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13981
Understanding continued use of smart learning platforms: psychological wellbeing in an extended TAM-ISCM model
Published 2025-05-01“…Recognizing that technological performance and psychological experiences shape user engagement, this research extends the Technology Acceptance Model (TAM) by integrating constructs such as perceived trust, enjoyment, ideological alignment, and psychological states—including satisfaction, wellbeing, and anxiety.MethodsData were collected from 782 higher vocational college students in China using an online questionnaire. …”
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13982
Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD
Published 2025-04-01“…Within cervical squamous cell carcinoma SiHa cells, models were established using miR-125b mimic and inhibitor constructs to scrutinize cellular physiological processes and assess the expression profiles of miR-125b, TAZ, TEAD, and E6. …”
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13983
Botulinum toxin type A inhibits microglia pyroptosis by suppressing Cblb-mediated degradation of Pdlim1 to attenuate neuropathic pain
Published 2025-07-01“…Pdlim1 knockdown lentiviral plasmid was constructed and stable Pdlim1 knockdown microglial cell lines were established for rescue experiments. …”
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13984
Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats
Published 2025-02-01“…However, the expression patterns and functions of these molecules across different developmental stages of dairy goat seminiferous tubules remain poorly understood. …”
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13985
Bibliometric and Visualization Analysis of DprE1 Inhibitors to Combat Tuberculosis
Published 2025-04-01“…VOSviewer, CiteSpace, and bibliometrics (http://bibliometric.com/) were used to construct networks based on an analysis of journals, countries, funding, institutions, authors, references, and keywords.Results: A total of 184 publications were retrieved; the total citations were 3405 times and the mean citation was 17.28 per article. …”
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13986
Integrated transcriptomic and immune profiling reveals crucial molecular pathways and hub genes associated with postoperative delirium in elderly patients
Published 2025-05-01“…A total of 18,894 protein-coding genes were extracted for analysis.ResultsWe constructed a gene co-expression network using WGCNA and performed GSVA to investigate the link between POD and different types of cell death. …”
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13987
Oxygenated VOC Detection Using SnO<sub>2</sub> Nanoparticles with Uniformly Dispersed Bi<sub>2</sub>O<sub>3</sub>
Published 2024-12-01“…The abundant Bi<sub>2</sub>O<sub>3</sub>/SnO<sub>2</sub> interfaces are constructed by the uniform dispersion of Bi<sub>2</sub>O<sub>3</sub> particles on the SnO<sub>2</sub> surface. …”
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13988
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade
Published 2017-05-01“…Electrophoresis mobility shift assay and chromatin immunoprecipitation demonstrated a functional activator protein 1 binding site within 37-kDa laminin receptor precursor gene regulatory sequence located at −271 relative to the transcriptional initiation point. …”
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13989
Expression Characteristics and Prognostic Value of KLRG2 in Endometrial Cancer: A Comprehensive Analysis Based on Multi-Omics Data
Published 2025-06-01“…Prognostic models were constructed via Cox regression and time-dependent ROC analysis. …”
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13990
Research on the Stability Prediction and Optimization of CNC Milling Based on Bagging–NSGAⅡ Under the Influence of Multiple Factors
Published 2024-07-01“…Under each position, impact testing is then carried out at the tool tip for different tool-overhang lengths to obtain the corresponding frequency response functions (FRFs). Then, limiting axial cutting depth <italic>a</italic><sub>plim</sub> values are theoretically predicted using the tool-tip FRFs and machining parameters. …”
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13991
Analysis of the atomization performance of hydrodynamic rotating spray dust suppression device with setting fan
Published 2025-06-01“…At the same time, the fan blade is set on the water shaft, so that the device has both rotating spray and negative pressure suction dust reduction functions; we build a coal mine dust experimental system, collect coal dust samples from Inner Mongolia 5013 excavation face, and measure the total dust and respiratory dust concentrations of three dust reduction schemes through CCZ-20A dust sampler. …”
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13992
A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma
Published 2024-12-01“…In this study, we used triptolide (TP), a bioactive constituent in Tripterygium wilfordii Hook F, as a model drug to develop a novel nano-liposome drug delivery system for the treatment of liver tumours.Methods: We constructed a functionally-modified triptolide liposome (FA+TPP-TP-Lips) using the film-dispersion method and investigated its physicochemical properties, mitochondrial targeting of hepatic tumour cells, in vitro and in vivo anti-hepatic tumour activity and its mechanism.Results: The prepared FA+TPP-TP-Lips had a particle size of 99.28 ± 5.7 nm, a PDI of 0.20 ± 0.02, a zeta potential of 1.2 ± 0.08 mV, and an encapsulation rate of 74.37% ± 1.07%.FA+TPP-TP-Lips facilitates the cellular uptake of drug delivery systems and improves their targeted delivery to mitochondria. …”
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13993
Screening of novel β-carotene hydroxylases for the production of β-cryptoxanthin and zeaxanthin and the impact of enzyme localization and crowding on their production in Yarrowia l...
Published 2024-11-01“…An intermediate between β-carotene and zeaxanthin, β-cryptoxanthin, is found only in specific fruits and vegetables and has several important functions for human health. The low concentration of β-cryptoxanthin in these sources results in low extraction yields, making biotechnological production a promising alternative for achieving higher yields. …”
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13994
The Use of Economic and Mathematical Modeling in Assessing the Competitiveness of Tourism Industry Enterprises
Published 2020-12-01“…The implementation of such a system is directly related to the analysis and assessment of the whole variety of conditions and factors for the functioning of the subjects of the tourism industry.…”
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13995
Exploring the Anti-depression Mechanism of Polygonatum ordoratum Based on GEO Database Combined with Network Pharmacology and Molecular Docking Technology
Published 2025-01-01“…The "drug-component-target" and PPI networks were constructed using Cytoscape 3.7.1 software. GO and KEGG enrichment analyses were performed using the DAVID database. …”
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13996
The validation and cross-cultural adaptation of the PainDETECT questionnaire in osteoarthritis-related pain
Published 2025-01-01“…Abstract Background Patients with knee osteoarthritis (KOA) often experience persistent pain and functional impairment after total knee arthroplasty (TKA), which presents challenges for pain management. …”
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13997
RETRACTED ARTICLE: NR3C2 affects the proliferation and invasiveness of colon cancer cells through the Wnt/β-Catenin signaling pathway
Published 2024-09-01“…Single-cell transcriptome data identified the subset of circulating T and B cells with high expression of NR3C2, which is involved in TNF signaling pathway. Functional experiments show that downregulation of NR3C2 resultsed in the activation of the Wnt/β-catenin signaling pathway, and promotesd the proliferation and invasion of colon cancer cells while suppressing cell autophagy and apoptosis. …”
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13998
Beyond the SAFE strategy: Systematic review and meta-analysis of prevalence and associated factors of active trachoma among children in Ethiopia.
Published 2025-01-01“…Therefore, it is imperative to fine-tune the intervention focus on personal hygiene-related activities in removing dirt, fly-eye contact, and a well-structured approach for both constructing and ensuring the functionality of household taps and latrines. …”
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13999
Translation, cultural adaptation and validation of the Danish version of the haematological malignancy patient-reported outcome measure (HM-PRO)
Published 2025-04-01“…After cognitive debriefing interviews, it underwent psychometric testing with a variety of hematologic malignancies. Construct validity, internal consistency, dimensionality, item response theory (IRT) and differential item functioning were investigated. …”
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14000
Novel epidermal–cortical pattern and root apical silencing of VcCPC promoter activity in Arabidopsis might suggest a joint contribution to hairless roots in blueberry
Published 2025-05-01“…Complementation of the cpc mutant with a chimeric VcCPCpro::VcCPC construct did not restore the root hair-deficient phenotype. …”
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