Exploring the impact of chronic intermittent EU-GMP certified Cannabis sativa L. therapy and its relevance in a rat model of aging by Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carmen Solcan, Mitica Ciorpac, Andrei Szilagyi, Daniela-Carmen Ababei, Raluca-Maria Gogu, Bogdan-Ionel Tamba

“…Abstract Background Aging is a multifaceted process marked by the progressive accumulation of cellular damage in various tissues, resulting in a decline in physiological functions. The primary aim of aging research is to identify compounds that can delay or mitigate these detrimental changes. …”
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COMPARATIVE EVALUATION OF OSTEOTROPIC ACTION OF ENDODONTIC FILLING MATERIALS ON THE MODEL OF EXPERIMENTAL DESTRUCTION OF BONE TISSUE OF THE JAW OF RATS by I. Han

“…For 90 day after modeling of degradation activity of LF and CF in the bone tissue was decreasing and approaching to the values of their activity in the group of intact animals, indicating the restoration of balance of processes of osteogenesis and osteolysis. However, analysis of the results shows that in the V and VI experimental groups content of KF is the lowest and almost closed to the value of intact animals (p> 0.05), while LF content remains the highest among all the indicators of research groups (p <0.001), indicating a decrease of the function of osteoclasts and stimulation of the activity of osteoblasts and proves that the proposed compositions stimulate osteogenesis the most actively. …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…Their development is mutual. The function of the latter is undoubtedly linked to the existence of the former. …”
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Representation of Iran among Iraqi social media users (A case study of Facebook users after the defeat of ISIS until the martyrdom of Hajj Qassem Soleimani) by mohsen finizadeh bidgoli

“…The study employed thematic analysis to examine content posted by Iraqi Facebook users from the period following the defeat of ISIS up to the martyrdom of General Qassem Soleimani. …”
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High‐Frequency Mutations in TP53, AXIN1, CTNNB1, and KRAS, and Polymorphisms in JAK1 Genes Among Mongolian HCC Patients by Nomin Bold, Khurelsukh Buyanbat, Ariya Enkhtuya, Nomin Myagmar, Gerelsuren Batbayar, Zolzaya Sandag, Dolgion Damdinbazar, Nomuun Oyunbat, Tuul Boldbaatar, Ankhbayar Enkhbaatar, Gan‐Erdene Baatarjav, Taivan Nanzaddorj, Tsendsuren Oyunsuren, Gantulga Davaakhuu

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Protein phosphatase 1 regulatory subunit 15 A (PPP1R15A) promoted the progression of gastric cancer by activating cell autophagy under energy stress by Yingnan Cui, Xueyuan Cao, Yangyu Zhang, Chenhao Fu, Dongming Li, Yuanlin Sun, Yuzheng Zhang, Tingshuang Xu, Tetsuya Tsukamoto, Donghui Cao, Jing Jiang

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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…This engineering approach does not require a priori knowledge of structural and functional mapping of antibody–antigen interaction and thus is generally applicable for therapeutic antibody development when desired ortholog binding is lacking. …”
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A case-control study of the interaction of the eNOS gene polymorphisms rs1799983 and rs1800780 with acute coronary syndrome (ACS) risk factors by Liting Cai, Yufei Chen, Chunfang Shan, Qian Zhao, Junyi Luo, Xiaomei Li, Fen Liu, Yining Yang

“…Abstract Background Endothelial nitric oxide synthase (eNOS) gene polymorphisms may affect its enzymatic activity and nitric oxide (NO) production, which in turn interfere with endothelial function, regulate vascular tone, and participate in inflammatory responses. …”
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A Prediction Model of Stable Warfarin Doses in Patients After Mechanical Heart Valve Replacement Based on a Machine Learning Algorithm by Bowen Guo, Cong Chen, Junhang Jia, Jubing Zheng, Yue Song, Taoshuai Liu, Kui Zhang, Yang Li, Ran Dong

“…The variables were selected using analysis of covariance (ANCOVA). Algorithms for predicting the stable warfarin dose were constructed using a traditional linear model, general linear model (GLM), and 10 ML algorithms. …”
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Targeted microwave ablation of localised prostate cancer: Initial results of VIOLETTE trial by Nicolas Barry Delongchamps, Alexandre Peltier, Eric Potiron, Franck Bladou, Julien Anract, Romain Diamand, Grégoire Robert, Aurel Messas, Roland Van Velthoven

“…Patients were treated under general anaesthesia or conscious IV sedation in an outpatient setting. …”
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Quantifying axonal features of human superficial white matter from three-dimensional multibeam serial electron microscopy data assisted by deep learning by Qiyuan Tian, Chanon Ngamsombat, Hong-Hsi Lee, Daniel R. Berger, Yuelong Wu, Qiuyun Fan, Berkin Bilgic, Ziyu Li, Dmitry S. Novikov, Els Fieremans, Bruce R. Rosen, Jeff W. Lichtman, Susie Y. Huang

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Sample preparation using multiple microbial pattern recognition proteins and magnetic bead ratcheting by Jessica Martinez, Dong Jin M. Park, Samantha Abate, James Hill, George Downey, Craig Galligan, Tyler Hammond, Michael T. McCurdy, Surekha Gurung, Shanjana Shawon, Ralf Lenigk, Kuangwen Hsieh, Michael Super, Erik Kvam, Tza-Huei Wang, Coleman Murray, Chris Puleo

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The Dynamic Characteristics and Influencing Factors of Soil Respiration in Different Types of Grasslands in the Barkol Lake Basin by Xiangdong Cao, Chengyi Zhao, Hongtao Jia, Jinyu Yang

“…The results revealed that (1) the daily average soil respiration was highest in the lowland meadow (0.07 to 5.76 μmol·m⁻²·s⁻¹), followed by the alpine meadow (−0.57 to 0.95 μmol·m⁻²·s⁻¹), the temperate desert steppe (−0.45 to 3.0 μmol·m⁻²·s⁻¹) and the temperate steppe desert (−1.29 to 1.61 μmol·m⁻²·s⁻¹); (2) the soil respiration rates of the four grassland types were significantly correlated with the temperature in the 5–15 cm soil layer, and the best model was an exponential function; the peak values generally appeared between 13:00 and 17:00 (h), with the minimum values at 2:00 or 8:00 (h); the maximum value was observed in July–August, and the minimum value was observed in October; and the soil respiration in the lowland meadow was higher than that in the other three types of grassland during the same period. …”
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Complex Metabolomic Changes in a Combined Defect of Glycosylation and Oxidative Phosphorylation in a Patient with Pathogenic Variants in <i>PGM1</i> and <i>NDUFA13</i> by Silvia Radenkovic, Isabelle Adant, Matthew J. Bird, Johannes V. Swinnen, David Cassiman, Tamas Kozicz, Sarah C. Gruenert, Bart Ghesquière, Eva Morava

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del Nido versus St. Thomas’ blood cardioplegia in the young (DESTINY) trial: protocol for a multicentre randomised controlled trial in children undergoing cardiac surgery by Massimo Caputo, Serban Stoica, Kelly Handley, Timothy J Jones, Nigel E Drury, Barnaby R Scholefield, Martin Kostolny, Alex Robertson, Yongzhong Sun, Carin Van Doorn, Warwick B Dunn, John V Pappachan, Hugh Jarrett, Carly Tooke, Tina Griffin, Indie Bilkhoo

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Household wealth and its association with non-adherence, quality of life, anxiety and depression amongst hemodialysis patients in two centers in Cameroon by Hermine Danielle Epse Ebana Menye Fouda, Franck Niverd Mefeya Mouaffo, Victorine Bandolo Nzana, Pamela Tumchou, Lionel Elimby, Denis Teuwafeu, Ronald Gobina, Marie-Patrice Halle

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Detecting and routing of dust event using remote sensing and numerical modeling in Isfahan Province by Mehdii Jafari, Gholamreza Zehtabian, Hasan Ahmadi, Tayebeh Mesbahzadeh, Ali Akbar Norouzi

“…In order to visualize the dust phenomenon, after the geometric correction of the images, the radian values of the images were converted to brightness temperature using the Planck function. Corrections and processing of images were done in ENVI software. …”
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Acute effect of exercise with or without the integration of cooperative activities on inhibitory control in preadolescent school children by Melanie Berger, Markus Gerber, Sebastian Ludyga

“…The nature and organization of individual differences in executive functions: Four general conclusions. Current Directions in Psychological Science, 21(1), 8–14. https://doi.org/10.1177/0963721411429458 Oberste, M., Javelle, F., Sharma, S., Joisten, N., Walzik, D., Bloch, W., & Zimmer, P. (2019). …”
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“Youth 2.0 project”: Multi-professional Intervention to Protect Adolescents from NPS and Other Drug Use by V. Rapaccini, S. Biscontini, A. Molinaro, G.P. Di Loreto, A. Pasini, O. Corazza, A. Metastasio

“…Results: A general increase in substance addictions rate (smoking, alcohol, drugs) was recorded. …”
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Mitochondria-Targeting Virus-Like Gold Nanoparticles Enhance Chemophototherapeutic Efficacy Against Pancreatic Cancer in a Xenograft Mouse Model by Meng Y, Chen C, Lin R, Zheng L, Fan Y, Zhang M, Zhang Z, Shi H, Zheng X, Chen J, Chen D, Teng T, Chen B

“…Youshuai Meng,1,&ast; Chuan Chen,1,2,&ast; Ronggui Lin,1,3,&ast; Linlin Zheng,4 Yanying Fan,5 Mengdi Zhang,1 Ziqi Zhang,1 Han Shi,1,3 Xiaohan Zheng,1,3 Junyu Chen,1 Dezhao Chen,1,3 Tianhong Teng,1,3 Bing Chen1 1Key Laboratory of Nanomedical Technology (Education Department of Fujian Province), Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Innovation Center for Enzyme Catalysis and Drug Synthesis, School of Pharmacy, Xiamen Medical College, Xiamen, 361023, People’s Republic of China; 3Department of General Surgery/ Department of Obstetrics & Gynecology, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 4Department of Oncology, Affiliated Hospital of Putian University, Putian, 351199, People’s Republic of China; 5Fuzhou Children’s Hospital of Fujian Province, Fuzhou, 350005, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bing Chen, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China, Email BingChen_001@126.com, BingChen_001@fjmu.edu.cn Tianhong Teng, Fujian Medical University Union Hospital, Fujian Medical University, Fuzhou, 350122, People’s Republic of China, Email tianhongteng24@fjmu.edu.cnBackground: The dense and fibrotic nature of the pancreatic tumor microenvironment significantly contributes to tumor invasion and metastasis. …”
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