Potential Molecular Mechanisms of Paederia Foetida L. In Gout Treatment Through Network Pharmacology And Molecular Docking by Tuan Hoang Quoc, Vy Hoang Ngoc Phuong, Thu Nguyen Thi Anh, Quynh Phan Le Nhu

“…A Venn diagram was employed to determine the common targets, and Cytoscape software was used to construct the compound-target-pathway interaction network. …”
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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…Meanwhile, protein-protein interaction (PPI) networks were constructed using STRING to identify core genes. Feature selection methods such as LASSO, SVM-RFE and random forest algorithm were applied to localize possible therapeutic target genes. …”
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deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria by Yao Xiao, Yan Zhang

“…This algorithm uses a Transformer-based neural network architecture to construct an optimal model for detecting Sec-encoding UGA codons and a homology search-based strategy to remove additional false positives. …”
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Expression characteristics, molecular mechanisms, and clinical significance of DICER1 in breast cancer by Xi Zhang, Long Yu, Cuizhi Geng

“…A nomogram model was constructed based on clinical data to evaluate its prognostic value. …”
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The Role of the Arctic Economic Council in the International Legal Framework of the Arctic Ocean Environmental Governing by A. N. Vylegzhanin, N. V. Korchunov, A. R. Tevatrosyan

“…The status and the functioning of the said international forum, particularly with regard to the activities within its Working Groups, have been examined based on the analysis of the documents adopted by the forum since its establishment. …”
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Reasonable Support Parameters for Loess Tunnel Under Different Water Contents: A Case Study by Hao Chen, Yanbin Luo, Jianxun Chen, Hui Chen, Yanfeng Li, Pengkun Wang, Lele Guo

“…The research findings indicate that the strength of the surrounding rock is functionally related to its water content, with the cohesive force <i>c</i> exhibiting an exponential relationship and the angle of internal friction <i>φ</i> showing a linear relationship, and that the cohesive force <i>c</i> is more affected by changes in water content than the internal friction angle <i>φ</i>. …”
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Research on the Characteristics of Electrolytes in Integrated Carbon Capture and Utilization Systems: The Key to Promoting the Development of Green and Low-Carbon Technologies by Guoqing You, Yunzhi Li, Lihan Dong, Yichun Li, Yu Zhang

“…Ionic liquids (ILs) demonstrate unique advantages due to their tunability: imidazolium-based ILs improve formate selectivity to 85% via carboxylate intermediate formation, while amino-functionalized task-specific ILs (TSILs) achieve a 1:1 stoichiometric CO₂ absorption ratio. …”
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Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma by Xueyan Wang, Lei Gao, Haiyuan Li, Yanling Ma, Bofang Wang, Baohong Gu, Xuemei Li, Lin Xiang, Yuping Bai, Chenhui Ma, Hao Chen

“…Furthermore, we present compelling experimental evidence that PLG functions as a significant tumor promoter, suggesting its potential as a target for the formulation of tailored therapeutic strategies for HCC.…”
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Statistics on the Industry Structure of the Russian Economy and its Optimization Model by O. V. Morozov, M. A. Vasiliev

“…Optimization of the scale of industries is the formation of structural conditions for a more efficient functioning of the Russian economy; it can be recognized as a macroeconomic condition and a strategic reserve for the economic growth.…”
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Green solvents assisted de-novo synthesis and defect-engineered UiO-66 for improved CO2 adsorption and kinetics- experimental and DFT approach by Saleem Nawaz Khan, Ming Zhao

“…Furthermore, through periodic Density Functional Theory (DFT) calculations, a variety of linker defects are engineered onto the UiO-66 structure to preserve more open metal sites. …”
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Unlocking The Potential of Hybrid Models for Prognostic Biomarker Discovery in Oral Cancer Survival Analysis: A Retrospective Cohort Study by Leila Nezamabadi Farahani, Anoshirvan Kazemnejad, Mahlagha Afrasiabi, Leili Tapak

“…Concordance index (C-index), mean absolute error (MAE), mean squared error (MSE) and R-squares, were used to evaluate the performance of the models using selected features. Functional enrichment analysis was performed using DAVID database, and external validation utilized three independent datasets (GSE9844, GSE75538, GSE37991, GSE42743).Results: The findings indicated that the PSO-based method outperformed the GA-based method, achieving a smaller MAE (0.061) and MSE (0.005), R-square (0.99) and C-index (0.973), selecting 291 probes from 1069 screened. …”
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The prevalence and long-term effects of PTSD and moral injury in Swedish military veterans by Sofia Nilsson, Alicia Ohlsson, Sofia Svensén, Gerry Larsson, Gerry Larsson

“…The findings suggest that there is a considerable overlap between the two constructs. In addition, the results suggest that the risk of PTSD and MI is highest when an event is perceived as both highly stressful (fear-based) and morally challenging. …”
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Personalization of closed-chain shoulder models yields high kinematic accuracy for multiple motions by Claire V. Hammond, Heath B. Henninger, Benjamin J. Fregly, Jonathan A. Gustafson

“…Subsequently, closed-chain shoulder models including scapula, clavicle, and humerus were constructed and optimized through a two-stage personalization approach. …”
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Potential immunomodulatory effects of the extract from Artemisia frigida Willd on loaches infested with Aeromonas hydrophila revealed by microRNA analysis by Yue Zhao, Yue Zhao, Yue Zhao, Yuqing Qiu, Lishang Dai, Hong Wang

“…Further target gene prediction and functional analysis of 30 differential miRNAs showed that the target genes of these miRNAs were involved in the regulation of several innate and antibacterial immunity-related pathways, including endocytosis, apoptosis, phosphatidylinositol signaling system, RLR signaling pathway, TLR signaling pathway and NLR signaling pathway. …”
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Reactive Oxygen Species: A Double-Edged Sword in the Modulation of Cancer Signaling Pathway Dynamics by Manisha Nigam, Bajrang Punia, Deen Bandhu Dimri, Abhay Prakash Mishra, Andrei-Flavius Radu, Gabriela Bungau

“…Recent breakthroughs in redox biosensors (i.e., redox-sensitive fluorescent proteins, HyPer variants, and peroxiredoxin–FRET constructs) enable precise, real-time ROS imaging across subcellular compartments. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…VTSaRNet integrates the instance segmentation for copy&#x2013;paste mechanism (ISCP) using a Union Transformer Network that functions in both Visible (V) and Thermal (T) bimodalities. …”
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The phenomenon of the information-meaning field from a cultural-historical perspective by V.T. Kudryavtsev, K.V. Zlokazov, S.N. Enikolopov, N.V. Meshkova, M.S. Rybakova

“…The significance of information in the life and development of personality is analyzed, for which it possesses not only instrumental functions. The proposed (psychological) approach to understanding information is based on the correlation of the theoretical concepts of "information" and "meaning" within the boundaries of a person's personal world. …”
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Mental health in children with and without disabilities in a register-based Swedish sample supports the two-continua model: a latent class analysis by Lina Homman, Lilly Augustine, Mats Granlund

“…These features differed significantly between children with and without disabilities, especially relating to participation, social bonds, family functioning, digital media use, and perceived safety. …”
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2, 2′, 4, 4′-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells by Guangshan Xie, Jinping Lu, Jiayi Song, Jianqing Zhang

“…Given the pivotal role of the V-Raf murine sarcoma viral oncogene homolog B (BRAF) and the downstream mitogen-activated protein kinase kinase (MEK)- signal-regulated kinase (ERK) pathway in cell proliferation, differentiation, cell cycle and thyroid functions, in this study, we constructed BRAF knockout (BRAF-KO) and overexpression (BRAF-OE) cell models using Nthy-ori 3-1 cells, to evaluate the effect of BDE-47 on human thyroid cells and explore the potential mechanisms. …”
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LncRNA-TUG1: Implications in the Myocardial and Endothelial Cell Oxidative Stress Injury Caused by Hemorrhagic Shock and Fluid Resuscitation by Wei Li, Huaiyu Chen, Xueli Zhu, Mingrui Lin

“…Myocardial functional impairment was assessed via Triphenyl-2H-Tetrazolium Chloride (TTC), Hematoxylin and eosin, and Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) stainings. …”
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