Isolation and molecular characterization of the FLOWERING LOCUS C gene promoter sequence in radish (Raphanus sativus L.) by Yuan-yuan XU, Jing WANG, Shan-shan NIE, Dan-qiong HUANG, Yan WANG, Liang XU, Rong-hua WANG, Xiao-bo LUO, Li-wang LIU

“…FLOWERING LOCUS C (FLC) plays a key role in plant flowering by functioning as a repressor. Two genomic DNA sequences, a 3 046-bp from an early- and a 2 959-bp from a late-bolting radish line were isolated and named as RsFLC1 and RsFLC2, respectively, for they share approximately 87.03% sequence identity to the FLC cDNA sequences. …”
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Bioinformatics methods for identifying differentially expressed genes and signaling pathways in nano-silica stimulated macrophages by Lin Zhang, Changfu Hao, Juan Li, Yaqian Qu, Lei Bao, Yiping Li, Zhongzheng Yue, Miao Zhang, Xinghao Yu, Huiting Chen, Jianhui Zhang, Di Wang, Wu Yao

“…To identify the differentially expressed genes and explore their potential functions, we adopted the gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis and also constructed protein–protein interaction network. …”
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Vessel Fractional Flow Reserve and Graft Vasculopathy in Heart Transplant Recipients by Sakura Nagumo, Emanuele Gallinoro, Alessandro Candreva, Takuya Mizukami, Giovanni Monizzi, Monika Kodeboina, Sofie Verstreken, Riet Dierckx, Ward Heggermont, Jozef Bartunek, Marc Goethals, Dimitri Buytaert, Bernard De Bruyne, Jeroen Sonck, Carlos Collet, Marc Vanderheyden

“…Recently, vessel fractional flow reserve (vFFR) derived from COR has emerged as a diagnostic computational tool to quantify the functional severity of coronary artery disease. Purpose. …”
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Innovative nomogram for cervical cancer prediction: integrating high-risk HPV infection, p53 genotype, and blood routine parameters by Cheng Sun, Jun Zhang, Lili Pan, Shuang Yao, Fenghua Zhang, Linjuan Ji, Miaomei Yu, Guanghua Luo, Guanghua Luo, Xiping Jiang

“…The p53 gene influences cellular response to DNA damage and has a functional polymorphism (rs1042522, p.Arg72Pro) that affects susceptibility to degradation by HPV E6 protein. …”
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Validation of the European Oncology toolkit for the self-assessment of Quality of Life (EUonQoL-Kit) in cancer patients and survivors: study protocol of a pan European survey by G. Apolone, M. Costantini, L. Caselli, N. Bos, A. Caraceni, G. Ciliberto, N. Couespel, M. Ferrer, M. Groenvold, S. Kaasa, C. Lombardo, R. Pietrobon, G. Pravettoni, A. Sirven, H. Vachon, G. Velikova, O. Garin, A. Gilbert, A. Machiavelli, C. Marzorati, R. Miceli, M. Pe, MA. Petersen, A. Tanzilli, F. van Schelven, C. Dantas, I Minnée-van Braak, L. Pinnavaia, C. Brunelli

“…Psychometric analyses will encompass exploratory and confirmatory factor analyses (measurement model and structural validity), Cronbach's alpha (internal consistency), intraclass correlation coefficient (test–retest reliability), Pearson/Spearman correlation (concurrent validity), comparison of group scores (construct validity), and Differential Item Functioning (cross-country item equivalence). …”
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N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility by Yalun He, Jie Ding, Tonglin Bai, Yangshuo Li, Xiaolan Liang, Yiming Chen, Yi Lin, Wen Cheng, Chaoqin Yu

“…Functional enrichment analysis of differentially expressed genes (DEGs) between these clusters, along with immune cell infiltration analysis, was subsequently conducted. …”
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Decoding dengue’s neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model by Minyue Qiu, Lixin Zhao, Xiaojia Li, Yipei Fan, Minchi Liu, Dong Hua, Yunkai Zhu, Yinyin Liang, Yu Zhang, Wen Xiao, Xiaofeng Xu, Jintao Li

“…Finally, motor and sensory functions of mice were detected by open field test and hot plate test, respectively. …”
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Spatial complex correlation characteristics of carbon emissions and carbon transboundary transfer: Assessment of the carbon footprint in four mega-urban agglomerations in China by Chengxue Yu, Haimeng Lei, Hongbo Zheng, Tong Xu, Zhanfeng Dong

“…This study investigates these issues from the dual perspectives of ''carbon sources'' and ''carbon sinks,'' utilizing a modified gravity model to construct a spatial correlation matrix of carbon footprint pressure. …”
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Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid‐Range and Preserved Ejection Fraction: A Multicenter Study by Wenxian Wang, Yan Gao, Jian Wang, Congshan Ji, Hui Gu, Xianshun Yuan, Shifeng Yang, Ximing Wang

“…After fully adjusting, EAT remained associated with the outcome (HR, 1.62 [95% CI, 1.42–1.86], P<0.001). We constructed a baseline multivariable model including comorbidities, New York Heart Association functional class, extracellular volume, age, body mass index, left ventricular ejection fraction, and N‐terminal pro‐brain natriuretic peptide. …”
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Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation by Yang Z, Kao X, Zhang L, Huang N, Chen J, He M

“…Then, protein-protein interaction (PPI) network, molecular docking, and functional enrichment analysis were conducted. In vivo, cecal ligation and puncture (CLP) was used to construct a sepsis mouse model, and the therapeutic effects of DCHD on SALI were evaluated using hematoxylin and eosin (H&E) staining, quantitative real-time PCR (qRT-PCR), and ELISA. …”
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The essence and structure of the scientific outlook of future teachers of natural and mathematical specialties by Zelinha Yulia, Halitsan Olha

“…The scientific outlook of the future teacher of natural and mathematical specialties is represented by a multicomponent synthetic construct, that reproduces its essential features at the intersection of the coordinates of the “personal / professional” dichotomy; assumes the presence of a methodological and innovative professional culture, systematic and logical scientific thinking, reflectiveness of the individual and the teacher’s desire for self-development, self-realization and selfimprovement in professional and pedagogical activities; functions as a dynamic synthesis of scientific-researchanalytical and pedagogical-methodical skills, which allow to overcoming discreteness in the formation of specialized (science-mathematical) and general-specialist competences (pedagogical, didactic, methodologicalresearch) of a science-mathematics teacher; provides comprehensive updating of scientific information in pedagogy, mathematics, physics, natural science, biology and physiology, teaching methods of professional disciplines, which leads to the student’s awareness of the holistic nature of natural and mathematical sciences as a scientific and socio-cultural phenomenon; records the deployment of a multi-vector research search with the aim of developing an individual scientific strategy for teaching natural and mathematical disciplines; produces the teacher’s ability to actualize interdisciplinary connections in the system of natural and mathematical sciences; provides an adequate selection of personalized methods of teaching science and mathematics disciplines, developed on the basis of the activation of cognitive self-projection of the future science and mathematics teacher as a scientist and researcher. …”
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ARID1A deficiency attenuates the response to EGFR-TKI treatment in lung adenocarcinoma by Fangfang Yang, Fangfang Yang, Helei Hou, Guanqun Wang, Guangming Fu, Xingfa Huo, Xueqin Duan, Na Zhou, Xiaochun Zhang

“…AT-rich interactive domain 1A (ARID1A), which is a key subunit of SWI/SNF complexes, demonstrates critical regulatory functions as a tumour suppressor gene in cancer. The aim of this study is to determine the role of ARID1A deficiency in the therapeutic efficacy of EGFR-TKIs in LUAD.MethodsWe identified the ARID1A mutation as a potential prognostic marker in EGFR-mutant LUAD by analysing data from cBioPortal. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…One manifestation of violation of protective functions in this group of patients are changes in the synthesis of interleukin blood. …”
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Pretreatment HIV‐1 Drug Resistance Among Newly Diagnosed People in Eastern Ethiopia by Abdella Gemechu, Adane Mihret, Mesfin Mengesha, Dawit Hailu Alemayehu, Eleni Kidane, Abraham Aseffa, Rawleigh Howe, Berhanu Seyoum, Andargachew Mulu

“…A maximum likelihood phylogenetic tree was constructed using PhyML version 3.0 and visualized using the iTOL tool. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…And then, we adopted the quantitative real-time PCR (RT-qPCR) assay to validate the hub genes among several CKD animal models. Furthermore, we constructed a competitive endogenous RNA (ceRNA) network for the hub genes utilizing the ENCORI and miRDB databases, while also calculating Spearman correlation coefficients. …”
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Transcription factor networks and novel immune biomarkers reveal key prognostic and therapeutic insights in ovarian cancer by Aiqin Zhao, Sufang Zhou, Xiaoyi Yang, Haiying Lu, Dan Zou, Xuan Zhang, Li Liu

“…JCHAIN and UBD expression in OC tissues was found to be low according to qPCR and IHC analyses, whereas RARRES1 expression was found to be high. The functional experiment results indicated that downregulation of JCHAIN and UBD and overexpression of RARRES1 could suppress the proliferation, migration, and invasion of OC cells in vitro. …”
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Simulation and Test of Key Decorticating Components of Spiral Ramie Decorticator by Wenlong Zheng, Lan Ma, Jiajie Liu, Bo Yan, Yiping Duan, Sixun Chen, Jiangnan Lyu, Wei Xiang

“…To address the production challenges posed by high labor intensity and the scarcity of small, direct-feeding ramie decorticators in hilly and mountainous regions, this study designed and optimized a spiral ramie decortication component that integrated functions of ramie stalk crushing, xylem removal, outer shell scraping, and phloem separating and throwing. …”
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A ROLE OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES M49-16 IN PROMOTING INFECTION AND INHIBITION OF ENDOTHELIAL CELL PROLIFERATION by E. A. Starikova, A. B. Karaseva, L. A. Burova, A. N. Suvorov, A. V. Sokolov, V. B. Vasilyev, I. S. Freidlin

“…., inhibits proliferation and other endothelial cell functions related to angiogenesis. To confirm a leading role of arginine deiminase, as a factor responsible for the anti-proliferative effect, we have constructed an isogenic S. pyogenes M49-16 mutant unable to express arginine deiminase. …”
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The implementation, use and sustainability of a clinical decision support system for medication optimisation in primary care: A qualitative evaluation. by Mark Jeffries, Nde-Eshimuni Salema, Libby Laing, Azwa Shamsuddin, Aziz Sheikh, Anthony Avery, Antony Chuter, Justin Waring, Richard N Keers

“…Engagement between stakeholders was considered important for the intervention in ensuring prescribers continued to utilise its functionality. Sustained implementation might be enhanced by careful profile management of the suite of alerts in the system. …”
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Travel in Omani Maqamat Writings: A Textual Semiotic Study [In Arabic] by Saeed Al-Salti

“…What matters most to Greimas is the underlying and constructive grammar of narratives, not individual texts. …”
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