The dynamics of the cognitive and social functioning of patients with Alzheimer’s disease on therapy with antidementiv drugs: the results of observational study by N. M. Zalutskaya, I. A. Beltceva, N. G. Neznanov

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Exploring the Pleiotropy of PCSK9: A Wide Range of Influences from Lipid Regulation to Extrahepatic Function by Wang H, Tang G, Wu J, Qin X

“…The purpose of this review is to systematically explore the pleiotropy of PCSK9, extending from its important role in lipid regulation to its extensive effects in extrahepatic tissues, and to reveal its potential role in cardiovascular health, nervous system function, and tumor biology. By integrating the latest research findings, this paper summarizes the complex mechanisms of action of PCSK9 in different biological processes and explores its potential and challenges as a therapeutic target.Keywords: PCSK9, pleiotropy, blood lipid regulation, extrahepatic function…”
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Protocol to derive postganglionic parasympathetic neurons using human pluripotent stem cells for electrophysiological and functional assessment by Christina James, Hsueh-Fu Wu, Jennifer Art, Archie Patel, Nadja Zeltner

“…We then detail procedures for functional assays via multielectrode array (MEA) analysis.For complete details on the use and execution of this protocol, please refer to Wu et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Functionalized Boron Carbide Nanoparticles as Active Boron Delivery Agents Dedicated to Boron Neutron Capture Therapy by Rudawska A, Szermer-Olearnik B, Szczygieł A, Mierzejewska J, Węgierek-Ciura K, Żeliszewska P, Kozień D, Chaszczewska-Markowska M, Adamczyk Z, Rusiniak P, Wątor K, Rapak A, Pędzich Z, Pajtasz-Piasecka E

“…Keywords: boron carbide, nanoparticles, targeted functionalization, anticancer therapy, BNCT…”
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Analysis of the Dbzh Reflectivity of a Radar and the Precipitation in Bogota Using Functional Statistics and Data Mining Techniques by Angel Villabona-Ortiz, Rodrigo Ortega-Toro, Yessica Ramirez-Yara

“…This study aims to identify the sweep angle of the dual polarimetric weather radar located in Bogotá, owned by the District Institute for Risk Management and Climate Change (IDIGER), which presents the greatest statistical variability and spatial coverage, in terms of the horizontal component of reflectivity, using functional data analysis, in order to take this reflectivity sweep angle as a reference for correlation analysis between the data recorded by the radar and the accumulated precipitation measured on the surface. …”
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Evidence for the Immunosuppressive Potential of Calcineurin Inhibitor-Sparing Regimens in Liver Transplant Recipients with Impaired Renal Function by Kentaro Ide, Yuka Tanaka, Takashi Onoe, Masataka Banshodani, Hirofumi Tazawa, Yuka Igarashi, Nabin Bahadur Basnet, Marlen Doskali, Hirotaka Tashiro, Hideki Ohdan

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Highly sensitive, responsive, and selective iodine gas sensor fabricated using AgI-functionalized graphene by Zhuo Chen, Qiong Lei, Yinchang Ma, Jinrong Wang, Yuan Yan, Jun Yin, Jiaqiang Li, Jie Shen, Guanxing Li, Tingting Pan, Xinglong Dong, Bambar Davaasuren, Yaping Zhang, Jefferson Zhe Liu, Jun Tao, Yu Han

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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. by Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth

“…Many of these were not previously associated with skin disease in the organ (Mysm1, Vangl1, Trpc4ap, Nom1, Sparc, Farp2, and Prkab1), while others were ascribed new cutaneous functions on the basis of the screening approach (Krt76, Lrig1, Myo5a, Nsun2, and Nf1). …”
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Usefulness of endoscopic ultrasonography for differentiating between non-functional pancreatic neuroendocrine neoplasm and intrapancreatic accessory spleen by Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Takeshi Yamamura, Kazuhiro Furukawa, Masanao Nakamura, Hiroki Kawashima

“…This retrospective pilot study enrolled 136 patients with pathologically confirmed non-functional PanNEN or IPAS who underwent EUS at our institution. …”
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Effects of Bu-Zhong-Yi-Qi-Tang for the treatment of functional dyspepsia: a feasibility study protocol by Jihye Kim, Hyunho Kim, Keun Ho Kim

“…The aim of this feasibility study is to assess the effectiveness and safety of BZYQT for the treatment of functional dyspepsia (FD) with spleen qi deficiency. …”
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Development of a Noninfectious Japanese Encephalitis Virus Replicon for Antiviral Drug Screening and Gene Function Studies by Yang Yang, Jiayang Zheng, Yafang Lin, Yan Zhang, Qianming Zhao, Hailong Zhang, Junjie Zhang, Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Zhiyong Ma, Jianchao Wei

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Molecular parameters governing antibody FcγR signaling and effector functions in the context of HIV envelope by Michael V. Bick, Eduard Puig, David Beauparlant, Rebecca Nedellec, Iszac Burton, Keihvan Ardaghi, Thea R. Zalunardo, Raiza Bastidas, Xuduo Li, Javier Guenaga, Wen-Hsin Lee, Richard Wyatt, Wenwen Zhu, Max Crispin, Gabriel Ozorowski, Andrew B. Ward, Dennis R. Burton, Lars Hangartner

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Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography by Pavel V. Subochev, Xosé Luís Deán-Ben, Zhenyue Chen, Maxim B. Prudnikov, Vladimir A. Vorobev, Alexey A. Kurnikov, Anna G. Orlova, Anna S. Postnikova, Alexey V. Kharitonov, Mikhail D. Proyavin, Roman I. Ovsyannikov, Anatoly G. Sanin, Mikhail Y. Kirillin, Francisco Montero de Espinosa, Ilya V. Turchin, Daniel Razansky

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Level of cognitive functioning among elderly patients in urban area of Bangladesh: A cross-sectional study. by Joynal Abedin Imran, Pradip Kumar Saha, Marzana Afrooj Ria, Syeda Saika Sarwar, Jannatul Ferdous Konok

“…This study aims to investigate the prevalence of cognitive decline and its associated factors among urban-dwelling elderly adults in Bangladesh, using the Rowland Universal Dementia Assessment Scale (RUDAS) to assess cognitive function. This cross-sectional study employed systematic random sampling among 150 elderly participants (aged 60-85 years) from the outpatient department of the National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR) in Dhaka, Bangladesh. …”
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Pulmonary exacerbations as a risk factor for lung function decline-experiences of the National Cystic Fibrosis Center by Gojšina Bojana Z., Rodić Milan, Višekruna Jelena, Trajković Goran Z., Sovtić Aleksandar D., Minić Predrag B.

“…Pulmonary exacerbations have negative impact on clinical course of cystic fibrosis (CF) lung disease being associated with a steeper decline in the lung function, unfavorable prognosis and impaired quality of life. …”
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Depth-electrode stimulation and concurrent functional MRI in humans: Factors influencing heating with body coil transmission by Hiroyuki Oya, Ralph Adolphs, Matthew A. Howard, J. Michael Tyszka

“…Electrical-stimulation fMRI (es-fMRI) combines direct stimulation of the brain via implanted electrodes with simultaneous rapid functional magnetic resonance imaging of the evoked response. …”
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Functional MRI-guided microsurgery of intracranial arteriovenous malformations: study protocol for a randomised controlled trial by Shuo Wang, Yuanli Zhao, Jun Wu, Bing Zhao, Yong Cao

“…Modern microsurgery has improved the results of surgical treatment of AVMs; however, the treatment of AVMs, particularly eloquently located AVMs, still carries a high risk. Functional MRI (fMRI) has been reported to be used for the preoperative evaluation of AVMs in small case series. …”
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An Observational Study on Functional Outcome of Tympanoplasty in Canal Wall Down Mastoidectomy in Patients with Chronic Otitis Media by Diptanshu Mukherjee, Maumita De, Prodymna Kundu, Dipankar Biswas, Divya Daga, Saumendra Nath Bandyopadhyay

“…This study will focus on this advancement of gain in audiological function following canal wall down mastoidectomy with appropriate tympanoplasty and ossicular reconstruction. …”
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Role of obturator in restoring quality of life and function in maxillary oncological defect cases- A systematic review by Neelima Manoj, Ahila Singaravel Chidambaranathan, MuthuKumar Balasubramanium, Ganesh RamKumar Rajapandi

“…Statement of problem: Whether prosthetic rehabilitation significantly affects quality of life and functions of post maxillectomy patients. Objective: Systematically analyze the effects of different types of obturators on post-maxillectomy patients focusing on quality of life and function. …”
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Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation by Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni

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