CASES OF DIFFUSE LARGE B-CELL LYMPHOMA WITH FUNCTIONAL INTRON MUTATIONS IN THE TP53 GENE by E. N. Voropaeva, M. I. Voevoda, T. I. Pospelova, V. N. Maksimov

“…We present two case reports that are of interest as the cases for detection of functionally significant intron TP53 mutations in dlBCl tissue, first published in the Russian scientific literature. the first clinical case of dlBCl was clinically characterized by extranodal tumor at the onset of the disease, severe symptoms of tumor intoxication, high paraclinical tumor activity, and early hemoblastosis recurrence. the second case of dlBCl was characterized by initially massive tumor lesion, rapidly progressive course of the disease, severe symptoms of tumor intoxication, high paraclinical tumor activity and poor response to therapy with subsequent generalization of lymphoma. Conclusion. Mutations in the TP53 gene are the driver of the tumor process, serve not only as a marker of aggressive tumor progression, but also as an independent predictor of reduced sensitivity to treatment. the presented clinical cases show that an in-depth analysis of the results of the TP53 sequencing in tumors and functional assessment of all detected changes, including changes in the introns of the gene and involving in silico analysis techniques, are necessary.…”
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The relationship between depression and academic burnout among undergraduate students majoring in eldercare services: a moderated mediation model by Yingjie Lin, Siyu Pan, Jianyao He, Qi Cheng, Hongmin Wei, Li Zhao

“…Using SPSS 22.0 for descriptive analysis and Pearson correlation analysis, and constructed a moderated mediation model using PROCESS.ResultsThe findings reveal that 26.92% of students suffer from academic burnout. …”
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Control of physical conditions of students of special medical groups with disorders of the musculoskeletal system as a prerequisite for the development of programs of physical ther... by O. Z. Blavt, V. M. Koriahin, E. Yu. Doroshenko, L. I. Levchenko, S. H. Puzik, A. M. Hurieieva, O. Ye. Chernenko, M. O. Oliinyk

“…The following methods were used in the research process: analysis and generalization of scientific literature and Internet data; analysis of medical records of students; instrumental methods of morphometric and psychophysiological studies; pedagogical observations; pedagogical experiment of ascertaining orientation; methods of mathematical statistics. …”
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GLOBE Observer: A Case Study in Advancing Earth System Knowledge with AI-Powered Citizen Science by Peder V. Nelson, Russanne Low, Holli Kohl, David Overoye, Di Yang, Xiao Huang, Sriram Chellappan, Farhat Binte Azam, Ryan M. Carney, Monika Falk, Joan Garriga, Larisa Schelkin, Rebecca Boger, Theresa Schwerin

“…Citizen science generates terabytes of raw numerical, text, and image data, the analysis of which requires automated techniques to process in an efficient manner. …”
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The 2nd Baltic Osseointegration Academy and Lithuanian University of Health Sciences Consensus Conference 2019. Summary and Consensus Statements: Group II - Extraction Socket Prese... by Pablo Galindo-Moreno, Fernando Suárez López del Amo, Ricardo Faria-Almeida, Bruno Leitão Almeida, Inesa Astramskaite-Januseviciene, Shayan Barootchi, Tiago Borges, André Correia, Francisco Correia, Jad Majzoub, Miguel Padial-Molina, Mindaugas Pranskunas, Algirdas Puisys, Ausra Ramanauskaite, Andrea Ravida, Thomas Starch-Jensen, Mustafa Tattan

“…Results: The results and conclusions of the review process are presented in the respective papers. Three systematic reviews and one systematic review and meta-analysis were performed. …”
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Association between social frailty and quality of life in older patients with chronic heart failure: sequential multiple mediating effects of family insufficiency and social networ... by Junting Huang, Xiaobo Liu, Duolao Wang, Xiaorong Luan, Wanxia Yao

“…Hierarchical regression analysis was used to assess the factors influencing quality of life; the SPSS PROCESS Marco Plug-in was employed to conduct mediation analysis.ResultsThe results showed that age, the number of hospitalizations, and NYHA classification influenced the quality of life in older patients with chronic heart failure. …”
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Interpretable Deep Learning Model for Grape Leaf Disease Classification Based on EfficientNet with Grad-CAM Visualization by Castaka Agus Sugianto, Dini Rohmayani, Jhoanne Fredricka, Mohamed Doheir

“…The proposed model achieved 99.36% accuracy, with evaluation metrics including precision (99%), recall (99%), and F1-score (99%), demonstrating its reliability in distinguishing disease categories. Further analysis using a confusion matrix and Grad-CAM visualization provided insights into the model’s decision-making process. …”
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Improving Cell Nuclei Segmentation in Pathological Tissues Using Self-Supervised Regression Method by Hesham Ali, Mostafa Hammouda, Mustafa Elattar, Sahar Selim

“…Recent advances in deep learning, specifically Convolutional Neural Networks (CNNs), have proven effective in processing digital pathology data. Yet, CNNs generally require extensive labeled datasets, often unavailable in medical imaging. …”
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Need for Redo Surgery of Maxillofacial Fractures by Hanna Thorén, Sami Suojanen, Anna Liisa Suominen, Tero Puolakkainen, Miika Toivari, Johanna Snäll

“…Altogether, 1176 patients were identified for the analysis. Of these, 25 (2.1%) underwent redo surgery for 28 fracture sites. …”
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Optimization of COD removal of raw landfill leachate using the magnetic graphene oxide/WO3 nanocomposite: Isotherms, kinetics, and thermodynamics studies by Zahra Mirkazehi, Mohammad Rezaei, Mohammad Sayadi

“…The thermodynamic results indicated that the adsorption was spontaneous and exothermic for COD adsorption. In general, the adsorption process of the synthesized GO-Fe3O4/WO3 nanocomposite revealed that it is highly effective for landfill leachate treatment and has great practical value in leachate treatment.…”
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Control of Organic Impurities in Semisynthetic Antibiotics by E. L. Kovaleva, K. S. Arhipova, E. A. Bulova, A. A. Stralkovskaya, O. O. Terentieva

“…This includes covering the impurity determination procedures, reference standards, and limits used, because general-purpose methods and limits do not always allow for correct assessment of impurity profiles in substances produced by different manufacturing processes. …”
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Hospitals’ financial performance across European countries: a scoping review protocol by Katarzyna Dubas‐Jakóbczyk, Costase Ndayishimiye, Przemysław Szetela, Christoph Sowada

“…The proposed review will, therefore, fill in an important research gap and build a knowledge base on the topic of assessing and monitoring the financial sustainability of hospitals in Europe. The general objective is to identify, synthetise and map existing evidence on hospital financial performance across European countries.Methods and analysis This scoping review will follow six stages: (1) defining the research question, (2) identifying relevant literature, (3) studies selection, (4) data extraction, (5) collating, summarising and reporting of results and (6) consultation process and involvement of knowledge users. …”
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Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-κB Signaling by Yuanyuan Hou, Xi Xiao, Wei Yu, Sihua Qi

“…In this study, we aimed to uncover the downstream targets of propofol in this process. Methods. RNA sequencing analysis to identify genes implicated in the propofol-mediated neuroprotective effect. …”
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The pedagogical model of the development of intercultural competence of future lecturers of the higher military educational institutions by Rybchuk Oleh, Aristarkhova Marharyta

“…During the research, methods such as systematic analysis and synthesis, induction and deduction, comparison, generalization, forecasting, and pedagogical modeling were used. …”
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Elevated Zinc and Potassium Levels in Renal Calculi Indicate Distinct Pathophysiological Mechanisms in Urolithiasis by Maciej Jaromin, Marcin Cichocki, Tomasz Konecki, Piotr Kutwin, Waldemar Maniukiewicz, Piotr Wysocki, Magdalena Gajek, Małgorzata Iwona Szynkowska-Jóźwik, Dariusz Moczulski

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SESN3 restrains the progress of idiopathic pulmonary fibrosis by targeting the activity of FOSL2 by Yun Sun, Dan Chen, Fengjie Liu, Ting Liu

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Local non-Hermitian Hamiltonian formalism for dissipative fermionic systems and loss-induced population increase in Fermi superfluids by Teng Xiao, Gentaro Watanabe

“…To resolve this issue, we present a framework called the local NHH formalism, which describes the loss process in each individual mode locally. This formalism is applicable to general dissipative fermionic systems and remains consistent with the underlying Lindblad master equation at the level of the equations of motion of local observables. …”
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Landscape Strategies in Architecture by Daniel Jauslin

“…This project was initially designed in 1999 in a process of layering - in principle, similar to the layer model analysis of this thesis. …”
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Method for designing specialized computing systems based on hardware and software co-optimization by I. Е. Tarasov, P. N. Sovietov, D. V. Lulyava, D. I. Mirzoyan

“…The considered development approaches are suitable for accelerating the process of designing specialized computing systems with a massively parallel architecture based on pipeline or processor computing nodes.…”
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Optimization of Medicinal Treatment of Patients with Glaucoma in Combination with Concurrent System Pathology. Part 1: Cardiovascular Pathology by A. N. Zhuravleva, M. V. Zueva, E. B. Shustov

“…Analysis of the pharmacological effects of the available and used arsenal of medicinal products allows you to generalize the array of data obtained, to form model algorithms for deciding by an ophthalmologist on the choice of medications. …”
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