Insomnia increases the risk for specific autoimmune diseases: a large-scale retrospective cohort study by Sarah Stenger, Artem Vorobyev, Katja Bieber, Tanja Lange, Ralf J. Ludwig, Ralf J. Ludwig, Jennifer E. Hundt

“…These findings underscore the necessity of recognizing and treating sleep disorders not only for general wellbeing but also as a potential strategy to mitigate the long-term risk of autoimmune disease development.…”
Get full text

Exploring the Role of Patient Preferences in Hepatocellular Carcinoma Treatment Decisions: A Qualitative Study by Andrew M. Moon, Daniel Richardson, Gabriel V. Lupu, Donna M. Evon, Hanna K. Sanoff, Jessica Carda-Auten, Randall Teal, Myra Waheed, Ethan Basch, David M. Mauro, Ted K. Yanagihara, David A. Gerber, Neil D. Shah, Oren K. Fix, Hersh Shroff, Tammy Triglianos, Jonathan D. Sorah, Jingquan Jia, Ashwin Somasundaram, Lynne I. Wagner, Michael D. Kappelman, Matthew Schooler, Julia R. Phillips, Hiwot A. Ekuban, Ariel E. Sanderford, A. Sidney Barritt

“…Providers primarily discussed the role of Barcelona Clinic Liver Cancer stage, liver function, performance status, and eligibility of liver transplantation in making treatment recommendations. …”
Get full text

Psychopersonal characteristics of women with varying degrees of menopausal disorders by N. S. Lutsenko, O. D. Mazur, O. S. Shapoval, L. I. Zvarich, N. F. Efimenko

“…Eisenko's test questionnaire, the Women's Sexual Function Index (FSFI) questionnaire, used the SF-36 (Medical Outcomes Study Short Form) general questionnaire to assess quality of life. …”
Get full text

Features of estimation of left ventricular geometry in patients with arterial hypertension by V. V. Syvolap, Ye. V. Novikov, V. A. Lysenko, A. O. Bogun

“…Echocardiography was performed on Esaote My Lab Seven (Italy) according to generally accepted rules. The distribution according to the types of left ventricular geometry was carried out in accordance with the recommendations for quantifying the structure and function of the left ventricle. …”
Get full text

Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations by Yaxin Hou, Guoheng Tang, Qizhi Wang, Meng Zhou, Ran Xu, Xuehui Chen, Guizhi Shi, Zhuoran Wang, Xiyun Yan, Jie Zhuang, Kelong Fan

Get full text

A home exercise programme is no more beneficial than advice and education for people with neurogenic claudication: results from a randomised controlled trial. by Christine Comer, Anthony C Redmond, Howard A Bird, Elizabeth M A Hensor, Philip G Conaghan

“…Secondary outcomes included measures of physical function, pain and general well-being at eight weeks and 12 months.…”
Get full text

A comprehensive investigation of Clerodendrum Infortunatum Linn. using LC-QTOF-MS/MS metabolomics as a promising anti-alzheimer candidate by Fatma Atef, Mostafa A. Abdelkawy, Basma M. Eltanany, Laura Pont, Ahmed M. Fayez, Mohamed F. Abdelhameed, Fernando Benavente, Inas Y. Younis, Asmaa M. Otify

Get full text

Are long-lasting nonspecific symptoms related to vitamin D deficiency among older adults living in nursing homes? by Rebeka Arnljots, Egill Snaebjörnsson Arnljots, Jörgen Thorn, Marie Elm, Michael Moore, Pär-Daniel Sundvall

Get full text

Silencing NEDD4L Effectively Inhibits the Malignant Behaviors of Hepatocellular Carcinoma by Dai J, Zhu T, Wan J, Liu R, Song Y, Zhang D, Wang X, Zhang H, Li W, Lin J, Zhu X, Liu Y

“…Junze Dai,1,2,* Tong Zhu,3,* Jun Wan,4,* Ruibin Liu,5 Yuxuan Song,5 Dingye Zhang,5 Xin Wang,5 Huiyu Zhang,5 Wenxin Li,2,* Jie Lin,5 Xudong Zhu,5,6 Yefu Liu2,6 1Graduate School, Dalian Medical University, Dalian, Liaoning, 116044, People’s Republic of China; 2Department of Hepatopancreatobiliary Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 3Department of Breast Surgery, Panjin Central Hospital, Panjin, 124010, People’s Republic of China; 4Second General Surgery Department, Central Hospital of Shenyang Sujiatun, Shenyang, Liaoning, 110101, People’s Republic of China; 5Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China; 6Liaoning Provincial Key Laboratory of Precision Medicine for Malignant Tumors, Shenyang, Liaoning, 110042, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xudong Zhu, Department of General Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, People’s Republic of China, Email xdzhu@cmu.edu.cn Yefu Liu, Department of Hepatopancreatobiliary Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, People’s Republic of China, Email 97902153@cmu.edu.cnBackground: NEDD4L, an E3 ubiquitin ligase, has served a pivotal function in the malignant progression of different cancers. …”
Get full text

Causes and MEchanisms foR non-atopic Asthma in Children (CAMERA) study: rationale and protocol by Mary Njoroge, Gabriela Pimentel Pinheiro, Cinthia Vila Nova Santana, Hajar Ali, Stephanie Hobbs, Santiago Mena-Bucheli, Natalia Romero-Sandoval, Steven Robertson, Charlotte E. Rutter, Donna Davoren, Collin Brooks, Jeroen Douwes, Philip J. Cooper, Harriet Mpairwe, Camila A. Figueiredo, Alvaro A. Cruz, Mauricio L. Barreto, Neil Pearce, Lucy Pembrey, the CAMERA study group

“…Phase I consists of skin prick tests to define atopy, a general CAMERA questionnaire that covers respiratory and general health to identify asthma cases, followed by an asthma control questionnaire for asthmatics only. …”
Get full text

Efficacy of Tirzepatide Dual GIP/GLP‐1 Receptor Agonist in Patients With Idiopathic Intracranial Hypertension. A Real‐World Propensity Score‐Matched Study by Ahmed Y. Azzam, Muhammed Amir Essibayi, Nathan Farkas, Mohammed A. Azab, Mahmoud M. Morsy, Osman Elamin, Adam Elswedy, Ahmed Saad Al Zomia, Hammam A. Alotaibi, Ahmed Alamoud, Oday Atallah, Hana J. Abukhadijah, Adam A. Dmytriw, Amanda Baker, Deepak Khatri, Neil Haranhalli, David J. Altschul

Get full text

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells by Mengzhen Li, Woonghee Kim, Han Jin, Hong Yang, Xiangtai Kong, Xiya Song, Hasan Turkez, Yuefeng Bi, Chengxue Pan, Ling Fu, Hongmin Liu, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu

Get full text

Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction by Hongyuan Zhang, Honglin Xu, Fangchao Zhou, Tayyiba Azam, Sultan Samman, Pablo Binder, Binh Nguyen, Elizabeth J. Cartwright, Oliver J. Müller, Susanne S. Hille, Fay Pu, Darren Green, Yanrong Liu, Min Zi, Xin Wang

Get full text

Effectiveness of remdesivir for hospitalized COVID-19 patients depending on the severity of respiratory status: a multicenter retrospective study in Japan by Hidero Yoshimoto, Kazuma Yamakawa, Yoshihiro Tanaka, Itsuki Osawa, Takashi Tagami, Akira Endo, Ryo Yamamoto, Mineji Hayakawa, Takayuki Ogura, Atsushi Hirayama, Hideo Yasunaga, Akira Takasu, Sang-Woong Lee, J-RECOVER study group

Get full text

Prediction and Mapping of Soil Total Nitrogen Using GF-5 Image Based on Machine Learning Optimization Modeling by LIU Liqi, WEI Guangyuan, ZHOU Ping

“…Fieldwork involved the careful collection of 171 soil samples, obtaining soil spectral data, chemical analysis data of soil TN content, and the GF-5 hyperspectral data. …”
Get full text

LINGUO-CULTURAL COMPETENCE AND ITS ROLE IN PROFESSIONAL FORMATION OF FUTURE SPECIALISTS OF EDUCATIONAL INSTITUTIONS by Inna D. Davydchenko

“…Methods of linguocultural competence: a diachronic method based on a comparative analysis of various linguocultural units in time; synchronous method, compares simultaneously existing linguocultural units; structural and functional method, which involves the distribution of a cultural object into parts and the identification of connections between parts; a historical and genetic method focused on the study of a linguoculturological fact from the point of view of its occurrence, the development of further destiny; a typological method designed to identify the typological proximity of various linguoculturological units of the historical and cultural process; the comparative-historical method is based on the comparison of original linguoculturological units in time and insight into their essence. …”
Get full text

Aldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression by Shau-Hsuan Li, Wan-Ting Huang, Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Hsin-Ting Tsai, Chang-Han Chen

Get full text

Прийоми реновації замкових комплексів та їх пристосування під сучасне використання на прикладі замку Свірж... by Sergiy Buravchenko, Oleksandr Pivovarov, Oleksandr Khlyupin, Iryna Shashkova

“…The article uses traditional scientific methods of comparative analysis, generalization of positive experience and the method of system-structural analysis. …”
Get full text

Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study by Yi-Guang Wang, Chih-Chung Huang, Ta-Chuan Yeh, Wan-Ting Chen, Wei-Chou Chang, Ajeet B. Singh, Chin-Bin Yeh, Yi-Jen Hung, Kuo-Sheng Hung, Hsin-An Chang

Get full text

RESULTS OF COMPREHENSIVE STUDIES OF THE UNDERGROUND HYDROSPHERE WITHIN THE WESTERN SHOULDER OF THE BAIKAL RIFT (AS EXEMPLIFIED BY THE BAYANDAI – KRESTOVSKY CAPE SITE) by Konstantin Zh. Seminsky, Marina A. Tugarina

“…With the detail data on the Bayandai – Krestovsky Cape site, the above conclusions are more precisely determined, and it is generally concluded that the structural tectonic factor controls the hydrogeology of the region.The analysis of mineralization, composition, temperature and other characteristics of the underground waters (Fig. 3–6) show that at the low hierarchic level the NW boundary of the Obruchev interblock zone performs a function of a distinct hydrogeological barrier which represents the marginal suture of the Siberian platform. …”
Get full text