Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation by Sujan Devkota, Masato Maesako, Michael S. Wolfe

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FEATURES OF DIAGNOSTICS AND TREATMENT OF IMPACTED TEETH (A LITERATURE REVIEW) by P.S. Flis, L.O. Brodetska

“…The presence of impacted teeth requires a thorough diagnostics and a balanced approach to the choice of treatment method; the latter depends on the clinical situation, the patient’s age and general somatic status. With the right choice of treatment method, the success of restoring the integrity of the dental arch, aesthetics and function is significant. …”
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Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review by César Galván, Rafael Durán, Cristian Matos, Cristiana Indolfi, Angela Klain

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On the Structure of Rationality in the Thought and Invention or Creation of Physical Theories by Michel Paty

“…However, the analysis of scientific thought through its inventive and creative processes leads to characterize this thought as a type of rational form whose configurations can be detailed rather precisely. …”
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Effects of an exercise intervention based on the COM-B model among community-dwelling prefrail older adults with diabetes: study protocol for a randomised controlled trial by Yang Zhao, Lu Chen, Ting-Ting Wang, Jun Yang, Ju Qiu, Wen-Xin Wang, Ling-Na Kong

“…Participants in the intervention group will receive a 16-week multicomponent exercise intervention based on the COM-B model, while those in the control group will receive usual diabetes care and general advice on physical activity. The primary outcome is frailty status, and the secondary outcomes include physical function, quality of life, depressive symptoms, self-efficacy for exercise and fasting blood glucose. …”
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Acute kidney injury and outcomes in hospitalized children with autoimmune rheumatic disease by Chien-Hung Lin, Wen-Sheng Liu, Chuan Wan, Hsin-Hui Wang

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The status of a woman in the ancient world: features of marital and family relations in Ancient Athens by I. A. Lohvynenko, Ye. S. Lohvynenko

“…Relevant generalizations and conclusions were made stating that the status of women of different social groups differed, but they were united by the general degrading treatment of men and the absence of any civil and property rights. …”
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Laparoscopic-enhanced recovery after surgery protocol for incarcerated inguinal hernia: a paradigm shift toward precision emergency herniology by Xinqiang Zhu, Siwei Shan, Jianwei Zhang

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The clinical application of mitoxantrone hydrochloride tracing in endoscopic radical resection of thyroid carcinoma by Xiaozhou Cheng, Lijun Chen, Honggang Zang, Yaping Li

“…A retrospective analysis was conducted on 82 patients with primary papillary thyroid carcinoma (PTC) who were treated at the Department of General Surgery, Gansu Provincial People’s Hospital, from May, 2022 to May, 2024. …”
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THE ROLE OF OPERATIONAL UNITS OF THE NATIONAL POLICE IN PREVENTING CYBERCRIME IN THE CONTEXT OF ECONOMIC GLOBALISATION AND EXISTENTIAL CHALLENGES by Viacheslav Davydenko, Anna Kavunska, Viacheslav Barba

“…From the standpoint of a company's economic security, measures to prevent cybercrime are crucial, due to both local and global economic factors. The analysis of cybercrime legislation enabled the identification of measures of general and special competence taken by the operational units of the National Police. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Similarly, while there was no significant difference in response (QIDS-SR reduction from baseline > 50%) and remission (QIDS-SR score ≤ 5) at 12 weeks, there was an advantage of pramipexole for response (46% vs. 6%; p = 0.026) and remission (31% vs. 0%; p = 0.030) rates at exit from the trial. Secondary analysis indicated significant improvements in psychosocial function at 36 and 48 weeks. …”
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Determining the Bioavailability Percentage of Bone Ash Phosphorus Compared to Monocalcium Phosphate and Its Effect on Performance, Bone Quality and Phosphorus Digestibility in Broi... by Mohammad Sedghi, Zahra Sarrami, Raziye Ghasemi, Mahdi Zanghae

“…Phosphorus plays a vital role in muscle function, enzyme activity, lipid metabolism, bone mineralization, maintaining osmotic and acid-base balance, energy metabolism, amino acid metabolism, and protein synthesis. …”
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Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model by Chaoyue Ding, Yuqing Sun, Kunchi Li, Sangma Xie, Hao Yan, Peng Li, Jun Yan, Jun Chen, Huiling Wang, Huaning Wang, Yunchun Chen, Yongfeng Yang, Luxian Lv, Hongxing Zhang, Lin Lu, Dai Zhang, Yaojing Chen, Zhanjun Zhang, Tianzi Jiang, Bing Liu

“…Abstract Neurodynamic models that simulate how micro-level alterations propagate upward to impact macroscopic neural circuits and overall brain function may offer valuable insights into the pathological mechanisms of schizophrenia (SCZ). …”
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The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis by Yuanyuan Liu, Jian Li, Chenhui Wang, Jiangbo Li, Kai Luo, Kang Tao, Yuan Tian, Xiang Song, Zhifang Zhai, Yuandong Tao, Jia You, Lihua Wu, Wenqian Li, Yuanyuan Jiao, Rongya Yang, Mingwang Zhang

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CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype by Binle Tian, Zhilong Wang, Mei Cao, Na Wang, Xuebing Jia, Yuanyuan Zhang, Jingyi Zhou, Sijia Liu, Wen Zhang, Xiao Dong, Zheng Li, Junli Xue, JianFei Wang, Guo-Huang Fan, Qi Li

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Designing a Business Model in the Tourism Industry of Iran by Amirhossein Samadian, Saeid Ehdaie, kamyar Raissifar

“…The key resources component describes the most important assets required for the business model to function properly. Key activities describe the most important tasks required for the business model to function properly. …”
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Construction of a circRNA-miRNA-mRNA Regulatory Network for the Immune Regulation of Lung Adenocarcinoma by Hanyi Li, Xin Jin, Wei Li, Fan Ren, Tong Li, Xuanguang Li, Haochuan Yu, Dianxun Fu, Zuoqing Song, Song Xu

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Promotion of the invasion and metastasis of breast cancer by B7-H3 through CCR5High tumor-associated macrophages by Tiantian Dai, Zhihua Xu, Yadi Li, Mengni Wu, Yue Qiu, ZhuJun Chao, Renhai Jiang, Yan Chen, Linlin Lu

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Construction and validation of a risk prediction model for postoperative frailty in older adults:a multicenter study by Shilong Lu, Hao Liang, Jiamin Fang, Rui Chen, Huilian Liao, Mingming Xu, Yumei Chen, Huijin Sun, Lijuan Dong, Yingui Guo, Zhixia Jiang, Hui Xiao, Lin Wei

“…Model performance was assessed through calibration curves, the area under the ROC curve (AUC), and decision curve analysis (DCA). Results The final model included the following variables: American Society of Anesthesiologists (ASA) grade, intraoperative blood loss, economic income, caregiver status, sedentary behavior, cognitive function, Activities of Daily Living (ADL), postoperative hemoglobin (Hb) level, and postoperative ICU admission. …”
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Association between sleep quality and mild cognitive impairment in Chinese patients with type 2 diabetes mellitus: a cross-sectional study by Rehanguli Maimaitituerxun, Hengxue Wang, Wenhang Chen, Jingsha Xiang, Yu Xie, Fang Xiao, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Songning Ding, Wenjie Dai

“…Abstract Background Globally, the number of individuals with type 2 diabetes mellitus (T2DM) is increasing, and they are at a higher risk of developing mild cognitive impairment (MCI) than the general population. Sleep quality is thought to be a modifiable factor that may contribute to MCI, as previous studies have linked it to cognitive function in older adults. …”
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