Transcutaneous Electrical Acupoint Stimulation in Early Life Changes Synaptic Plasticity and Improves Symptoms in a Valproic Acid-Induced Rat Model of Autism by Xiaoxi Wang, Rui Ding, Yayue Song, Juan Wang, Chen Zhang, Songping Han, Jisheng Han, Rong Zhang

“…Additional studies demonstrated that the dendritic spine density of the primary sensory cortex was decreased with Golgi staining. Results of the transcriptomic study showed that expression of some transcription factors such as the neurotrophic factor were downregulated in the hypothalamus of the VPA model of ASD. …”
Get full text

Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy by Constanza J. Cortes, Kefeng Qin, Eric M. Norstrom, William N. Green, Vytautas P. Bindokas, James A. Mastrianni

“…We found PrP carrying the disease-associated T182A mutation (Mut-PrP) was delivered to lysosomes in a Golgi-independent manner. Time-lapse live cell imaging revealed early formation and uptake of GFP-tagged Mut-PrP aggregates into LysoTracker labeled vesicles. …”
Get full text

Neonatal Tactile Stimulation Downregulates Dendritic Spines in Layer V Pyramidal Neurons of the WAG/Rij Rat Somatosensory Cortex by Gul Ilbay, Aymen Balıkcı, Sibel Köktürk, Melda Yardımoglu Yılmaz, Nurbay Ates, Canan Baydemır, Sibel Balcı

“…In the present research, morphology and density of dendritic spines were analyzed in layer V pyramidal neurons of the somatosensory cortex (SoCx) of WAG/Rij rats (nonstimulated control, tactile-stimulated, and maternal separated rats) and healthy Wistar (nonepileptic) rats. To achieve this, a Golgi-Cox method was used. Results. Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at postnatal day 150 in comparison to nonepileptic adult control Wistar rats (p<0.001). …”
Get full text

INFECCIÓN POR PROTOZOARIOS EN INDIVIDUOS DE TITÍ BEBE LECHE -S. fuscicollis-, TITÍ CABEZA BLANCA -S. oedipus-, TITÍ ARDILLA -S. sciureus-, SURICATO -S. suricatta- Y WALLABIE DE BEN... by G. L. K. López, J. Peña, C. I. Brieva

“…La toxoplasmosis es una de las zoonosis parasitarias más comunes y de especial atención en medicina humana y veterinaria en todo el mundo. Toxoplasma gondii comparte mu - chos de sus parámetros biológicos con otros parásitos apicomplexa, pero es único por su extremadamente amplio rango de huéspedes y su especificidad tisular. …”
Get full text

Analysis of Hydrogeochemical Characteristics of Tunnel Groundwater Based on Multivariate Statistical Technology by Chen Peng, Yuanming Liu, Huiyu Chen, Qiaowei Yuan, Qingzhi Chen, Shilong Mei, Zhonghu Wu

“…Based on five sets of 38 samples collected in the Tongzi Tunnel in 2020 and 2021, the main geochemical processes and water quality conditions of the karst aquifer system during tunnel construction were revealed by multivariate statistical analysis and graphical methods. …”
Get full text

Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport by Wang-Jong Lee, Ernest Mazigo, Jin-Hee Han, Seok Ho Cha

“…Sequence and structural analyses revealed a conserved binding pocket for cationic amino acids in Plasmodium species, distinct from that in Toxoplasma gondii NPT1. These findings highlight the potential of targeting PvApiAT8 in developing new treatments for P. vivax malaria.…”
Get full text

The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT by Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li

“…Objectives To analyze the differences in clinical manifestations between children and adults with intestinal involvement in IgAV and to identify the specific subtypes requiring particular attention.Methods A systematic review of the HIS system was conducted on patient data from four centers at Tongji Hospital between January 2015 and October 2022. …”
Get full text

Evaluation of Awareness, Knowledge, Attitude and Practices Related to Toxoplasmosis Among Females in Algeria by Mohamed Lounis, Samah Aissaoui, Fatima Ghouissem, Karim Souttou

“…Toxoplasmosis is a major veterinary and public health issue affecting humans and animals, where felids represent the definitive hosts of the causative agent <i>Toxoplasma gondii</i>. While the infections are mostly asymptomatic, the disease could be severe in immune-compromised patients and pregnant women. …”
Get full text

Effects of Programmatic Assessment in Clinical Reasoning Courses in General Practice by ZHAI Jiayi, LU Yuan, SHI Jianjun, YU Dehua

“…Methods From September to December 2022, 38 master&apos;s degree students of the Medical School of Tongji University were divided into the in-service group (16) and residential training group (22). …”
Get full text

Investigation of TORCH seroprevalence in a tertiary university hospital by Samet Kirat

“…This study aimed to investigate the seroprevalence of TORCH (Toxoplasma gondii, other agents, Rubella, Cytomegalovirus (CMV), and herpes simplex virus (HSV)) in pregnant women at a tertiary university hospital and determine the level of immunity in the community. …”
Get full text

Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study by Zhao X, Zhao H, Chen R, Zhou J, Li N, Li J, Yan S, Liu C, Zhou P, Chen Y, Song L, Yan H

“…Xiaoxiao Zhao,1 Hanjun Zhao,1 Runzhen Chen,1 Jinying Zhou,1 Nan Li,1 Jiannan Li,1 Shaodi Yan,2 Chen Liu,1 Peng Zhou,1 Yi Chen,1 Li Song,1 Hongbing Yan2 1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, BeiJing, People’s Republic of China; 2Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, ShenZhen, People’s Republic of ChinaCorrespondence: Hongbing Yan, Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, ShenZhen, 12 Langshan Road, Shenzhen, 518000, People’s Republic of China, Tel +86-13701339287, Email hbyanfuwai2018@163.com Hanjun Zhao, Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, No. 167, Beijing, 100037, People’s Republic of China, Tel +86-15210020808, Email 15210020808@163.comBackground: The protein known as Fatty Acid-Binding Protein 4 (FABP4), predominantly found in adipocytes, macrophages, and endothelial cells, has emerged as a pivotal biomarker linking inflammation and metabolism in the context of cardiovascular diseases.Aim: The present investigation sought to elucidate the influence of FABP4 on the prognostic ramifications for patients experiencing ischemic vascular events, which encompass ischemic cerebrovascular occurrences, myocardial infarctions, and cardiovascular mortality.Methods: A total of 1102 consecutive patients diagnosed with acute myocardial infarction (AMI) and aged over 55 years were prospectively enrolled from March 2017 to January 2020. …”
Get full text

EVALUACIÓN DEL PROGRAMA DEL SEGURO POPULAR DEL 2002 AL 2005. Impacto en la utilización de servicios médicos, en el gasto en salud y en el mercado laboral. by Erika Arenas, Susan Parker, Luis Rubalcava, Graciela Teruel

“…El análisis se realiza por género y origen de la población (urbano y rural) utilizando datos longi - tudinales de la Encuesta Nacional sobre Niveles de Vida de los Hogares ( ENNViH ) , y el método de emparejamiento de marcadores de propensión. …”
Get full text

PROSPECTS AND CHALLENGES OF RESCUING THE SHRINKING LAKE CHAD THROUGH THE UNITED NATIONS’ GREEN CLIMATE FUND by DAIYABU HASSAN MUHAMMAD

“…The most viable plan is the idea of an inter-basin water transfer (IBWT), developed by the Italian Engineering Company Bonfica which involves diverting about 4% of the waters of the tributaries of River Bongi in the Democratic Republic of Congo (DRC) that discharge into the Atlantic Ocean through a series of canals and dams to River Chari (that feeds the Lake) in the Central African Republic (CAR). …”
Get full text

The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis by Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds

“…Unbiased quantitative proteomics identified a profound effect on proteoglycans, driven by rapid loss of type II transmembrane proteins of the Golgi, including enzymes required for glycosaminoglycan (GAG) synthesis, combined with a reduction in the core proteins themselves. …”
Get full text

Histopathological characterization of skin and muscle lesions induced by lionfish (Pterois volitans) venom in a murine experimental model by Cecilia Díaz, Arturo Chang-Castillo, Natalia Ortiz

“…This is the case of an abundant protein, present in venom, with homology to a Golgi-associated plant pathogenic protein 1-like (GAPR1), which belongs to the same protein superfamily as venom CRISPs and insect allergens. …”
Get full text

Genetic Diversity and Population Structure of <i>Macrobrachium nipponense</i> Populations in the Saline–Alkaline Regions of China by Romaric Iko, Zijian Gao, Sufei Jiang, Yiwei Xiong, Wenyi Zhang, Hui Qiao, Shubo Jin, Hongtuo Fu

“…A total of 264 individuals were successfully sequenced from nine sites, including Daqing in Heilongjiang Province (HLJ), Songyuan in Jilin Province (JL), Ulanhot in the east of inner Mongolia (NMG), Jingtai in Gansu Province (GS), Dongying in Shandong Province (SD), Dongtai in Jiangsu Province (JS), Nanchang in Jiangxi province (JX), Tianjin in mainland China (TJ), and Yinchuan in Ningxia Province (NX). …”
Get full text

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection. by Xiaoyuan Lin, Beibei Fu, Yan Xiong, Na Xing, Weiwei Xue, Dong Guo, Mohamed Zaky, Krishna Pavani, Dusan Kunec, Jakob Trimpert, Haibo Wu

“…However, unconventionally secreted ORF8 does not undergo glycosylation without experiencing the ER-Golgi trafficking, thereby activating the downstream NF-κB signaling pathway and facilitating a burst of cytokine release. …”
Get full text

Hailey-Hailey disease successfully treated with naloxone: 2 case reports and Review of the literature on efficacy of opioid receptor antagonist in Hailey-Hailey disease patients by Junyou Zheng, Zhimin Duan, Beilei Xu, Hao Song, Jianbing Wu, Fang Fang, Nan Sheng, Chengrang Li

“…Background Hailey–Hailey disease (HHD), a genetic blistering disease, is caused by a mutation in a calcium transporter protein in the Golgi apparatus encoded by the ATP2C1 gene. Clinically, HHD is characterized by flaccid vesicles, blisters, erosions, fissures, and maceration mainly in intertriginous regions. …”
Get full text

Patterns of Location and Other Determinants of Retail Stores in Urban Commercial Districts in Changchun, China by Feilong Hao, Yuxin Yang, Shijun Wang

“…The emergence of shopping malls has challenged the traditional single-center structure, resulting in the transformation of commercial districts from single-center to multicenter layouts, while also producing a hierarchical trend in development. (2) The Chongqing Road and Hongqi Street commercial districts have a relatively high spatial concentration of retail stores. …”
Get full text

Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial by Fang Chen, Cheng Li, Dongliang Li, Jinxuan Tang, Jiayu Huang

“…The secondary outcomes are the incidence of choking and injection pain, the type and dose of vasoactive drugs used during the operation, and the level of postoperative satisfaction among surgeons, anaesthesiologists and patients.Ethics and dissemination This trial was approved by the Medical Ethics Committee of Shanghai Fourth People’s Hospital, School of Medicine, Tongji University and registered with the Chinese Clinical Trials Registry (Identifier: ChiCTR2200063048) on 29 August 2022. …”
Get full text