The meaning of “total pain” in the context of living and dying with dementia by Sarah Elizabeth Field-Richards, Louise Bramley, Jemima Collins, Alison Cowley, Rowan Harwood

“…The holistic focus of “total pain” should be extended to incorporate balanced consideration of “painful” and “functional” experience. We introduce a balanced model of total pain incorporating a dual focus on “pain” and “personhood” within a critical context, to facilitate translation to practice. …”
Get full text

New energy effect in non-cylindrical domains with a thermally insulated moving boundary by E. M. Kartashov

“…A new mathematical apparatus for the equivalence of functional constructions for the originals of the obtained operational solutions, which considers the computational difficulties in finding analytical solutions to boundary value problems for equations of hyperbolic type in the domain with a moving boundary, is developed.Results. …”
Get full text

How do strategic attributes of electronic commerce impel the perceived value and electronic loyalty of online food delivery applications (OFDAs) by Muhammad Asif Zaheer, Tanveer Muhammad Anwar, Zoia Khan, Muhammad Ali Raza, Hira Hafeez

“…In this globalized world and competitive environment, e-commerce demands have increased and organizations are giving special attention to web development, website design and functions to hold the current consumers with sustainable performance in the globalized and competitive environment. …”
Get full text

A novel bispecific aptamer targeting LAG3 and HER2 enhances T cell-mediated immunotherapy against HER2-positive cancer cells by Rui Guo, Xiaoyang Chen, Lu Ying, Wenjing Zhang, Zufa Sabeel, Lianhui Zhao, Jian Dong, Yiyang Dong, Zhao Yang

“…Herein, we developed a novel bispecific aptamer (HLB-apt) to investigate its dual-targeting therapeutic potential in regulating tumor-immune cell interactions.MethodFirstly, the Moe algorithm was used to simulate the docking results between the aptamer and the corresponding protein. Then, the constructed HLB-apt was validated. In addition, based on A549, HepG2 cells and Jurkat cells, the functions and mechanisms of HLB-apt acting simultaneously with A549, HepG2 cells and Jurkat cells were verified through in vivo and in vitro experiments.ResultsHLB-apt demonstrated specific binding capacity to both HER2-expressing tumor cells (A549 and HepG2) and LAG3-positive Jurkat cells. …”
Get full text

Identification of Plasma Exosomes hsa_circ_0001360 and hsa_circ_0000038 as Key Biomarkers of Coronary Heart Disease by Wan Zhang, Jiasen Cui, Li Li, Ting Zhu, Zhenyu Guo

“…LncRNAs/circRNAs and mRNAs with the cotargeted miRNAs were selected to construct an interaction network. Multiple machine learning algorithms have been used to explore potential biomarkers, followed by verification in patients with CHD using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR). …”
Get full text

STYLISTIC NEOLOGISMS IN ENGLISH-LANGUAGE CHICK LIT: MORPHOSEMANTIC ASPECT by Maryna A. Bielova

“…As such, they stand out as means of conveying humor, playfulness, and creativity, as well as serve as tools to build and maintain relationships, construct identities and the world around them, mitigate and persuade. …”
Get full text

Research progress on high-entropy alloys for extreme loading environments by GAO Wei, ZHOU Xichen, ZHU Qianyong, PANG Shujie, ZHAO Shiteng

“…They have fundamentally challenged traditional design paradigms and exhibited exceptional mechanical properties and functional characteristics，thereby positioning themselves as promising candidates for significant engineering applications in the future. …”
Get full text

Identification of cell-type-specific, transcriptionally active transposable elements using long-read RNA-sequencing data-based comprehensive annotation by Chaemin Lim, Hyunsu An, Jihwan Park

“…Abstract Background The biological functions of transposable element (TE)-derived transcripts during physiological development, disease development, and progression have been previously reported. …”
Get full text

Soil Health Assessment in the Qinling Reclamation Area Based on Minimum Data Set and Risk Index by ZHANG Le, LI Chunyue, GAO Chuanyu, GUO Huan, LI Yifan

“…［Objective］ To explore the impact of different vegetation types on soil health in the Qinling region, to assess the relationship between aboveground plants and soil health, and construct a comprehensive soil quality health evaluation model. …”
Get full text

Identification of small molecule drugs and development of a novel autophagy‐related prognostic signature for kidney renal clear cell carcinoma by Qianwei Xing, Chengjian Ji, Bingye Zhu, Rong Cong, Yi Wang

“…Then, networks between TFs and ARGs, gene ontology functional annotations and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were conducted. …”
Get full text

Simulation Analysis of Water Resource Scheduling in Nansu River Based on Coupled Water Quality-Quantity Model by HOU Xiang-dong, ZHAO Xiang-ling

“…A one-dimensional hydrodynamic-water environment coupled MIKE11 model was constructed, utilizing chemical oxygen demand (COD) and ammonia nitrogen (NH3-N) as key indicators. …”
Get full text

Multidimensional Environmental Drivers of Bamboo Species Richness on Subtropical Islands by Weifeng Zhan, Yanqiu Xie, Xinran Xie, Zujian Chen, Chuanyuan Deng, Hui Huang

“…Furthermore, a partial least squares structural equation model (PLS-SEM) was constructed to explore the driving mechanisms underlying bamboo species richness. …”
Get full text

Critical gene network and signaling pathway analysis of the extracellular signal-regulated kinase (ERK) pathway in ischemic stroke by Rui Mao, Lei Wang, Haitao Zhang, Jiaojiao Gong, Hua Liu

“…Gene Ontology (GO) enrichment and protein–protein interaction (PPI) network analyses further elucidated the functional and interaction landscapes of the key ERK pathway genes, collectively termed GSERK. …”
Get full text

Arthroscopic Superior Capsular Reconstruction With Knotless Double-Row Dermal Allograft and Margin Convergence Augmentation by Jonathan D. Groothoff MA, Thomas W. Mason BS, Anthony P. Fiegen MD, Jelle P. van der List MD PhD, Brian R. Waterman MD

“…Graft augmentation to strengthen the overall construct reduces this risk. Dermal allografts less than 3 mm thick are associated with greater failure rates. …”
Get full text

Bibliometric analysis of scientific literature on the use of suppositories in the treatment of prostate cancer patients by I. V. Bushuieva, M. V. Parchenko, O. O. Maliuhina

“…Using the VOSviewer functional program, bibliometric networks were constructed and visualized. …”
Get full text

Intractable prefrontal and limbic white matter network disruption in adolescents with drug-naïve nonsuicidal self-injury by Yuwei Chen, Xiongxiong Yang, Kaike Liao, Rui Yu, Xinyue Chen, Wenjing Zhang, Nian Liu

Get full text

Novel and conserved drought-responsive microRNAs expression analysis in root tissues of wheat (Triticum asetivum L.) at reproductive stage by Pradeep Sharma, Shefali Mishra, Amandeep Kaur, O. P. Ahlawat, Ratan Tiwari

“…The integration of sequencing, computational analysis, and qRT-PCR validation strengthens the utility of these findings for future functional genomics studies and breeding programs aimed at developing drought-tolerant wheat varieties.…”
Get full text

Integrated analysis of microRNA and mRNA interactions regulating fecundity in the ovaries of two distinct sheep breeds by Salsabeel Yousuf, Waqar Afzal Malik, Hui Feng, Tianyi Liu, Lingli Xie, Xiangyang Miao

“…Subsequently, we constructed a DEmiRNA-mRNA regulatory network, highlighting candidate miRNA-mRNA pairs like chi-miR-130a-3p-WNT2B, oar-miR-103-FSHR, and oar-miR-16b-AMH. …”
Get full text

Identification of prognostic and therapeutic biomarkers associated with macrophage and lipid metabolism in pancreatic cancer by Lili Wu, Feihong Liang, Changgan Chen, Yaxin Zhang, Heguang Huang, Yu Pan

“…Regression analyses were performed to pinpoint potential biomarkers and construct a risk model, which underwent evaluation. …”
Get full text

Internal Speech in Natural Discourse Communication: A Systematic Review and Modeling by Лариса Калмикова, Наталія Харченко, Георгій Калмиков, Інна Мисан, Віктор Коцур

“…These models are logical (sign models) constructions, that recreate certain descriptions of the investigated object, and give new information about it. …”
Get full text