Who gets referred for knee or hip replacement? A theoretical model of the potential impact of evidence-based referral thresholds using data from a retrospective review of clinic re... by Andrew J Price, Andrew Judge, Alastair Gray, Rachael Gooberman-Hill, David Beard, Adrian Sayers, Rob Middleton, Stephanie Smith, Karen L Barker, David Murray, Sujin Kang, Elena Benedetto, James Smith, Ray Fitzpatrick, Helen A Dakin, Peter Eibich, Nigel Arden, Andy Carr, Kristina Harris, Elizabeth Gibbons, Jill Dawson, Laura Miller, Elsa Marques, Ashley Blom

“…Objectives To estimate the relationship between patient characteristics and referral decisions made by musculoskeletal hubs, and to assess the possible impact of an evidence-based referral tool.Design Retrospective analysis of medical records and decision tree model evaluating policy changes using local and national data.Setting One musculoskeletal interface clinic (hub) in England.Participants 922 adults aged ≥50 years referred by general practitioners with symptoms of knee or hip osteoarthritis.Interventions We assessed the current frequency and determinants of referrals from one hub and the change in referrals that would occur at this centre and nationally if evidence-based thresholds for referral (Oxford Knee and Hip Scores, OKS/OHS) were introduced.Main outcome measure OKS/OHS, referrals for surgical assessment, referrals for arthroplasty, costs and quality-adjusted life years.Results Of 110 patients with knee symptoms attending face-to-face hub consultations, 49 (45%) were referred for surgical assessment; the mean OKS for these 49 patients was 18 (range: 1–41). …”
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Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial by Patrick Stone, Ollie Minton, Alison Richardson, Peter Buckle, Zinat E Enayat, Louise Marston, Nick Freemantle

“…Primary outcome Fatigue at 6 (± 2) weeks measured using the Functional Assessment of Chronic Illness Therapy – Fatigue Scale score. …”
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Implementation and effectiveness of a nurse-enabled, shared-care follow-up model for early breast cancer survivors (The IBIS-Survivorship Study): protocol for a stepped-wedge clust... by Karla Hemming, Jane Turner, Meinir Krishnasamy, Nicolas H Hart, Patsy Yates, Helen Skerman, Elizabeth Eakin, Jon Emery, Jane Mahony, Kerry Patford, Bogda Koczwara, Fiona Crawford-Williams, Caroline Kristunas, Raymond J Chan, G Bruce Mann, Mary Azer, Louisa G Collins, Jasotha Sanmugarajah, Bethany Crowe, Gillian Blanchard, Laura Healey, Rhea Liang, Paul Craft, Amy Shorthouse, Ruth McCaffery

“…Health-related quality of life at 12 months assessed by the Functional Assessment of Cancer Therapy - Breast Cancer questionnaire will be the primary endpoint, along with a range of patient-reported outcomes, safety indicators and cost-effectiveness measures as secondary endpoints. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Secondary outcomes included patient self-reported measures of BMI and eating psychopathology, visual analogue scale measuring motivation and ability to recover; psychosocial functioning (assessed using the Work and Social Adjustment Scale). …”
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Influence of drainage retinotomy on anatomical and visual outcomes of pars plana vitrectomy for primary rhegmatogenous retinal detachment by Andrew Davies, Imran Khan, David Yorston, David H Steel, Jonathan Smith, Assad Jalil, Timothy Cochrane, Heinrich Heimann, Carl Groenewald, Roxane Hillier, Mariantonia Ferrara, Tsveta Ivanova, Teresa Sandinha, Abdallah A Ellabban, David H W Steel, Craig Goldsmith, G Anthony, Jonathan Park, Aman Chandra, Huw Jenkins, Sonali Tarafdar, Vaughan Tanner, James Paget, George Moussa, Stephen Winder, Nikolaos Tzoumas, Andrew H.C Morris, Angelina Meireles, Assad Jalil Casswell, Atiq Babar, David Alistair H Laidlaw, Deepak Vayalambrone, Diego Sanchez-Chicharro, Edward H Hughes, Edward N Herbert, Enslin Uys, Ian A. Pearce, Ibrahim Masri, Izabela Mitrut, J Julio, Rumana N Hussain, Sandro Di Simplicio Cherubini, Shi Z. Tan, Tom H. Williamson, Vasileios T Papastavrou

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Targeting GPR84 to alleviate acute immune-mediated liver injury by Yanan Zheng, Yumeng Wang, Yujie Xu, Shanshan Shen, Haozhe Xu, Chao Hu, Yongzhen Chen, Fengmeng Teng, Jinshun Pan, Shuqian Zheng, Junqi Wang, Zhongping Su, Qiang You

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Beyond access: assessing WASH service delivery models in healthcare facilities of North Mecha, Dera, and Farta, Ethiopia by Abireham Misganaw Ayalew

“…Hygiene services were made accessible through both fixed and mobile handwashing devices; however, many of these devices were non-functional during our visit. All HCFs implemented a three-bin waste collection system, with disposal methods involving incinerators and secured dump pits. …”
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Formulasi dan Uji Aktivitas Krim Pengkelat Merkuri Berbahan Dasar Ekstrak Etanol Alga Coklat (Sargassum sp.) by Inda Putrinesia, Yoga Pratama, Nurul Asyikin, Winda Rahmalia

“…The FTIR spectrum shows that ethanol extract of brown algae was dominated by glutathione functional group. The best cream formulation was composed by 0,035% (w/v) brown algae, formed as a creamy gel that was thick and odorless and had a texture like soft facial cream in general with slightly oily.The cream was homogeneous and stable until the 21st day of the experiment with pH = 5. …”
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Peat oxic and anoxic controls of <i>Sphagnum</i> decomposition rates in the Holocene Peatland Model decomposition module estimated from litterbag data by H. Teickner, H. Teickner, E. Pebesma, K.-H. Knorr

“…This discrepancy may be caused by ignoring the effects of water table fluctuations on aerobic and anaerobic decomposition rates. Moreover, our analysis suggests that maximum possible decomposition rates of individual species (<span class="inline-formula"><i>k</i>_0,<i>i</i></span>) vary more than suggested by the standard parameter values of the HPM plant functional types. …”
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High Genetic Diversity Among <i>Bacillus cereus</i> Isolates Contaminating Donated Milk at a Canadian Human Milk Bank by Mathew Gene, Jennifer L. Guthrie, Kevin Li, Sarah Teatero, Aimee Paterson, Angel Li, Alain Doyen, Deborah Yamamura, Sarah Khan, Jocelyn A. Srigley, Debbie Stone, Deborah L. O’Connor, Susan Poutanen, Sharon Unger, Allison McGeer, Nahuel Fittipaldi

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Prognostic value of global plaque volume calculated from the 3D reconstruction of the coronary tree in patients without significant coronary artery disease. A multicenter study by Carlos Cortés, Julio Ruiz-Ruiz, Fernando Rivero, Ramón López-Palop, Octavio Jiménez, Alfonso Freites, Luis R. Gonçalves-Ramírez, María Rosario Ortas Nadal, Sara Blasco, Mario García-Gómez, Clara Fernández, Luca Scorpiglione, J. Alberto San Román Calvar, Ignacio J. Amat-Santos

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Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…The primary objective of this study is to provide comprehensive analysis of nitrifying bacteria in mangrove sediments by conducting a systematic review. …”
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Novel pyrochlores in the Bi2O3–MgO–Ta2O5 (BMT) system: Synthesis optimisation, phase equilibria and dielectric properties by K.B. Tan, P.Y. Tan, Y. Feng, C.C. Khaw, V. Raman, H.C. Ananda Murthy, R. Balachandran, S.K. Chen, O.J. Lee, K.Y. Chan, D. Zhou, M. Lu

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Treatment decision-making and care among older adults with kidney failure: protocol for a multicentre, prospective observational cohort study with nested substudies and linked qual... by Martin Gallagher, Vasi Naganathan, Gian Luca Di Tanna, Celine Foote, Angela Makris, Chris Gianacas, Nicholas A Gray, Isaac Yeboah Addo, Amanda Siriwardana, Chenlei Kelly Li, Kenneth Yong, Yachna Mehta, Jannel Ramos, Sarah Roxburgh

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The Influence of Zero‐Profile Implant Selection on the Outcomes of Anterior Cervical Discectomy and Fusion by Xing‐Jin Wang, Jun‐Bo He, Ting‐Kui Wu, Bei‐Yu Wang, Xin Rong, Quan Gong, Hao Liu

“…In addition, radiographical analysis encompassed cervical lordosis (CL), functional spinal unit (FSU) angle, range of motion (ROM) of the total cervical spine and the FSU, anterior and posterior FSU height, C1–C7 sagittal vertical axis (SVA), C2–C7 SVA, the center of gravity of the head (CGH)‐C7 SVA as well as T1 slope (T1S) measurements. …”
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Incidence, causes and prognostic outcomes of acute coma: a nationwide population-based retrospective cohort study in Taiwan by Chih-Ching Liu, Chih-Yuan Lin, Yue-Chune Lee, Jen-Feng Liang, Mingche Tsai, Meng-Ling Chang

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Barriers to and facilitators of clinician acceptance and use of artificial intelligence in healthcare settings: a scoping review by Alex Federman, Yufei Wang, Jalayne J Arias, Catherine E A Scipion, Margaret A Manchester

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Genetic association of the kynurenine pathway to suicidal behavior by Rabah Tamimou, Christine Montout, Thibault Mura, Ismael Conejero, Alexandre Evrard, Philippe Courtet, Pablo Bonilla-Escribano, Carlos Riaza, Concepción Vaquero-Lorenzo, Enrique Baca-Garcia, Fabrice Jollant, Serge Lumbroso, Kevin Mouzat, Jorge Lopez-Castroman

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Comparison of clinical efficacy between Percutaneous Endoscopic Large channels nerve decompression through Translaminar approach and Percutaneous Endoscopy Conventional channels ne... by Junlin Liu, Qingquan Kong, Junsong Ma, Pin Feng, Bin Zhang

“…There was no statistically significant difference in functional scores between the two groups at each follow-up time point (p > 0.05). …”
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