Network pharmacology-based study in polymetformin’s new function of blocking ages/rage pathway curing diabetic complications by Linghong Kong, Hui Wang, Weiwei Jiang, Yun Chen, Zhuoling Du, Qiong Zhang, Jianyue Dong, Changchun Zeng, Hanping Liu

Get full text

Vascular function assessed by flow-mediated vasodilation and nitroglycerine-induced vasodilation in subjects with first-degree atrioventricular block by Aya Mizobuchi, Tatsuya Maruhashi, Yusuke Saito, Takayuki Yamaji, Takahiro Harada, Farina Mohamad Yusoff, Shinji Kishimoto, Masato Kajikawa, Ayumu Nakashima, Yukihito Higashi

Get full text

TaMs6, encoding a GDSL esterase/lipase protein, functions in male fertility in common wheat by Zheng Wang, Guoliang Zhang, Jing Yang, Guochen Qin, Xiaoyu Liu, Hang He, Lei Li, Xing Wang Deng, Jian Li

Get full text

Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma by Huihui Hu, Liangmiao Wu, Xiaodie Hu, Minghua Wang, Yewei Sun, Gaoxiao Zhang, Yuqiang Wang, Peng Yi, Zaijun Zhang

Get full text

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 by Juraj Ahel, Arda Balci, Victoria Faas, Daniel B. Grabarczyk, Roosa Harmo, Daniel R. Squair, Jiazhen Zhang, Elisabeth Roitinger, Frederic Lamoliatte, Sunil Mathur, Luiza Deszcz, Lillie E. Bell, Anita Lehner, Thomas L. Williams, Hanna Sowar, Anton Meinhart, Nicola T. Wood, Tim Clausen, Satpal Virdee, Adam J. Fletcher

Get full text

Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators by Hugo M. Botelho, Miquéias Lopes-Pacheco, Madalena C. Pinto, Violeta Railean, Ines Pankonien, Mariana F. Caleiro, Luka A. Clarke, Vasco Cachatra, Beate Neumann, Christian Tischer, Cristina Moiteiro, Jiraporn Ousingsawat, Karl Kunzelmann, Rainer Pepperkok, Margarida D. Amaral

Get full text

Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations by Yiyue Jiang, Zheng Zhang, Kangkang Ren, Shujuan Zhou, Yang Qiao, Weilu Huang, Nanyang Zhang, Hanyan Xu, Xinping Xu, Bing Wen, Wei Zhang, Lu Yin

Get full text

Association of choroid plexus volume with white matter microstructure, glymphatic function, and peripheral systemic inflammation in Alzheimer’s disease by Huwei Xia, Yijia Feng, Han Zhu, Danlu Yang, Chaoqun Wang, Zhipeng Wang, Hanyuan Zhang, Wenhao Pan, Yifan Zhao, for the Alzheimer’s Disease Neuroimaging Initiative, Weihong Song, Yili Wu

Get full text

Ligamental reconstruction improved the functional outcomes of patients with anterior cruciate ligament injury and early-stage symptomless osteoarthritis by Guang-nian Liu, Xing Chen, Ying Jin, Xiu-qi Liu, Shu-hong Wu, Hua-zhang Xiong

“…Data on demographic characteristics, pain and functional outcomes (visual analogue scale, Tegner, Lysholm, and International Knee Documentation Committee scores and range of motion), and imaging outcomes were collected. …”
Get full text

Impact of hyperglycaemia on cellular microenvironment and function of endometrium and uterine tube: scoping review focused on infertility in diabetic women by Peter Jackuliak, Martin Jankovský, Magdaléna Kovářová, Jaroslav Voller, Claudia Feitscherová, Ivan Varga

“…Our work evaluates literature mechanisms of DM-induced uterine tube and endometrial dysfunction, corresponding impacts on female fertility, and potential evidence-based intervention targets.MethodsWe conducted a scoping review (mapping review) follows the Joanna Briggs Institute (Manual for Evidence Synthesis, 2020 version). …”
Get full text

Morpho–functional monitoring of the esophagus status as the base for the dispenser observation in the patients with achalasia of cardia after surgical esophagocardiomyotomy by S. D. Myasoyedov, S. A. Andreieshchev

“…From 1972 to 2008 yr in the Institute of Surgery and Transplantology named after O. …”
Get full text

Functional outcome after Brachytherapy with bi-nuclide (Ru-106/Iodine-125) plaques in large uveal melanomas by Leyla Jabbarli, Miltiadis Fiorentzis, Philipp Rating, Boerge Schmidt, Eva Biewald, Nika Guberina, Dirk Flühs, Norbert Bornfeld, Wolfgang Sauerwein, Martin Stuschke, Nikolaos E. Bechrakis, Maja Guberina

“…The aim of our study was analyzing the functional outcome after brachytherapy with bi-nuclide plaques (BBNP), maintaining prognostic factors for legal blindness (LB). …”
Get full text

A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability by Amy K Schmid, David J Reiss, Min Pan, Tie Koide, Nitin S Baliga

Get full text

The effect of radiation dose to the brain on early self-reported cognitive function in brain and head-and-neck cancer patients by Femke Vaassen, David Hofstede, Catharina M.L. Zegers, Jeanette B. Dijkstra, Ann Hoeben, Monique H.M.E. Anten, Ruud M.A. Houben, Frank Hoebers, Inge Compter, Wouter van Elmpt, Daniëlle B.P. Eekers

Get full text

Effect of streptococcal arginine deiminase on the function of CD4⁺ and CD8⁺T lymphocytes by E. A. Starikova, J. T. Mammedova, A. Ozhiganova, A. M. Lebedeva, T. A. Leveshko, L. A. Burova, I. V. Kudryavtsev

Get full text

Unique Function in Cancer Stemness and Prognostic Significance of <i>EMX2</i> in Esophageal Squamous Cell Carcinoma by Shoichi Fumoto, Keiji Tanimoto, Takuya Noguchi, Jun Hihara, Eiso Hiyama, Keiko Otani, Megu Ohtaki, Yutaka Shimada, Masahiko Nishiyama, Keiko Hiyama

Get full text

Long-Term Follow-Up Evaluation of Renal Function in Patients with Chronic Kidney Disease Undergoing Cardiac Surgery by Eduesley Santana-Santos, Felipe Kenji Oshiro Kamei, Tarcísia Karoline do Nascimento, Anas Abou Ismail, Jurema da Silva Herbas Palomo, Marcia Cristina da Silva Magro, Fátima Gil Ferreira, Larissa Bertacchini de Oliveira, Adriano Rogério Baldacin Rodrigues, José Jayme Galvão de Lima

Get full text

The Contractile Function of Ventricular Cardiomyocytes Is More Sensitive to Acute 17β-Estradiol Treatment Compared to Atrial Cardiomyocytes by Tatiana A. Myachina, Xenia A. Butova, Raisa A. Simonova, Denis A. Volzhaninov, Anastasia M. Kochurova, Galina V. Kopylova, Daniil V. Shchepkin, Anastasia D. Khokhlova

Get full text

Changes in prefrontal hemodynamics and mood states during screen use: a functional near-infrared spectroscopy study by Daniel Fehring, Alexandra Gaillard, Emiliano Mazzoli, Susan Rossell, Paddy Dempsey, Michael Wheeler, Neville Owen, David W. Dunstan, Mats Hallgren

Get full text

Genomic and Functional Characterization of Multidrug-Resistant <i>E. coli</i>: Insights into Resistome, Virulome, and Signaling Systems by Vijaya Bharathi Srinivasan, Naveenraj Rajasekar, Karthikeyan Krishnan, Mahesh Kumar, Chankit Giri, Balvinder Singh, Govindan Rajamohan

Get full text