Value of Epicardial Adipose Tissue Thickness in Predicting Major Adverse Cardiovascular Events in Patients with Coronary Artery Disease and Metabolic Syndrome by Andrey R. Kim, Rano B. Alieva, Aleksandr B. Shek, Shokhistakhon S. Akhmedova, Liliya E. Kan

“…Methods and Results: The study included 224 patients diagnosed with CAD, specifically those with functional class III angina pectoris and MetS. MetS criteria were defined in accordance with the IDF criteria (2005). …”
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2bRAD-M reveals differences in microbial communities between Modic changes and disc herniation by Fang Yang, Jingtao Zhang, Junpu Zha, Guolei Zhang, Jia Li, Wei Du, Lin Liu, Jun Di

“…A functional annotation analysis showed that differentially abundant taxa between the Modic change and herniated disc groups could be assigned to 4093 COGs (Clusters of Orthologous Groups) and 342 related signaling pathways.ConclusionThis study represents the first application of 2bRAD-M to Modic changes and disc herniation, revealing significant differences in microbial taxa between the two groups. …”
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Identification of QTLs for early maturity-related traits based on RIL population of two elite cotton cultivars by Xiaoge Wang, Fanjin Kong, Liying Gao, Guifang Shen, Bing Duan, Zongwen Wang, Dongdong Xu, Degang Fan, Yongsheng Deng, Zongfu Han

“…A genetic map spanning 2213.71 cM was constructed using the 794 bin markers. Based on this map, we identified a total of 78 early maturity-related QTLs, including 12 QTLs for WGP, 4 for SSP, 12 for SFP, 3 for FBP, 11 for NFFB, 8 for NFB, 16 for HNFFB and 12 for PH. …”
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Identification and validation of a lenvatinib resistance-related prognostic signature in HCC, in which PFKFB4 contributes to tumor progression and lenvatinib resistance by Jinfeng Wang, Jianfei Shi, Lili Mi, Ning Li, Xin Han, Man Zhao, Xiaoling Duan, Guangjie Han, Jiaojiao Hou, Fei Yin

“…Mutation signatures, therapeutic response, functional enrichment, and immune profile analyses were performed in the two groups. …”
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Diagnostic purposes of education: Problems, strategies and solutions by А. P. Usol’tsev, Т. N. Shamalo, Е. P. Аntipovа

“…The diagnostic purpose deformation is caused by dividing the functions between those who control education and those who perform it – teachers. …”
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Estimation of mangrove heights and aboveground biomass using UAV-LiDAR, Sentinel-1 and ZY-3 stereo images by Bolin Fu, Yingying Wei, Linhang Jiang, Hang Yao, Xiaomin Li, Yanli Yang, Mingming Jia, Weiwei Sun

“…Tree height is a key indicator of mangrove health; however, accurately estimating mangrove height in complex coastal environments is challenging. In this study, we constructed mangrove height inversion models using multiple types of remote sensing data and machine learning algorithms (partial least squares regression (PLSR), random forest (RF), and mixture density network (MDN)). …”
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Numerical Solution to the Problem of Thermal Conductivity in a Porous Plate with a Topology of Triply Periodic Minimal Surfaces by K. V. Gubareva, A. V. Eremin

“…Since these materials have unique structural and functional characteristics, understanding the relationship between their geometry and thermal parameters plays a key role in optimizing their use. …”
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Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods by Ankita Lawarde, Ankita Lawarde, Masuma Khatun, Prakash Lingasamy, Prakash Lingasamy, Andres Salumets, Andres Salumets, Andres Salumets, Vijayachitra Modhukur, Vijayachitra Modhukur

“…Furthermore, in silico validation revealed that many of the top miRNAs, including miR-21-5p, miR-93-5p, and miR-10b-5p, were not only highly central in the network but also correlated with patient survival and drug response. In addition, functional enrichment analyses indicated significant involvement of miRNAs in pathways such as TGF-beta signaling, epithelial-mesenchymal transition, and immune modulation. …”
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Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

“…CD44, a pivotal cell surface molecule, plays a crucial role in many cellular functions, including cell-cell interactions, adhesion, and migration. …”
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Acute Renal Injury in Cardiac Surgery Patients by S. I. Rey, G. A. Berdnikov, L. N. Zimina, N. V. Rubtsov, M. K. Mazanov, D. A. Kosolapov, V. V. Sokolov

“…To identify the factors in the development of acute renal damage, a stepwise regression analysis was performed by constructing a regression model of Cox proportional hazards. …”
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Development of a machine learning-based predictive risk model combining fatty acid metabolism and ferroptosis for immunotherapy response and prognosis in prostate cancer by Zhenwei Wang, Zhihong Dai, Yuren Gao, Zhongxiang Zhao, Zhen Li, Liang Wang, Xiang Gao, Qiuqiu Qiu, Xiaofu Qiu, Zhiyu Liu

“…This study integrated bulk RNA sequencing, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics to construct a prognostic model based on genes shared between ferroptosis and fatty acid metabolism (FAM). …”
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SLC3A2 as a key anoikis−related gene for prognosis and tumor microenvironment remodeling in melanoma by Xiaojin Liu, Jiaheng Xie, Yingying Xiao

“…The clinical relevance and functional role of SLC3A2 were further validated using the BEST database and in vitro experiments, including shRNA-mediated knockdown, colony formation, and Transwell migration assays. …”
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Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation by Li Chunxiao, Hou Xin, Liu Bowen, Sun Bingqing, Zhou Mengqi, Zhang Shuwen, Zhang Jingyuan, Lin Jiangtao

“…Protein–protein interaction networks were constructed using Cytoscape 3.9.1 software. Molecular docking validation of the binding capacity between Res and targets was performed using AutoDock Vina and visualized in PyMOL version 3.0.4. …”
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Overexpression of the inwardly rectifying potassium channel Kir4.1 or Kir4.1 Tyr9Asp in Müller cells exerts neuroprotective effects in an experimental glaucoma model by Fang Li, Zhen Li, Shuying Li, Hong Zhou, Yunhui Guo, Yongchen Wang, Bo Lei, Yanying Miao, Zhongfeng Wang

“…Collectively, these results suggest that the tyrosine residue at position nine in Kir4.1 may serve as a functional modulation site in the retina in an experimental model of glaucoma. …”
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Identification of components in scorpion and centipede traditional Chinese medicine formulations with potentially beneficial actions in asthma: network pharmacology and molecular d... by Yi-Ren Chen, Ya-Da Zhang, Wei Zhang, Bin-Qing Tang

“…The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and gene ontology (GO) functional enrichment analysis were carried out on the targets associated with scorpion and centipede-derived TCM components. …”
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Voxel- and surface-based morphometry in the cortical thickness and cortical and subcortical gray matter volume in patients with mild-to-moderate Alzheimer’s disease by Kaidi Li, Kaidi Li, Dingling Xie, Zhengyong Zhang, Chunyu Fu, Chunyu Fu, Chunyang Li

“…Predictive models were constructed using CT (from SBM), cortical GMV, and subcortical GMV (from VBM) metrics derived from ROIs, both individually and in combination. …”
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Introducing Angle B: A Novel Quantitative Approach for Sagittal Alignment Reduction in Atlanto-Axial Dislocation Surgery by Cui S, Wang X, Li K, Feng H, Liu Z, Jian F, Wang K

“…Shengyu Cui,1– 4 Xinyu Wang,1– 5 Kang Li,1– 4 Hailong Feng,6 Zhenlei Liu,1– 4 Fengzeng Jian,1– 4 Kai Wang1– 4 1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Spine Center, China International Neuroscience Institute (CHINA-INI), Beijing, People’s Republic of China; 3Research Center of Spine and Spinal Cord, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, People’s Republic of China; 4Lab of Spinal Cord Injury and Functional Reconstruction, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Baylor College of Medicine, Huston, TX, USA; 6Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of ChinaCorrespondence: Fengzeng Jian; Kai Wang, China International Neuroscience Institute (CHINA-INI), Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, People’s Republic of China, Tel +86-1083198277, Email jianfengzeng@xwh.ccmu.edu.cn; sammas1883@sina.comObjective: This study aims to establish a quantitative relationship between cervical lordosis (CL) and the rotation angle of the axis for the surgical reduction of atlantoaxial dislocation (AAD) and to explore the potential applications of this relationship in preoperative planning and selection of surgical techniques.Methods: To construct the correlation between horizontal gaze and location of axis, we introduced the angle B, defined as the angle between the Frankfort horizontal line and the extension line of the posterior edge of the axis, and explored its application in surgical planning. …”
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Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activ... by Junbin Hong, Zhendong Guo, XiaoMei Huang, Peng Wu, Xinying Chen, Xiaoyi Liu, Jinghua Yang, Yanni Lai

“…Therefore, as one probable molecular candidate for the co-infection with SARS-CoV-2 and RSV, probenecid was researched in this exploration.MethodsUsing systems pharmacology and bioinformatics, we characterized the targets associated with probenecid for the treatment of SARS-CoV-2/RSV co-infection, focusing on their biological functions, mechanisms and binding activities. To further validate these findings, we conducted molecular docking, MD simulations, electrostatic potential mapping, and SAR analysis to explore the binding interactions between probenecid and the identified core targets.ResultsWe identified 141 targets that overlapped with the co-infection and probenecid, and used these shared targets to construct a protein-protein interaction (PPI) network. …”
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Biofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses by Bruna Gonçalves, Diana Priscila Pires, Liliana Fernandes, Miguel Pacheco, Tiago Ferreira, Hugo Osório, Ana Raquel Soares, Mariana Henriques, Sónia Silva

“…Accordingly, various genes and matrix proteins with predicted functions in the regulation of carbohydrate metabolism, sugar binding, sugar transport, and adhesion (including Epa family) were repressed by Zap1. …”
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Exploring the mechanism of Bu Zhong Yi Qi Tang in the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) based on network pharmacology and molecular docking by Pengfei Zhou, Yang Xuan, Zaisheng Zhu, Han Wu, Yang Hu, Liangyou Chen, Qianya Zhou

“…Key targets were further subjected to Gene Ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. …”
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