Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain by Liu Y, Hao S, Hao H, Zheng G, Bing J, Kang L, Li J, Zhao H, Hao H

“…Yang Liu,1 Shikang Hao,2 Hongyu Hao,3 Guona Zheng,1 Jie Bing,1 Lin Kang,1 Jia Li,4 Huanfen Zhao,1,* Han Hao5,* 1Department of Pathology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2The First Clinical Medical School, Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Neurology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 4Outpatient Department, Hebei Medical University, Shijiazhuang, People’s Republic of China; 5Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, Center of Innovative Drug Research and Evaluation, Hebei Medical University, Shijiazhuang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Han Hao; Huanfen Zhao, Email 18800790@hebmu.edu.cn; ZHAO552588@126.comBackground: Recent studies have shown necroptosis may play a role in the development of inflammation-associated pain. …”
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Glycemic Management of Patients with Hospital Hyperglycemia: A Retrospective Cohort Study on Adults Admitted in the Non-ICU Wards by Zheng R, Zeng X, Shen R, Wang Y, Liu J, Zhang M

“…Ruoxuan Zheng,1,2 Xiangman Zeng,1 Ruiting Shen,1 Yueqiu Wang,1 Jing Liu,1,3 Mingchen Zhang1 1Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China; 2School of Medicine, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Mingchen Zhang, Department of Endocrinology and Metabolism, Ningbo No.2 hospital, Ningbo, Zhejiang Province, People’s Republic of China, Email zhangmc1015@163.comPurpose: To identify the key populations for Hospital Hyperglycemia (HH) management and to assess recent trends in the management of HH.Patients and Methods: This retrospective study analyzed 1,136,092 point-of-care blood glucose (POC-BG) measurements from 40,758 patients with HH in non-intensive care unit (non-ICU) wards at Ningbo No.2 hospital from January 2020 to December 2022. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Shuyu Zheng,1,2 Zejuan Xie,1 Ziao Zhou,1 Shanshan Wang,1 Yanlin Xin,1 Jiamin Lin,1 Keyu Cheng,1 Tianming Lu,1 Ruogu Qi,1 Yuanyuan Guo1 1Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaCorrespondence: Ruogu Qi; Yuanyuan Guo, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Email rqi@njucm.edu.cn; guoyy@njucm.edu.cnPurpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. …”
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Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis by Zheng H, Xu S, Yang R, Jiao WE, Qiao YL, Liu JY, Fan HM, Zhou YT, Ni HF, Chen J, Deng YQ, Chen SM

“…Han Zheng,1,* Shan Xu,1,* Rui Yang,1,* Wo-Er Jiao,1 Yue-Long Qiao,1,2 Jia-Yu Liu,1 Hui-Ming Fan,1 Yan-Ting Zhou,1 Hai-Feng Ni,3 Jin Chen,1 Yu-Qin Deng,1 Shi-Ming Chen1 1Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland; 3Department of Otolaryngology-Head and Neck Surgery, Zhejiang Hospital, Hangzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu-Qin Deng; Shi-Ming Chen, Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China, Email bamboo0723@126.com; shimingchen0468@163.comBackground: The role of memory B cells and their subgroups in allergic rhinitis (AR) and allergen immunotherapy (AIT) remains unclear. …”
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Research on the Anxiety and Depression of Patients with Mechanical Ocular Injuries: A Cross-Sectional Study by Li M, Wang Y, Chen H, Zheng F, Su Z, Li J, Yan H

“…Mengxuan Li,1– 3 Yuhao Wang,4 Hanhui Chen,4 Fang Zheng,5 Zhitao Su,5 Jie Li,4 Hua Yan1– 3 1Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China; 2Laboratory of Molecular Ophthalmology, Tianjin Medical University, Tianjin, 300070, People’s Republic of China; 3Key Laboratory of Ocular Trauma, Tianjin, 300070, People’s Republic of China; 4Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, 300222, People’s Republic of China; 5Eye Center, The Second Affiliated Hospital Zhejiang University School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaCorrespondence: Hua Yan, Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China, Fax +86-22-27813550, Email zyyyanhua@tmu.edu.cnPurpose: The present study aimed to investigate the prevalence of anxiety and depression in patients with mechanical ocular injuries, and the effects of worry and resilience on anxiety and depression.Patients and Methods: Patients with one eye of mechanical ocular injuries and healthy residents were recruited from June 8, 2022, to March 1, 2023. …”
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N-2-Hydroxypropyl Trimethyl Ammonium Chloride Chitosan-Aluminum Nano-Adjuvant Elicit Strong Immune Responses in Porcine Epidemic Diarrhea Inactivated Vaccine by Jin Z, Liu J, Guo S, Xu S, Gong X, Zhang C, Zhao K

“…Zheng Jin,1 Jiali Liu,1 Sihan Guo,2 Shangen Xu,1 Xiaochen Gong,1,3 Chunjing Zhang,3 Kai Zhao1,2 1Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Taizhou University, Taizhou, Zhejiang, 318000, People’s Republic of China; 2Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, China; Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin, Heilongjiang, 150080, People’s Republic of China; 3School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, People’s Republic of ChinaCorrespondence: Kai Zhao; Chunjing Zhang, Email zybin395@126.com; cjzhang2005@163.comBackground: Porcine epidemic diarrhea virus (PEDV) inactivated vaccine lacks an effective vaccine adjuvant as an immune activator. …”
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Predictors and Prognostic Effects of Perioperative Myocardial Injury After Transcatheter Aortic Valve Replacement According to VARC-3 Criteria by Hu X, Zhao Z, Wang C, Feng D, Chen Y, Niu G, Zhou Z, Zhang H, Li Z, Ye Y, Wang M, Wu Y

“…Xiangming Hu,1,* Zhenyan Zhao,1,* Can Wang,1,* Dejing Feng,1 Yang Chen,2 Guannan Niu,1 Zheng Zhou,1 Hongliang Zhang,1 Zhe Li,1 Yunqing Ye,1 Moyang Wang,1 Yongjian Wu1 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2Department of Cardiology, Peking University People’s Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Moyang Wang; Yongjian Wu, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, People’s Republic of China, Email wangmoyang1983@vip.sina.com; fuwaiwyj@163.comPurpose: The impact of periprocedural myocardial injury (PPMI) according to VARC-3 criteria in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. …”
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Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance by Ma ZP, Zhu YM, Zhang XD, Zhao YX, Zheng W, Yuan SR, Li GY, Zhang TL

“…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection by Yu ZC, Fang ZK, Yu Y, Liu SY, Wang KD, Shi ZJ, Jin LM, Huang XK, Lu Y, Shen GL, Liu JW, Huang DS, Zhang CW, Liang L

“…Zi-Chen Yu,1,2 Zheng-Kang Fang,1,2 Yang Yu,3 Si-Yu Liu,4 Kai-Di Wang,1,5 Zhe-Jin Shi,1,5 Li-Ming Jin,1 Xiao-Kun Huang,1,2 Yi Lu,1 Guo-Liang Shen,1 Jun-Wei Liu,1 Dong-Sheng Huang,1 Cheng-Wu Zhang,1 Lei Liang1 1Department of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, General Surgery, Cancer Center, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Postgraduate Training Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Urology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 4Department of Laboratory Medicine, The Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Zhejiang University Lishui Hospital, Lishui, Zhejiang, People’s Republic of China; 5Department of the second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Lei Liang, General Surgery, Cancer Center, Department of Hepatobiliary and Pancreatic Surgery and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China, Email liangl1992@hotmail.comBackground & Aims: Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and is characterized by the co-expression of both CHCC and cholangiocyte markers. …”
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Optimizing Obstructive Sleep Apnea Risk Assessment in Hypertension: Development of a Predictive Nomogram in China by Yang Y, Sun X, Liang J, Liao WF, Ye W, Zheng Z, Du L, Chen M, Zhang Y, Lin W, Huang J, Yao W, Chen R

“…Yitian Yang,1,* Xishi Sun,2,* Jinhua Liang,1,* Wei Feng Liao,1,* Weilong Ye,1 Zhenzhen Zheng,1 Lianfang Du,1 Mingdi Chen,1 Yuan Zhang,3 Wenjia Lin,2 Jinyu Huang,2 Weimin Yao,1 Riken Chen1,4 1The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 2Emergency Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People’s Republic of China; 3The First Clinical School of Medicine, Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China; 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Riken Chen; Weimin Yao, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524003, People’s Republic of China, Tel +13560244631 ; +13822521722, Email chenriken@126.com; 490296443@qq.comPurpose: Obstructive sleep apnea (OSA) is common in patients with hypertension. …”
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Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…Qian Li,1,* Jing-Wen Zheng,1,* Zi-Yao Wang,1 Shi-Ping Liao,2 Ling Zhu,1 Xia Wang,3,* Li-Hong Wan1,4,* 1Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 2Functional Laboratory, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 3Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China; 4NHC Key Laboratory of Chronobiology (Sichuan University), West China School of Basic Medical Sciences & Forensic Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li-Hong Wan, Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 3-17 Renmin South Road, Sichuan, 610041, People’s Republic of China, Tel +86-28-85501278, Email wanlihong1976@sina.com Xia Wang, Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China, Email 80832491@qq.comObjective: Neuronal damage is criminal to cognitive dysfunction, closely related to endoplasmic reticulum stress (ERS). …”
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The Mediating Role of Avoidant Personality Disorder Features in the Relationship Between Stressful Life Events and Depression Among First-Year University Students by Zhou H, Niu S, Guo Y, Qin Y, Sun H, Mu F, Duan X, Zheng Y, Zhang Y, Liu Y, Liu N

“…Huihui Zhou,1,* Sifang Niu,1,2,* Yangziye Guo,1,3 Yan Qin,1,3 Hao Sun,4 Fuqin Mu,5 Ximing Duan,5 Yi Zheng,5 Ying Zhang,6 Yan Liu,1 Ning Liu7 1School of Public Health, Jining Medical University, Jining, 270213, People’s Republic of China; 2School of Public Health and Management, Binzhou Medical University, Yantai, 264003, People’s Republic of China; 3School of Public Health, Shandong First Medical University, Jinan, 250117, People’s Republic of China; 4School of Clinical Medicine, Jining Medical University, Jining, 270213, People’s Republic of China; 5School of Mental Health, Jining Medical University, Jining, 272013, People’s Republic of China; 6School of Public Health, University of Sydney, Sydney, NSW, 2006, Australia; 7School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Liu, School of Public Health, Jining Medical University, Jining, 272065, People’s Republic of China, Email hakunaly@163.com Ning Liu, Department of Graduate, Jining Medical University, Jining, 272065, People’s Republic of China, Email 631864@qq.comPurpose: Stressful life events are risk factors of depression. …”
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PCT/ALB Ratio in Initial Three days for the Prediction of Secondary Infection in Septic Patients by Zhang C, Huang G, Li H, Zhang T, Jian M, Huang C, Zhang Y, Wang Z, Hou X, Xia Y, Jiang W

“…Chunmei Zhang,1,* Guoge Huang,2,* Haizhong Li,1,3,* Tiancao Zhang,1 Mengling Jian,1 Chunyang Huang,1 Yingqin Zhang,1,4 Zheng Wang,5 Xun Hou,1 Yuanyuan Xia,6 Wenqiang Jiang1,7 1Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Emergency Medicine, People’s Hospital of Longhua, Shenzhen, Guangdong, People’s Republic of China; 3Department of Emergency, Boai Hospital of Zhongshan, Zhongshan, Guangdong, People’s Republic of China; 4School of Medicine, South China University of Technology, Guangzhou University City, Guangzhou, Guangdong, People’s Republic of China; 5Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 6Medical Oncology Department, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 7Emergency Intensive Care Unit, Department of Emergency Medicine, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University; Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang Jiang; Yuanyuan Xia, Email jiangwenqiang@gdph.org.cn; xiayuany1021@163.comBackground: Procalcitonin (PCT) to albumin (ALB) ratio (PAR) in initial three days is a rapidly available indicator to assess the prognosis of patients with sepsis. …”
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TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma by Wang W, Zhang Q, Cui Y, Zhang S, Li B, Xia T, Song Y, Zhou S, Ye F, Xiao W, Cao K, Chi Y, Qu J, Zhou G, Chen Z, Zhang T, Chen X, Ju S, Wang YC

“…Weilang Wang,1,* Qi Zhang,2,* Ying Cui,1,* Shuhang Zhang,1 Binrong Li,1 Tianyi Xia,1 Yang Song,3 Shuwei Zhou,1 Feng Ye,4 Wenbo Xiao,5 Kun Cao,6 Yuan Chi,7 Jinrong Qu,8 Guofeng Zhou,9,10 Zhao Chen,11 Teng Zhang,12 Xunjun Chen,13 Shenghong Ju,1 Yuan-Cheng Wang1 1Department of Radiology, Zhongda Hospital, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of China; 2Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China; 3MR Scientific Marketing, Siemens Healthineers Ltd, Shanghai, People’s Republic of China; 4Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 5Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 6Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, People’s Republic of China; 7Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China; 8Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China; 9Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 10Shanghai Institute of Medical Imaging, Shanghai, People’s Republic of China; 11Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 12Institute for Artificial Intelligence in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, People’s Republic of China; 13Department of Radiology, The People’s Hospital of Xuyi County, Huaian, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuan-Cheng Wang, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, Jiangsu, 210009, People’s Republic of China, Tel +086 25 83272121, Fax +086 25 83311083, Email yuancheng_wang@seu.edu.cnPurpose: To develop and validate a predictive model for predicting six-month outcome by integrating pretreatment MRI features and one-month treatment response after TACE.Methods: A total of 108 patients with 160 hCCs from a single-arm, multicenter clinical trial (NCT03113955) were analyzed and served as the training cohort. …”
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Microfluidic Synthesis of miR-200c-3p Lipid Nanoparticles: Targeting ZEB2 to Alleviate Chondrocyte Damage in Osteoarthritis by Zheng D, Chen T, Yang K, Yin G, Chen Y, Gui J, Xu C, Lv S

“…Dong Zheng,1,* Tong Chen,2,* Kaiyuan Yang,1 Guangrong Yin,1 Yang Chen,3 Jianchao Gui,4 Chao Xu,1 Songwei Lv5 1Department of Orthopedics, The Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3Changzhou Productivity Development Center, Changzhou, People’s Republic of China; 4Department of Sports Medicine and Joint Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 5School of Pharmacy, Changzhou University, Changzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chao Xu; Songwei Lv, Email xuchao_06@163.com; lvsw@cczu.edu.cnIntroduction: Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration. …”
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Sedentary Behavior and Its Association With Psychological Well-Being and Sleep Quality in Adolescents: Evidence from a Propensity Score Analysis by Zhang L, Zhao S, Zhao S, Zheng H, Ke Y, Yang W, Lei M

“…Lirong Zhang,1 Shaocong Zhao,1 Shuangyin Zhao,1 Hua Zheng,2 Yizhen Ke,1 Weichen Yang,1 Mingxing Lei3,4 1Department of Physical Education, Xiamen University of Technology, Xiamen, Fujian, 361024, People’s Republic of China; 2College of Physical Education and Health Science, Chongqing Normal University, Chongqing, 401331, People’s Republic of China; 3Department of Orthopaedics, Hainan Hospital of Chinese PLA General Hospital, Sanya, 572013, People’s Republic of China; 4Nursing Department, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of ChinaCorrespondence: Lirong Zhang, Department of Physical Education, Xiamen University of Technology, No. 600, Ligong Road, Jimei District, Xiamen, 361024, Fujian, People’s Republic of China, Tel +86 13806063882, Email 22674481@qq.com Mingxing Lei, Department of Orthopedic Surgery, Chinese PLA General Hospital, Beijing, 100039, People’s Republic of China, Tel +86 18811772189, Email leimingxing2@sina.comBackground: Sedentary lifestyles among adolescents have been associated with various health concerns, particularly regarding psychological well-being and sleep quality. …”
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Association of Estimated Glomerular Filtration Rate (eGFR) and High-Sensitivity C-Reactive Protein (Hs-CRP) with the Risk of New-Onset Atrial Fibrillation in Patients with Diabetes by Liu Y, Liu H, Sun D, Zheng Y, Tse G, Chen K, Qiu J, Wu S, Liu T

“…Ying Liu,1,* Hongmin Liu,1,2,* Dongkun Sun,1,* Yi Zheng,1 Gary Tse,1,3,4 Kangyin Chen,1 Jiuchun Qiu,1 Shouling Wu,2 Tong Liu1 1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, People’s Republic of China; 2Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China; 3School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong, People’s Republic of China; 4Diabetes Research Unit, Cardiovascular Analytics Group, PowerHealth Research Institute, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tong Liu, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People’s Republic of China, Email liutong@tmu.edu.cn; liutongdoc@126.com Shouling Wu, Department of Cardiology, Kailuan General Hospital, Tangshan, 063001, People’s Republic of China, Email drwusl@163.comBackground: Both renal function decline and systemic inflammation may synergistically increase the risk of atrial fibrillation (AF). …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…Bing Liu,1– 3,* Zhiyao Bao,1– 3,* Wei Chen,1– 3,* Xiaotong Xi,4,5,* Xiao Ge,1– 3 Jun Zhou,1– 3 Xiaoyan Zheng,6 Peipei Zhang,4,5 Wanglong Deng,4,5 Ran Ding,4,5 Min Zhou,1– 3 Jie Fang7 1Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 3Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai, 200025, People’s Republic of China; 4State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Diagnostics Co., Ltd., Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing, 210018, People’s Republic of China; 5Nanjing Simcere Medical Laboratory Science Co., Ltd., Nanjing, 210018, People’s Republic of China; 6Department of Pulmonary and Critical Care Medicine, Zhoushan Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Zhoushan, 316000, People’s Republic of China; 7Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Fang, Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email fj40517@rjh.com.cn Min Zhou, Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Rui Jin 2nd Road, Shanghai, 200025, People’s Republic of China, Email doctor_zhou_99@163.comBackground: Targeted next-generation sequencing (tNGS) is a high-throughput and cost-effective diagnostic alternative for pneumonia, with the ability to simultaneously detect pathogens, antimicrobial resistance genes, and virulence genes. …”
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Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…Yuxin Sun,1,* Die Hu,1,* Mingkun Yu,2 Shi-Bing Liang,3– 5 Youyou Zheng,6 Xin Wang,7 Guangdong Tong1,8 1Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, People’s Republic of China; 2Department of Oncology, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, People’s Republic of China; 3Clinical Study Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 4Centre for Evidence-Based Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 5Postdoctoral Research Station, Shandong University of Traditional Chinese Medicine, Jinan, People’s Republic of China; 6Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 7Department of Traditional Chinese Medicine, Sanbo Brian Hospital of Capital Medical University, Beijing, People’s Republic of China; 8Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guangdong Tong, Shenzhen Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Shenzhen, People’s Republic of China, Email tgd755@163.comPurpose: In recent decades, numerous non-invasive tests (NITs) for diagnosing nonalcoholic fatty liver disease (NAFLD) have been developed, however, a comprehensive comparison of their relative diagnostic accuracies is lacking. …”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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