Chidamide functions as a VISTA/PSGL-1 blocker for cancer immunotherapy by Xiaoshuang Niu, Wenshan Zhao, Xiuman Zhou, Feiyu Luo, Youmei Xiao, Tao Luo, Xinghua Sui, Wanqiong Li, Qingyu Dong, Xin Yang, Zhuoying He, Wenzhi Shang, Yixuan Sun, Yanfeng Gao

“…Here, by screening a library of marketed drugs, we identified Chidamide had a strong binding affinity toward VISTA (K D  = 5 nM) and blocked VISTA/PSGL-1 under acidic conditions, thereby significantly enhancing the function of CD8+ T cells and inhibiting the tumor growth in immunocompetent murine CT26 tumor model. …”
Get full text

Regulation of Heat Exchange across the Hornbill Beak: Functional Similarities with Toucans? by T M F N van de Ven, R O Martin, T J F Vink, A E McKechnie, S J Cunningham

Get full text

Predicting kidney graft function and failure among kidney transplant recipients by Yi Yao, Brad C. Astor, Wei Yang, Tom Greene, Liang Li

“…Methods We built and internally validated a prediction model on 3,893 patients from the Wisconsin Allograft Recipient Database (WisARD) who had a functioning graft 6 months after kidney transplantation. …”
Get full text

Physicochemical properties and bioturbation analysis of high-temperature Daqu by functional microflora by Tingyan Xu, Anqin Zhu, Shuting Zhong, Yunsheng Wang, Chao Wang, Jin Zhang, Yincui Chen, Rui Wang, Chuanbo Zhang

“…While biofortification with functional strains enhances HTD quality, the ecological dynamics and mechanisms of HTD fermentation influenced by synthetic functional microflora (SFM) remain unclear. …”
Get full text

Developmental changes in brain activation and functional connectivity during Chinese handwriting by Huan Ren, Junjun Li, Zhenglong Lin, Yanzhi Xu, Hong-Yan Bi, Min Xu, Yang Yang

“…However, how brain systems develop to support handwriting remains unclear. Using functional magnetic resonance imaging (fMRI), this study examined the differences in regional activation and functional network connectivity during Chinese handwriting between 52 children (9-13 years old) and 40 young adults. …”
Get full text

Effect of biocorrective supplements on functional and technological properties of complex food systems by T. V. Alexeeva, E. S. Popov, L. A. Albycheva, Yu. O. Kalgina

“…In the course of the research it was found that the model compositions had higher indicators of functional and technological properties compared with the control ones. …”
Get full text

Yokukansan improves behavioral and psychological symptoms of dementia by suppressing dopaminergic function by Takeyoshi K, Kurita M, Nishino S, Teranishi M, Numata Y, Sato T, Okubo Y

“…Patients in the yokukansan group had significantly decreased plasma homovanillic acid levels from baseline. …”
Get full text

Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment by Bio Joo, Mina Park, Song Soo Kim, Sung Jun Ahn, Han-Kyeol Kim, Hanna Cho, Chul Hyoung Lyoo, Sang Hyun Suh

“…Abstract This study aimed to identify morphologic and functional differences in the parasagittal dural space (PSD) between patients with mild cognitive impairment (MCI) and cognitively unimpaired participants using dynamic contrast-enhanced MRI (DCE MRI). …”
Get full text

New Functional Fermented Mare’s Milk Product: Biological Assessment in vivo by Elena S. Simonenko, Sergey V. Simonenko, Anna V. Begunova, Andrey N. Petrov, Elena S. Semenovа

“…The growing consumer interest in healthy foods increases the demand for new functional products. Mare’s milk and its products possess some unique nutritional properties. …”
Get full text

Pulmonary function and medication effect in mild-stage subjects with Parkinson's disease by Renata Terra de Oliveira, Fabiana Maria dos Santos, Alessandro Gomes Ramos, Karla Luciana Magnani Seki, Paulo de Tarso Müller, Gustavo Christofoletti

“…The differences regarding the spirometric results indicate an incipient obstructive ventilatory disorder in patients with PD. Levodopa had small effect on pulmonary function in the mild stage of the disease.…”
Get full text

Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function by Qingtao Yang, Xuxia Sui, Junjun Cao, Caixia Liu, Shukai Zheng, Mian Bao, Yuanni Huang, Kusheng Wu

Get full text

Surface functionalized on polystyrene-gold urchin for determining brain injury biomarker by Ming Qiao, Yan Peng, Ting Yan, Jie Liu, JingFang Yue, Qing Zhu, XueGang Peng, Shuangxia Xiong, Gang Wen

Get full text

The Assessment of Morphological and Functional Changes in the Detection of the Initial Stage of Primary Glaucoma by N. I. Kurysheva, L. V. Lepeshkina

“…Purpose — to study morphological and functional changes in the detection of primary glaucoma progression.Patients and methods. 128 patients (128 eyes, among them — 64 eyes with primary open angle glaucoma (POAG) and 64 with primary angle closure glaucoma (PACG)) with the initial MD of –6.0 dB were examined at the Ophthalmology Center of the FMBA of Russia from May 2016 to November 2019. …”
Get full text

Ecological and Functional Changes in the Hindgut Microbiome of Holstein Cows at High Altitudes by Gong Chen, Haibo Lu, Shangzhen Huang, Congcong Zhang, Xiaojuan Ma, Bin Li, Lingling Hou, Qing Xu, Yachun Wang

Get full text

Functional amyloid protein FXR1 is recruited into neuronal stress granules by Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin

“…In particular, this protein is known to be a negative regulator of the key proinflammatory cytokine TNF alpha. We had previously shown that FXR1 functioned in the amyloid form in neurons of the brain of jawed vertebrates. …”
Get full text

High survivorship and excellent functional outcome in third‐generation patellofemoral arthroplasty by Mustafa Hariri, Hannah Schwab, Kevin‐Arno Koch, Paul Mick, Timo Nees, Johannes Weishorn, Tilman Walker, Tobias Reiner

Get full text

Incomplete functionalization of glycodendrimers: Effects on binding affinity with wheat germ agglutinin by Takahiko Matsushita, Naomichi Toda, Tetsuo Koyama, Ken Hatano, Koji Matsuoka

Get full text

Quality analysis and function research of Rosa roxburghii Tratt leaves tea by MU Xian, TU Qing, CHEN Qiuhui, LU Hongmei, YANG Shuangquan, CHEN Li

“…Using the spring tender leaves of Rosa roxburghii Tratt. trees as raw materials, green tea, black tea, and white tea from R. roxburghii Tratt. leaves were prepared by three traditional processes, and their quality and function were studied. Using sensory evaluation combined with fuzzy mathematics evaluation, the weights of polyphenols, flavonoids, and sensory scores were determined using analytic hierarchy process (AHP). …”
Get full text

The Epidemiology of Functional Gastrointestinal Disorders in Mexico: A Population-Based Study by Aurelio López-Colombo, Douglas Morgan, Dalia Bravo-González, Alvaro Montiel-Jarquín, Socorro Méndez-Martínez, Max Schmulson

“…Aims. The frequency of functional gastrointestinal disorders (FGIDs) in the general population of Mexico is unknown. …”
Get full text

The Association of Retinal Disease with Vision Impairment and Functional Status in Medicare Patients by Vincent Garmo, Xiaohui Zhao, Carmen D. Ng, Aimee Near, Tania Banerji, Keiko Wada, Gary Oderda, Diana Brixner, Joseph Biskupiak, Ferhina S. Ali, Archad M. Khanani, Alicia Menezes, Ibrahim M. Abbass

“…# Background The association of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) with functional status in the general Medicare population are not well established…”
Get full text