Obesity and risk of death or dialysis in younger and older patients on specialized pre-dialysis care. by Ellen K Hoogeveen, Kenneth J Rothman, Pauline W M Voskamp, Renée de Mutsert, Nynke Halbesma, Friedo W Dekker, PREPARE-2 Study Group

“…<h4>Background</h4>Obesity is associated with increased mortality and accelerated decline in kidney function in the general population. Little is known about the effect of obesity in younger and older pre-dialysis patients. …”
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DIDACTIC POTENTIAL OF MOBILE APPLICATIONS FOR LEARNING ENGLISH AS A FOREIGN LANGUAGE by Blynova Neliia, Kyrylova Oksana, Dolzhenko Maryna

“…Research methods: the analysis of sources on the topic of research made it possible to understand the state of development of the topic, the main directions of domestic and foreign research on mobile learning; descriptive provided an opportunity to generalize the experience gained during reconnaissance; synthesis of the obtained data contributed to the conclusion of the research concept and its implementation. …”
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Bilateral Streak Ovaries in a Patient with Isochromosome Xq: A Case Report of a Turner Syndrome Variant by Hartanto AI, Anwar R, Ismail M, Asmara EC, Adriansyah PNA

“…One structural variant, isochromosome Xq [46,X,i(Xq)], results in duplication of the long arm and loss of the short arm of the X chromosome (Xp), which contains genes essential for normal ovarian development and function. This chromosomal imbalance leads to accelerated germ cell apoptosis and subsequent ovarian dysfunction. …”
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The role of UBR2 in triple-negative breast cancer and its implications for immune checkpoint blockade therapy by Yanlin Jiang, Yi Fu, Xinyan Song, Yongjie Xie, Xiaobin Shang, Xi Liang

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Experience of using gene replacement therapy with Zolgensma® (onasemnogene abeparvovec) in real clinical practice in Russia by S. B. Artemyeva, Yu. O. Papina, O. A. Shidlovskaya, A. V. Monakhova, D. V. Vlodavets

“…The drug tolerance was assessed and the analysis of side effects after drug administration was based on the criteria for adverse events (General criteria Adverse Event Terminology (CTCAE) v. 5.0) Patient motor function was assessed prior to treatment initiation and every 3–6 months after therapy using the Philadelphia Pediatric Hospital’s CHOP INTEND scale, total motor development based on Hammersmith Hospital Neurological Assessment Scale in Young Children, Part 2 (HINE-2), and the acquisition of new motor skills.Results. 41 children aged 5 to 47 months (weighing no more than 21 kg) received therapy with onasemnogene abeparvovec in the period from April 2020 to December 2021. …”
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Exploring district implementation of national guidelines and maintenance of essential health services during the COVID-19 pandemic in Uganda by Fredrick E Makumbi, Freddie Ssengooba, Charles Olaro, Dorit Talia Stein, Adrian Ssessanga, Jesca Nsungwa Sabiiti, Betty Kyaddondo, Catherine Mbabazi

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Women-specific reference ranges for serum TSH in Liguria: the impact of age and year of collection in a single-center cross-sectional study by Massimo Giusti, Marilena Sidoti

“…Abstract Background TSH is the first-line test of thyroid function, and the normal TSH references provided by manufacturers are generally used in diagnoses. …”
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Clinical and endoscopical and morphofunctional scores in evaluation of development of gastroesophageal reflux disease in various age groups by M. A. Osadchuk, A. M. Zolotovitskaya, N. V. Kireyeva, S. N. Nikolenko, I. M. Kvetnoy

“…To develop diagnostic and prognostic criteria of gastroesophageal reflux disease (GERD) at patients of various age groups on the basis of analysis of clinical and endoscopical, functional and morphological data.Material and methods. …”
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Optimal number of the examined lymph nodes for different N stages in colorectal cancer by Ye Tian, Xinyu Qiao, Gaozan Zheng, Hanjun Dan, Xinyu Dou, Guangming Ren, Liaoran Niu, Pengfei Wang, Siyuan Wang, Fengsu Wu, Yumao Yang, Jianyong Zheng, Fan Feng

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Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy re... by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu, Qi Hou

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Study of unusable liquid propellant residues evaporation processes parameters in the tanks of launch vehicle worked-off stage in microgravity by V. I. Trushlyakov, V. A. Urbansky

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Subclinical Aortic Root Pathology in Close Relatives of Patients with Bicuspid Aortic Valve by Ivaniv Y., Lozynska N., Ivaniv I.

“…So, the aortic root in FDRs of patients with BAV is wider and demonstrates functional abnormality with potential pathological meaning in a future.…”
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Patient Reported Outcomes from an Open Label, Multi-Center, Retrospective Study of a Biodegradable Graft for Soft Tissue Reconstruction in Patients Suffering from Chronic Lateral A... by Bryan G. Vopat MD, Ryan Scott DPM

“…Patient demographics, patient reported outcomes (PROs), safety, and complications were collected. PROs included Foot Function Index (FFI), Foot and Ankle Ability Measure (FAAM), visual analog pain score (VAS), and Veterans Rand-12 (VR-12) at 2-, 6-, 12-weeks, 6-months and 1- and 2-year follow-up visits. …”
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Overexpression of ST8Sia1 inhibits tumor progression by TGF-β1 signaling in rectal adenocarcinoma and promotes the tumoricidal effects of CD8+ T cells by granzyme B and perforin by Chang Zhang, Yeli Wang, Yao Yu, Yanchao Pang, Xiao Xiao, Leilei Hao

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A study on land use change simulation based on PLUS model and the U-net structure: A case study of Jilin Province by Jiafu Liu, Xiangli Kong, Yue Zhu, Baihao Zhang

“…It is more sensitive to short-term land use changes, but its generalization ability is constrained by sample size and balance. …”
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Remodelling Features of Heart and Postinfarction Cardiosclerosis Type 2 Diabetes: Relationship to Gene Polymorphisms LEPR Q223R by Stanislavchuk M. A., Al Salim A.

“…Echocardiographic studies were performed in M­, B­ and D­mode on the ″Logic 500 Sono Series″ (General Electric, Korea). Results and discussion. …”
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MiR‐766‐3p Inhibit the Proliferation, Stemness, and Cell Cycle of Pancreatic Cancer Cells Through the MAPK/ERK Signaling Pathway by Zhipeng Quan, Ziwei Yin, Yuelin Huang, Xuemei Huang, Hao Huang, Qingrong Mo, Jianhua Gong, Lingyun Liu, Yi Zhou, Yaqun Yu

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Genetic screening of tuberous sclerosis complex in Sicily with a focus on neurological manifestations by Andrea Domenico Praticò, Claudia Di Napoli, Stefania Salafia, Edoardo Dammino, Maria Piccione, Francesco Calì, Renato Scifo, Michele Vecchio, Andrea Zonta, Maria Bonsignore, Maurizio Elia, Manuela Lo Bianco, Agata Polizzi, Martino Ruggieri

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Molecular determinants of substrate specificity in the efflux pump CraA from Acinetobacter baumannii by Wuen Ee Foong, Xinxin Xiang, Klaas M. Pos, Heng-Keat Tam

“…Furthermore, we show that the aromaticity of Y42 is crucial for phenicol recognition, while general hydrophobicity at this position is critical for mitomycin C specificity. …”
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Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload by Yunxia Zhang, Qiqian Wu, Furong Bai, Yanqin Hu, Bufang Xu, Yujie Tang, Jingwen Wu

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