks after transplantation, respectively. …”
Get full text

Anatomical variations of the popliteal artery as a risk factor for its laceration during total knee arthroplasty: Controversies with illustrative case report by Boljanović Jelena, Glišić Miodrag, Ilijevski Nenad, Bećirović Matija, Stojanović Smiljana, Pavković Ivana, Đurđević Katarina, Blagojević Valentina

“…O n t he third day following surgery, the patient had complaints that caused a suspicion of graft occlusion, and she was transferred to the Clinic for Cardiovascular Surgery. …”
Get full text

New Anatomic Anterolateral Ligament Reconstruction Used in a Complex Revision ACL Reconstruction by Luke V. Tollefson BS, Nicholas I. Kennedy MD, Robert F. LaPrade MD, PhD

“…An anterolateral ligament reconstruction (ALLR) attempts to restore the native function of the anterolateral complex to augment the ACL. …”
Get full text