Durability of benralizumab effectiveness in severe eosinophilic asthma patients with and without chronic rhinosinusitis with nasal polyps: a post hoc analysis from the ANANKE study by Luisa Brussino, Maria Aliani, Elena Altieri, Pietro Bracciale, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Giorgio Walter Canonica, Cristiano Caruso, Cristiano Caruso, Stefano Centanni, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Laura Malerba, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Jan Walter Schroeder, Gianenrico Senna, Alessandra Vultaggio, Maria D’Amato

Get full text

Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity by Markus Engelmann, Markus Engelmann, Juliane Götze, Juliane Götze, Philipp Baumbach, Philipp Baumbach, Charles Neu, Charles Neu, Utz Settmacher, Michael Ardelt, Hermann Kissler, Sina M. Coldewey, Sina M. Coldewey

Get full text

Efficacy of argatroban plus alteplase according to time from onset to thrombolysis in acute ischemic stroke: a prespecified post-hoc analysis of the ARAIS trial by Yu Cui, Er-Qiang Wang, Yi-Han Wang, Hui-Sheng Chen

Get full text

Integrated analysis of myeloperoxidase in gastric health and cancer: associations with pepsinogen levels, immune regulation, and prognosis in a large healthy population-based and T... by Junteng Zhou, Qihang Kong, Xiaojing Liu, Xiaojing Liu, Yan Huang, Yan Huang, Yan Huang, Yan Huang

Get full text

Pyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approach... by Tathagat Banerjee, Prachi Chhabra, Manoj Kumar, Abhay Kumar, Kumar Abhishek, Mohd. Asif Shah

“…Abstract Brain tumors are a significant challenge to human health as they impair the proper functioning of the brain and the general quality of life, thus requiring clinical intervention through early and accurate diagnosis. …”
Get full text

Dynamic association of serum albumin changes with inflammation, nutritional status and clinical outcomes: a secondary analysis of a large prospective observational cohort study by Yonghao Li, Liru Chen, Xin Yang, Hongyuan Cui, Zijian Li, Wei Chen, Hanping Shi, Mingwei Zhu

Get full text

Development of a breast cancer invasion score to predict tumor aggressiveness and prognosis via PI3K/AKT/mTOR pathway analysis by Xiujuan Li, Ya Zhang, Jianping Gong, Wenjia Liu, Hanchen Zhao, Wei Xue, Zhaojun Ren, Jun Bao, Ziao Lin

Get full text

Association of ambient sulfur dioxide with stroke incidence among residents of Shanghai: a time-series analysis of incidence registration and monitoring data from 2017 to 2021 by Yuzhuo WANG, Xuena LA, Mengyin WU, Yingquan WANG, Danni LIU, Qundi YANG, Yang ZHENG, Yan SHI

“…Daily mean concentrations of atmospheric pollutants-including SO2, nitrogen dioxide (NO2), ozone (O3), particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5), and particulate matter with an aerodynamic diameter < 10 μm (PM10), as well as meteorological factors such as daily average temperature and relative humidity, were obtained from the national air pollution monitoring stations of the Ministry of Ecology and Environment during the same period. A generalized additive model with a quasi-Poisson distribution link function was used to analyze the time-series relationship between atmospheric SO2 concentration and the daily number of stroke cases. …”
Get full text

Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the <i>BCR-ABL</i> Gene: An Hierarchical Biochemoinformatics Analysis by Vitor H. da S. Sanches, Cleison C. Lobato, Luciane B. Silva, Igor V. F. dos Santos, Elcimar de S. Barros, Alexandre de A. Maciel, Elenilze F. B. Ferreira, Kauê S. da Costa, José M. Espejo-Román, Joaquín M. C. Rosa, Njogu M. Kimani, Cleydson B. R. Santos

“…This stability is a positive indicator that LMQC01 and LMQC04 can potentially inhibit enzyme function. Synthetic accessibility (SA) analysis performed on the AMBIT and SwissADME webservers showed that LMQC01 and LMQC04 can be considered easy to synthesize. …”
Get full text

Efficacy and safety of volar locking plate versus cast immobilization for distal radius fractures: a systematic review and meta-analysis of randomized controlled trials by Faxiang Li, Yuzhong Tan, Liuchao Cui, Lin Tian

“…Overall complications did not significantly differ. Subgroup analysis in patients < 60 years generally supported these findings, while in patients ≥ 60 years, radiological outcomes aligned, yet only lower DASH scores were observed with VLPs at 3 months (p < 0.001). …”
Get full text

Liver tissue fragments obtained from males are the most promising source of human hepatocytes for cell-based therapies - Flow cytometric analysis of albumin expression. by Karolina Ewa Zakrzewska, Anna Samluk, Agnieszka Wencel, Krzysztof Dudek, Dorota Genowefa Pijanowska, Krzysztof Dariusz Pluta

“…Cell-based therapies that could provide an alternative treatment for the end-stage liver disease require an adequate source of functional hepatocytes. There is little scientific evidence for the influence of patient's age, sex, and chemotherapy on the cell isolation efficiency and metabolic activity of the harvested hepatocytes. …”
Get full text

Identification of key genes regulating brown adipose tissue thermogenesis in goat kids (Capra hircus) by using weighted gene co-expression network analysis by Minhao Li, Qingjun Zhu, Haili Yang, Yunyi Hu, Le Zhao, Yongju Zhao

“…By combining the gene co-expression network analysis of the turquoise module genes and the differentially expression genes (DEG) analysis, we identified 5 candidate key genes (ACO2, MRPS27, IMMT, MRPL12, and TUFM) involved in regulation of perirenal adipose tissue thermogenesis. …”
Get full text

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases by Sarah L. Stenton, Kristen Laricchia, Nicole J. Lake, Sushma Chaluvadi, Vijay Ganesh, Stephanie DiTroia, Ikeoluwa Osei-Owusu, Lynn Pais, Emily O’Heir, Christina Austin-Tse, Melanie O’Leary, Mayada Abu Shanap, Chelsea Barrows, Seth Berger, Carsten G. Bönnemann, Kinga M. Bujakowska, Dean R. Campagna, Alison G. Compton, Sandra Donkervoort, Mark D. Fleming, Lyndon Gallacher, Joseph G. Gleeson, Goknur Haliloglu, Eric A. Pierce, Emily M. Place, Vijay G. Sankaran, Akiko Shimamura, Zornitza Stark, Tiong Yang Tan, David R. Thorburn, Susan M. White, Maha S. Zaki, Eric Vilain, Monkol Lek, Heidi L. Rehm, Anne O’Donnell-Luria

Get full text

Analysis of SMN protein in umbilical cord blood and postnatal peripheral blood of neonates with SMA: a rationale for prompt treatment initiation to prevent SMA development by Noriko Otsuki, Tamaki Kato, Mamoru Yokomura, Mari Urano, Mari Matsuo, Emiko Kobayashi, Kazuhiro Haginoya, Hiroyuki Awano, Yasuhiro Takeshima, Toshio Saito, Kayoko Saito

Get full text

Site Selection Analysis and Prediction of New Retail Stores from an Urban Commercial Space Perspective: A Case Study of Luckin Coffee and Starbucks in Shanghai by Zhengxu Zhao, Gang Chen, Jianshu Duan, Youheng Xu

“…This study divides the research area into 100 m × 100 m grids and employs a random forest model and related interpretability methods to conduct an empirical analysis of the site selection and influencing factors of Luckin Coffee and Starbucks stores in Shanghai. …”
Get full text

The contribution of antimicrobials and antimicrobial resistance to climate change and a possible way to reverse it whilst still offering high quality healthcare—a conceptual analys... by Jeanette Sams-Dodd, Frank Sams-Dodd

“…Microbes created an atmosphere on Earth that supports eukaryotic life-forms and are essential for our normal physiological functions. However, despite their critical importance, microbes are mostly associated with infectious diseases, and antimicrobials are extensively used to eradicate them. …”
Get full text

Aplicação da lógica fuzzy na análise sensorial de pão de forma enriquecido Fuzzy logic application in sensory analysis of enriched loaf by Mônica T. Cavalcanti, Flávio L. H. da Silva, José H. F. Cavalcanti, Eliane R. Florentino, Isanna M. Florêncio, Ricardo T. Moreira

Get full text

Integrated Genome-Wide Analysis of Gene Expression and DNA Copy Number Variations Highlights Stem Cell-Related Pathways in Small Cell Esophageal Carcinoma by Di Liu, Xinyan Xu, Junmiao Wen, Liyi Xie, Junhua Zhang, Yuxin Shen, Guoliang Jiang, Jiayan Chen, Min Fan

“…Gene enrichments in addition to functional annotation and gene interaction networks were performed using DAVID 6.8 and STRING 10.0, respectively. …”
Get full text

Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma by Fanyan Ou, Yi Pan, Qiuli Chen, Lixiong Zeng, Kanglai Wei, Delin Liu, Qian Guo, Liquan Zhou, Jie Yang

Get full text

Secular trends in physical fitness and cardiovascular risks among Chinese college students: an analysis of five successive national surveys between 2000 and 2019Research in context by Shan Cai, Yihang Zhang, Ziyue Chen, Yunfei Liu, Jiajia Dang, Jiaxin Li, Tianyu Huang, Ziyue Sun, Yanhui Dong, Jun Ma, Yi Song

Get full text