Interpretable machine learning for predicting isolated basal septal hypertrophy. by Lei Gao, Boyan Tian, Qiqi Jia, Xingyu He, Guannan Zhao, Yueheng Wang

“…This is a common echocardiographic finding with a prevalence of approximately 7-20%, which may indicate early structural and functional remodeling of the left ventricle in certain pathologies. …”
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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland by Tämer El Saadany, Judith Lupatsch, Michael Mark, Michaela Barbier, Tarun Mehra, Matthias Schwenkglenks, Roger von Moos

“…RESULTS: Log-normal functions best fitted the survival curves from CodeBreak 200. …”
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Whole Transcriptome-Based ceRNA Regulatory Network Analysis of Radiation-Induced Esophageal Epithelial Cell Injury by Lin H, Feng Y, Liu H, Zhang J, Zhang X, Ying X, Shi Y, Tan H, Tu W

“…A ceRNA network was constructed using co-expression analysis and binding site prediction. …”
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Tradition Beyond Formal Fiqh: Ethnic Perspectives on Negotiating Kafā’ah in Marriage within the Aceh Singkil Community by Fatimah Zuhrah, Wakhid Sugiyarto, Marpuah Marpuah, Ahsanul Khalikin, Titi Isnaini Fauzah

“…The data are analyzed through a structural-functional sociological approach, conceptualizing legal practice as a social phenomenon. …”
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Multi-Target Synergy Against Acute Lung Injury: Systems Pharmacology Decoding Dahuang-Huangqin Herb Pair’s Therapeutic Mechanism by Zhang J, Zhu X, Chen X, Liu H, Yan Z, Chen Z, Li Q, Yu W

“…PPI network analysis revealed five key regulatory targets: GAPDH, IL1B, IL10, MMP9, and TP53. Functional enrichment analyses demonstrated DH-HQ’s modulation of critical pathways including HIF-1 signaling and cytokine-cytokine receptor interaction. …”
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Molecular mechanisms of arecoline-induced oral cancer: a network toxicology and molecular docking techniques integrated analysis by Linghan Leng, Xin Wang, Hao Wang, Yingchun Hu, Yaxing Deng, Chenglin Wang

“…Enrichment analysis comprehensively elucidated the molecular functions, biological processes, cellular components, and associated pathways of these overlapping targets. …”
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Enhanced Long-Term Antibacterial and Osteogenic Properties of Silver-Loaded Titanium Dioxide Nanotube Arrays for Implant Applications by Yao Y, Lin P, Ye D, Miao H, Cao L, Zhang P, Xu J, Dai L

“…Yicun Yao,1,2 Peifen Lin,1 Dongping Ye,1 Haixiong Miao,1 Lin Cao,3 Peng Zhang,3 Jiake Xu,4,5 Libing Dai1,2 1Department of Orthopedics, Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, 510220, People’s Republic of China; 2Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong, 510220, People’s Republic of China; 3Institute of Advanced Wear & Corrosion Resistant and Functional Materials, National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology, Jinan University, Guangzhou, 510632, People’s Republic of China; 4Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, ShenZhen, Guangdong, 518107, People’s Republic of China; 5School of Biomedical Sciences, The University of Western Australia, Perth, 6009, AustraliaCorrespondence: Peng Zhang, Email tzhangpeng@jnu.edu.cn Libing Dai, Email libingdai@ext.jnu.edu.cnObjective: This study explored constructing silver-loaded titanium dioxide nanotube (TiO2 NT) arrays on titanium surfaces using anodic oxidation combined with ion implantation. …”
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Impact of Di-(2-Ethylhexyl)-Phthalate on Metabolic Syndrome: Insights from Network Toxicology and Molecular Docking and Dynamics by Chen L, Huang YL, Liu F, Huang N, Zeng DC, Zhong YB, Liao JH, Wang MY

“…DEHP-related targets were obtained from STITCH, SwissTargetPrediction, and ChEMBL. Constructed PPI networks of intersecting targets and visualized and screened core targets in Cytoscape 3.7.1. …”
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CD151 Promotes Cancer Progression in Triple-Negative Breast Cancer by Inducing EMT through the MAPK Signaling Pathway by Lv H, Zhang B, Weng X, Li Y, Deng C, Wang R, Shi L, Yin Y

“…However, the specific functions of CD151 in triple-negative breast cancer (TNBC) remain unclear. …”
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Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease by Limei Zhang, Limei Zhang, Dailin Li, Xu Zheng, Moli Wu, Qijun Yao, Haoran Chen, Zhiqiang Ye, Bo Yuan

“…These genes play critical roles in biological processes, cellular components, and molecular functions relevant to the pathogenesis of both diseases. …”
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Early identification of mild cognitive impairment: an innovative model using ocular biomarkers by Lingjing Zhang, Lingjing Zhang, Yanwei Wang, Yuming Liu, Zi Ye, Zhaohui Li

“…The least absolute shrinkage and selection operator (LASSO) method and multivariate logistic regression analysis were performed using R software for dimensionality reduction and variable selection. A nomogram was constructed, and its discriminative ability was evaluated using receiver operating characteristic (ROC) curve, area under the ROC curve (AUC) with 95% confidence interval (CI), as well as sensitivity and specificity. …”
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Impact mechanism of anaerobic digestion of sulfur-rich coal to H2S by graphene by Wenjie ZHAO, Xianbo SU, Weizhong ZHAO, Yixuan ZHOU

“…Using high-sulfur coal extracted from Jincheng as a carbon and sulfur source, an anaerobic fermentation system is constructed with graphene as the conductive material. …”
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Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers by Wentong Li, Yiyi Zhang, Chuanhong Li, Mingyang Jiang, Dong Wang, Luomeng Chao, Luomeng Chao, Luomeng Chao, Yuxia Yang

“…Protein-protein interaction (PPI) networks were constructed using the STRING database. Biomarker validation was performed through cross-validation using LASSO, SVM-RFE, and Random Forest algorithms. …”
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The effect of chloroquine on cervical cancer via the PI3K/AKT/MDM2 pathway by Dandan Xu, Chenyang Hou, Jianliang Chang, Shuaibo Yang, Zhicong Yang, Zelong Yuan, Jingqi Li, Shuqin Liu, Yaqun Liu, Yingpeng Su, Peng Gao, Xiaojuan Liu

“…A protein–protein interaction (PPI) network was constructed to screen for key targets. Furthermore, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to predict the underlying biological functions and mechanisms involved in the anti-colorectal cancer effects of CQ. …”
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Cloning, Identification, and Light Response Analysis of Two Circadian Clock Genes Cryptochrome and Period in Boring Giant Clam Tridacna crocea by Wenhong YANG, Yihan NAN, Meng LI, Chunsheng LIU, Yi YANG, Feng YU, Zhifeng GU

“…The phylogenetic tree of Cryptochrome and Period was constructed and analyzed using the neighbor-joining method in MEGA 7.0. …”
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Architecture and the Time of Space by Deborah Hauptman

“…The concerns that have always called me towards thinking about architecture as the imagined and constructed world in which we live are those that query the very nature of concepts, notions, ideologies and intellectual constructions and beliefs upon which culture and society – architecture as both a cultural product and a social actor – are formed. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated immunotherapeutic approaches. Methods We constructed a single-cell transcriptional atlas of DCM and normal patients. …”
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Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma by Faris Durmo, Jimmy Lätt, Anna Rydelius, Elisabet Englund, Tim Salomonsson, Patrick Liebig, Johan Bengzon, Peter C. M. van Zijl, Linda Knutsson, Pia C. Sundgren

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miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis by Yufei Xie, Maosheng Chai, Yixiao Xing, Peiru Zhou, Pan Wei, Hong Hua

“…These small RNAs are essential for EV-mediated functions, particularly in regulating gene expression and modulating the immune microenvironment. …”
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AIM2 activation mediated by RIPK1/3-dependent mitochondrial DNA release drives Aβ1−40-Induced retinal pigment epithelium injury by Xiaoxu Huang, Tongqi Li, Guanran Zhang, Jieqiong Chen, Tong Li, Shiqi Yang, Qiyu Bo, Xiaohuan Zhao, Xiaoling Wan, Xinyue Zhu, Bo Yu, Xiaodong Sun, Junran Sun

“…Adeno-associated virus vector 2/2 (AAV2/2)-shAIM2 was constructed to knockdown AIM2 expression in mice RPE cells. …”
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