A prospective randomized controlled trial comparing biphasic cartilage repair implant with microfracture in small chondral lesions of knee: findings at five-year-follow-up by Yao-Yi Kuo, Si-Qi Chiu, Wen-Pei Chang, Chih-Yu Chen, Chih-Hwa Chen, Chen-Kun Liaw, Cheng-Aun Tan, Pei-Wei Weng

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Predicting the risk of left ventricular diastolic dysfunction in obesity by G. A. Chumakova, O. V. Gritsenko, O. V. Gruzdeva, A. V. Zateev

“…After 4,7±0,3 years, echocardiography was repeated in order to assess LV diastolic function.Results.  Comparative analysis of metabolic risk factors revealed a significant increase in the level of total cholesterol (p=0,001), low-density lipoprotein cholesterol (LDL-C) (p<0,0001), triglycerides (TGs) (p<0,0001). …”
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Ketoanalogue use is associated with a lower risk of worsening frailty among patients with diabetic kidney disease of advanced stage: A retrospective cohort study by Jui Wang, Szu-Ying Lee, Chia-Ter Chao, Jenq-Wen Huang, Kuo-Liong Chien

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Feasibility, safety and tolerability of the CREB-binding protein/β-catenin inhibitor OP-724 in patients with advanced primary biliary cholangitis: an investigator-initiated, open-l... by Eiichi Ogawa, Atsushi Tanaka, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Masamichi Kimura, Jun Imamura, Masanao Saio, Yoshihiro Ikura, Kouichi Miura, Ichiro Ieiri, Kiminori Kimura

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Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

“…The study found higher VR-QOL scores in General Health, Distance activities, and Near activities, while lower scores were observed in Mental health, Dependency, Social functioning, Ocular pain, General vision, and Role difficulties. …”
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Optical correction of hyperopia in school-aged children: a scoping review protocol by Su-Hsun Liu, Tawna L Roberts, Gayathri Srinivasan, Kristen L Kerber, Vivian M Manh, Kristine Huang, Alexandra Williamson, Soumen Sadhu, Morgan C Ollinger, Zahra Tajbakhsh, Jennifer H Fisher, Nathan L Cheung, Jasmine Junge, Kevin C H Chan, Jameel Rizwana Hussaindeen, Patrick Simard, Kelsey R Trast, Christina E Morettin, Samantha Krueger, Augustine N Nti, Debora M Lee Chen

“…This scoping review aims to identify and map the current literature on optical correction and catalogue outcomes reported, particularly in the domains of vision, vision-related functional outcomes and quality of life (QoL) in school-aged children with hyperopia.Methods and analysis This protocol was developed in accordance with the Joanna Briggs Institute’s Manual for Evidence Synthesis. …”
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Pathophysiological and Prognostic Importance of an ExtraCardiac Comorbidity Burden in Patients with Heart Failure with Preserved Ejection Fraction by Yuki Saito, MD, PhD, Tomonari Harada, MD, PhD, Naoki Yuasa, MD, Kazuki Kagami, MD, PhD, Yuta Tani, MSc, Ayami Naito, MD, Fumitaka Murakami, MD, Tomoaki Ishii, RS, Toshimitsu Kato, MD, PhD, Naoki Wada, MD, PhD, Yasuo Okumura, MD, PhD, Hideki Ishii, MD, PhD, Masaru Obokata, MD, PhD

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HLA-mismatched stem cell microtransplant prolonged overall survival and promoted immunological reconstitution for multiple myeloma by Yangyang Lei, Yangyang Lei, Bo Cai, Zhiqing Liu, Anli Xie, Jianhui Qiao, Yi Wang, Xinrui Chen, Fei Peng, Yingxin Zhao, Jiaxin Chen, Wei Guan, Changlin Yu, Xiao Lou, Kaixun Hu, Ang Zhang, Qiyun Sun, Yajing Huang, Yajing Huang, Huisheng Ai, Mei Guo

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Providing a Robust Dynamic Pricing Model and Comparing It with Static Pricing in Multi-level Supply Chains Using a Game Theory Approach by Sara Mehrjoo, Hanan Amoozad Mahdirji, Jalil Heidary Dahoei, Seyyed Hossein Razavi Haji Agha, Mahnaz Hosseinzadeh

“…Initially, the model underwent analysis in static mode, followed by dynamic mode analysis using Games software. …”
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Cyclodextrin host-guest complexes-derived exosomal miRNAs for enhancing the antifatigue effects of resveratrol by Hurong Ge, Peipei Ma, Qing Huang, Shijie Wei, Zhizhong Wang

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The Efficacy of Sodium Bicarbonate Ringer’s Solution and Lactate Ringer’s Solution in Patients Undergoing Long-Term Abdominal Open Surgery: A Multicenter Prospe... by Zhou S, Zhao K, Liu C, Luo H, Shi J, Liu C, Li X, Gao F, Wu X, Shen Q, Yuan W, Chai X, Wei X

“…The primary outcome was the incidence of postoperative hyperlactacidemia, while secondary outcomes included serum lactate (Lac), pH, base excess (BE), buffered base (BB), bicarbonate (HCO3−), blood glucose (Glu), electrolytes, postoperative liver and kidney function, and postoperative complications. Linear regression analysis was performed to identify factors influencing lactate concentration.Results: The incidence of hyperlactic acidemia was lower in Group A compared to Group B (9.1% vs 19.3%, P = 0.177), although the difference did not reach statistical significance. …”
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ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer by Fangqi Ma, Mingming Ren, Zhongqiu Li, Yujing Tang, Xiaoyu Sun, Yi Wang, Nida Cao, Xiaohong Zhu, Yan Xu, Rui Wang, Yumiao Shen, Ruohan Zhao, Zhaoyan Li, Milad Ashrafizadeh, Gautam Sethi, Furong Wang, Aiguang Zhao

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Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac mon... by Jesus Hernandez-Hernandez, Ana Martin-Garcia, Javier Jimenez-Candil, Pedro L Sanchez, Carlos González-Juanatey, Javier García-Fernández, Alba Cruz-Galban, Olga Duran-Bobin, Javier Garcia-Seara, Teba Gonzalez-Ferrero, Jose Morinigo, Manuel Sanchez-Garcia, Gonzalo Fernandez-Palacios, Jose Seijas-Amigo, Juliana Elices, Javier Portales-Fernandez, Francisco Martin-Herrero, Ana García-Campos, Jose A Perez-Rivera, Marta Alonso-Fernandez-Gatta, Alfonso Macías, Paloma Perez-Espejo

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Mono-HOPE Versus Dual-HOPE in Liver Transplantation: A Propensity Score-Matched Evaluation of Early Graft Outcome by Dominik Thomas Koch, Dominik Thomas Koch, Micol Tamai, Malte Schirren, Malte Schirren, Moritz Drefs, Moritz Drefs, Severin Jacobi, Severin Jacobi, Christian M. Lange, Christian M. Lange, Matthias Ilmer, Matthias Ilmer, Matthias Ilmer, Hanno Nieß, Hanno Nieß, Bernhard Renz, Bernhard Renz, Jens Werner, Jens Werner, Markus Guba, Markus Guba, Dionysios Koliogiannis, Dionysios Koliogiannis

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Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway and gut m... by Lei Li, Lei Li, Lei Li, Jun Ma, Jun Ma, Zeshi Li, Zeshi Li, Juelin Chen, Jiawei Zhou, Yawei Wang, Yankun Pei, Yitong Gong, Jianyao You, Yangyang Cao, Man Wang, Jikuai Chen, Wenjun Chang, Weiyi Ma, Hanyu Zhu, Chuhan Xiang, Shuogui Xu, Qing Song, Qing Song

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Association of oral health with geriatric syndromes and clinical outcomes in hospitalized older adults by Sheau-Wen Shyu, Cheng-Fu Lin, Shu-Hui Yang, Wei-Min Chu, Chiann-Yi Hsu, Shih-Yi Lin, Ya-Hui Yeh

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Transcriptomic responses of sponge holobionts to in situ, seasonal anoxia and hypoxia by Strehlow, Brian W., Schuster, Astrid, Francis, Warren R., Eckford-Soper, Lisa, Kraft, Beate, McAllen, Rob, Nielsen, Ronni, Mandrup, Susanne, Canfield, Donald E.

“…Holobiont gene expression was species-and oxygen-level dependent, though there were some shared interspecific responses to deoxygenation. In general, few changes occurred in the expression of sponge metabolic genes as a function of oxygenation level, indicating that they may remain metabolically active under anoxia. …”
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Laparoscopically assisted versus open oesophagectomy for patients with oesophageal cancer—the Randomised Oesophagectomy: Minimally Invasive or Open (ROMIO) study: protocol for a ra... by Chris Rogers, Jane M Blazeby, Fergus Noble, Grant Sanders, Simon L Parsons, Rachael Heys, Lucy Culliford, Natalie S Blencowe, Daisy Gaunt, Andrew Hollowood, Alex Boddy, Newton Wong, Benjamin Howes, William Hollingworth, Jackie Elliott, Marcus Jepson, Peter Lamb, Rachel Melhado, Richard Krysztopik, Bilal Alkhaffaf, Tim Underwood, Paul Wilkerson, Christopher Streets, Dan Titcomb, Tim Wheatley, Arun Ariyarathenam, Jamie Kelly, Graeme Couper, Chris Deans, David Bowrey, David Exon, Paul Turner, Ram Chaparala, Khurshid Akhtar, Naheed Farooq, Nicola Rea, Sian Cousins, Alexandra Williams, Richard J E Skipworth, Joanna Nicklin, James P Byrne, Rachel C Brierley, Richard G Berrisford, Kerry N L Avery, Caoimhe T Rice, Aida Moure-Fernandez, Ravi Vohra, James A Catton, Kish Pursnani, Katy Chalmers, Robin A Wickens, Martyn Lee Humphreys, Sukhbir Ubhi, Robert Williams, Vinutha Daya Shetty, Neil T Welch, Rebecca J Houlihan, Joanne Smith, Rachel Schranz, Jill Cooke, Carolyn Hindmarsh, Sally Maitland, Christopher Paul Barham

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Topical Application of VitB6 Ameliorates PM2.5-Induced Dry Eye via NFκB Pathway in a Murine Model by Jinyu Hu, Yanmei Zeng, Liying Tang, Lei Ye, Cheng Chen, Qian Ling, Xiaoyu Wang, Liangqi He, Xu Chen, Yixin Wang, Qianmin Ge, Yi Shao

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Relationship between cognitive impairments and psychopathological symptoms in female schizophrenia subsequent to 8 weeks treatment with antipsychotic drugs by Shuzhan Gao, Qing Xu, Yanlin Han, Jing Jiang, Fan Wu, Ting Peng, Chenxi Ling, Sulin Ni, Rongrong Zhang, Yidan Ming, Xuzhen Liu, Xijia Xu

“…Psychopathological symptoms and overall cognitive functioning improved significantly (p < 0.05), with the exception of verbal learning and social cognition (p > 0.05). …”
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