OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer by Qihui Sun, Xiaoqi Zhu, Qi Zou, Yang Chen, Tingting Wen, Tingting Jiang, Xiaojia Li, Fang Wei, Keping Xie, Jia Liu

“…We integrated multi-dataset analyses, single-cell transcriptomic data, and functional experiments to explore the role of OSBPL3 in pancreatic cancer. …”
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Integrative single-cell RNA sequencing and bulk RNA sequencing reveals the characteristics of glutathione metabolism and protective role of GSTA4 gene in pancreatic cancer by Xinya Jia, Qiang Zhang, Zhe Wang, Jianliang Cao, Anran Song, Chao Lan, Yuepeng Hu

“…Additionally, transcriptomic data from multiple repositories, including TCGA, ICGC, and GEO, comprising a total of 930 patients with PC, were integrated to construct a prognostic molecular classifier related to GSH metabolism. …”
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Real‐Climatic Microcontroller‐in‐the‐Loop (RCMIL) Framework: A Novel, Rapid, and Cost‐Effective Approach for Verifying Photovoltaic Control Systems by Ambe Harrison, Idriss Dagal, Wulfran Fendzi Mbasso, Fritz Nguemo Kemdoum, Reagan Jean Jacques Molu, Hamid Belghiti, Pradeep Jangir

“…The study describes a clear, reproducible process for constructing the RCMIL platform and illustrates its efficacy through a series of experiments with proven MPPT controllers. …”
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In silico and in vivo Study of the Anti-Inflammatory Activity of Azomethine Derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide and 2-substituted 5,6,7,8-tetra... by Chiriapkin, A.S., Kodonidi, I.P., Abisalova, I.L., Diakova, I.N.

“…The virtual structures of the test compounds were constructed in HyperChem 8.0.4. Their final geometry optimizations were carried out in ORCA 4.1, using the density functional theory (UB3LYP) method and the 6–311G** basis set. …”
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GPR65 is a novel immune biomarker and regulates the immune microenvironment in lung adenocarcinoma by Hanxu Zhou, Zhi Chen, Shuang Gao, Chaoqun Lian, Junjie Hu, Jin Lu, Lei Zhang

“…GPR65 is an extracellular pH-sensing G protein-coupled receptor and a glycosphingolipid receptor, which is engaged in the functions of regulating tumor immunity. However, the prognostic value of GPR65 and its relevance to immune infiltration in LUAD are unknown.MethodsThe proportion of immune, stromal and tumor cells in LUAD samples was assessed by ESTIMATE algorithm scores with RNA sequence data and clinical information from LUAD patients downloaded from The Cancer Genome Atlas (TCGA) database. …”
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Biochar Is Superior to Organic Substitution for Vegetable Production—A Revised Approach for Net Ecosystem Economic Benefit by Ruiyu Bi, Bingxue Wang, Xintong Xu, Yubing Dong, Ying Jiao, Zhengqin Xiong

“…One kilogram of harvested vegetables for carbon/Nr footprints and one hectare of cultivated land per crop for cost and benefit were adopted as functional units considering the multi-cropping characteristics for intensive vegetable production. …”
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Potential of a CO2-Responsive supramolecular drug-carrier system as a safer and more effective treatment for cancer by Enyew Alemayehu Bayle, Fasih Bintang Ilhami, Jem-Kun Chen, Chih-Chia Cheng

“…We combined carbon dioxide (CO2)-responsive cytosine-containing rhodamine 6G (Cy-R6G) as a hydrophobic anticancer agent with hydrogen-bonded cytosine-functionalized polyethylene glycol (Cy-PEG) as a hydrophilic supramolecular carrier to construct a CO2-responsive drug delivery system, with the aim of enhancing the responsiveness of the system to the tumor microenvironment and thus the overall effectiveness of anticancer therapy. …”
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Integrated Analysis to Reveal Heterogeneity of Tumor‐Associated Neutrophils in Glioma by Wen Wang, Junsheng Li, Qiheng He, Chenglong Liu, Siyu Wang, Zhiyao Zheng, Bojian Zhang, Siqi Mou, Wei Sun, Jizong Zhao

“…In vitro experiments were also performed for functional verification, including CCK8, EdU, Transwell, and TUNEL assays. …”
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CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach by Yue Peng, Qiang Ji, Qiang Ji, Xiangyu Guo, Weichunbai Zhang, Zixuan Yang, Wenbin Li, Wenbin Li

“…This study evaluates the prognostic significance and functional mechanisms of tetraspanin CD9 in glioma to establish its clinical relevance and identify therapeutic strategies.MethodsMulti-omics analyses were performed using 1,033 glioma samples from TCGA and CGGA cohorts. …”
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Identification and prognostic analysis of propionate metabolism-related genes in head and neck squamous cell carcinoma by Shitong Zhou, Shitong Zhou, Yu Jiang, Panhui Xiong, Zhongwan Li, Lifeng Jia, Wei Yuan, Xiufu Liao, Xiang An, Jie Hu, Rui Luo, Hailan Mo, Hongyan Fang, Yucheng Yang

“…A prognostic model was constructed using Cox regression and LASSO analysis. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…Key genes were selected based on integration with rank-sum test results. Functional enrichment analysis was performed for these key genes. …”
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Proteomic profiling of saliva reveals association of complement system with primary Sjögren's syndrome by Mingde Li, Yajun Qi, Guizhen Wang, Su Bu, Ming Chen, Jiahui Yu, Tianyang Luo, Lulu Meng, Anran Dai, Yong Zhou, Shuai Liu, Xingxing Huo

“…Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to functionally annotate the DEPs. The protein–protein interaction (PPI) network was constructed and the core proteins were identified with the STRING website and Cytoscape software. …”
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Screening of biomarkers for diagnosing chronic kidney disease and heart failure with preserved ejection fraction through bioinformatics analysis by Can Hou, Jiayi Xu, Min Zhou, Junyu Huo, Xiaofei Wang, Wanying Jiang, Tong Su, Hui Wang, Fang Jia

“…The R software package “limma” was employed to conduct differential expression analysis. Functional annotation was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). …”
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Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth. by Aishwarya P Yadama, Hooman Mirzakhani, Thomas F McElrath, Augusto A Litonjua, Scott T Weiss

“…<h4>Objectives</h4>To investigate early pregnancy gene expression signatures associated with both vitamin D insufficiency and sPTB. We further constructed a network of these gene signatures and identified the common biological pathways involved.…”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Network modeling further uncovered coordinated interactions between JUN, HLA-A, and RAS events in immune genes, implicating their synergistic roles in modulating T cell effector functions. Conclusion: Our multi-omics integration identifies JUN and HLA-A as central coordinators of alternative splicing programs in SLE T cells. …”
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Interleukin-21 engineering enhances CD19-specific CAR-NK cell activity against B-cell lymphoma via enriched metabolic pathways by Bailin He, Hong Chen, Jiaxu Wu, Shiqiu Qiu, Qiusui Mai, Qing Zeng, Cong Wang, Shikai Deng, Zihong Cai, Xiaoli Liu, Li Xuan, Chengyao Li, Hongsheng Zhou, Qifa Liu, Na Xu

“…The phenotypic profile, transcriptomic characteristics, functionality and anti-tumor activity of CAR-21 NK cells and CAR-15 NK cells were compared. …”
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How Does Nature Create the Painting “Gradient Coloration of ‘Manicure Finger’ Grape”? Integrated Omics Unveil the Pigments Basis and Metabolism Networks of Its Formation by Shihan Bao, Jianing Li, Jiaqi Wang, Tian Lan, Mengyuan Wei, Xiangyu Sun, Yulin Fang, Tingting Ma

“…In ‘Manicure Finger’, eight anthocyanins including malvidin‐3‐O‐glucoside, peonidin‐3‐O‐glucoside, and cyanidin‐3‐O‐glucoside were identified as color‐presenting substances, while flavones and flavonols, especially kaempferol‐3‐O‐rutinoside and quercetin‐3‐O‐glucoside, functioned as co‐pigments. Spatial differences in their accumulation were substances basis for gradient coloration. …”
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Genome-wide association study and transcriptome analysis reveal candidate genes related to drought stress in the germination stage of soybean by Keke Kong, Mengge Xu, Lanhua Wu, Huiwen Zhou, Ruikai Wang, Tuanjie Zhao, Chune Wang, Yingpei Song

“…By utilizing these DEGs, a weighted gene co-expression network analysis (WGCNA) was constructed, and 13 distinct modules were obtained, among which four modules were considered as key modules. …”
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Genome-Wide Identification and Pollen-Specific Promoter Analysis of the <i>DIR</i> Gene Family in <i>Rosa chinensis</i> by Qijing Dong, Qian Yang, Zitong Wang, Yuan Zhao, Sixu Guo, Yifang Peng, Qi Li, Yu Han

“…Dirigent proteins (DIRs) are pivotal regulators of lignin/lignan biosynthesis and play multifaceted roles in plant development and stress adaptation. Despite their functional significance, <i>DIR</i> genes remain unexplored in <i>Rosa chinensis</i>, a globally important woody ornamental species. …”
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Virtual human retina: Simulating neural signalling, degeneration, and responses to electrical stimulation by Keith Ly, Michael L. Italiano, Mohit N. Shivdasani, David Tsai, Jia-Yi Zhang, Chunhui Jiang, Nigel H. Lovell, Socrates Dokos, Tianruo Guo

“…Our study additionally highlights the importance of controlling inhibitory circuits in the retinal network to induce functionally relevant retinal activity. Conclusion: This study demonstrates the potential of this software package and highlights its utility as a valuable tool for engineers, scientists, and clinicians in the design and optimization of retinal stimulation devices for both research and educational applications.…”
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