Decoding per- and polyfluoroalkyl substances (PFAS) in hepatocellular carcinoma: a multi-omics and computational toxicology approach by Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang, Jiajun Li

“…Molecular docking simulations were conducted to assess the binding affinities between PFAS compounds and selected target proteins. Results Functional enrichment studies revealed that PFAS targets were associated with metabolic signaling pathways, which are actively involved in lipid, glucose, drug metabolism, etc. …”
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Network pharmacological approach combined with weighted gene co-expression network analysis identifies CDKN2A as the keg target of Changweiqing against colorectal cancer by Ma Zushuai, Ji Yanrong, Zhao Chengdu, Zhu Xu, Ding Qianshan

“…A protein-protein interaction network was constructed to screen core targets, with STRING database and Cytoscape software. …”
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Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E by Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong

“…Furthermore, the newly constructed PM disorder criteria indicated that patients with high PM levels were associated with a lack of response to immunotherapy and an immunosuppressive microenvironment. …”
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Protocol for a cluster-randomized clinical trial to evaluate the effectiveness of mindfulness-based cognitive therapy for depression, implemented in Vietnamese Buddhist pagoda by Bahr Weiss, Van Vu, Hoang-Minh Dang, Lam Trung

“…Several Implementation Science constructs such as Treatment Acceptability and Program Attitudes will be assessed. …”
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Item-level measurement properties of the pediatric awareness and sensory motor assessment in children with medical complexity by Brooke Mulrenin, Bryant A. Seamon, Carrie Cormack, Kimberly Lane Kascak, Cynthia Dodds

“…Person misfit did not degrade item measures or model statistics. Differential item functioning (DIF) was noted for the three easiest items on specific days. …”
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Psychometric evaluation of the Chinese version of the Patient Self-Advocacy Scale using classical test theory and item response theory by Jialu Cui, Jing Wang, Ailin Yue, Jiayan Cao, Zhijie Zhang, Baoxin Shi

“…The Wright map showed good matching between item difficulty and person ability. Differential item functioning (DIF) analysis revealed no significant differences across gender. …”
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Combining gene expression microarrays and Mendelian randomization: exploring key immune-related genes in multiple sclerosis by Shuangfeng Ding, Yunyun Zhang, Yunzhe Tang, Ying Zhang, Mingyuan Liu

“…GO and KEGG analyses were subsequently performed to elucidate the functions and pathways associated with the IM-DEGs. …”
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PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma by Yichong Liu, Haiyue Wang, Qian Zhang, Xiaodi Gao, Yiqing Ji, Yuanzhang Zhu, Jingjing Zhang, Wenjuan Luo

“…Through this study, we hope to explore the effect of PLEK2 on the prognosis of UVM patients and to discover the potential functional role and intrinsic mechanism of PLEK2.MethodsThe GEO datasets GSE211763 and GSE149920 were analyzed using GEO2R to identify differentially expressed genes that may be associated with UVM progression and metastasis. …”
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Are we working (too) comfortably?: the systematic development of an intervention to support workers to move more while working at home by Divya Sivaramakrishnan, Claire Fitzsimons, Sarah Morton, Jillian Manner, Ruth Jepson, Ailsa Niven

“…In step 4, the intervention functions and behaviour change technique elements of the BCW were used to accurately and consistently specify the active ingredients of the intervention. …”
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Identification and Validation of Feature Genes Related to Mitochondrial Dysfunction and Oxidative Stress in Ulcerative Colitis by Wu Y, Tan Z, Lan Q, Liu Y, Liu C, He H, Zhang J, Dong W

“…The receiver operating characteristic (ROC) curves were plotted, and a nomogram was constructed to evaluate the diagnostic efficacy of feature genes for UC. …”
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Models of symmetric three-layer waveguide structures with graded-index core and nonlinear optical liners by S. E. Savotchenko

“…The analytical methods of mathematical physics and the theory of special functions applied to nonlinear and waveguide optics are used herein.Results. …”
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The C-reactive protein-to-albumin ratio as a diagnostic biomarker for rheumatoid arthritis: a cross-sectional NHANES analysis by Fan Yang, Weihua Sang, Yongqing Liu, Jun Wang

“…BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disorder that leads to joint damage, cartilage and bone destruction, and functional disability. The C-Reactive Protein to Albumin Ratio (CAR), an emerging biomarker reflecting systemic inflammation and nutritional status, has demonstrated prognostic value in various diseases. …”
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Minimal Clinically Important Difference in Patients with Acute Neck Pain Undergoing Conservative Treatment with Korean Medicine by Kim JS, Kim E, Shin S, Ha IH, Lee YJ

“…The MCID and SCB of pain, functional disability, and quality of life were assessed using anchor-based methods. …”
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Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…Single-gene Gene Set Enrichment Analysis (GSEA) identified biological functions, while nomograms and ROC curves assessed diagnostic potential. …”
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Exploring the Views of Dermatologists, General Practitioners, and Melanographers on the Use of AI Tools in the Context of Good Decision-Making When Detecting Melanoma: Qualitative... by Brad Partridge, Nicole Gillespie, H Peter Soyer, Victoria Mar, Monika Janda

“…However, AI-based support may entail a wide range of specific functions for AI. To appropriately integrate AI into decision-making processes, it is crucial to understand the precise role that clinicians see AI playing within their clinical deliberations. …”
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A New Mobile App to Train Attention Processes in People With Traumatic Brain Injury: Logical and Ecological Content Validation Study by Roxanne Laverdière, Philip L Jackson, Frédéric Banville

“…Another way to stimulate attention functions is to engage in the daily practice of mindfulness, a multicomponent concept that can be explained by the theoretical model of Baer and colleagues. …”
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Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma by Lizhi Zhou, Hengcheng Lu, Bin Fu, Jianhan Fu

“…MMP9 was identified as a key prognostic gene (HR = 1.5, p = 0.016) associated with anoikis resistance and RCC metastasis. Functional assays confirmed that MMP9 knockdown increased anoikis by 59% and significantly reduced wound-healing migration by about 30% and transwell invasion by 50%, reinforcing its role in RCC progression.Conclusions Targeting anoikis-related genes, particularly MMP9, enhances anoikis sensitivity and reduces RCC invasiveness, offering a potential therapeutic strategy to mitigate metastasis and improve clinical outcomes.…”
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Sternal Resections: An Attempt to Find the Ideal Reconstruction Method by Emanuel Palade, Ioana-Medeea Titu, Lucian Fodor, Ion Mircea Ciorba, Ion Jentimir, Florin Teterea, Monica Mlesnite, Ioana Tichil

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Designing the outsourcing model in central government organizations by Mahnaz Moradi, Morteza Ghasemi, Maryam Majidi, Gholamreza Amjadi

“…Outsourcing is related to the transfer of a complete functional department of the business or some activities of a functional department and keeping the rest of the activities of that department internally. …”
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Evaluating the value of machine learning models for predicting hematoma expansion in acute spontaneous intracerebral hemorrhage based on CT imaging features of hematomas and surrou... by Tianyu Yang, Tianyu Yang, Zhen Zhao, Yan Gu, Shengkai Yang, Yonggang Zhang, Lei Li, Ting Wang, Zhongchang Miao

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